Gene Symbol | OCIAD2 |
Entrez Gene ID | 132299 |
Full Name | OCIA domain containing 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
ORF » Species Summary » Homo sapiens » OCIAD2 cDNA ORF clone
gRNAs
Gene Symbol | OCIAD2 |
Entrez Gene ID | 132299 |
Full Name | OCIA domain containing 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001286773.1 | NP_001273702.1 | OCIA domain-containing protein 2 isoform 2 |
NM_152398.3 | NP_689611.1 | OCIA domain-containing protein 2 isoform 2 |
NM_001014446.2 | NP_001014446.1 | OCIA domain-containing protein 2 isoform 1 |
NM_001286774.1 | NP_001273703.1 | OCIA domain-containing protein 2 isoform 3 |
NM_001014446.3 | NP_001014446.1 | OCIA domain-containing protein 2 isoform 1 |
Xenopus tropicalis (tropical clawed frog) | ociad2 | NP_001037952.1 |
Danio rerio (zebrafish) | ociad2 | NP_001038321.1 |
OCIAD2 | XP_001104131.1 | |
Bos taurus (cattle) | OCIAD2 | NP_001029430.1 |
Canis lupus familiaris (dog) | OCIAD2 | XP_003431872.1 |
Homo sapiens (human) | OCIAD2 | NP_001014446.1 |
Pan troglodytes (chimpanzee) | OCIAD2 | XP_003310442.1 |
Mus musculus (house mouse) | Ociad2 | NP_081226.1 |
Rattus norvegicus (Norway rat) | Ociad2 | NP_001258110.1 |
OCIAD2 suppressed tumor growth and invasion via AKT pathway in Hepatocelluar carcinoma.
Wu D, Yang X, Peng H, Guo D, Zhao W, Zhao C, Zhou X
Carcinogenesis38(9)910-919(2017 Sep)
OCIAD2 activates ?-secretase to enhance amyloid ? production by interacting with nicastrin.
Han J, Jung S, Jang J, Kam TI, Choi H, Kim BJ, Nah J, Jo DG, Nakagawa T, Nishimura M, Jung YK
Cellular and molecular life sciences : CMLS71(13)2561-76(2014 Jul)
Pathway bridge based multiobjective optimization approach for lurking pathway prediction.
Zhang R, Zhao C, Xiong Z, Zhou X
BioMed research international2014351095(2014)
Increased expression of OCIA domain containing 2 during stepwise progression of ovarian mucinous tumor.
Nagata C, Kobayashi H, Sakata A, Satomi K, Minami Y, Morishita Y, Ohara R, Yoshikawa H, Arai Y, Nishida M, Noguchi M
Pathology international62(7)471-6(2012 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
these data indicate that reduced expression of OCIAD2 by DNA hypermethylation plays an important role in hepatocellular carcinoma tumor growth and invasion.
Title: OCIAD2 suppressed tumor growth and invasion via AKT pathway in Hepatocelluar carcinoma.
OCIAD2 also increased the interaction of nicastrin with C99 and stimulated APP processing via gamma-secretase activation, but did not affect Notch processing
Title: OCIAD2 activates ?-secretase to enhance amyloid ? production by interacting with nicastrin.
it well explained the mechanism of TGFbeta induced OCIAD2 expression in cancer microenvironment, therefore providing an important clue for the future functional analysis of OCIAD2 in tumor pathogenesis.
Title: Pathway bridge based multiobjective optimization approach for lurking pathway prediction.
Like OCIAD1, OCIAD2 is a cancer-related protein and its expression level increases during the course of malignant progression and is thought to be a very useful marker for evaluating the malignancy of ovarian mucinous tumors.
Title: Increased expression of OCIA domain containing 2 during stepwise progression of ovarian mucinous tumor.
The following OCIAD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OCIAD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu04151![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001014446.2 , NM_001014446.3 | |
Accession Version | NM_001014446.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-23 | |
Organism | Homo sapiens(human) | |
Product | OCIA domain-containing protein 2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI546814.1 and AK298305.1. On Nov 15, 2013 this sequence version replaced NM_001014446.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: BG748993.1, AK298305.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTTCAG CGTCTGCTCG TGGAAACCAA GATAAAGATG CCCATTTTCC ACCACCAAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001014446.1 |
CDS | 234..698 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTTCAG CGTCTGCTCG TGGAAACCAA GATAAAGATG CCCATTTTCC ACCACCAAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu04151![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001014446.2 , NM_001014446.3 | |
Accession Version | NM_001014446.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-25 | |
Organism | Homo sapiens(human) | |
Product | OCIA domain-containing protein 2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK298305.1 and AC105444.2. On May 17, 2019 this sequence version replaced NM_001014446.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK298305.1, AW248322.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000508632.6/ ENSP00000423014.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTTCAG CGTCTGCTCG TGGAAACCAA GATAAAGATG CCCATTTTCC ACCACCAAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001014446.1 |
CDS | 180..644 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTTCAG CGTCTGCTCG TGGAAACCAA GATAAAGATG CCCATTTTCC ACCACCAAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05711![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001286773.1 , NM_152398.3 | |
Accession Version | NM_001286773.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-12-22 | |
Organism | Homo sapiens(human) | |
Product | OCIA domain-containing protein 2 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI546814.1, W68799.1, BC032808.1 and BG748993.1. Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform. ##Evidence-Data-START## Transcript exon combination :: W68799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTTCAG CGTCTGCTCG TGGAAACCAA GATAAAGATG CCCATTTTCC ACCACCAAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001273702.1 |
CDS | 257..556 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTTCAG CGTCTGCTCG TGGAAACCAA GATAAAGATG CCCATTTTCC ACCACCAAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05711![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001286773.1 , NM_152398.3 | |
Accession Version | NM_152398.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-12-22 | |
Organism | Homo sapiens(human) | |
Product | OCIA domain-containing protein 2 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI546814.1, BC032808.1 and BG748993.1. On Nov 15, 2013 this sequence version replaced NM_152398.2. Transcript Variant: This variant (2) lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform. ##Evidence-Data-START## Transcript exon combination :: BC032808.1, BG167015.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTTCAG CGTCTGCTCG TGGAAACCAA GATAAAGATG CCCATTTTCC ACCACCAAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_689611.1 |
CDS | 234..533 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTTCAG CGTCTGCTCG TGGAAACCAA GATAAAGATG CCCATTTTCC ACCACCAAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05712 | |
Clone ID Related Accession (Same CDS sequence) | NM_001286774.1 | |
Accession Version | NM_001286774.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-12-22 | |
Organism | Homo sapiens(human) | |
Product | OCIA domain-containing protein 2 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI546814.1, BU508058.1 and BG748993.1. Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.704216.1, SRR1163658.182804.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTTGTCA CCCAGGGACT AGTCTACCAA GGTTATTTGG CAGCTAATTC TAGATTTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001273703.1 |
CDS | 323..601 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTTGTCA CCCAGGGACT AGTCTACCAA GGTTATTTGG CAGCTAATTC TAGATTTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
OCIAD2 suppressed tumor growth and invasion via AKT pathway in Hepatocelluar carcinoma. |
OCIAD2 activates ?-secretase to enhance amyloid ? production by interacting with nicastrin. |
Pathway bridge based multiobjective optimization approach for lurking pathway prediction. |
Increased expression of OCIA domain containing 2 during stepwise progression of ovarian mucinous tumor. |