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ADARB2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol ADARB2
Entrez Gene ID 105
Full Name adenosine deaminase, RNA-specific, B2 (non-functional)
Synonyms ADAR3, RED2
General protein information
Preferred Names
double-stranded RNA-specific editase B2
Names
double-stranded RNA-specific editase B2
RED2 homolog
homolog of rat BLUE
RNA-editing enzyme 2
RNA-editing deaminase 2
dsRNA adenosine deaminase B2
RNA-dependent adenosine deaminase 3
adenosine deaminase, RNA-specific, B2 (RED1 homolog rat)
adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10p15.3

Summary This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602065


mRNA and Protein(s)

mRNA Protein Name
NM_018702 NP_061172 double-stranded RNA-specific editase B2


Homo sapiens (human) ADARB2 NP_061172.1
Pan troglodytes (chimpanzee) ADARB2 XP_003312479.1
Canis lupus familiaris (dog) ADARB2 XP_005617264.1
Bos taurus (cattle) ADARB2 NP_001179517.1
Mus musculus (house mouse) Adarb2 NP_443209.2
Rattus norvegicus (Norway rat) Adarb2 NP_579836.1
Gallus gallus (chicken) ADARB2 XP_418563.4
Danio rerio (zebrafish) adarb2 XP_686426.5
Xenopus (Silurana) tropicalis (western clawed frog) adarb2 XP_002935222.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ADARB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADARB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu22812
NM_018702 Homo sapiens adenosine deaminase, RNA-specific, B2 (non-functional) (ADARB2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$279.50-$391.30
$559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu22812
Clone ID Related Accession (Same CDS sequence) NM_018702
Accession Version NM_018702.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2220bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product double-stranded RNA-specific editase B2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF034837.1, BC140852.1 and AL392083.17. On Jun 1, 2011 this sequence version replaced gi:161377416. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF034837.1, BC137477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
ATGGCCTCGG TCCTGGGGAG CGGCAGAGGG TCTGGAGGGC TGAGCAGTCA ACTCAAATGC 
AAGTCCAAGA GGAGGAGGAG GCGGAGGTCC AAGCGGAAAG ATAAAGTAAG CATATTGTCA
ACCTTCCTCG CTCCTTTCAA GCACCTGAGT CCTGGCATCA CAAACACGGA GGATGACGAC
ACCCTCAGTA CCAGCAGCGC GGAGGTGAAG GAGAACCGCA ACGTGGGCAA CCTGGCCGCG
CGGCCACCGC CCTCCGGGGA CCGGGCCCGG GGCGGCGCGC CCGGCGCGAA GAGGAAGCGG
CCGCTGGAGG AGGGGAATGG GGGCCACTTG TGCAAACTGC AGCTGGTCTG GAAGAAGCTG
TCGTGGTCGG TGGCGCCCAA GAACGCGCTG GTGCAGCTGC ACGAGCTGAG GCCGGGCCTG
CAGTACCGGA CAGTGTCGCA GACGGGCCCG GTGCATGCCC CGGTCTTCGC GGTAGCGGTG
GAGGTGAACG GGCTCACGTT CGAGGGCACA GGCCCCACCA AGAAGAAGGC CAAGATGCGC
