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SLC26A3 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SLC26A3
Entrez Gene ID 1811
Full Name solute carrier family 26 member 3
Synonyms CLD,DRA
General protein information
Preferred Names

solute carrier family 26 member 3

Names

chloride anion exchanger
down-regulated in adenoma protein
solute carrier family 26 (anion exchanger), member 3

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

7

7q22.3-q31.1

Summary The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008].
Disorder MIM:

126650

Disorder Html: ?Colon cancer (1); Chloride diarrhea, congenital, Finnish type,

mRNA and Protein(s)

mRNA Protein Name
NM_000111.2 NP_000102.1 chloride anion exchanger
XM_011515867.1 XP_011514169.1 chloride anion exchanger isoform X1
XM_011515867.2 XP_011514169.1 chloride anion exchanger isoform X1



Macaca mulatta (rhesus monkey) SLC26A3 XP_001090155.2
Gallus gallus (chicken) SLC26A3 NP_001186373.1
Homo sapiens (human) SLC26A3 NP_000102.1
Mus musculus (house mouse) Slc26a3 NP_067328.1
Rattus norvegicus (Norway rat) Slc26a3 NP_446207.1
Pan troglodytes (chimpanzee) SLC26A3 XP_527858.2
Bos taurus (cattle) SLC26A3 NP_001077145.1
Caenorhabditis elegans (roundworm) sulp-6 NP_491138.2
Xenopus tropicalis (tropical clawed frog) LOC101731072 XP_004913063.1
Canis lupus familiaris (dog) SLC26A3 XP_540380.3
Danio rerio (zebrafish) slc26a3 NP_001129155.1
Danio rerio (zebrafish) si:dkey-31f5.1 NP_001035265.1


Related articles in PubMed

After Intestinal Transplantation Kidney Function Is Impaired by Downregulation of Epithelial Ion Transporters in the Ileum.
Reiner J, Hsieh CJ, Straarup C, Bodammer P, Schäffler H, Graepler F, Stüker D, Kratt T, Linnebacher M, Nadalin S, Witte M, Königsrainer A, Lamprecht G
Transplantation proceedings48(2)499-506(2016 Mar)

SLC26A3 gene mutations in Tunisian patients with congenital chloride diarrhea.
Azzabi O, Fetni I, Selmi I, Halioui S, Ben Hariz M, Giuseppe C, Siala N, Maherzi A
La Tunisie medicale94(1)83(2016 Jan)

Japanese neonate with congenital chloride diarrhea caused by SLC26A3 mutation.
Fuwa K, Hosono S, Nagano N, Munakata S, Fukamachi R, Okada T, Takahashi S, Takahashi S, Sato N, Nakayama T
Pediatrics international : official journal of the Japan Pediatric Society57(1)e11-3(2015)

Probiotic Bifidobacterium species stimulate human SLC26A3 gene function and expression in intestinal epithelial cells.
Kumar A, Hecht C, Priyamvada S, Anbazhagan AN, Alakkam A, Borthakur A, Alrefai WA, Gill RK, Dudeja PK
American journal of physiology. Cell physiology307(12)C1084-92(2014 Dec)

Lactobacillus acidophilus attenuates downregulation of DRA function and expression in inflammatory models.
Singh V, Kumar A, Raheja G, Anbazhagan AN, Priyamvada S, Saksena S, Jhandier MN, Gill RK, Alrefai WA, Borthakur A, Dudeja PK
American journal of physiology. Gastrointestinal and liver physiology307(6)G623-31(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression of NHE3 and DRA was reduced with high tacrolimus levels and impaired renal function after intestinal transplantation.
Title: After Intestinal Transplantation Kidney Function Is Impaired by Downregulation of Epithelial Ion Transporters in the Ileum.

We report the first Tunisian case of SLC26A3 gene mutation in congenital chloride diarrhea. Our patient was homozygous for G187X mutation. Both parents were heterozygous for the same mutation.
Title: SLC26A3 gene mutations in Tunisian patients with congenital chloride diarrhea.

A variety of mutations in SLC26A3 are responsible for CCD. A total of 55 mutations in SLC26A3 have been reported
Title: Japanese neonate with congenital chloride diarrhea caused by SLC26A3 mutation.

Data demonstrate an upregulation of SLC26A3 via activation of the ERK1/2 pathway that may underlie potential antidiarrheal effects of Bifidobacterium sp.
Title: Probiotic Bifidobacterium species stimulate human SLC26A3 gene function and expression in intestinal epithelial cells.

Efficacy of lactobacillus acidophilus or its secreted soluble factors in alleviating inflammation and inflammation-associated dysregulation of DRA activity could justify their therapeutic potential in inflammatory diarrheal diseases.
Title: Lactobacillus acidophilus attenuates downregulation of DRA function and expression in inflammatory models.

