HOXA13 cDNA ORF clone, Homo sapiens(Human)
| Gene Symbol | HOXA13 |
| Entrez Gene ID | 3209 |
| Full Name | homeobox A13 |
| Synonyms | HOX1,HOX1J |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(Human) |
| Genome | |
| Summary | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Hand-foot-uterus syndrome, 140000 (3); Guttmacher syndrome, 176305 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_000522.4 | NP_000513.2 | homeobox protein Hox-A13 |
| NM_000522.5 | NP_000513.2 | homeobox protein Hox-A13 |
| XM_011515344.1 | XP_011513646.1 | homeobox protein Hox-A13 isoform X1 |
| Mus musculus (house mouse) | Hoxa13 | NP_032290.1 |
| Rattus norvegicus (Norway rat) | LOC102550333 | XP_006257773.1 |
| Rattus norvegicus (Norway rat) | Hoxa13 | NP_001258284.1 |
| Gallus gallus (chicken) | HOXA13 | NP_989470.1 |
| Pan troglodytes (chimpanzee) | HOXA13 | XP_527701.3 |
| Canis lupus familiaris (dog) | HOXA13 | XP_539492.4 |
| Bos taurus (cattle) | HOXA13 | XP_002686896.2 |
| Gallus gallus (chicken) | LOC100859244 | XP_003640766.2 |
| Homo sapiens (human) | HOXA13 | NP_000513.2 |
| HOXA13 | XP_002803404.1 | |
| Danio rerio (zebrafish) | hoxa13b | NP_571269.1 |
| Xenopus tropicalis (tropical clawed frog) | hoxa13 | XP_002933431.1 |
| Gallus gallus (chicken) | LOC100859005 | XP_003640757.1 |
Related articles in PubMed
High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models.
Quagliata L, Quintavalle C, Lanzafame M, Matter MS, Novello C, di Tommaso L, Pressiani T, Rimassa L, Tornillo L, Roncalli M, Cillo C, Pallante P, Piscuoglio S, Ng CK, Terracciano LM
Laboratory investigation; a journal of technical methods and pathology98(1)95-105(2018 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Findings indicated that HOTTIP modulated HOXA13 at both the transcriptional and posttranscriptional levels in ESCC cells.
Title: Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells.
using both knockdown and knockout approaches we show that Hottip expression is required for activation of the 5' Hoxa genes (Hoxa13 and Hoxa10/11) and for retaining Mll1 at the 5' end of Hoxa. Moreover, we demonstrate that artificially inducing Hottip expression is sufficient to activate the 5' Hoxa genes and that Hottip RNA binds to the 5' end of Hoxa
Title: Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip.
HOXA13 is involved in HSAinduced EMT in HKC cells and upregulation of HOXA13 exerts a beneficial effect in EMT, which may be associated with the GR signaling pathway.
Title: HOXA13 exerts a beneficial effect in albumin-induced epithelial-mesenchymal transition via the glucocorticoid receptor signaling pathway in human renal tubular epithelial cells.
expression levels of HOTTIP and HOXA13 were both higher in gastric cancer which was poorly differentiated, at advanced TNM stages and exhibited lymph node-metastasis. Spearman analyses indicated that HOTTIP and HOXA13 had a highly positive correlation both in non-tumor mucosae and cancer lesions. Collectively, these findings suggest that HOTTIP and HOXA13 play important roles in gastric cancer progression.
Title: HOTTIP and HOXA13 are oncogenes associated with gastric cancer progression.
Knockdown of HoxA13 caused the downregulation of long non-coding RNA HOTTIP and insulin growth factor-binding protein 3 (IGFBP-3) genes, indicating that both were targets of HoxA13.
Title: Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer.
The following HOXA13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXA13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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| CloneID | OHu20269 | |
| Clone ID Related Accession (Same CDS sequence) | NM_000522.4 , NM_000522.5 , XM_011515344.1 | |
| Accession Version | NM_000522.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-12-22 | |
| Organism | Homo sapiens(human) | |
| Product | homeobox protein Hox-A13 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC075791.1, AC004080.2 and BC016712.1. This sequence is a reference standard in the RefSeqGene project. On Apr 2, 2008 this sequence version replaced NM_000522.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC075791.1, AA160421.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGACAGCCT CCGTGCTCCT CCACCCCCGC TGGATCGAGC CCACCGTCAT GTTTCTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_000513.2 |
| CDS | 30..1196 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_000522.4 |
ORF Insert Sequence:
1 | ATGACAGCCT CCGTGCTCCT CCACCCCCGC TGGATCGAGC CCACCGTCAT GTTTCTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20269 | |
| Clone ID Related Accession (Same CDS sequence) | NM_000522.4 , NM_000522.5 , XM_011515344.1 | |
| Accession Version | NM_000522.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-26 | |
| Organism | Homo sapiens(human) | |
| Product | homeobox protein Hox-A13 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC075791.1 and AC004080.2. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2019 this sequence version replaced NM_000522.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC075791.1, DRR138528.1024657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000649031.1/ ENSP00000497112.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGACAGCCT CCGTGCTCCT CCACCCCCGC TGGATCGAGC CCACCGTCAT GTTTCTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_000513.2 |
| CDS | 15..1181 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_000522.5 |
ORF Insert Sequence:
1 | ATGACAGCCT CCGTGCTCCT CCACCCCCGC TGGATCGAGC CCACCGTCAT GTTTCTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20269 | |
| Clone ID Related Accession (Same CDS sequence) | NM_000522.4 , NM_000522.5 , XM_011515344.1 | |
| Accession Version | XM_011515344.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-03-11 | |
| Organism | Homo sapiens(Human) | |
| Product | homeobox protein Hox-A13 isoform X1 | |
| Comment | ||
1 | ATGACAGCCT CCGTGCTCCT CCACCCCCGC TGGATCGAGC CCACCGTCAT GTTTCTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011513646.1 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011515344.1 |
ORF Insert Sequence:
1 | ATGACAGCCT CCGTGCTCCT CCACCCCCGC TGGATCGAGC CCACCGTCAT GTTTCTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models. |