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GPS2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol GPS2
Entrez Gene ID 2874
Full Name G protein pathway suppressor 2
Synonyms AMF-1
General protein information
Preferred Names

G protein pathway suppressor 2

Names

G protein pathway suppressor 2
GPS-2

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

17

17p13.1

Disorder MIM:

601935


mRNA and Protein(s)

mRNA Protein Name
NM_004489.4 NP_004480.1 G protein pathway suppressor 2



Pan troglodytes (chimpanzee) GPS2 XP_511971.3
Canis lupus familiaris (dog) GPS2 XP_003639092.1
Macaca mulatta (rhesus monkey) LOC721816 XP_002800321.1
Homo sapiens (human) GPS2 NP_004480.1
Bos taurus (cattle) GPS2 NP_001069242.1
Mus musculus (house mouse) Gps2 NP_062700.2
Danio rerio (zebrafish) gps2 NP_957267.1
Xenopus tropicalis (tropical clawed frog) gps2 NP_001107718.1
Rattus norvegicus (Norway rat) Gps2 NP_001017477.1


Related articles in PubMed

Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation.
Huang J, Cardamone MD, Johnson HE, Neault M, Chan M, Floyd ZE, Mallette FA, Perissi V
The Journal of biological chemistry290(31)19044-54(2015 Jul)

Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child.
O'Meara E, Stack D, Phelan S, McDonagh N, Kelly L, Sciot R, Debiec-Rychter M, Morris T, Cochrane D, Sorensen P, O'Sullivan MJ
Genes, chromosomes & cancer53(12)991-8(2014 Dec)

SUMOylation of GPS2 protein regulates its transcription-suppressing function.
Bi H, Li S, Wang M, Jia Z, Chang AK, Pang P, Wu H
Molecular biology of the cell25(16)2499-508(2014 Aug)

SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation.
Toubal A, Clément K, Fan R, Ancel P, Pelloux V, Rouault C, Veyrie N, Hartemann A, Treuter E, Venteclef N
The Journal of clinical investigation123(1)362-79(2013 Jan)

GPS2 is required for the association of NS5A with VAP-A and hepatitis C virus replication.
Xu G, Xin X, Zheng C
PloS one8(11)e78195(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our studies identify GPS2 functions as a tumor suppressor in LPS and its downregulation is correlated to prognosis of LPS.
Title: G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma.

The study of adipose tissue from humans with and without obesity revealed correlations between reduced GPS2 expression in macrophages, elevated systemic and adipose tissue inflammation, and diabetic status.
Title: Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.

regulation of GPS2 by posttranslational modifications provides an effective strategy for modulating its molecular function within the nuclear compartment.
Title: Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation.

Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in fusion gene MLL4-GPS2, the expression of which promotes independent growth.
Title: Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child.

Posttranslational modification of GPS2 by SUMOylation may serve as a key factor that regulates the function of GPS2 in vivo.
Title: SUMOylation of GPS2 protein regulates its transcription-suppressing function.

The following GPS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu04401 NM_004489.4
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Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu04401
Clone ID Related Accession (Same CDS sequence) NM_004489.4
Accession Version NM_004489.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 984bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-06
Organism Homo sapiens(Human)
Product G protein pathway suppressor 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC013652.1 and BC014192.2. On or before Oct 6, 2004 this sequence version replaced NM_032938.1, NM_004489.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013652.1, BC107738.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCCCGCAC TCCTGGAGCG CCCCAAGCTT TCCAACGCCA TGGCCAGGGC GCTGCACCGG 
CACATTATGA TGGAGCGGGA GCGCAAGCGG CAGGAGGAAG AAGAGGTGGA TAAGATGATG
GAACAGAAGA TGAAGGAAGA ACAGGAGAGA AGGAAGAAAA AGGAGATGGA AGAGAGAATG
TCATTAGAGG AGACCAAGGA ACAAATTCTG AAGTTGGAGG AGAAGCTTTT GGCTCTACAG
GAAGAGAAGC ACCAGCTTTT CCTGCAGCTC AAGAAAGTTT TACATGAGGA AGAAAAACGG
AGGCGAAAGG AACAGAGTGA CCTGACCACC CTAACATCAG CTGCATACCA GCAGAGCCTG
ACTGTTCACA CAGGAACTCA TCTCCTCAGC ATGCAGGGGA GCCCTGGAGG ACACAATCGC
CCAGGCACCC TCATGGCAGC TGACAGAGCC AAACAAATGT TTGGACCCCA AGTGCTTACG
ACCCGGCACT ACGTGGGCTC AGCAGCTGCT TTTGCAGGGA CACCAGAGCA TGGACAATTC
CAAGGCAGTC CTGGTGGTGC CTATGGGACT GCTCAGCCCC CACCTCACTA TGGGCCCACA
CAGCCAGCTT ATAGTCCTAG TCAGCAGCTC AGAGCTCCTT CGGCATTCCC TGCAGTGCAG
TACCTATCTC AGCCACAGCC ACAGCCCTAT GCTGTGCATG GCCACTTTCA GCCCACTCAG
ACAGGTTTCC TCCAGCCTGG TGGTGCCCTG TCCTTGCAAA AGCAGATGGA ACATGCTAAC
CAGCAGACTG GCTTCTCCGA CTCATCCTCT CTGCGCCCCA TGCACCCCCA GGCTCTGCAT
CCAGCCCCTG GACTCCTTGC TTCCCCCCAG CTCCCTGTGC AGATGCAGCC AGCAGGAAAG
TCGGGCTTTG CAGCTACCAG CCAACCTGGC CCTCGGCTCC CCTTCATCCA ACACAGCCAG
AACCCGCGAT TCTACCACAA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004480.1
CDS77..1060
Misc Feature(1)89..952
Exon (1)1..9
Exon (2)10..170
Exon (3)171..280
Exon (4)281..393
Exon (5)394..473
Exon (6)474..556
Exon (7)557..710
Exon (8)711..800
Exon (9)801..880
Exon (10)881..976
Exon (11)977..1157
Translation