The following SLC26A3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC26A3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu26676
NM_000111.2
Latest version!
Homo sapiens solute carrier family 26 member 3 (SLC26A3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$279.50-$391.30
$559.00
OHu26676
XM_011515867.2
Latest version!
Homo sapiens solute carrier family 26 member 3 (SLC26A3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$279.50-$391.30
$559.00
View Old Accession Versions >>
OHu26676
XM_011515867.1 Homo sapiens solute carrier family 26 (anion exchanger), member 3 (SLC26A3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$279.50-$391.30
$559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26676
Clone ID Related Accession (Same CDS sequence) NM_000111.2 , XM_011515867.1 , XM_011515867.2
Accession Version NM_000111.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2295bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-03
Organism Homo sapiens(Human)
Product chloride anion exchanger
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP262081.1, BC025671.1 and AC002467.1. This sequence is a reference standard in the RefSeqGene project. On Apr 1, 2008 this sequence version replaced NM_000111.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025671.1, L02785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGATTGAAC CCTTTGGGAA TCAGTATATT GTGGCCAGGC CAGTGTATTC TACAAATGCT 
TTTGAGGAAA ATCATAAAAA GACAGGAAGA CATCATAAGA CATTTCTGGA TCATCTCAAA
GTGTGTTGTA GCTGTTCCCC ACAAAAGGCC AAGAGAATTG TCCTCTCTTT GTTCCCCATA
GCATCTTGGT TGCCAGCATA CCGGCTTAAA GAATGGTTGC TCAGTGATAT TGTTTCTGGT
ATCAGCACAG GGATTGTGGC CGTACTACAA GGTTTAGCAT TTGCTCTGCT GGTCGACATT
CCCCCAGTCT ATGGGTTGTA TGCATCCTTT TTCCCAGCCA TAATCTACCT TTTCTTCGGC
ACTTCCAGAC ACATATCCGT GGGTCCGTTT CCGATTCTGA GTATGATGGT GGGACTAGCA
GTTTCAGGAG CAGTTTCAAA AGCAGTCCCA GATCGCAATG CAACTACTTT GGGATTGCCT
AACAACTCGA ATAATTCTTC ACTACTGGAT GACGAGAGGG TGAGGGTGGC GGCGGCGGCA
TCAGTCACAG TGCTTTCTGG AATCATCCAG TTGGCTTTTG GGATTCTGCG GATTGGATTT
GTAGTGATAT ACCTGTCTGA GTCCCTCATC AGTGGCTTCA CTACTGCTGC TGCTGTTCAT
GTTTTGGTTT CCCAACTCAA ATTCATTTTT CAGTTGACAG TCCCGTCACA CACTGATCCA
GTTTCAATTT TCAAAGTACT ATACTCTGTA TTCTCACAAA TAGAGAAGAC TAATATTGCA
GACCTGGTGA CAGCTCTGAT TGTCCTTTTG GTTGTATCCA TTGTTAAAGA AATAAATCAG
CGCTTCAAAG ACAAACTTCC AGTGCCCATT CCAATCGAAT TCATTATGAC CGTGATTGCA
GCAGGTGTAT CCTACGGCTG TGACTTTAAA AACAGGTTTA AAGTGGCTGT GGTTGGGGAC
