MRPS18B cDNA ORF clone, Homo sapiens(human)
Gene Symbol | MRPS18B |
Entrez Gene ID | 28973 |
Full Name | mitochondrial ribosomal protein S18B |
Synonyms | C6orf14,HSPC183,HumanS18a,MRP-S18-2,MRPS18-2,PTD017,S18amt |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
XM_024446408.1 | XP_024302176.1 | 28S ribosomal protein S18b, mitochondrial isoform X1 |
NM_014046.3 | NP_054765.1 | 28S ribosomal protein S18b, mitochondrial |
NM_014046.4 | NP_054765.1 | 28S ribosomal protein S18b, mitochondrial |

Pan troglodytes (chimpanzee) | MRPS18B | NP_001035204.1 |
MRPS18B | NP_001098635.1 | |
Canis lupus familiaris (dog) | MRPS18B | XP_532057.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100489063 | XP_002939509.2 |
Homo sapiens (human) | MRPS18B | NP_054765.1 |
Danio rerio (zebrafish) | mrps18b | NP_001017759.1 |
Bos taurus (cattle) | MRPS18B | NP_001033613.1 |
Mus musculus (house mouse) | Mrps18b | NP_080154.1 |
Rattus norvegicus (Norway rat) | Mrps18b | NP_997699.2 |

Related articles in PubMed
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development?
Kashuba E, Mushtaq M
Experimental oncology39(1)12-16(2017 Mar)
S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma.
Mushtaq M, Ali RH, Kashuba V, Klein G, Kashuba E
Oncotarget7(34)55649-55662(2016 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Studies suggest that mitochondrial ribosomal protein S18-2 protein, together with the retinoblastoma protein (RB), plays a crucial role in the control on cell stemness and differentiation.
Title: Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development?
We conclude that high expression of S18-2 and free E2F...1might be a good set of prognostic markers for endometrial cancer
Title: Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1.
S18-2 is a newly identified oncoprotein that may be involved in cancerogenesis
Title: Mitochondrial ribosomal protein S18-2 evokes chromosomal instability and transforms primary rat skin fibroblasts.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
The following MRPS18B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPS18B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu30577 | |
Clone ID Related Accession (Same CDS sequence) | NM_014046.3 , NM_014046.4 | |
Accession Version | NM_014046.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-10 | |
Organism | Homo sapiens(human) | |
Product | 28S ribosomal protein S18b, mitochondrial | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP369345.1, BG773408.1, AF100761.1 and BE220785.1. On Apr 29, 2008 this sequence version replaced NM_014046.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF151017.1, SRR1163655.53704.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGT CTGTATTAAA CACCGTGCTG AGGCGGCTTC CTATGCTATC TCTCTTCCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_054765.1 |
CDS | 158..934 |
Translation |

Target ORF information:
Target ORF information:
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ORF Insert Sequence:
1 | ATGGCGGCGT CTGTATTAAA CACCGTGCTG AGGCGGCTTC CTATGCTATC TCTCTTCCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu30577 | |
Clone ID Related Accession (Same CDS sequence) | NM_014046.3 , NM_014046.4 | |
Accession Version | NM_014046.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | 28S ribosomal protein S18b, mitochondrial | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG773408.1, AF100761.1 and BE220785.1. On Nov 23, 2018 this sequence version replaced NM_014046.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.963164.1, AF151017.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000259873.5/ ENSP00000259873.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCGGCGT CTGTATTAAA CACCGTGCTG AGGCGGCTTC CTATGCTATC TCTCTTCCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_054765.1 |
CDS | 27..803 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGT CTGTATTAAA CACCGTGCTG AGGCGGCTTC CTATGCTATC TCTCTTCCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu40273 | |
Clone ID Related Accession (Same CDS sequence) | XM_024446408.1 | |
Accession Version | XM_024446408.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | 28S ribosomal protein S18b, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGATCTA AGAGTCGTAG TGACTGGCCA AAAAAAACCG CAATTTTGGG GTCTAATTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024302176.1 |
CDS | 310..912 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCGATCTA AGAGTCGTAG TGACTGGCCA AAAAAAACCG CAATTTTGGG GTCTAATTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Architecture of the human interactome defines protein communities and disease networks. |
![]() |
Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? |
![]() |
S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma. |