GCGGCGGAGC TGGCACTCAG GTCCTTCGTG CAGTTCCCCA ACGCCTGCCA GGCGCACCTG
GCCATGGGCG GGGGCCCGGG CCCCGGCACG GACTTCACCT CCGACCAGGC CGATTTCCCC
GACACGCTCT TCCAGGAGTT CGAGCCCCCG GCGCCGCGCC CCGGACTCGC GGGAGGCCGC
CCCGGGGACG CCGCGCTTCT GTCCGCGGCC TACGGGCGAC GGCGGCTGCT GTGCCGCGCG
CTGGACCTGG TGGGCCCGAC CCCCGCCACC CCCGCGGCCC CGGGCGAGCG CAACCCCGTG
GTGCTGCTGA ACCGCCTGCG CGCCGGGCTG CGCTACGTGT GTCTGGCAGA ACCGGCCGAG
CGGCGCGCGC GGAGCTTCGT GATGGCCGTG AGCGTGGACG GCAGGACGTT CGAGGGCTCG
GGGCGCAGCA AGAAGCTGGC CCGGGGTCAG GCCGCGCAGG CCGCACTGCA GGAGCTGTTC
GACATCCAGA TGCCCGGCCA CGCGCCCGGC AGGGCCAGGA GGACGCCAAT GCCGCAGGAA
TTCGCAGACT CCATATCCCA GCTGGTCACA CAGAAGTTCC GCGAGGTGAC GACGGACCTC
ACGCCCATGC ACGCCCGCCA TAAAGCGCTG GCAGGAATCG TCATGACCAA AGGCCTGGAT
GCTCGGCAGG CGCAGGTCGT GGCCCTGTCC TCGGGGACCA AGTGCATCAG CGGCGAGCAC
CTCAGTGACC AGGGGCTGGT GGTGAATGAC TGCCACGCGG AGGTCGTGGC CCGGCGGGCG
TTCCTGCACT TCCTCTACAC GCAGCTGGAG CTGCACCTGA GCAAGCGGCG CGAGGACTCA
GAGCGATCGA TATTCGTGCG GTTAAAAGAA GGTGGCTACC GGCTGCGAGA GAACATCCTC
TTCCATCTCT ACGTGAGCAC CTCCCCCTGT GGAGACGCAA GACTCCACTC TCCCTACGAG
ATCACCACAG ACCTGCACAG CAGCAAACAC CTCGTCAGGA AGTTCCGCGG GCACCTGCGC
ACCAAGATCG AGTCCGGGGA AGGGACGGTC CCCGTGCGTG GCCCCAGCGC AGTGCAGACC
TGGGACGGCG TCCTGCTGGG GGAGCAGCTG ATCACCATGT CCTGCACGGA CAAGATCGCC
AGGTGGAACG TCCTGGGGCT GCAGGGCGCG CTCCTGTCCC ACTTCGTGGA GCCCGTGTAC
CTGCAGAGCA TCGTGGTGGG CAGCCTGCAC CACACGGGCC ACCTCGCACG CGTCATGAGC
CACCGCATGG AGGGTGTCGG CCAGCTGCCC GCCTCCTACC GGCACAACCG GCCTCTCCTC
AGCGGCGTGA GTGACGCCGA GGCGCGCCAG CCGGGGAAGT CGCCCCCCTT CAGCATGAAC
TGGGTCGTGG GCAGCGCGGA CCTGGAGATT ATCAACGCCA CCACTGGGCG GAGGAGCTGT
GGGGGCCCAT CCCGGCTCTG CAAGCACGTG CTGTCTGCAC GGTGGGCGCG GCTGTATGGC
AGGCTGAGCA CACGGACACC CAGCCCTGGA GACACGCCCT CCATGTACTG TGAGGCCAAG
CTGGGGGCGC ACACCTACCA GTCTGTGAAA CAGCAGCTGT TCAAGGCCTT TCAGAAGGCT
GGCCTGGGCA CCTGGGTGAG GAAACCACCG GAGCAGCAGC AGTTTCTACT GACTCTCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_061172.1
CDS327..2546
Misc Feature(1)147..149(+)
Misc Feature(2)393..431(+)
Misc Feature(3)702..893(+)
Misc Feature(4)717..860(+)
Misc Feature(5)1158..1343(+)
Misc Feature(6)1158..1310(+)
Misc Feature(7)1407..2534(+)
Exon (1)1..426
Gene:ADARB2
Gene Synonym:
Exon (2)427..513
Gene:ADARB2
Gene Synonym:
Exon (3)514..1403
Gene:ADARB2
Gene Synonym:
Exon (4)1404..1518
Gene:ADARB2
Gene Synonym:
Exon (5)1519..1687
Gene:ADARB2
Gene Synonym:
Exon (6)1688..1839
Gene:ADARB2
Gene Synonym:
Exon (7)1840..2008
Gene:ADARB2
Gene Synonym:
Exon (8)2009..2190
Gene:ADARB2
Gene Synonym:
Exon (9)2191..2369
Gene:ADARB2
Gene Synonym:
Exon (10)2370..8426
Gene:ADARB2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_018702
Organism Homo sapiens (human)
Definition Homo sapiens adenosine deaminase, RNA-specific, B2 (non-functional) (ADARB2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_018702