ATGAATCCTG GATTTCAGCC CCCTATTACA CCTGACGTGG AGACTTTCCA AAACACCGTA
GGAGATTGCT TCGGCATCGC AATGGTTGCA TTTGCAGTGG CCTTTTCAGT TGCCAGCGTC
TATTCCCTCA AATACGATTA TCCACTTGAT GGCAATCAGG AGTTAATAGC CTTGGGACTG
GGTAACATAG TCTGTGGAGT ATTCAGAGGA TTTGCTGGGA GTACTGCCCT CTCCAGATCA
GCAGTTCAGG AGAGCACAGG AGGCAAAACA CAGATTGCTG GGCTTATTGG TGCCATCATC
GTGCTGATTG TCGTTCTAGC CATTGGATTT CTCCTGGCGC CTCTACAAAA GTCCGTCCTG
GCAGCTTTAG CATTGGGAAA CTTAAAGGGA ATGCTGATGC AGTTTGCTGA AATAGGCAGA
TTGTGGCGAA AGGACAAATA TGATTGTTTA ATTTGGATCA TGACCTTCAT CTTCACCATT
GTCCTGGGAC TCGGGTTAGG CCTGGCAGCT AGTGTGGCAT TTCAACTGCT AACCATCGTG
TTCAGGACCC AATTTCCAAA ATGCAGCACG CTGGCTAATA TTGGAAGAAC CAACATCTAT
AAGAATAAAA AAGATTATTA TGATATGTAT GAGCCAGAAG GAGTGAAAAT TTTCAGATGT
CCATCTCCTA TCTACTTTGC AAACATTGGT TTCTTTAGGC GGAAACTTAT CGATGCTGTT
GGCTTTAGTC CACTTCGAAT TCTACGCAAG CGCAACAAAG CTTTGAGGAA AATCCGAAAA
CTGCAGAAGC AAGGCTTGCT ACAAGTGACA CCAAAAGGAT TTATATGTAC TGTTGACACC
ATAAAAGATT CTGACGAAGA GCTGGACAAC AATCAGATAG AAGTACTGGA CCAGCCAATC
AATACCACAG ACCTGCCTTT CCACATTGAC TGGAATGATG ATCTTCCTCT CAACATTGAG
GTCCCCAAAA TCAGCCTCCA CAGCCTCATT CTTGACTTTT CAGCAGTGTC CTTTCTTGAT
GTTTCTTCAG TGAGGGGCCT TAAATCGATT TTGCAAGAAT TTATCAGGAT CAAGGTAGAT
GTGTATATCG TTGGAACTGA TGATGACTTC ATTGAGAAGC TTAACCGGTA TGAATTTTTT
GATGGTGAAG TGAAAAGCTC AATATTTTTC TTAACAATCC ATGATGCTGT TTTGCATATT
TTGATGAAGA AAGATTACAG TACTTCAAAG TTTAATCCCA GTCAGGAAAA AGATGGAAAA
ATTGATTTTA CCATAAATAC AAATGGAGGA TTACGTAATC GGGTATATGA GGTGCCAGTT
GAAACAAAAT TCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000102.1
CDS212..2506
Misc Feature(1)11
Misc Feature(2)131..133
Misc Feature(3)428..1636
Misc Feature(4)440..502
Misc Feature(5)509..571
Misc Feature(6)584..646
Misc Feature(7)737..799
Misc Feature(8)803..865
Misc Feature(9)983..1045
Misc Feature(10)1238..1300
Misc Feature(11)1334..1396
Misc Feature(12)1337..1507
Misc Feature(13)1445..1507
Misc Feature(14)1619..1681
Misc Feature(15)1718..1720
Misc Feature(16)1736..1738
Misc Feature(17)1769..1771
Misc Feature(18)1787..2347
Exon (1)1..123
Exon (2)124..342
Exon (3)343..482
Exon (4)483..593
Exon (5)594..781
Exon (6)782..946
Exon (7)947..1099
Exon (8)1100..1182
Exon (9)1183..1330
Exon (10)1331..1444
Exon (11)1445..1522
Exon (12)1523..1618
Exon (13)1619..1725
Exon (14)1726..1795
Exon (15)1796..1888
Exon (16)1889..1984
Exon (17)1985..2218
Exon (18)2219..2273
Exon (19)2274..2416
Exon (20)2417..2482
Exon (21)2483..2894
Translation

