Gene Symbol | UTP25 |
Entrez Gene ID | 27042 |
Full Name | digestive organ expansion factor homolog (zebrafish) |
Synonyms | C1orf107,DEF,DJ434O14.5,UTP25 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
ORF » Species Summary » Homo sapiens » UTP25 cDNA ORF clone
Gene Symbol | UTP25 |
Entrez Gene ID | 27042 |
Full Name | digestive organ expansion factor homolog (zebrafish) |
Synonyms | C1orf107,DEF,DJ434O14.5,UTP25 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006711275.3 | XP_006711338.1 | digestive organ expansion factor homolog isoform X1 |
XM_011509418.2 | XP_011507720.1 | digestive organ expansion factor homolog isoform X2 |
XM_011509418.3 | XP_011507720.1 | digestive organ expansion factor homolog isoform X2 |
NM_014388.6 | NP_055203.4 | digestive organ expansion factor homolog |
NM_014388.7 | NP_055203.4 | digestive organ expansion factor homolog |
XM_006711275.4 | XP_006711338.1 | digestive organ expansion factor homolog isoform X1 |
Canis lupus familiaris (dog) | DIEXF | XP_547394.3 |
Kluyveromyces lactis | KLLA0E08229g | XP_454321.1 |
Neurospora crassa | NCU01022 | XP_961634.1 |
Gallus gallus (chicken) | DIEXF | NP_001026222.1 |
Danio rerio (zebrafish) | diexf | NP_775380.1 |
Drosophila melanogaster (fruit fly) | CG3735 | NP_611851.1 |
Saccharomyces cerevisiae (baker's yeast) | UTP25 | NP_012175.1 |
Xenopus tropicalis (tropical clawed frog) | diexf | NP_001008035.1 |
Pan troglodytes (chimpanzee) | DIEXF | XP_525053.2 |
Mus musculus (house mouse) | Diexf | NP_663390.2 |
Rattus norvegicus (Norway rat) | Diexf | NP_001014008.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_10652 | XP_003710081.1 |
DIEXF | XP_001109922.1 | |
Oryza sativa (rice) | Os05g0295100 | NP_001055109.1 |
Homo sapiens (human) | DIEXF | NP_055203.4 |
Bos taurus (cattle) | DIEXF | NP_001098822.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP011170 | XP_309479.4 |
Eremothecium gossypii | AGOS_ADL209C | NP_983887.1 |
Schizosaccharomyces pombe (fission yeast) | SPCC1827.01c | NP_588547.1 |
Arabidopsis thaliana (thale cress) | NOF1 | NP_564032.1 |
The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.
Tao T, Sondalle SB, Shi H, Zhu S, Perez-Atayde AR, Peng J, Baserga SJ, Look AT
Oncogene36(27)3852-3867(2017 Jul)
MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease.
Lei H, Tang J, Li H, Zhang H, Lu C, Chen H, Li W, Xia Y, Tang W
BMC gastroenterology14123(2014 Jul)
Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.
Tao T, Shi H, Guan Y, Huang D, Chen Y, Lane DP, Chen J, Peng J
Cell research23(5)620-34(2013 May)
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)
Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.
Chen J, Ruan H, Ng SM, Gao C, Soo HM, Wu W, Zhang Z, Wen Z, Lane DP, Peng J
Genes & development19(23)2900-11(2005 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
DEF is highly expressed in human neuroblastoma, and its depletion in human neuroblastoma cell lines induces apoptosis.
Title: The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.
Colonic tissue from patients with Hirschsprung's disease showed lower expression levels of digestive-organ expansion factor (DIEXF).
Title: MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease.
characterization of the related zebrafish protein
Title: Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.
The following UTP25 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UTP25 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu67038 | |
Clone ID Related Accession (Same CDS sequence) | XM_011509418.2 , XM_011509418.3 | |
Accession Version | XM_011509418.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1416bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | digestive organ expansion factor homolog isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011509418.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAATTCTT ACCGGGACCT GTTCTACCCG GAAAGGACTG CTCTGAAGAA CGGGGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011507720.1 |
CDS | 977..2392 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011509418.2 |
1 | ATGAATTCTT ACCGGGACCT GTTCTACCCG GAAAGGACTG CTCTGAAGAA CGGGGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu67038 | |
Clone ID Related Accession (Same CDS sequence) | XM_011509418.2 , XM_011509418.3 | |
Accession Version | XM_011509418.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1416bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | digestive organ expansion factor homolog isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011509418.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAATTCTT ACCGGGACCT GTTCTACCCG GAAAGGACTG CTCTGAAGAA CGGGGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011507720.1 |
CDS | 968..2383 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011509418.3 |
1 | ATGAATTCTT ACCGGGACCT GTTCTACCCG GAAAGGACTG CTCTGAAGAA CGGGGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu34316 | |
Clone ID Related Accession (Same CDS sequence) | XM_006711275.3 , XM_006711275.4 | |
Accession Version | XM_006711275.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | digestive organ expansion factor homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006711275.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGCAAAC GCGGGAGCCG GAGCCAGAGC CAGCTACTCA ACACCCTAAC TAAAAAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006711338.1 |
CDS | 98..1804 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006711275.3 |
1 | ATGGGCAAAC GCGGGAGCCG GAGCCAGAGC CAGCTACTCA ACACCCTAAC TAAAAAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu34316 | |
Clone ID Related Accession (Same CDS sequence) | XM_006711275.3 , XM_006711275.4 | |
Accession Version | XM_006711275.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | digestive organ expansion factor homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006711275.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGCAAAC GCGGGAGCCG GAGCCAGAGC CAGCTACTCA ACACCCTAAC TAAAAAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006711338.1 |
CDS | 93..1799 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006711275.4 |
1 | ATGGGCAAAC GCGGGAGCCG GAGCCAGAGC CAGCTACTCA ACACCCTAAC TAAAAAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08799 | |
Clone ID Related Accession (Same CDS sequence) | NM_014388.6 , NM_014388.7 | |
Accession Version | NM_014388.6 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2271bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | digestive organ expansion factor homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA256510.1, AL022398.1, BC022964.1, AL022728.1 and CR749825.1. On Jul 21, 2010 this sequence version replaced NM_014388.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CR749825.1, SRR1803613.7274.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCAAAC GCGGGAGCCG GAGCCAGAGC CAGCTACTCA ACACCCTAAC TAAAAAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055203.4 |
CDS | 98..2368 |
Translation |
Target ORF information:
Target ORF information:
|
NM_014388.6 |
1 | ATGGGCAAAC GCGGGAGCCG GAGCCAGAGC CAGCTACTCA ACACCCTAAC TAAAAAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08799 | |
Clone ID Related Accession (Same CDS sequence) | NM_014388.6 , NM_014388.7 | |
Accession Version | NM_014388.7 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2271bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-05-01 | |
Organism | Homo sapiens(human) | |
Product | digestive organ expansion factor homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA256510.1, AL022398.1, BC022964.1, AL022728.1 and CR749825.1. On Nov 22, 2018 this sequence version replaced NM_014388.6. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CR749825.1, SRR1803613.7274.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000491415.7/ ENSP00000419005.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGGCAAAC GCGGGAGCCG GAGCCAGAGC CAGCTACTCA ACACCCTAAC TAAAAAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055203.4 |
CDS | 93..2363 |
Translation |
Target ORF information:
Target ORF information:
|
NM_014388.7 |
1 | ATGGGCAAAC GCGGGAGCCG GAGCCAGAGC CAGCTACTCA ACACCCTAAC TAAAAAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma. |
MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease. |
Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. |
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. |
Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. |