Gene Symbol | PKN3 |
Entrez Gene ID | 29941 |
Full Name | protein kinase N3 |
Synonyms | UTDP4-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » PKN3 cDNA ORF clone
gRNAs
Gene Symbol | PKN3 |
Entrez Gene ID | 29941 |
Full Name | protein kinase N3 |
Synonyms | UTDP4-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_013355.4 | NP_037487.2 | serine/threonine-protein kinase N3 isoform 1 |
XM_005251946.3 | XP_005252003.1 | serine/threonine-protein kinase N3 isoform X2 |
NM_013355.3 | NP_037487.2 | serine/threonine-protein kinase N3 |
XM_006717080.3 | XP_006717143.1 | serine/threonine-protein kinase N3 isoform X1 |
NM_001317926.1 | NP_001304855.1 | serine/threonine-protein kinase N3 isoform 2 |
XM_017014649.2 | XP_016870138.1 | serine/threonine-protein kinase N3 isoform X3 |
NM_001317926.2 | NP_001304855.1 | serine/threonine-protein kinase N3 isoform 2 |
NM_013355.5 | NP_037487.2 | serine/threonine-protein kinase N3 isoform 1 |
XM_006717080.2 | XP_006717143.1 | serine/threonine-protein kinase N3 isoform X1 |
XM_017014649.1 | XP_016870138.1 | serine/threonine-protein kinase N3 isoform X3 |
XM_017014650.1 | XP_016870139.1 | serine/threonine-protein kinase N3 isoform X4 |
Pan troglodytes (chimpanzee) | PKN3 | XP_001159776.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100145241 | NP_001120197.1 |
Bos taurus (cattle) | PKN3 | NP_001192495.1 |
Gallus gallus (chicken) | PKN3 | XP_004945892.1 |
PKN3 | XP_001110500.2 | |
Homo sapiens (human) | PKN3 | NP_037487.2 |
Canis lupus familiaris (dog) | PKN3 | XP_005625334.1 |
Mus musculus (house mouse) | Pkn3 | NP_722500.1 |
PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.
Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, Danno S, Mehruba M, Satoh R, Sugiura R
Scientific reports618979(2016 Jan)
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)
Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.
Falk MD, Liu W, Bola?os B, Unsal-Kacmaz K, Klippel A, Grant S, Brooun A, Timofeevski S
Bioscience reports34(2)(2014 Apr)
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
Cheng CY, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJ, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, St Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Mishra A, Wang YX, Wang JJ, Rochtchina E, Polasek O, Wright AF, Amin N, van Leeuwen EM, Wilson JF, Pennell CE, van Duijn CM, de Jong PT, Vingerling JR, Zhou X, Chen P, Li R, Tay WT, Zheng Y, Chew M, , Burdon KP, Craig JE, Iyengar SK, Igo RP Jr, Lass JH Jr, , Chew EY, Haller T, Mihailov E, Metspalu A, Wedenoja J, Simpson CL, Wojciechowski R, H?hn R, Mirshahi A, Zeller T, Pfeiffer N, Lackner KJ, , Bettecken T, Meitinger T, Oexle K, Pirastu M, Portas L, Nag A, Williams KM, Yonova-Doing E, Klein R, Klein BE, Hosseini SM, Paterson AD, , Makela KM, Lehtimaki T, Kahonen M, Raitakari O, Yoshimura N, Matsuda F, Chen LJ, Pang CP, Yip SP, Yap MK, Meguro A, Mizuki N, Inoko H, Foster PJ, Zhao JH, Vithana E, Tai ES, Fan Q, Xu L, Campbell H, Fleck B, Rudan I, Aung T, Hofman A, Uitterlinden AG, Bencic G, Khor CC, Forward H, P?rssinen O, Mitchell P, Rivadeneira F, Hewitt AW, Williams C, Oostra BA, Teo YY, Hammond CJ, Stambolian D, Mackey DA, Klaver CC, Wong TY, Saw SM, Baird PN
American journal of human genetics93(2)264-77(2013 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
PKN3 is the major regulator of angiogenesis in humans and mice and tumor metastasis in mice.
Title: PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.
Steady-state kinetic analysis revealed that PKN1-3 follows a sequential ordered Bi-Bi kinetic mechanism, where peptide substrate binding is preceded by ATP binding. This kinetic mechanism was confirmed by additional kinetic studies for product inhibition and affinity of small molecule inhibitors.
Title: Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.
PKN3 can be considered a novel protein implicated in remodeling the actin-adherens junction, possibly by linking ICAM-1-signaling with actin/AJ dynamics.
Title: Depletion of protein kinase N3 (PKN3) impairs actin and adherens junctions dynamics and attenuates endothelial cell activation.
PKN isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It
Title: Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration.
PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of phosphoinositide 3-kinase
Title: PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.