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
ATGGCCTCGG TCCTGGGGAG CGGCAGAGGG TCTGGAGGGC TGAGCAGTCA ACTCAAATGC 
AAGTCCAAGA GGAGGAGGAG GCGGAGGTCC AAGCGGAAAG ATAAAGTAAG CATATTGTCA
ACCTTCCTCG CTCCTTTCAA GCACCTGAGT CCTGGCATCA CAAACACGGA GGATGACGAC
ACCCTCAGTA CCAGCAGCGC GGAGGTGAAG GAGAACCGCA ACGTGGGCAA CCTGGCCGCG
CGGCCACCGC CCTCCGGGGA CCGGGCCCGG GGCGGCGCGC CCGGCGCGAA GAGGAAGCGG
CCGCTGGAGG AGGGGAATGG GGGCCACTTG TGCAAACTGC AGCTGGTCTG GAAGAAGCTG
TCGTGGTCGG TGGCGCCCAA GAACGCGCTG GTGCAGCTGC ACGAGCTGAG GCCGGGCCTG
CAGTACCGGA CAGTGTCGCA GACGGGCCCG GTGCATGCCC CGGTCTTCGC GGTAGCGGTG
GAGGTGAACG GGCTCACGTT CGAGGGCACA GGCCCCACCA AGAAGAAGGC CAAGATGCGC
GCGGCGGAGC TGGCACTCAG GTCCTTCGTG CAGTTCCCCA ACGCCTGCCA GGCGCACCTG
GCCATGGGCG GGGGCCCGGG CCCCGGCACG GACTTCACCT CCGACCAGGC CGATTTCCCC
GACACGCTCT TCCAGGAGTT CGAGCCCCCG GCGCCGCGCC CCGGACTCGC GGGAGGCCGC
CCCGGGGACG CCGCGCTTCT GTCCGCGGCC TACGGGCGAC GGCGGCTGCT GTGCCGCGCG
CTGGACCTGG TGGGCCCGAC CCCCGCCACC CCCGCGGCCC CGGGCGAGCG CAACCCCGTG
GTGCTGCTGA ACCGCCTGCG CGCCGGGCTG CGCTACGTGT GTCTGGCAGA ACCGGCCGAG
CGGCGCGCGC GGAGCTTCGT GATGGCCGTG AGCGTGGACG GCAGGACGTT CGAGGGCTCG
GGGCGCAGCA AGAAGCTGGC CCGGGGTCAG GCCGCGCAGG CCGCACTGCA GGAGCTGTTC
GACATCCAGA TGCCCGGCCA CGCGCCCGGC AGGGCCAGGA GGACGCCAAT GCCGCAGGAA
TTCGCAGACT CCATATCCCA GCTGGTCACA CAGAAGTTCC GCGAGGTGAC GACGGACCTC
ACGCCCATGC ACGCCCGCCA TAAAGCGCTG GCAGGAATCG TCATGACCAA AGGCCTGGAT
GCTCGGCAGG CGCAGGTCGT GGCCCTGTCC TCGGGGACCA AGTGCATCAG CGGCGAGCAC
CTCAGTGACC AGGGGCTGGT GGTGAATGAC TGCCACGCGG AGGTCGTGGC CCGGCGGGCG
TTCCTGCACT TCCTCTACAC GCAGCTGGAG CTGCACCTGA GCAAGCGGCG CGAGGACTCA
GAGCGATCGA TATTCGTGCG GTTAAAAGAA GGTGGCTACC GGCTGCGAGA GAACATCCTC
TTCCATCTCT ACGTGAGCAC CTCCCCCTGT GGAGACGCAA GACTCCACTC TCCCTACGAG
ATCACCACAG ACCTGCACAG CAGCAAACAC CTCGTCAGGA AGTTCCGCGG GCACCTGCGC
ACCAAGATCG AGTCCGGGGA AGGGACGGTC CCCGTGCGTG GCCCCAGCGC AGTGCAGACC
TGGGACGGCG TCCTGCTGGG GGAGCAGCTG ATCACCATGT CCTGCACGGA CAAGATCGCC
AGGTGGAACG TCCTGGGGCT GCAGGGCGCG CTCCTGTCCC ACTTCGTGGA GCCCGTGTAC
CTGCAGAGCA TCGTGGTGGG CAGCCTGCAC CACACGGGCC ACCTCGCACG CGTCATGAGC
CACCGCATGG AGGGTGTCGG CCAGCTGCCC GCCTCCTACC GGCACAACCG GCCTCTCCTC
AGCGGCGTGA GTGACGCCGA GGCGCGCCAG CCGGGGAAGT CGCCCCCCTT CAGCATGAAC
TGGGTCGTGG GCAGCGCGGA CCTGGAGATT ATCAACGCCA CCACTGGGCG GAGGAGCTGT
GGGGGCCCAT CCCGGCTCTG CAAGCACGTG CTGTCTGCAC GGTGGGCGCG GCTGTATGGC
AGGCTGAGCA CACGGACACC CAGCCCTGGA GACACGCCCT CCATGTACTG TGAGGCCAAG
CTGGGGGCGC ACACCTACCA GTCTGTGAAA CAGCAGCTGT TCAAGGCCTT TCAGAAGGCT
GGCCTGGGCA CCTGGGTGAG GAAACCACCG GAGCAGCAGC AGTTTCTACT GACTCTCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

