DEXI cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEXI
Entrez Gene ID	28955
Full Name	Dexi homolog
Synonyms	MYLE
General protein information	Preferred Names Dexi homolog Names dexamethasone-induced protein dexamethasone-induced transcript
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.13

mRNA and Protein(s)

mRNA	Protein	Name
NM_014015.3	NP_054734.2	dexamethasone-induced protein
XM_011522455.2	XP_011520757.1	dexamethasone-induced protein isoform X1
NM_014015.4	NP_054734.2	dexamethasone-induced protein
XM_017023171.1	XP_016878660.1	dexamethasone-induced protein isoform X2
XM_011522455.3	XP_011520757.1	dexamethasone-induced protein isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	DEXI	NP_054734.2
	DEXI	XP_002802444.1
Bos taurus (cattle)	DEXI	NP_001178098.1
Gallus gallus (chicken)	DEXI	NP_001264543.1
Mus musculus (house mouse)	Dexi	NP_067403.2
Rattus norvegicus (Norway rat)	Dexi	NP_001102496.1
Danio rerio (zebrafish)	dexi	NP_001003764.1
Pan troglodytes (chimpanzee)	DEXI	XP_003315015.1
Xenopus tropicalis (tropical clawed frog)	dexi	XP_004918001.1
Canis lupus familiaris (dog)	DEXI	XP_005621602.1

Gene Ontology
Bibliography

Related articles in PubMed

Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13.
Tomlinson MJ 4th, Pitsillides A, Pickin R, Mika M, Keene KL, Hou X, Mychaleckyj J, Chen WM, Concannon P, Onengut-Gumuscu S
Diabetes63(12)4360-8(2014 Dec)

Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.
Leikfoss IS, Mero IL, Dahle MK, Lie BA, Harbo HF, Spurkland A, Berge T
Genes and immunity14(1)62-6(2013 Jan)

Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer.
Miyaki Y, Suzuki K, Koizumi K, Kato T, Saito M, Kamiyama H, Maeda T, Shibata K, Shiya N, Konishi F
International journal of oncology40(1)217-26(2012 Jan)

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.
Davison LJ, Wallace C, Cooper JD, Cope NF, Wilson NK, Smyth DJ, Howson JM, Saleh N, Al-Jeffery A, Angus KL, Stevens HE, Nutland S, Duley S, Coulson RM, Walker NM, Burren OS, Rice CM, Cambien F, Zeller T, Munzel T, Lackner K, Blakenberg S, , Fraser P, Gottgens B, Todd JA, Attwood T, Belz S, Braund P, Cambien F, Cooper J, Crisp-Hihn A, Diemert P, Deloukas P, Foad N, Erdmann J, Goodall AH, Gracey J, Gray E, Williams RG, Heimerl S, Hengstenberg C, Jolley J, Krishnan U, Lloyd-Jones H, Lugauer I, Lundmark P, Maouche S, Moore JS, Muir D, Murray E, Nelson CP, Neudert J, Niblett D, O'Leary K, Ouwehand WH, Pollard H, Rankin A, Rice CM, Sager H, Samani NJ, Sambrook J, Schmitz G, Scholz M, Schroeder L, Schunkert H, Syvannen AC, Tennstedt S, Wallace C
Human molecular genetics21(2)322-33(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Reduced DEXI mRNA level was associated with type 1 diabetes risk alleles of CLEC16A.
Title: Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13.

The data indicates a possible regulatory role for multiple sclerosis-associated non-coding CLEC16A SNPs and a common control mechanism for the expression of CLEC16A, SOCS1 and DEXI.
Title: Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.

Silencing of DEXI leads to drug resistance in colon cancer.
Title: Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer.

DEXI is an unappreciated autoimmune disease candidate gene, and illustrate the power of the 3C approach in progressing from genome-wide association studies results to candidate causal genes
Title: Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.

The following DEXI gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEXI cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31000	NM_014015.4 Latest version!	Homo sapiens Dexi homolog (DEXI), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31000	XM_017023171.1 Latest version!	Homo sapiens Dexi homolog (DEXI), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu67272	XM_011522455.3 Latest version!	Homo sapiens Dexi homolog (DEXI), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu31000	NM_014015.3	Homo sapiens Dexi homolog (DEXI), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu67272	XM_011522455.2	Homo sapiens Dexi homolog (DEXI), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEXI ( NM_014015.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_054734.2 Homo sapiens Dexi homolog (DEXI), mRNA.

Price & Availability↑

CloneID	OHu31000
Clone ID Related Accession (Same CDS sequence)	NM_014015.3 , NM_014015.4 , XM_017023171.1
Accession Version	NM_014015.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Homo sapiens(human)
Product	dexamethasone-induced protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC037569.1. On Aug 13, 2003 this sequence version replaced NM_014015.2. ##Evidence-Data-START## Transcript exon combination :: BC037569.1, ERR279873.1079.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation ##RefSeq-Attributes-END##

ATGCTCGGCG CCCGGGTCGC GGCCCACCTG GACGCACTGG GCCCCCTGGT CCCCTACGTG 
CCGCCGCCGC TGCTGCCCTC TATGTTCTAC GTGGGCCTGT TCTTCGTCAA TGTGCTGATC 
CTGTACTACG CCTTCCTCAT GGAGTACATC GTCCTCAACG TGGGCCTCGT CTTCCTGCCC 
GAGGACATGG ACCAGGCGCT CGTGGACCTC GGCGTGCTCT CCGACCCCGG CTCGGGCCTT 
TACGATGCTG ACTCGGAGCT CGACGTCTTT GATGCGTACT TGGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054734.2
CDS	396..683
Translation	MLGARVAAHLDALGPLVPYVPPPLLPSMFYVGLFFVNVLILYYAFLMEYIVLNVGLVFLPEDMDQALVDLGVLSDPGSGLYDADSELDVFDAYLE

Target ORF information:

RefSeq Version	NM_014015.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Dexi homolog (DEXI), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014015.3

ORF Insert Sequence:

ATGCTCGGCG CCCGGGTCGC GGCCCACCTG GACGCACTGG GCCCCCTGGT CCCCTACGTG 
CCGCCGCCGC TGCTGCCCTC TATGTTCTAC GTGGGCCTGT TCTTCGTCAA TGTGCTGATC 
CTGTACTACG CCTTCCTCAT GGAGTACATC GTCCTCAACG TGGGCCTCGT CTTCCTGCCC 
GAGGACATGG ACCAGGCGCT CGTGGACCTC GGCGTGCTCT CCGACCCCGG CTCGGGCCTT 
TACGATGCTG ACTCGGAGCT CGACGTCTTT GATGCGTACT TGGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEXI ( NM_014015.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_054734.2 Homo sapiens Dexi homolog (DEXI), mRNA.

Price & Availability↑

CloneID	OHu31000
Clone ID Related Accession (Same CDS sequence)	NM_014015.3 , NM_014015.4 , XM_017023171.1
Accession Version	NM_014015.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Homo sapiens(human)
Product	dexamethasone-induced protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC133065.3 and BC037569.1. On Nov 23, 2018 this sequence version replaced NM_014015.3. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.986743.1, SRR3476690.913599.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000331808.5/ ENSP00000330509.4 NMD candidate :: translation inferred from conservation RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCGGCG CCCGGGTCGC GGCCCACCTG GACGCACTGG GCCCCCTGGT CCCCTACGTG 
CCGCCGCCGC TGCTGCCCTC TATGTTCTAC GTGGGCCTGT TCTTCGTCAA TGTGCTGATC 
CTGTACTACG CCTTCCTCAT GGAGTACATC GTCCTCAACG TGGGCCTCGT CTTCCTGCCC 
GAGGACATGG ACCAGGCGCT CGTGGACCTC GGCGTGCTCT CCGACCCCGG CTCGGGCCTT 
TACGATGCTG ACTCGGAGCT CGACGTCTTT GATGCGTACT TGGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054734.2
CDS	464..751
Translation	MLGARVAAHLDALGPLVPYVPPPLLPSMFYVGLFFVNVLILYYAFLMEYIVLNVGLVFLPEDMDQALVDLGVLSDPGSGLYDADSELDVFDAYLE

Target ORF information:

RefSeq Version	NM_014015.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Dexi homolog (DEXI), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014015.4

ORF Insert Sequence:

ATGCTCGGCG CCCGGGTCGC GGCCCACCTG GACGCACTGG GCCCCCTGGT CCCCTACGTG 
CCGCCGCCGC TGCTGCCCTC TATGTTCTAC GTGGGCCTGT TCTTCGTCAA TGTGCTGATC 
CTGTACTACG CCTTCCTCAT GGAGTACATC GTCCTCAACG TGGGCCTCGT CTTCCTGCCC 
GAGGACATGG ACCAGGCGCT CGTGGACCTC GGCGTGCTCT CCGACCCCGG CTCGGGCCTT 
TACGATGCTG ACTCGGAGCT CGACGTCTTT GATGCGTACT TGGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEXI ( XM_017023171.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016878660.1 Homo sapiens Dexi homolog (DEXI), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu31000
Clone ID Related Accession (Same CDS sequence)	NM_014015.3 , NM_014015.4 , XM_017023171.1
Accession Version	XM_017023171.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	dexamethasone-induced protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCGGCG CCCGGGTCGC GGCCCACCTG GACGCACTGG GCCCCCTGGT CCCCTACGTG 
CCGCCGCCGC TGCTGCCCTC TATGTTCTAC GTGGGCCTGT TCTTCGTCAA TGTGCTGATC 
CTGTACTACG CCTTCCTCAT GGAGTACATC GTCCTCAACG TGGGCCTCGT CTTCCTGCCC 
GAGGACATGG ACCAGGCGCT CGTGGACCTC GGCGTGCTCT CCGACCCCGG CTCGGGCCTT 
TACGATGCTG ACTCGGAGCT CGACGTCTTT GATGCGTACT TGGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016878660.1
CDS	1003..1290
Translation	MLGARVAAHLDALGPLVPYVPPPLLPSMFYVGLFFVNVLILYYAFLMEYIVLNVGLVFLPEDMDQALVDLGVLSDPGSGLYDADSELDVFDAYLE

Target ORF information:

RefSeq Version	XM_017023171.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Dexi homolog (DEXI), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017023171.1

ORF Insert Sequence:

ATGCTCGGCG CCCGGGTCGC GGCCCACCTG GACGCACTGG GCCCCCTGGT CCCCTACGTG 
CCGCCGCCGC TGCTGCCCTC TATGTTCTAC GTGGGCCTGT TCTTCGTCAA TGTGCTGATC 
CTGTACTACG CCTTCCTCAT GGAGTACATC GTCCTCAACG TGGGCCTCGT CTTCCTGCCC 
GAGGACATGG ACCAGGCGCT CGTGGACCTC GGCGTGCTCT CCGACCCCGG CTCGGGCCTT 
TACGATGCTG ACTCGGAGCT CGACGTCTTT GATGCGTACT TGGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEXI ( XM_011522455.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520757.1 Homo sapiens Dexi homolog (DEXI), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu67272
Clone ID Related Accession (Same CDS sequence)	XM_011522455.2 , XM_011522455.3
Accession Version	XM_011522455.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	dexamethasone-induced protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011522455.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCCGC AGCTGGTTGG GGGCACCATC TGGACGGGGA TGGTTCCCCA GGAGGAGACC 
CTCCCCTGCC TCCGAGGCCT GGACATGGAC CTGTGCAGAG ACAGGCAGCT TCTCCTTTGC 
CGTCTGTCTC CTTCCGGCCA CCAGGAGACA GCCAGACCCC AGCCATGCCT TCATTCTGAG 
ATAAGACCTG CTCCCCTCAA AAGCTTCGTG CCAACAGAGA GGTTCCTGTT TGAACCCAGG 
AGAGTGGAAG AGAGATTGGG ACTGAGTGCT GAGGTTGGGA AGGCACCTGC TCCCACAGAA 
GGGGGAACGC AAGAGGCATC CCAAGACCTC ATCTGCCTGC AGTGTCAAAT CGATGGCCTG 
GCCTTGGCTT CTGATTATTT GCAGCTGCGA TGGATGTTTA CAGGAACCCA GCCAGAGTTT 
GCCTCCCTGC ACTTCATCCC GGAGCGCACC TGCTTCCCCC ACTTCACCTT CGGAGAGGAC 
ACTTCAAACT GCGGACACAC GCAAAAGCGA CTCCCAGCTC CGTTTGATGT GAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520757.1
CDS	30..566
Translation	MPPQLVGGTIWTGMVPQEETLPCLRGLDMDLCRDRQLLLCRLSPSGHQETARPQPCLHSEIRPAPLKSFVPTERFLFEPRRVEERLGLSAEVGKAPAPTEGGTQEASQDLICLQCQIDGLALASDYLQLRWMFTGTQPEFASLHFIPERTCFPHFTFGEDTSNCGHTQKRLPAPFDVS

Target ORF information:

RefSeq Version	XM_011522455.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Dexi homolog (DEXI), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522455.2

ORF Insert Sequence:

ATGCCGCCGC AGCTGGTTGG GGGCACCATC TGGACGGGGA TGGTTCCCCA GGAGGAGACC 
CTCCCCTGCC TCCGAGGCCT GGACATGGAC CTGTGCAGAG ACAGGCAGCT TCTCCTTTGC 
CGTCTGTCTC CTTCCGGCCA CCAGGAGACA GCCAGACCCC AGCCATGCCT TCATTCTGAG 
ATAAGACCTG CTCCCCTCAA AAGCTTCGTG CCAACAGAGA GGTTCCTGTT TGAACCCAGG 
AGAGTGGAAG AGAGATTGGG ACTGAGTGCT GAGGTTGGGA AGGCACCTGC TCCCACAGAA 
GGGGGAACGC AAGAGGCATC CCAAGACCTC ATCTGCCTGC AGTGTCAAAT CGATGGCCTG 
GCCTTGGCTT CTGATTATTT GCAGCTGCGA TGGATGTTTA CAGGAACCCA GCCAGAGTTT 
GCCTCCCTGC ACTTCATCCC GGAGCGCACC TGCTTCCCCC ACTTCACCTT CGGAGAGGAC 
ACTTCAAACT GCGGACACAC GCAAAAGCGA CTCCCAGCTC CGTTTGATGT GAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEXI ( XM_011522455.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520757.1 Homo sapiens Dexi homolog (DEXI), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu67272
Clone ID Related Accession (Same CDS sequence)	XM_011522455.2 , XM_011522455.3
Accession Version	XM_011522455.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	dexamethasone-induced protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011522455.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGCCGCCGC AGCTGGTTGG GGGCACCATC TGGACGGGGA TGGTTCCCCA GGAGGAGACC 
CTCCCCTGCC TCCGAGGCCT GGACATGGAC CTGTGCAGAG ACAGGCAGCT TCTCCTTTGC 
CGTCTGTCTC CTTCCGGCCA CCAGGAGACA GCCAGACCCC AGCCATGCCT TCATTCTGAG 
ATAAGACCTG CTCCCCTCAA AAGCTTCGTG CCAACAGAGA GGTTCCTGTT TGAACCCAGG 
AGAGTGGAAG AGAGATTGGG ACTGAGTGCT GAGGTTGGGA AGGCACCTGC TCCCACAGAA 
GGGGGAACGC AAGAGGCATC CCAAGACCTC ATCTGCCTGC AGTGTCAAAT CGATGGCCTG 
GCCTTGGCTT CTGATTATTT GCAGCTGCGA TGGATGTTTA CAGGAACCCA GCCAGAGTTT 
GCCTCCCTGC ACTTCATCCC GGAGCGCACC TGCTTCCCCC ACTTCACCTT CGGAGAGGAC 
ACTTCAAACT GCGGACACAC GCAAAAGCGA CTCCCAGCTC CGTTTGATGT GAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520757.1
CDS	37..573
Translation	MPPQLVGGTIWTGMVPQEETLPCLRGLDMDLCRDRQLLLCRLSPSGHQETARPQPCLHSEIRPAPLKSFVPTERFLFEPRRVEERLGLSAEVGKAPAPTEGGTQEASQDLICLQCQIDGLALASDYLQLRWMFTGTQPEFASLHFIPERTCFPHFTFGEDTSNCGHTQKRLPAPFDVS