The following PKN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PKN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu13198![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_013355.4 , NM_013355.3 , NM_013355.5 | |
Accession Version | NM_013355.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2670bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-26 | |
Organism | Homo sapiens(human) | |
Product | serine/threonine-protein kinase N3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN364780.1, BC062558.1 and BQ009753.1. On Dec 15, 2015 this sequence version replaced NM_013355.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062558.1, AB019692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGGAGG GGGCGCCGCG GCAGCCTGGG CCGAGCCAGT GGCCCCCAGA GGATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_037487.2 |
CDS | 413..3082 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGGAGG GGGCGCCGCG GCAGCCTGGG CCGAGCCAGT GGCCCCCAGA GGATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13198![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_013355.4 , NM_013355.3 , NM_013355.5 | |
Accession Version | NM_013355.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2670bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-14 | |
Organism | Homo sapiens(Human) | |
Product | serine/threonine-protein kinase N3 | |
Comment |
1 | ATGGAGGAGG GGGCGCCGCG GCAGCCTGGG CCGAGCCAGT GGCCCCCAGA GGATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_037487.2 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGAGG GGGCGCCGCG GCAGCCTGGG CCGAGCCAGT GGCCCCCAGA GGATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13198![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_013355.4 , NM_013355.3 , NM_013355.5 | |
Accession Version | NM_013355.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2670bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-01 | |
Organism | Homo sapiens(human) | |
Product | serine/threonine-protein kinase N3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL441992.17. On Nov 23, 2018 this sequence version replaced NM_013355.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062558.1, AB019692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000291906.5/ ENSP00000291906.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGAGGAGG GGGCGCCGCG GCAGCCTGGG CCGAGCCAGT GGCCCCCAGA GGATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_037487.2 |
CDS | 414..3083 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGAGG GGGCGCCGCG GCAGCCTGGG CCGAGCCAGT GGCCCCCAGA GGATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu98621 | |
Clone ID Related Accession (Same CDS sequence) | XM_017014650.1 | |
Accession Version | XM_017014650.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2292bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | serine/threonine-protein kinase N3 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCCACA CGTGCGCCAG TGGCACCCCC AAGGAGAGGA AGCTCCTGGC AGCTGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016870139.1 |
CDS | 1000..3291 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGACCCACA CGTGCGCCAG TGGCACCCCC AAGGAGAGGA AGCTCCTGGC AGCTGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43232 | |
Clone ID Related Accession (Same CDS sequence) | NM_001317926.1 , NM_001317926.2 | |
Accession Version | NM_001317926.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2502bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-25 | |
Organism | Homo sapiens(human) | |
Product | serine/threonine-protein kinase N3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN364780.1, BC041581.1 and BQ009753.1. On Dec 15, 2015 this sequence version replaced XM_006717082.2. Transcript Variant: This variant (2) uses an alternate splice site in the penultimate exon, compared to variant 1, resulting in a novel 3' coding region and shorter 3' UTR. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041581.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGGAGG GGGCGCCGCG GCAGCCTGGG CCGAGCCAGT GGCCCCCAGA GGATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001304855.1 |
CDS | 413..2914 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGGAGG GGGCGCCGCG GCAGCCTGGG CCGAGCCAGT GGCCCCCAGA GGATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43232 | |
Clone ID Related Accession (Same CDS sequence) | NM_001317926.1 , NM_001317926.2 | |
Accession Version | NM_001317926.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2502bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-03 | |
Organism | Homo sapiens(human) | |
Product | serine/threonine-protein kinase N3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL441992.17. On Jun 1, 2019 this sequence version replaced NM_001317926.1. Transcript Variant: This variant (2) uses an alternate splice site in the penultimate exon, compared to variant 1, resulting in a novel 3' coding region and shorter 3' UTR. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041581.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGGAGG GGGCGCCGCG GCAGCCTGGG CCGAGCCAGT GGCCCCCAGA GGATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001304855.1 |
CDS | 414..2915 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGGAGG GGGCGCCGCG GCAGCCTGGG CCGAGCCAGT GGCCCCCAGA GGATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43229 | |
Clone ID Related Accession (Same CDS sequence) | XM_006717080.3 , XM_006717080.2 | |
Accession Version | XM_006717080.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2691bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | serine/threonine-protein kinase N3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006717080.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGAGGGG AGCGGCCTCC CCCGCCCCAG GGCGGGAACC TTTGGCCTGG GCCGAGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006717143.1 |
CDS | 463..3153 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGAGGGG AGCGGCCTCC CCCGCCCCAG GGCGGGAACC TTTGGCCTGG GCCGAGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43229 | |
Clone ID Related Accession (Same CDS sequence) | XM_006717080.3 , XM_006717080.2 | |
Accession Version | XM_006717080.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2691bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | serine/threonine-protein kinase N3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006717080.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGAGGGG AGCGGCCTCC CCCGCCCCAG GGCGGGAACC TTTGGCCTGG GCCGAGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006717143.1 |
CDS | 461..3151 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGAGGGG AGCGGCCTCC CCCGCCCCAG GGCGGGAACC TTTGGCCTGG GCCGAGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43230 | |
Clone ID Related Accession (Same CDS sequence) | XM_005251946.3 | |
Accession Version | XM_005251946.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2661bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | serine/threonine-protein kinase N3 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005251946.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAACACA GAGAGCCTGG GCCGAGCCAG TGGCCCCCAG AGGATGAGAA GGAGGTGATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005252003.1 |
CDS | 977..3637 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAACACA GAGAGCCTGG GCCGAGCCAG TGGCCCCCAG AGGATGAGAA GGAGGTGATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu98620 | |
Clone ID Related Accession (Same CDS sequence) | XM_017014649.2 , XM_017014649.1 | |
Accession Version | XM_017014649.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2523bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | serine/threonine-protein kinase N3 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017014649.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGAGGGG AGCGGCCTCC CCCGCCCCAG GGCGGGAACC TTTGGCCTGG GCCGAGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016870138.1 |
CDS | 465..2987 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGAGGGG AGCGGCCTCC CCCGCCCCAG GGCGGGAACC TTTGGCCTGG GCCGAGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu98620 | |
Clone ID Related Accession (Same CDS sequence) | XM_017014649.2 , XM_017014649.1 | |
Accession Version | XM_017014649.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2523bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | serine/threonine-protein kinase N3 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGAGGGG AGCGGCCTCC CCCGCCCCAG GGCGGGAACC TTTGGCCTGG GCCGAGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016870138.1 |
CDS | 463..2985 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGAGAGGGG AGCGGCCTCC CCCGCCCCAG GGCGGGAACC TTTGGCCTGG GCCGAGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. |
Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors. |
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. |