Target ORF information:

RefSeq Version NM_004489.4
Organism Homo sapiens(Human)
Definition Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004489.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCCCGCAC TCCTGGAGCG CCCCAAGCTT TCCAACGCCA TGGCCAGGGC GCTGCACCGG 
CACATTATGA TGGAGCGGGA GCGCAAGCGG CAGGAGGAAG AAGAGGTGGA TAAGATGATG
GAACAGAAGA TGAAGGAAGA ACAGGAGAGA AGGAAGAAAA AGGAGATGGA AGAGAGAATG
TCATTAGAGG AGACCAAGGA ACAAATTCTG AAGTTGGAGG AGAAGCTTTT GGCTCTACAG
GAAGAGAAGC ACCAGCTTTT CCTGCAGCTC AAGAAAGTTT TACATGAGGA AGAAAAACGG
AGGCGAAAGG AACAGAGTGA CCTGACCACC CTAACATCAG CTGCATACCA GCAGAGCCTG
ACTGTTCACA CAGGAACTCA TCTCCTCAGC ATGCAGGGGA GCCCTGGAGG ACACAATCGC
CCAGGCACCC TCATGGCAGC TGACAGAGCC AAACAAATGT TTGGACCCCA AGTGCTTACG
ACCCGGCACT ACGTGGGCTC AGCAGCTGCT TTTGCAGGGA CACCAGAGCA TGGACAATTC
CAAGGCAGTC CTGGTGGTGC CTATGGGACT GCTCAGCCCC CACCTCACTA TGGGCCCACA
CAGCCAGCTT ATAGTCCTAG TCAGCAGCTC AGAGCTCCTT CGGCATTCCC TGCAGTGCAG
TACCTATCTC AGCCACAGCC ACAGCCCTAT GCTGTGCATG GCCACTTTCA GCCCACTCAG
ACAGGTTTCC TCCAGCCTGG TGGTGCCCTG TCCTTGCAAA AGCAGATGGA ACATGCTAAC
CAGCAGACTG GCTTCTCCGA CTCATCCTCT CTGCGCCCCA TGCACCCCCA GGCTCTGCAT
CCAGCCCCTG GACTCCTTGC TTCCCCCCAG CTCCCTGTGC AGATGCAGCC AGCAGGAAAG
TCGGGCTTTG CAGCTACCAG CCAACCTGGC CCTCGGCTCC CCTTCATCCA ACACAGCCAG
AACCCGCGAT TCTACCACAA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation.
The Journal of biological chemistry290(31)19044-54(2015 Jul)
Huang J,Cardamone MD,Johnson HE,Neault M,Chan M,Floyd ZE,Mallette FA,Perissi V


book

Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child.
Genes, chromosomes & cancer53(12)991-8(2014 Dec)
O'Meara E,Stack D,Phelan S,McDonagh N,Kelly L,Sciot R,Debiec-Rychter M,Morris T,Cochrane D,Sorensen P,O'Sullivan MJ


book

SUMOylation of GPS2 protein regulates its transcription-suppressing function.
Molecular biology of the cell25(16)2499-508(2014 Aug)
Bi H,Li S,Wang M,Jia Z,Chang AK,Pang P,Wu H


book

SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation.
The Journal of clinical investigation123(1)362-79(2013 Jan)
Toubal A,Clément K,Fan R,Ancel P,Pelloux V,Rouault C,Veyrie N,Hartemann A,Treuter E,Venteclef N


book

GPS2 is required for the association of NS5A with VAP-A and hepatitis C virus replication.
PloS one8(11)e78195(2013)
Xu G,Xin X,Zheng C


 
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