| Gene Symbol | lis-1 |
| Entrez Gene ID | 176758 |
| Full Name | Lissencephaly-1 homolog |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
IVD Raw Materials
ORF » Species Summary » Caenorhabditis elegans » lis-1 cDNA ORF clone
| Gene Symbol | lis-1 |
| Entrez Gene ID | 176758 |
| Full Name | Lissencephaly-1 homolog |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
| mRNA | Protein | Name |
|---|---|---|
| NM_067354.6 | NP_499755.1 | Lissencephaly-1 homolog |
| NM_067354.5 | NP_499755.1 | Lissencephaly-1 homolog |
| Gallus gallus (chicken) | PAFAH1B1 | NP_989655.1 |
| Pan troglodytes (chimpanzee) | PAFAH1B1 | NP_001029263.1 |
| Mus musculus (house mouse) | Pafah1b1 | NP_038653.1 |
| Danio rerio (zebrafish) | pafah1b1a | NP_958502.1 |
| Caenorhabditis elegans (roundworm) | lis-1 | NP_499755.1 |
| Xenopus tropicalis (tropical clawed frog) | pafah1b1 | NP_991399.1 |
| Bos taurus (cattle) | PAFAH1B1 | NP_777088.1 |
| PAFAH1B1 | XP_001087675.1 | |
| Rattus norvegicus (Norway rat) | Pafah1b1 | NP_113951.1 |
| Homo sapiens (human) | PAFAH1B1 | NP_000421.1 |
| Canis lupus familiaris (dog) | PAFAH1B1 | XP_854482.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_09369 | XP_003720251.1 |
| Neurospora crassa | NCU04534 | XP_956945.2 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
lis-1 induces a spindle checkpoint-dependent mitotic arrest in the germline and an increase in germ-cell apoptosis.
Title: Progression from mitotic catastrophe to germ cell death in Caenorhabditis elegans lis-1 mutants requires the spindle checkpoint.
Dynein and Lis1, albeit functioning in identical processes, are targeted partially independently of one another.
Title: lis-1 is required for dynein-dependent cell division processes in C. elegans embryos.
The convulsions mimicking epilepsy can be induced by a mutation in a C. elegans lis-1 allele (pnm-1), in combination with a chemical antagonist of gamma-aminobutyric acid (GABA) neurotransmitter signaling.
Title: Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
The following lis-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the lis-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OCa340257 | |
| Clone ID Related Accession (Same CDS sequence) | NM_067354.6 , NM_067354.5 | |
| Accession Version | NM_067354.6 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | Lissencephaly-1 homolog | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_067354.5. | |
1 | ATGAGTTTGT CGGAGAGGCA AAAAGAAGAA ATCAATCGGG CGATCGCCGA ATATATGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_499755.1 |
| CDS | 72..1286 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_067354.6 |
1 | ATGAGTTTGT CGGAGAGGCA AAAAGAAGAA ATCAATCGGG CGATCGCCGA ATATATGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa340257 | |
| Clone ID Related Accession (Same CDS sequence) | NM_067354.6 , NM_067354.5 | |
| Accession Version | NM_067354.5 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | Lissencephaly-1 homolog | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_067354.4. COMPLETENESS: incomplete on both ends. | |
1 | ATGAGTTTGT CGGAGAGGCA AAAAGAAGAA ATCAATCGGG CGATCGCCGA ATATATGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_499755.1 |
| CDS | 1..1215 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_067354.5 |
1 | ATGAGTTTGT CGGAGAGGCA AAAAGAAGAA ATCAATCGGG CGATCGCCGA ATATATGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |