List by Alphabet: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

humanized mouse models

Humanized mouse models are genetically modified mice that have been engrafted with human tissues, cells, or genes. These models are used in biomedical research to study human diseases and the human immune system in an in vivo setting. Humanized mice are valuable tools for understanding human biology and for developing and testing new therapies, especially when ethical or practical constraints limit the use of human subjects. Here are the key aspects of humanized mouse models:

1. Human Immune System Mice: One common type of humanized mouse is created by transplanting human hematopoietic stem cells (HSCs) into immunodeficient mice. These mice develop human immune cells, allowing researchers to study the human immune system in vivo.

2. Disease Models: Humanized mice are used to model various human diseases, including cancer, infectious diseases (like HIV), and autoimmune diseases. They are particularly useful for diseases where the human immune response plays a crucial role.

3. Drug Testing and Development: These models are extensively used in the preclinical testing of new drugs, including immunotherapies for cancer and treatments for autoimmune diseases. They provide valuable insights into how these therapies might work in humans.

4. Human Tissue Transplantation: In addition to HSCs, humanized mice can be engrafted with other types of human tissues, such as liver, skin, or tumors (xenografts), to study organ-specific diseases and treatments.

5. Genetic Modifications: Some humanized mouse models are genetically modified to express human genes. For example, mice can be engineered to express humanized versions of immune checkpoint molecules, which are important targets in cancer immunotherapy.

6. Ethical Considerations: Humanized mice offer an ethical alternative to using primates or conducting early-stage studies in humans, but they are still subject to ethical considerations and regulations regarding the use of animals in research.

7. Limitations: While humanized mice are powerful research tools, they are not perfect models of human biology. Differences in species-specific factors and the fact that these mice still contain some mouse cells can limit the translation of findings to humans.

8. Technological Advances: The development of humanized mouse models is a rapidly evolving field, with ongoing improvements in the methods used to create and use these models.

Humanized mouse models represent a significant advancement in the ability to study human diseases and test therapies in a living organism. They provide a more relevant physiological context than in vitro studies and are particularly valuable for studying human-specific pathogens and immune responses.


Related Biology Tools

  • GenSmart™ Codon Optimization

    GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.

    Learn More

  • DNA Construct Design Tool

    GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.

    Learn More

  • Codon Frequency Tables

    This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.

    Learn More

Service and Products

Antibody Production Services

Comprehensive custom antibody production services including monoclonal and polyclonal antibody production services with industry leading turnaround times.

Polyclonal Antibody Services

The fastest custom polyclonal antibody production services in the industry with unmatched guarantees.

Custom Monoclonal Antibody Development Services

Developing custom monoclonal antibodies with standard or fully custom protocols including everything from antigen synthesis to antibody scale-up options.

Phospho-Specific Antibody Services

Guaranteed ELISA titer of ≥ 1:64,000 and < 10% cross reactivity with non-phospho peptide.

Immunoassay Development Services

Our custom immunoassay development service offering comprehensive high-throughput assay development with fast turnaround and high efficiency.

Large-scale Antibody Manufacturing

Our large-scale antibody manufacturing services offer polyclonal and monoclonal antibody production of gram quantities for industrial antibody yields.

COVID-19 Reagent Antibodies

On demand SARS-CoV-2 control mAbs ideal for diagnostics, therapeutic, and vaccine development.

If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]

If your term is adopted, we will send 1,000 EzCoupon points to your GenScript account.
feedback

Do you like the current new website?

Hate

Dislike

Neutral

Like

Love

*