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ITPA cDNA ORF clone, Homo sapiens(Human)

Gene Symbol ITPA
Entrez Gene ID 3704
Full Name inosine triphosphatase
Synonyms C20orf37,HLC14-06-P,ITPase,My049,NTPase,dJ794I6.3
General protein information
Preferred Names

inosine triphosphatase

Names

inosine triphosphate pyrophosphatase
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
inosine triphosphate pyrophosphohydrolase
non-canonical purine NTP pyrophosphatase
non-standard purine NTP pyrophosphatase
nucleoside-triphosphate diphosphatase
putative oncogene protein HLC14-06-P

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

20

20p13

Summary This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].
Disorder MIM:

147520

Disorder Html: [Inosine triphosphatase deficiency] (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001324238.1 NP_001311167.1 inosine triphosphate pyrophosphatase isoform d
NM_181493.2 NP_852470.1 inosine triphosphate pyrophosphatase isoform b
NM_001324240.1 NP_001311169.1 inosine triphosphate pyrophosphatase isoform e
NM_001324236.1 NP_001311165.1 inosine triphosphate pyrophosphatase isoform d
NM_033453.3 NP_258412.1 inosine triphosphate pyrophosphatase isoform a
NM_181493.3 NP_852470.1 inosine triphosphate pyrophosphatase isoform b
XM_011529234.2 XP_011527536.1 inosine triphosphate pyrophosphatase isoform X3
NM_001324237.1 NP_001311166.1 inosine triphosphate pyrophosphatase isoform d
NM_001267623.1 NP_001254552.1 inosine triphosphate pyrophosphatase isoform c
XM_006723564.3 XP_006723627.1 inosine triphosphate pyrophosphatase isoform X1
XM_006723565.3 XP_006723628.1 inosine triphosphate pyrophosphatase isoform X2



Canis lupus familiaris (dog) ITPA XP_851574.3
Mus musculus (house mouse) Itpa NP_080198.2
Drosophila melanogaster (fruit fly) CG8891 NP_608890.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP008374 XP_317079.2
Xenopus tropicalis (tropical clawed frog) itpa XP_002934214.1
Rattus norvegicus (Norway rat) Itpa NP_001101244.1
Caenorhabditis elegans (roundworm) hap-1 NP_498121.1
Neurospora crassa NCU01441 XP_955963.1
Pan troglodytes (chimpanzee) ITPA XP_003953718.1
Bos taurus (cattle) ITPA NP_001069750.1
Gallus gallus (chicken) ITPA NP_001258859.1
Danio rerio (zebrafish) LOC101882233 XP_005160507.1
Danio rerio (zebrafish) itpa XP_005160503.1
Magnaporthe oryzae (rice blast fungus) MGG_06911 XP_003709645.1
Arabidopsis thaliana (thale cress) AT4G13720 NP_567410.1
Macaca mulatta (rhesus monkey) ITPA XP_001115179.1
Homo sapiens (human) ITPA NP_258412.1
Schizosaccharomyces pombe (fission yeast) SPCC830.10 NP_588480.1
Oryza sativa (rice) Os10g0457500 NP_001064763.1


Related articles in PubMed

High Prevalence of ITPA Alleles Associated with Ribavirin-Induced Hemolytic Anemia Among Mexican Population.
Gonzalez-Aldaco K, Rebello Pinho JO, Panduro A, Martinez-Lopez E, Gleyzer K, Fierro N, Roman S
Annals of hepatology16(2)221-229(2017 March-April)

TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects.
Steponaitiene R, Kupcinskas J, Survilaite S, Varkalaite G, Jonaitis L, Kiudelis G, Denapiene G, Valantinas J, Skieceviciene J, Kupcinskas L
Advances in medical sciences61(1)135-40(2016 Mar)

Rapidity and Severity of Hemoglobin Decreasing Associated with Erythrocyte Inosine Triphosphatase Activity and ATP Concentration during Chronic Hepatitis C Treatment.
Tanaka Y, Tamura Y, Yokomori H, Komiyama T
Biological & pharmaceutical bulletin39(4)615-9(2016)

Role of ITPA gene polymorphism in ribavirin-induced anemia and thrombocytopenia in Egyptian patients with chronic hepatitis C.
Nemr N, Kishk R, Mandour M
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology35(1)7-13(2016 Jan)

DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency.
Cao H, Hegele RA
Journal of human genetics47(11)620-2(2002)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inosine triphosphatase (IPTA) rs1127354 variants but not rs7270101 were found in Chinese patients infected with chronic hepatitis C. IPTA rs1127354 variants and related ITPase were not only related with ribavirin-induced hemolytic anemia but also directly affected the virological response to pegylated interferon plus ribavirin combination therapy in Chinese chronic hepatitis C virus-infected patients.
Title: The relationship between ITPA rs1127354 polymorphisms and efficacy of antiviral treatment in Northeast Chinese CHC patients.