Target ORF information:

RefSeq Version	XM_011522455.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Dexi homolog (DEXI), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522455.3

ORF Insert Sequence:

ATGCCGCCGC AGCTGGTTGG GGGCACCATC TGGACGGGGA TGGTTCCCCA GGAGGAGACC 
CTCCCCTGCC TCCGAGGCCT GGACATGGAC CTGTGCAGAG ACAGGCAGCT TCTCCTTTGC 
CGTCTGTCTC CTTCCGGCCA CCAGGAGACA GCCAGACCCC AGCCATGCCT TCATTCTGAG 
ATAAGACCTG CTCCCCTCAA AAGCTTCGTG CCAACAGAGA GGTTCCTGTT TGAACCCAGG 
AGAGTGGAAG AGAGATTGGG ACTGAGTGCT GAGGTTGGGA AGGCACCTGC TCCCACAGAA 
GGGGGAACGC AAGAGGCATC CCAAGACCTC ATCTGCCTGC AGTGTCAAAT CGATGGCCTG 
GCCTTGGCTT CTGATTATTT GCAGCTGCGA TGGATGTTTA CAGGAACCCA GCCAGAGTTT 
GCCTCCCTGC ACTTCATCCC GGAGCGCACC TGCTTCCCCC ACTTCACCTT CGGAGAGGAC 
ACTTCAAACT GCGGACACAC GCAAAAGCGA CTCCCAGCTC CGTTTGATGT GAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13.
Diabetes63(12)4360-8(2014 Dec)
Tomlinson MJ 4th,Pitsillides A,Pickin R,Mika M,Keene KL,Hou X,Mychaleckyj J,Chen WM,Concannon P,Onengut-Gumuscu S

Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.
Genes and immunity14(1)62-6(2013 Jan)
Leikfoss IS,Mero IL,Dahle MK,Lie BA,Harbo HF,Spurkland A,Berge T

Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer.
International journal of oncology40(1)217-26(2012 Jan)
Miyaki Y,Suzuki K,Koizumi K,Kato T,Saito M,Kamiyama H,Maeda T,Shibata K,Shiya N,Konishi F

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.
Human molecular genetics21(2)322-33(2012 Jan)
Davison LJ,Wallace C,Cooper JD,Cope NF,Wilson NK,Smyth DJ,Howson JM,Saleh N,Al-Jeffery A,Angus KL,Stevens HE,Nutland S,Duley S,Coulson RM,Walker NM,Burren OS,Rice CM,Cambien F,Zeller T,Munzel T,Lackner K,Blakenberg S,,Fraser P,Gottgens B,Todd JA,Attwood T,Belz S,Braund P,Cambien F,Cooper J,Crisp-Hihn A,Diemert P,Deloukas P,Foad N,Erdmann J,Goodall AH,Gracey J,Gray E,Williams RG,Heimerl S,Hengstenberg C,Jolley J,Krishnan U,Lloyd-Jones H,Lugauer I,Lundmark P,Maouche S,Moore JS,Muir D,Murray E,Nelson CP,Neudert J,Niblett D,O'Leary K,Ouwehand WH,Pollard H,Rankin A,Rice CM,Sager H,Samani NJ,Sambrook J,Schmitz G,Scholz M,Schroeder L,Schunkert H,Syvannen AC,Tennstedt S,Wallace C

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DEXI cDNA ORF clone, Homo sapiens(human)

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