Target ORF information:

RefSeq Version NM_000111.2
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier family 26 member 3 (SLC26A3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000111.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGATTGAAC CCTTTGGGAA TCAGTATATT GTGGCCAGGC CAGTGTATTC TACAAATGCT 
TTTGAGGAAA ATCATAAAAA GACAGGAAGA CATCATAAGA CATTTCTGGA TCATCTCAAA
GTGTGTTGTA GCTGTTCCCC ACAAAAGGCC AAGAGAATTG TCCTCTCTTT GTTCCCCATA
GCATCTTGGT TGCCAGCATA CCGGCTTAAA GAATGGTTGC TCAGTGATAT TGTTTCTGGT
ATCAGCACAG GGATTGTGGC CGTACTACAA GGTTTAGCAT TTGCTCTGCT GGTCGACATT
CCCCCAGTCT ATGGGTTGTA TGCATCCTTT TTCCCAGCCA TAATCTACCT TTTCTTCGGC
ACTTCCAGAC ACATATCCGT GGGTCCGTTT CCGATTCTGA GTATGATGGT GGGACTAGCA
GTTTCAGGAG CAGTTTCAAA AGCAGTCCCA GATCGCAATG CAACTACTTT GGGATTGCCT
AACAACTCGA ATAATTCTTC ACTACTGGAT GACGAGAGGG TGAGGGTGGC GGCGGCGGCA
TCAGTCACAG TGCTTTCTGG AATCATCCAG TTGGCTTTTG GGATTCTGCG GATTGGATTT
GTAGTGATAT ACCTGTCTGA GTCCCTCATC AGTGGCTTCA CTACTGCTGC TGCTGTTCAT
GTTTTGGTTT CCCAACTCAA ATTCATTTTT CAGTTGACAG TCCCGTCACA CACTGATCCA
GTTTCAATTT TCAAAGTACT ATACTCTGTA TTCTCACAAA TAGAGAAGAC TAATATTGCA
GACCTGGTGA CAGCTCTGAT TGTCCTTTTG GTTGTATCCA TTGTTAAAGA AATAAATCAG
CGCTTCAAAG ACAAACTTCC AGTGCCCATT CCAATCGAAT TCATTATGAC CGTGATTGCA
GCAGGTGTAT CCTACGGCTG TGACTTTAAA AACAGGTTTA AAGTGGCTGT GGTTGGGGAC
ATGAATCCTG GATTTCAGCC CCCTATTACA CCTGACGTGG AGACTTTCCA AAACACCGTA
GGAGATTGCT TCGGCATCGC AATGGTTGCA TTTGCAGTGG CCTTTTCAGT TGCCAGCGTC
TATTCCCTCA AATACGATTA TCCACTTGAT GGCAATCAGG AGTTAATAGC CTTGGGACTG
GGTAACATAG TCTGTGGAGT ATTCAGAGGA TTTGCTGGGA GTACTGCCCT CTCCAGATCA
GCAGTTCAGG AGAGCACAGG AGGCAAAACA CAGATTGCTG GGCTTATTGG TGCCATCATC
GTGCTGATTG TCGTTCTAGC CATTGGATTT CTCCTGGCGC CTCTACAAAA GTCCGTCCTG
GCAGCTTTAG CATTGGGAAA CTTAAAGGGA ATGCTGATGC AGTTTGCTGA AATAGGCAGA
TTGTGGCGAA AGGACAAATA TGATTGTTTA ATTTGGATCA TGACCTTCAT CTTCACCATT
GTCCTGGGAC TCGGGTTAGG CCTGGCAGCT AGTGTGGCAT TTCAACTGCT AACCATCGTG
TTCAGGACCC AATTTCCAAA ATGCAGCACG CTGGCTAATA TTGGAAGAAC CAACATCTAT
AAGAATAAAA AAGATTATTA TGATATGTAT GAGCCAGAAG GAGTGAAAAT TTTCAGATGT
CCATCTCCTA TCTACTTTGC AAACATTGGT TTCTTTAGGC GGAAACTTAT CGATGCTGTT
GGCTTTAGTC CACTTCGAAT TCTACGCAAG CGCAACAAAG CTTTGAGGAA AATCCGAAAA
CTGCAGAAGC AAGGCTTGCT ACAAGTGACA CCAAAAGGAT TTATATGTAC TGTTGACACC
ATAAAAGATT CTGACGAAGA GCTGGACAAC AATCAGATAG AAGTACTGGA CCAGCCAATC
AATACCACAG ACCTGCCTTT CCACATTGAC TGGAATGATG ATCTTCCTCT CAACATTGAG
GTCCCCAAAA TCAGCCTCCA CAGCCTCATT CTTGACTTTT CAGCAGTGTC CTTTCTTGAT
GTTTCTTCAG TGAGGGGCCT TAAATCGATT TTGCAAGAAT TTATCAGGAT CAAGGTAGAT
GTGTATATCG TTGGAACTGA TGATGACTTC ATTGAGAAGC TTAACCGGTA TGAATTTTTT
GATGGTGAAG TGAAAAGCTC AATATTTTTC TTAACAATCC ATGATGCTGT TTTGCATATT
TTGATGAAGA AAGATTACAG TACTTCAAAG TTTAATCCCA GTCAGGAAAA AGATGGAAAA
ATTGATTTTA CCATAAATAC AAATGGAGGA TTACGTAATC GGGTATATGA GGTGCCAGTT
GAAACAAAAT TCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26676
Clone ID Related Accession (Same CDS sequence) NM_000111.2 , XM_011515867.1 , XM_011515867.2