A high prevalence of the ITPA polymorphisms associated with ribavirin-induced hemolytic anemia was found in Mexican Native Amerindians.
Title: High Prevalence of ITPA Alleles Associated with Ribavirin-Induced Hemolytic Anemia Among Mexican Population.

This study concluded that HIV-infection seems to be interfering with the nucleotide metabolism in leukocytes, including CD4 lymphocytes, by decreasing ITPase expression, independently of ITPA genotype.
Title: Inosine Triphosphate Pyrophosphohydrolase Expression: Decreased in Leukocytes of HIV-Infected Patients Using Combination Antiretroviral Therapy.

We concluded that ITPase activity plays an important function and that ATP concentration changes due to therapy are related to the Hb decreasing mechanism in the early period of therapy with HCV treatment
Title: Rapidity and Severity of Hemoglobin Decreasing Associated with Erythrocyte Inosine Triphosphatase Activity and ATP Concentration during Chronic Hepatitis C Treatment.

ITPA polymorphism was associated with RBV-induced anemia and thrombocytopenia in Egyptian patients with hepatitis C virus genotype 4 infection.
Title: Role of ITPA gene polymorphism in ribavirin-induced anemia and thrombocytopenia in Egyptian patients with chronic hepatitis C.

The following ITPA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITPA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu23700 NM_033453.3
Latest version!
Homo sapiens inosine triphosphatase (ITPA), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu101659 NM_001324237.1
Latest version!
Homo sapiens inosine triphosphatase (ITPA), transcript variant 8, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu101659 NM_001324236.1
Latest version!
Homo sapiens inosine triphosphatase (ITPA), transcript variant 7, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu101659 NM_001324238.1
Latest version!
Homo sapiens inosine triphosphatase (ITPA), transcript variant 9, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu23830 NM_181493.3
Latest version!
Homo sapiens inosine triphosphatase (ITPA), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu23901 NM_001267623.1
Latest version!
Homo sapiens inosine triphosphatase (ITPA), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu58520 NM_001324240.1
Latest version!
Homo sapiens inosine triphosphatase (ITPA), transcript variant 10, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu52713 XM_006723564.3
Latest version!
Homo sapiens inosine triphosphatase (ITPA), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu52714 XM_006723565.3
Latest version!
Homo sapiens inosine triphosphatase (ITPA), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu58519 XM_011529234.2
Latest version!
Homo sapiens inosine triphosphatase (ITPA), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
View Old Accession Versions >>
OHu23830 NM_181493.2 Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23700
Clone ID Related Accession (Same CDS sequence) NM_033453.3
Accession Version NM_033453.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 585bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM560812.1, AF026816.2 and CA425905.1. This sequence is a reference standard in the RefSeqGene project. On Jun 9, 2012 this sequence version replaced NM_033453.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM560812.1, AF219116.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGGCCGGATC
GTGGCACCCA GAGGCTGCCA GGACTTTGGC TGGGACCCCT GCTTTCAGCC TGATGGATAT
GAGCAGACGT ACGCAGAGAT GCCTAAGGCG GAGAAGAACG CTGTCTCCCA TCGCTTCCGG
GCCCTGCTGG AGCTGCAGGA GTACTTTGGC AGTTTGGCAG CTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_258412.1
CDS193..777
Misc Feature(1)178..180
Misc Feature(2)196..198
Misc Feature(3)220..756
Misc Feature(4)232..249
Misc Feature(5)order(238..240,244..249,256..258,409..417,454..459,532..534,637..639,643..648,721..726)
Misc Feature(6)order(322..330,430..435,442..444,451..453,460..462)
Misc Feature(7)406..411
Misc Feature(8)637..648
Misc Feature(9)721..726
Exon (1)1..258
Exon (2)259..316
Exon (3)317..381
Exon (4)382..455
Exon (5)456..487
Exon (6)488..603
Exon (7)604..680
Exon (8)681..1185
Translation