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Del-Aguila JL, Beitelshees AL, Cooper-Dehoff RM, Chapman AB, Gums JG, Bailey K, Gong Y, Turner ST, Johnson JA and Boerwinkle E.


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Nat. Genet. 45 (8), 912-917 (2013)
Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimaki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schurks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Farkkila M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM, Zielman R, Heath AC, Madden PA, Montgomery GW, Martin NG, Borck G, Gobel H, Heinze A, Heinze-Kuhn K, Williams FM, Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkila K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG, Traynor BJ, Trabzuni D, Rossin E, Lage K, Jacobs SB, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman DI and Palotie A.


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A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration
Exp. Gerontol. 47 (2), 183-187 (2012)
Oguro R, Kamide K, Katsuya T, Akasaka H, Sugimoto K, Congrains A, Arai Y, Hirose N, Saitoh S, Ohishi M, Miura T and Rakugi H.


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Am. J. Respir. Crit. Care Med. 183 (1), 43-49 (2011)
Kong X, Cho MH, Anderson W, Coxson HO, Muller N, Washko G, Hoffman EA, Bakke P, Gulsvik A, Lomas DA, Silverman EK and Pillai SG.


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Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines
Genome Res. 20 (11), 1482-1492 (2010)
Niu N, Qin Y, Fridley BL, Hou J, Kalari KR, Zhu M, Wu TY, Jenkins GD, Batzler A and Wang L.


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Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae
PLoS Genet. 5 (2), E1000365 (2009)
Lowe JK, Maller JB, Pe'er I, Neale BM, Salit J, Kenny EE, Shea JL, Burkhardt R, Smith JG, Ji W, Noel M, Foo JN, Blundell ML, Skilling V, Garcia L, Sullivan ML, Lee HE, Labek A, Ferdowsian H, Auerbach SB, Lifton RP, Newton-Cheh C, Breslow JL, Stoffel M, Daly MJ, Altshuler DM and Friedman JM.


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A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease
Am. J. Hum. Genet. 78 (1), 78-88 (2006)
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrieze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J and Goate A.


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Nucleolar proteome dynamics
Nature 433 (7021), 77-83 (2005)
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI and Mann M.


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A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains
RNA 6 (5), 755-767 (2000)
Chen CX, Cho DS, Wang Q, Lai F, Carter KC and Nishikura K.


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Localization of a novel human RNA-editing deaminase (hRED2 or ADARB2) to chromosome 10p15
Hum. Genet. 100 (3-4), 398-400 (1997)
Mittaz L, Antonarakis SE, Higuchi M and Scott HS.


 
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