Accession Version XM_011515867.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2295bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-12
Organism Homo sapiens(Human)
Product chloride anion exchanger isoform X1
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGATTGAAC CCTTTGGGAA TCAGTATATT GTGGCCAGGC CAGTGTATTC TACAAATGCT 
TTTGAGGAAA ATCATAAAAA GACAGGAAGA CATCATAAGA CATTTCTGGA TCATCTCAAA
GTGTGTTGTA GCTGTTCCCC ACAAAAGGCC AAGAGAATTG TCCTCTCTTT GTTCCCCATA
GCATCTTGGT TGCCAGCATA CCGGCTTAAA GAATGGTTGC TCAGTGATAT TGTTTCTGGT
ATCAGCACAG GGATTGTGGC CGTACTACAA GGTTTAGCAT TTGCTCTGCT GGTCGACATT
CCCCCAGTCT ATGGGTTGTA TGCATCCTTT TTCCCAGCCA TAATCTACCT TTTCTTCGGC
ACTTCCAGAC ACATATCCGT GGGTCCGTTT CCGATTCTGA GTATGATGGT GGGACTAGCA
GTTTCAGGAG CAGTTTCAAA AGCAGTCCCA GATCGCAATG CAACTACTTT GGGATTGCCT
AACAACTCGA ATAATTCTTC ACTACTGGAT GACGAGAGGG TGAGGGTGGC GGCGGCGGCA
TCAGTCACAG TGCTTTCTGG AATCATCCAG TTGGCTTTTG GGATTCTGCG GATTGGATTT
GTAGTGATAT ACCTGTCTGA GTCCCTCATC AGTGGCTTCA CTACTGCTGC TGCTGTTCAT
GTTTTGGTTT CCCAACTCAA ATTCATTTTT CAGTTGACAG TCCCGTCACA CACTGATCCA
GTTTCAATTT TCAAAGTACT ATACTCTGTA TTCTCACAAA TAGAGAAGAC TAATATTGCA
GACCTGGTGA CAGCTCTGAT TGTCCTTTTG GTTGTATCCA TTGTTAAAGA AATAAATCAG
CGCTTCAAAG ACAAACTTCC AGTGCCCATT CCAATCGAAT TCATTATGAC CGTGATTGCA
GCAGGTGTAT CCTACGGCTG TGACTTTAAA AACAGGTTTA AAGTGGCTGT GGTTGGGGAC
ATGAATCCTG GATTTCAGCC CCCTATTACA CCTGACGTGG AGACTTTCCA AAACACCGTA
GGAGATTGCT TCGGCATCGC AATGGTTGCA TTTGCAGTGG CCTTTTCAGT TGCCAGCGTC
TATTCCCTCA AATACGATTA TCCACTTGAT GGCAATCAGG AGTTAATAGC CTTGGGACTG
GGTAACATAG TCTGTGGAGT ATTCAGAGGA TTTGCTGGGA GTACTGCCCT CTCCAGATCA
GCAGTTCAGG AGAGCACAGG AGGCAAAACA CAGATTGCTG GGCTTATTGG TGCCATCATC
GTGCTGATTG TCGTTCTAGC CATTGGATTT CTCCTGGCGC CTCTACAAAA GTCCGTCCTG
GCAGCTTTAG CATTGGGAAA CTTAAAGGGA ATGCTGATGC AGTTTGCTGA AATAGGCAGA
TTGTGGCGAA AGGACAAATA TGATTGTTTA ATTTGGATCA TGACCTTCAT CTTCACCATT
GTCCTGGGAC TCGGGTTAGG CCTGGCAGCT AGTGTGGCAT TTCAACTGCT AACCATCGTG
TTCAGGACCC AATTTCCAAA ATGCAGCACG CTGGCTAATA TTGGAAGAAC CAACATCTAT
AAGAATAAAA AAGATTATTA TGATATGTAT GAGCCAGAAG GAGTGAAAAT TTTCAGATGT
CCATCTCCTA TCTACTTTGC AAACATTGGT TTCTTTAGGC GGAAACTTAT CGATGCTGTT
GGCTTTAGTC CACTTCGAAT TCTACGCAAG CGCAACAAAG CTTTGAGGAA AATCCGAAAA
CTGCAGAAGC AAGGCTTGCT ACAAGTGACA CCAAAAGGAT TTATATGTAC TGTTGACACC
ATAAAAGATT CTGACGAAGA GCTGGACAAC AATCAGATAG AAGTACTGGA CCAGCCAATC
AATACCACAG ACCTGCCTTT CCACATTGAC TGGAATGATG ATCTTCCTCT CAACATTGAG
GTCCCCAAAA TCAGCCTCCA CAGCCTCATT CTTGACTTTT CAGCAGTGTC CTTTCTTGAT
GTTTCTTCAG TGAGGGGCCT TAAATCGATT TTGCAAGAAT TTATCAGGAT CAAGGTAGAT
GTGTATATCG TTGGAACTGA TGATGACTTC ATTGAGAAGC TTAACCGGTA TGAATTTTTT
GATGGTGAAG TGAAAAGCTC AATATTTTTC TTAACAATCC ATGATGCTGT TTTGCATATT
TTGATGAAGA AAGATTACAG TACTTCAAAG TTTAATCCCA GTCAGGAAAA AGATGGAAAA
ATTGATTTTA CCATAAATAC AAATGGAGGA TTACGTAATC GGGTATATGA GGTGCCAGTT
GAAACAAAAT TCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011514169.1
Translation

Target ORF information:

RefSeq Version XM_011515867.1
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier family 26 (anion exchanger), member 3 (SLC26A3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011515867.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGATTGAAC CCTTTGGGAA TCAGTATATT GTGGCCAGGC CAGTGTATTC TACAAATGCT 
TTTGAGGAAA ATCATAAAAA GACAGGAAGA CATCATAAGA CATTTCTGGA TCATCTCAAA
GTGTGTTGTA GCTGTTCCCC ACAAAAGGCC AAGAGAATTG TCCTCTCTTT GTTCCCCATA
GCATCTTGGT TGCCAGCATA CCGGCTTAAA GAATGGTTGC TCAGTGATAT TGTTTCTGGT
ATCAGCACAG GGATTGTGGC CGTACTACAA GGTTTAGCAT TTGCTCTGCT GGTCGACATT
CCCCCAGTCT ATGGGTTGTA TGCATCCTTT TTCCCAGCCA TAATCTACCT TTTCTTCGGC
ACTTCCAGAC ACATATCCGT GGGTCCGTTT CCGATTCTGA GTATGATGGT GGGACTAGCA
GTTTCAGGAG CAGTTTCAAA AGCAGTCCCA GATCGCAATG CAACTACTTT GGGATTGCCT
AACAACTCGA ATAATTCTTC ACTACTGGAT GACGAGAGGG TGAGGGTGGC GGCGGCGGCA
TCAGTCACAG TGCTTTCTGG AATCATCCAG TTGGCTTTTG GGATTCTGCG GATTGGATTT
GTAGTGATAT ACCTGTCTGA GTCCCTCATC AGTGGCTTCA CTACTGCTGC TGCTGTTCAT
GTTTTGGTTT CCCAACTCAA ATTCATTTTT CAGTTGACAG TCCCGTCACA CACTGATCCA
GTTTCAATTT TCAAAGTACT ATACTCTGTA TTCTCACAAA TAGAGAAGAC TAATATTGCA
GACCTGGTGA CAGCTCTGAT TGTCCTTTTG GTTGTATCCA TTGTTAAAGA AATAAATCAG
CGCTTCAAAG ACAAACTTCC AGTGCCCATT CCAATCGAAT TCATTATGAC CGTGATTGCA
GCAGGTGTAT CCTACGGCTG TGACTTTAAA AACAGGTTTA AAGTGGCTGT GGTTGGGGAC
ATGAATCCTG GATTTCAGCC CCCTATTACA CCTGACGTGG AGACTTTCCA AAACACCGTA
GGAGATTGCT TCGGCATCGC AATGGTTGCA TTTGCAGTGG CCTTTTCAGT TGCCAGCGTC
TATTCCCTCA AATACGATTA TCCACTTGAT GGCAATCAGG AGTTAATAGC CTTGGGACTG
GGTAACATAG TCTGTGGAGT ATTCAGAGGA TTTGCTGGGA GTACTGCCCT CTCCAGATCA
GCAGTTCAGG AGAGCACAGG AGGCAAAACA CAGATTGCTG GGCTTATTGG TGCCATCATC
GTGCTGATTG TCGTTCTAGC CATTGGATTT CTCCTGGCGC CTCTACAAAA GTCCGTCCTG
GCAGCTTTAG CATTGGGAAA CTTAAAGGGA ATGCTGATGC AGTTTGCTGA AATAGGCAGA
TTGTGGCGAA AGGACAAATA TGATTGTTTA ATTTGGATCA TGACCTTCAT CTTCACCATT
GTCCTGGGAC TCGGGTTAGG CCTGGCAGCT AGTGTGGCAT TTCAACTGCT AACCATCGTG
TTCAGGACCC AATTTCCAAA ATGCAGCACG CTGGCTAATA TTGGAAGAAC CAACATCTAT
AAGAATAAAA AAGATTATTA TGATATGTAT GAGCCAGAAG GAGTGAAAAT TTTCAGATGT
CCATCTCCTA TCTACTTTGC AAACATTGGT TTCTTTAGGC GGAAACTTAT CGATGCTGTT
GGCTTTAGTC CACTTCGAAT TCTACGCAAG CGCAACAAAG CTTTGAGGAA AATCCGAAAA
CTGCAGAAGC AAGGCTTGCT ACAAGTGACA CCAAAAGGAT TTATATGTAC TGTTGACACC
ATAAAAGATT CTGACGAAGA GCTGGACAAC AATCAGATAG AAGTACTGGA CCAGCCAATC
AATACCACAG ACCTGCCTTT CCACATTGAC TGGAATGATG ATCTTCCTCT CAACATTGAG
GTCCCCAAAA TCAGCCTCCA CAGCCTCATT CTTGACTTTT CAGCAGTGTC CTTTCTTGAT
GTTTCTTCAG TGAGGGGCCT TAAATCGATT TTGCAAGAAT TTATCAGGAT CAAGGTAGAT
GTGTATATCG TTGGAACTGA TGATGACTTC ATTGAGAAGC TTAACCGGTA TGAATTTTTT
GATGGTGAAG TGAAAAGCTC AATATTTTTC TTAACAATCC ATGATGCTGT TTTGCATATT
TTGATGAAGA AAGATTACAG TACTTCAAAG TTTAATCCCA GTCAGGAAAA AGATGGAAAA
ATTGATTTTA CCATAAATAC AAATGGAGGA TTACGTAATC GGGTATATGA GGTGCCAGTT
GAAACAAAAT TCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26676
Clone ID Related Accession (Same CDS sequence) NM_000111.2 , XM_011515867.1 , XM_011515867.2
Accession Version XM_011515867.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2295bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product chloride anion exchanger isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011515867.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGATTGAAC CCTTTGGGAA TCAGTATATT GTGGCCAGGC CAGTGTATTC TACAAATGCT 
TTTGAGGAAA ATCATAAAAA GACAGGAAGA CATCATAAGA CATTTCTGGA TCATCTCAAA
GTGTGTTGTA GCTGTTCCCC ACAAAAGGCC AAGAGAATTG TCCTCTCTTT GTTCCCCATA
GCATCTTGGT TGCCAGCATA CCGGCTTAAA GAATGGTTGC TCAGTGATAT TGTTTCTGGT
ATCAGCACAG GGATTGTGGC CGTACTACAA GGTTTAGCAT TTGCTCTGCT GGTCGACATT
CCCCCAGTCT ATGGGTTGTA TGCATCCTTT TTCCCAGCCA TAATCTACCT TTTCTTCGGC
ACTTCCAGAC ACATATCCGT GGGTCCGTTT CCGATTCTGA GTATGATGGT GGGACTAGCA
GTTTCAGGAG CAGTTTCAAA AGCAGTCCCA GATCGCAATG CAACTACTTT GGGATTGCCT
AACAACTCGA ATAATTCTTC ACTACTGGAT GACGAGAGGG TGAGGGTGGC GGCGGCGGCA
TCAGTCACAG TGCTTTCTGG AATCATCCAG TTGGCTTTTG GGATTCTGCG GATTGGATTT
GTAGTGATAT ACCTGTCTGA GTCCCTCATC AGTGGCTTCA CTACTGCTGC TGCTGTTCAT
GTTTTGGTTT CCCAACTCAA ATTCATTTTT CAGTTGACAG TCCCGTCACA CACTGATCCA
GTTTCAATTT TCAAAGTACT ATACTCTGTA TTCTCACAAA TAGAGAAGAC TAATATTGCA
GACCTGGTGA CAGCTCTGAT TGTCCTTTTG GTTGTATCCA TTGTTAAAGA AATAAATCAG
CGCTTCAAAG ACAAACTTCC AGTGCCCATT CCAATCGAAT TCATTATGAC CGTGATTGCA
GCAGGTGTAT CCTACGGCTG TGACTTTAAA AACAGGTTTA AAGTGGCTGT GGTTGGGGAC
ATGAATCCTG GATTTCAGCC CCCTATTACA CCTGACGTGG AGACTTTCCA AAACACCGTA
GGAGATTGCT TCGGCATCGC AATGGTTGCA TTTGCAGTGG CCTTTTCAGT TGCCAGCGTC
TATTCCCTCA AATACGATTA TCCACTTGAT GGCAATCAGG AGTTAATAGC CTTGGGACTG
GGTAACATAG TCTGTGGAGT ATTCAGAGGA TTTGCTGGGA GTACTGCCCT CTCCAGATCA
GCAGTTCAGG AGAGCACAGG AGGCAAAACA CAGATTGCTG GGCTTATTGG TGCCATCATC
GTGCTGATTG TCGTTCTAGC CATTGGATTT CTCCTGGCGC CTCTACAAAA GTCCGTCCTG
GCAGCTTTAG CATTGGGAAA CTTAAAGGGA ATGCTGATGC AGTTTGCTGA AATAGGCAGA
TTGTGGCGAA AGGACAAATA TGATTGTTTA ATTTGGATCA TGACCTTCAT CTTCACCATT
GTCCTGGGAC TCGGGTTAGG CCTGGCAGCT AGTGTGGCAT TTCAACTGCT AACCATCGTG
TTCAGGACCC AATTTCCAAA ATGCAGCACG CTGGCTAATA TTGGAAGAAC CAACATCTAT
AAGAATAAAA AAGATTATTA TGATATGTAT GAGCCAGAAG GAGTGAAAAT TTTCAGATGT
CCATCTCCTA TCTACTTTGC AAACATTGGT TTCTTTAGGC GGAAACTTAT CGATGCTGTT
GGCTTTAGTC CACTTCGAAT TCTACGCAAG CGCAACAAAG CTTTGAGGAA AATCCGAAAA
CTGCAGAAGC AAGGCTTGCT ACAAGTGACA CCAAAAGGAT TTATATGTAC TGTTGACACC
ATAAAAGATT CTGACGAAGA GCTGGACAAC AATCAGATAG AAGTACTGGA CCAGCCAATC
AATACCACAG ACCTGCCTTT CCACATTGAC TGGAATGATG ATCTTCCTCT CAACATTGAG
GTCCCCAAAA TCAGCCTCCA CAGCCTCATT CTTGACTTTT CAGCAGTGTC CTTTCTTGAT
GTTTCTTCAG TGAGGGGCCT TAAATCGATT TTGCAAGAAT TTATCAGGAT CAAGGTAGAT
GTGTATATCG TTGGAACTGA TGATGACTTC ATTGAGAAGC TTAACCGGTA TGAATTTTTT
GATGGTGAAG TGAAAAGCTC AATATTTTTC TTAACAATCC ATGATGCTGT TTTGCATATT
TTGATGAAGA AAGATTACAG TACTTCAAAG TTTAATCCCA GTCAGGAAAA AGATGGAAAA
ATTGATTTTA CCATAAATAC AAATGGAGGA TTACGTAATC GGGTATATGA GGTGCCAGTT
GAAACAAAAT TCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011514169.1
CDS193..2487
Misc Feature(1)409..1617
Misc Feature(2)1318..1488
Misc Feature(3)1768..2328
Translation

Target ORF information:

RefSeq Version XM_011515867.2
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier family 26 member 3 (SLC26A3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011515867.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGATTGAAC CCTTTGGGAA TCAGTATATT GTGGCCAGGC CAGTGTATTC TACAAATGCT 
TTTGAGGAAA ATCATAAAAA GACAGGAAGA CATCATAAGA CATTTCTGGA TCATCTCAAA
GTGTGTTGTA GCTGTTCCCC ACAAAAGGCC AAGAGAATTG TCCTCTCTTT GTTCCCCATA
GCATCTTGGT TGCCAGCATA CCGGCTTAAA GAATGGTTGC TCAGTGATAT TGTTTCTGGT
ATCAGCACAG GGATTGTGGC CGTACTACAA GGTTTAGCAT TTGCTCTGCT GGTCGACATT
CCCCCAGTCT ATGGGTTGTA TGCATCCTTT TTCCCAGCCA TAATCTACCT TTTCTTCGGC
ACTTCCAGAC ACATATCCGT GGGTCCGTTT CCGATTCTGA GTATGATGGT GGGACTAGCA
GTTTCAGGAG CAGTTTCAAA AGCAGTCCCA GATCGCAATG CAACTACTTT GGGATTGCCT
AACAACTCGA ATAATTCTTC ACTACTGGAT GACGAGAGGG TGAGGGTGGC GGCGGCGGCA
TCAGTCACAG TGCTTTCTGG AATCATCCAG TTGGCTTTTG GGATTCTGCG GATTGGATTT
GTAGTGATAT ACCTGTCTGA GTCCCTCATC AGTGGCTTCA CTACTGCTGC TGCTGTTCAT
GTTTTGGTTT CCCAACTCAA ATTCATTTTT CAGTTGACAG TCCCGTCACA CACTGATCCA
GTTTCAATTT TCAAAGTACT ATACTCTGTA TTCTCACAAA TAGAGAAGAC TAATATTGCA
GACCTGGTGA CAGCTCTGAT TGTCCTTTTG GTTGTATCCA TTGTTAAAGA AATAAATCAG
CGCTTCAAAG ACAAACTTCC AGTGCCCATT CCAATCGAAT TCATTATGAC CGTGATTGCA
GCAGGTGTAT CCTACGGCTG TGACTTTAAA AACAGGTTTA AAGTGGCTGT GGTTGGGGAC
ATGAATCCTG GATTTCAGCC CCCTATTACA CCTGACGTGG AGACTTTCCA AAACACCGTA
GGAGATTGCT TCGGCATCGC AATGGTTGCA TTTGCAGTGG CCTTTTCAGT TGCCAGCGTC
TATTCCCTCA AATACGATTA TCCACTTGAT GGCAATCAGG AGTTAATAGC CTTGGGACTG
GGTAACATAG TCTGTGGAGT ATTCAGAGGA TTTGCTGGGA GTACTGCCCT CTCCAGATCA
GCAGTTCAGG AGAGCACAGG AGGCAAAACA CAGATTGCTG GGCTTATTGG TGCCATCATC
GTGCTGATTG TCGTTCTAGC CATTGGATTT CTCCTGGCGC CTCTACAAAA GTCCGTCCTG
GCAGCTTTAG CATTGGGAAA CTTAAAGGGA ATGCTGATGC AGTTTGCTGA AATAGGCAGA
TTGTGGCGAA AGGACAAATA TGATTGTTTA ATTTGGATCA TGACCTTCAT CTTCACCATT
GTCCTGGGAC TCGGGTTAGG CCTGGCAGCT AGTGTGGCAT TTCAACTGCT AACCATCGTG
TTCAGGACCC AATTTCCAAA ATGCAGCACG CTGGCTAATA TTGGAAGAAC CAACATCTAT
AAGAATAAAA AAGATTATTA TGATATGTAT GAGCCAGAAG GAGTGAAAAT TTTCAGATGT
CCATCTCCTA TCTACTTTGC AAACATTGGT TTCTTTAGGC GGAAACTTAT CGATGCTGTT
GGCTTTAGTC CACTTCGAAT TCTACGCAAG CGCAACAAAG CTTTGAGGAA AATCCGAAAA
CTGCAGAAGC AAGGCTTGCT ACAAGTGACA CCAAAAGGAT TTATATGTAC TGTTGACACC
ATAAAAGATT CTGACGAAGA GCTGGACAAC AATCAGATAG AAGTACTGGA CCAGCCAATC
AATACCACAG ACCTGCCTTT CCACATTGAC TGGAATGATG ATCTTCCTCT CAACATTGAG
GTCCCCAAAA TCAGCCTCCA CAGCCTCATT CTTGACTTTT CAGCAGTGTC CTTTCTTGAT
GTTTCTTCAG TGAGGGGCCT TAAATCGATT TTGCAAGAAT TTATCAGGAT CAAGGTAGAT
GTGTATATCG TTGGAACTGA TGATGACTTC ATTGAGAAGC TTAACCGGTA TGAATTTTTT
GATGGTGAAG TGAAAAGCTC AATATTTTTC TTAACAATCC ATGATGCTGT TTTGCATATT
TTGATGAAGA AAGATTACAG TACTTCAAAG TTTAATCCCA GTCAGGAAAA AGATGGAAAA
ATTGATTTTA CCATAAATAC AAATGGAGGA TTACGTAATC GGGTATATGA GGTGCCAGTT
GAAACAAAAT TCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

After Intestinal Transplantation Kidney Function Is Impaired by Downregulation of Epithelial Ion Transporters in the Ileum.
Transplantation proceedings48(2)499-506(2016 Mar)
Reiner J,Hsieh CJ,Straarup C,Bodammer P,Schäffler H,Graepler F,Stüker D,Kratt T,Linnebacher M,Nadalin S,Witte M,Königsrainer A,Lamprecht G


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SLC26A3 gene mutations in Tunisian patients with congenital chloride diarrhea.
La Tunisie medicale94(1)83(2016 Jan)
Azzabi O,Fetni I,Selmi I,Halioui S,Ben Hariz M,Giuseppe C,Siala N,Maherzi A


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Pediatrics international : official journal of the Japan Pediatric Society57(1)e11-3(2015)
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American journal of physiology. Cell physiology307(12)C1084-92(2014 Dec)
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