Target ORF information:

RefSeq Version NM_033453.3
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (ITPA), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033453.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGGCCGGATC
GTGGCACCCA GAGGCTGCCA GGACTTTGGC TGGGACCCCT GCTTTCAGCC TGATGGATAT
GAGCAGACGT ACGCAGAGAT GCCTAAGGCG GAGAAGAACG CTGTCTCCCA TCGCTTCCGG
GCCCTGCTGG AGCTGCAGGA GTACTTTGGC AGTTTGGCAG CTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101659
Clone ID Related Accession (Same CDS sequence) NM_001324238.1 , NM_001324236.1 , NM_001324237.1
Accession Version NM_001324238.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 333bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform d
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF969192.1, AL121891.22, AL109976.23 and CA425905.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGCGCTCTG CACGTTTGCA CTCAGCACCG GGGACCCAAG CCAGCCCGTG CGCCTGTTCA 
GGGGCCGGAC CTCGGGCCGG ATCGTGGCAC CCAGAGGCTG CCAGGACTTT GGCTGGGACC
CCTGCTTTCA GCCTGATGGA TATGAGCAGA CGTACGCAGA GATGCCTAAG GCGGAGAAGA
ACGCTGTCTC CCATCGCTTC CGGGCCCTGC TGGAGCTGCA GGAGTACTTT GGCAGTTTGG
CAGCTTGACT TCTGCAGCTG GAGGAGGCCC CTCAGGCCGG GGATCTGGGG AGGGCTAGCC
CAAAACCTCC CGCATCGGGC AGGCACCCCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001311167.1
CDS441..773
Misc Feature(1)387..389
Exon (1)1..166
Exon (2)167..292
Exon (3)293..366
Exon (4)367..398
Exon (5)399..514
Exon (6)515..591
Exon (7)592..1096
Translation

Target ORF information:

RefSeq Version NM_001324238.1
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (ITPA), transcript variant 9, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001324238.1

ORF Insert Sequence:

1
61
121
181
241
301
ATGCGCTCTG CACGTTTGCA CTCAGCACCG GGGACCCAAG CCAGCCCGTG CGCCTGTTCA 
GGGGCCGGAC CTCGGGCCGG ATCGTGGCAC CCAGAGGCTG CCAGGACTTT GGCTGGGACC
CCTGCTTTCA GCCTGATGGA TATGAGCAGA CGTACGCAGA GATGCCTAAG GCGGAGAAGA
ACGCTGTCTC CCATCGCTTC CGGGCCCTGC TGGAGCTGCA GGAGTACTTT GGCAGTTTGG
CAGCTTGACT TCTGCAGCTG GAGGAGGCCC CTCAGGCCGG GGATCTGGGG AGGGCTAGCC
CAAAACCTCC CGCATCGGGC AGGCACCCCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101659
Clone ID Related Accession (Same CDS sequence) NM_001324238.1 , NM_001324236.1 , NM_001324237.1
Accession Version NM_001324236.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 333bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform d
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM560812.1, BE275997.1, BM703982.1, AF334680.1 and CA425905.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BE276070.1, BE275997.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGCGCTCTG CACGTTTGCA CTCAGCACCG GGGACCCAAG CCAGCCCGTG CGCCTGTTCA 
GGGGCCGGAC CTCGGGCCGG ATCGTGGCAC CCAGAGGCTG CCAGGACTTT GGCTGGGACC
CCTGCTTTCA GCCTGATGGA TATGAGCAGA CGTACGCAGA GATGCCTAAG GCGGAGAAGA
ACGCTGTCTC CCATCGCTTC CGGGCCCTGC TGGAGCTGCA GGAGTACTTT GGCAGTTTGG
CAGCTTGACT TCTGCAGCTG GAGGAGGCCC CTCAGGCCGG GGATCTGGGG AGGGCTAGCC
CAAAACCTCC CGCATCGGGC AGGCACCCCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001311165.1
CDS533..865
Misc Feature(1)479..481
Exon (1)1..258
Exon (2)259..384
Exon (3)385..458
Exon (4)459..490
Exon (5)491..606
Exon (6)607..683
Exon (7)684..1188
Translation

Target ORF information:

RefSeq Version NM_001324236.1
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (ITPA), transcript variant 7, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001324236.1

ORF Insert Sequence:

1
61
121
181
241
301
ATGCGCTCTG CACGTTTGCA CTCAGCACCG GGGACCCAAG CCAGCCCGTG CGCCTGTTCA 
GGGGCCGGAC CTCGGGCCGG ATCGTGGCAC CCAGAGGCTG CCAGGACTTT GGCTGGGACC
CCTGCTTTCA GCCTGATGGA TATGAGCAGA CGTACGCAGA GATGCCTAAG GCGGAGAAGA
ACGCTGTCTC CCATCGCTTC CGGGCCCTGC TGGAGCTGCA GGAGTACTTT GGCAGTTTGG
CAGCTTGACT TCTGCAGCTG GAGGAGGCCC CTCAGGCCGG GGATCTGGGG AGGGCTAGCC
CAAAACCTCC CGCATCGGGC AGGCACCCCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101659
Clone ID Related Accession (Same CDS sequence) NM_001324238.1 , NM_001324236.1 , NM_001324237.1
Accession Version NM_001324237.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 333bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform d
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF969192.1, AL121891.22, AL109976.23 and CA425905.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGCGCTCTG CACGTTTGCA CTCAGCACCG GGGACCCAAG CCAGCCCGTG CGCCTGTTCA 
GGGGCCGGAC CTCGGGCCGG ATCGTGGCAC CCAGAGGCTG CCAGGACTTT GGCTGGGACC
CCTGCTTTCA GCCTGATGGA TATGAGCAGA CGTACGCAGA GATGCCTAAG GCGGAGAAGA
ACGCTGTCTC CCATCGCTTC CGGGCCCTGC TGGAGCTGCA GGAGTACTTT GGCAGTTTGG
CAGCTTGACT TCTGCAGCTG GAGGAGGCCC CTCAGGCCGG GGATCTGGGG AGGGCTAGCC
CAAAACCTCC CGCATCGGGC AGGCACCCCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001311166.1
CDS438..770
Misc Feature(1)384..386
Exon (1)1..166
Exon (2)167..224
Exon (3)225..289
Exon (4)290..363
Exon (5)364..395
Exon (6)396..511
Exon (7)512..588
Exon (8)589..1093
Translation

Target ORF information:

RefSeq Version NM_001324237.1
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (ITPA), transcript variant 8, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001324237.1

ORF Insert Sequence:

1
61
121
181
241
301
ATGCGCTCTG CACGTTTGCA CTCAGCACCG GGGACCCAAG CCAGCCCGTG CGCCTGTTCA 
GGGGCCGGAC CTCGGGCCGG ATCGTGGCAC CCAGAGGCTG CCAGGACTTT GGCTGGGACC
CCTGCTTTCA GCCTGATGGA TATGAGCAGA CGTACGCAGA GATGCCTAAG GCGGAGAAGA
ACGCTGTCTC CCATCGCTTC CGGGCCCTGC TGGAGCTGCA GGAGTACTTT GGCAGTTTGG
CAGCTTGACT TCTGCAGCTG GAGGAGGCCC CTCAGGCCGG GGATCTGGGG AGGGCTAGCC
CAAAACCTCC CGCATCGGGC AGGCACCCCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23830
Clone ID Related Accession (Same CDS sequence) NM_181493.2 , NM_181493.3
Accession Version NM_181493.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 534bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform b
Comment

1
61
121
181
241
301
361
421
481
ATGGCGGCCT CATTGGTCGT TCAGATTCTA GGAGATAAGT TTCCATGCAC TTTGGTGGCA 
CAGAAAATTG ACCTGCCGGA GTACCAGGGG GAGCCGGATG AGATTTCCAT ACAGAAATGT
CAGGAGGCAG TTCGCCAGGT ACAGGGGCCC GTGCTGGTTG AGGACACTTG TCTGTGCTTC
AATGCCCTTG GAGGGCTCCC CGGCCCCTAC ATAAAGTGGT TTCTGGAGAA GTTAAAGCCT
GAAGGTCTCC ACCAGCTCCT GGCCGGGTTC GAGGACAAGT CAGCCTATGC GCTCTGCACG
TTTGCACTCA GCACCGGGGA CCCAAGCCAG CCCGTGCGCC TGTTCAGGGG CCGGACCTCG
GGCCGGATCG TGGCACCCAG AGGCTGCCAG GACTTTGGCT GGGACCCCTG CTTTCAGCCT
GATGGATATG AGCAGACGTA CGCAGAGATG CCTAAGGCGG AGAAGAACGC TGTCTCCCAT
CGCTTCCGGG CCCTGCTGGA GCTGCAGGAG TACTTTGGCA GTTTGGCAGC TTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_852470.1
Translation

Target ORF information:

RefSeq Version NM_181493.2
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_181493.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCGGCCT CATTGGTCGT TCAGATTCTA GGAGATAAGT TTCCATGCAC TTTGGTGGCA 
CAGAAAATTG ACCTGCCGGA GTACCAGGGG GAGCCGGATG AGATTTCCAT ACAGAAATGT
CAGGAGGCAG TTCGCCAGGT ACAGGGGCCC GTGCTGGTTG AGGACACTTG TCTGTGCTTC
AATGCCCTTG GAGGGCTCCC CGGCCCCTAC ATAAAGTGGT TTCTGGAGAA GTTAAAGCCT
GAAGGTCTCC ACCAGCTCCT GGCCGGGTTC GAGGACAAGT CAGCCTATGC GCTCTGCACG
TTTGCACTCA GCACCGGGGA CCCAAGCCAG CCCGTGCGCC TGTTCAGGGG CCGGACCTCG
GGCCGGATCG TGGCACCCAG AGGCTGCCAG GACTTTGGCT GGGACCCCTG CTTTCAGCCT
GATGGATATG AGCAGACGTA CGCAGAGATG CCTAAGGCGG AGAAGAACGC TGTCTCCCAT
CGCTTCCGGG CCCTGCTGGA GCTGCAGGAG TACTTTGGCA GTTTGGCAGC TTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23830
Clone ID Related Accession (Same CDS sequence) NM_181493.2 , NM_181493.3
Accession Version NM_181493.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 534bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM560812.1, EF213026.1, AF026816.2 and CA425905.1. On Apr 28, 2016 this sequence version replaced NM_181493.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM910626.1, BG332818.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
ATGGCGGCCT CATTGGTCGT TCAGATTCTA GGAGATAAGT TTCCATGCAC TTTGGTGGCA 
CAGAAAATTG ACCTGCCGGA GTACCAGGGG GAGCCGGATG AGATTTCCAT ACAGAAATGT
CAGGAGGCAG TTCGCCAGGT ACAGGGGCCC GTGCTGGTTG AGGACACTTG TCTGTGCTTC
AATGCCCTTG GAGGGCTCCC CGGCCCCTAC ATAAAGTGGT TTCTGGAGAA GTTAAAGCCT
GAAGGTCTCC ACCAGCTCCT GGCCGGGTTC GAGGACAAGT CAGCCTATGC GCTCTGCACG
TTTGCACTCA GCACCGGGGA CCCAAGCCAG CCCGTGCGCC TGTTCAGGGG CCGGACCTCG
GGCCGGATCG TGGCACCCAG AGGCTGCCAG GACTTTGGCT GGGACCCCTG CTTTCAGCCT
GATGGATATG AGCAGACGTA CGCAGAGATG CCTAAGGCGG AGAAGAACGC TGTCTCCCAT
CGCTTCCGGG CCCTGCTGGA GCTGCAGGAG TACTTTGGCA GTTTGGCAGC TTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_852470.1
CDS193..726
Misc Feature(1)178..180
Misc Feature(2)214..705
Misc Feature(3)order(271..279,379..384,391..393,400..402,409..411)
Exon (1)1..207
Exon (2)208..265
Exon (3)266..330
Exon (4)331..404
Exon (5)405..436
Exon (6)437..552
Exon (7)553..629
Exon (8)630..1134
Translation

Target ORF information:

RefSeq Version NM_181493.3
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (ITPA), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_181493.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCGGCCT CATTGGTCGT TCAGATTCTA GGAGATAAGT TTCCATGCAC TTTGGTGGCA 
CAGAAAATTG ACCTGCCGGA GTACCAGGGG GAGCCGGATG AGATTTCCAT ACAGAAATGT
CAGGAGGCAG TTCGCCAGGT ACAGGGGCCC GTGCTGGTTG AGGACACTTG TCTGTGCTTC
AATGCCCTTG GAGGGCTCCC CGGCCCCTAC ATAAAGTGGT TTCTGGAGAA GTTAAAGCCT
GAAGGTCTCC ACCAGCTCCT GGCCGGGTTC GAGGACAAGT CAGCCTATGC GCTCTGCACG
TTTGCACTCA GCACCGGGGA CCCAAGCCAG CCCGTGCGCC TGTTCAGGGG CCGGACCTCG
GGCCGGATCG TGGCACCCAG AGGCTGCCAG GACTTTGGCT GGGACCCCTG CTTTCAGCCT
GATGGATATG AGCAGACGTA CGCAGAGATG CCTAAGGCGG AGAAGAACGC TGTCTCCCAT
CGCTTCCGGG CCCTGCTGGA GCTGCAGGAG TACTTTGGCA GTTTGGCAGC TTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23901
Clone ID Related Accession (Same CDS sequence) NM_001267623.1
Accession Version NM_001267623.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 462bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform c
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM560812.1, BI115811.1, AF026816.2 and CA425905.1. Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI115811.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTAC AGGGGCCCGT GCTGGTTGAG GACACTTGTC TGTGCTTCAA TGCCCTTGGA
GGGCTCCCCG GCCCCTACAT AAAGTGGTTT CTGGAGAAGT TAAAGCCTGA AGGTCTCCAC
CAGCTCCTGG CCGGGTTCGA GGACAAGTCA GCCTATGCGC TCTGCACGTT TGCACTCAGC
ACCGGGGACC CAAGCCAGCC CGTGCGCCTG TTCAGGGGCC GGACCTCGGG CCGGATCGTG
GCACCCAGAG GCTGCCAGGA CTTTGGCTGG GACCCCTGCT TTCAGCCTGA TGGATATGAG
CAGACGTACG CAGAGATGCC TAAGGCGGAG AAGAACGCTG TCTCCCATCG CTTCCGGGCC
CTGCTGGAGC TGCAGGAGTA CTTTGGCAGT TTGGCAGCTT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001254552.1
CDS193..654
Misc Feature(1)178..180
Misc Feature(2)220..633
Misc Feature(3)order(238..240,244..249,256..258,286..294,331..336,409..411,514..516,520..525,598..603)
Exon (1)1..258
Exon (2)259..332
Exon (3)333..364
Exon (4)365..480
Exon (5)481..557
Exon (6)558..1062
Translation

Target ORF information:

RefSeq Version NM_001267623.1
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (ITPA), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001267623.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTAC AGGGGCCCGT GCTGGTTGAG GACACTTGTC TGTGCTTCAA TGCCCTTGGA
GGGCTCCCCG GCCCCTACAT AAAGTGGTTT CTGGAGAAGT TAAAGCCTGA AGGTCTCCAC
CAGCTCCTGG CCGGGTTCGA GGACAAGTCA GCCTATGCGC TCTGCACGTT TGCACTCAGC
ACCGGGGACC CAAGCCAGCC CGTGCGCCTG TTCAGGGGCC GGACCTCGGG CCGGATCGTG
GCACCCAGAG GCTGCCAGGA CTTTGGCTGG GACCCCTGCT TTCAGCCTGA TGGATATGAG
CAGACGTACG CAGAGATGCC TAAGGCGGAG AAGAACGCTG TCTCCCATCG CTTCCGGGCC
CTGCTGGAGC TGCAGGAGTA CTTTGGCAGT TTGGCAGCTT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu58520
Clone ID Related Accession (Same CDS sequence) NM_001324240.1
Accession Version NM_001324240.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 417bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform e
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM560812.1, AL121891.22 and AL109976.23. On Apr 28, 2016 this sequence version replaced XM_011529235.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GTTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001311169.1
CDS193..609
Misc Feature(1)178..180
Misc Feature(2)196..198
Misc Feature(3)220..>600
Misc Feature(4)232..249
Misc Feature(5)order(322..330,430..435,442..444,451..453,460..462)
Misc Feature(6)406..411
Exon (1)1..258
Exon (2)259..316
Exon (3)317..381
Exon (4)382..455
Exon (5)456..487
Exon (6)488..603
Exon (7)604..1370
Translation

Target ORF information:

RefSeq Version NM_001324240.1
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (ITPA), transcript variant 10, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001324240.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GTTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu52713
Clone ID Related Accession (Same CDS sequence) XM_006723564.3
Accession Version XM_006723564.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 717bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006723564.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGAACGCTGT
CATAGTAGCC GGCATCTGGC TTGTCCACGG AGTTCAGGGG CCGGATCGTG GCACCCAGAG
GCTGCCAGGA CTTTGGCTGG GACCCCTGCT TTCAGCCTGA TGGATATGAG CAGACGTACG
CAGAGATGCC TAAGGCGGAG AAGAACGCTG TCTCCCATCG CTTCCGGGCC CTGCTGGAGC
TGCAGGAGTA CTTTGGCAGT TTGGCAGCTT GACTTCTGCA GCTGGAGGAG GCCCCTCAGG
CCGGGGATCT GGGGAGGGCT AGCCCAAAAC CTCCCGCATC GGGCAGGCAC CCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006723627.1
CDS476..1192
Misc Feature(1)503..>883
Misc Feature(2)order(605..613,713..718,725..727,734..736,743..745)
Translation

Target ORF information:

RefSeq Version XM_006723564.3
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (ITPA), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006723564.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGAACGCTGT
CATAGTAGCC GGCATCTGGC TTGTCCACGG AGTTCAGGGG CCGGATCGTG GCACCCAGAG
GCTGCCAGGA CTTTGGCTGG GACCCCTGCT TTCAGCCTGA TGGATATGAG CAGACGTACG
CAGAGATGCC TAAGGCGGAG AAGAACGCTG TCTCCCATCG CTTCCGGGCC CTGCTGGAGC
TGCAGGAGTA CTTTGGCAGT TTGGCAGCTT GACTTCTGCA GCTGGAGGAG GCCCCTCAGG
CCGGGGATCT GGGGAGGGCT AGCCCAAAAC CTCCCGCATC GGGCAGGCAC CCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu52714
Clone ID Related Accession (Same CDS sequence) XM_006723565.3
Accession Version XM_006723565.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 594bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006723565.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTAC AGGGGCCCGT GCTGGTTGAG GACACTTGTC TGTGCTTCAA TGCCCTTGGA
GGGCTCCCCG GCCCCTACAT AAAGTGGTTT CTGGAGAAGT TAAAGCCTGA AGGTCTCCAC
CAGCTCCTGG CCGGGTTCGA GGACAAGTCA GCCTATGCGC TCTGCACGTT TGCACTCAGC
ACCGGGGACC CAAGCCAGCC CGTGCGCCTG TTCAGGGGCC GGACCTCGGA ACGCTGTCAT
AGTAGCCGGC ATCTGGCTTG TCCACGGAGT TCAGGGGCCG GATCGTGGCA CCCAGAGGCT
GCCAGGACTT TGGCTGGGAC CCCTGCTTTC AGCCTGATGG ATATGAGCAG ACGTACGCAG
AGATGCCTAA GGCGGAGAAG AACGCTGTCT CCCATCGCTT CCGGGCCCTG CTGGAGCTGC
AGGAGTACTT TGGCAGTTTG GCAGCTTGAC TTCTGCAGCT GGAGGAGGCC CCTCAGGCCG
GGGATCTGGG GAGGGCTAGC CCAAAACCTC CCGCATCGGG CAGGCACCCC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006723628.1
CDS476..1069
Misc Feature(1)503..>760
Translation

Target ORF information:

RefSeq Version XM_006723565.3
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (ITPA), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006723565.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTAC AGGGGCCCGT GCTGGTTGAG GACACTTGTC TGTGCTTCAA TGCCCTTGGA
GGGCTCCCCG GCCCCTACAT AAAGTGGTTT CTGGAGAAGT TAAAGCCTGA AGGTCTCCAC
CAGCTCCTGG CCGGGTTCGA GGACAAGTCA GCCTATGCGC TCTGCACGTT TGCACTCAGC
ACCGGGGACC CAAGCCAGCC CGTGCGCCTG TTCAGGGGCC GGACCTCGGA ACGCTGTCAT
AGTAGCCGGC ATCTGGCTTG TCCACGGAGT TCAGGGGCCG GATCGTGGCA CCCAGAGGCT
GCCAGGACTT TGGCTGGGAC CCCTGCTTTC AGCCTGATGG ATATGAGCAG ACGTACGCAG
AGATGCCTAA GGCGGAGAAG AACGCTGTCT CCCATCGCTT CCGGGCCCTG CTGGAGCTGC
AGGAGTACTT TGGCAGTTTG GCAGCTTGAC TTCTGCAGCT GGAGGAGGCC CCTCAGGCCG
GGGATCTGGG GAGGGCTAGC CCAAAACCTC CCGCATCGGG CAGGCACCCC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu58519
Clone ID Related Accession (Same CDS sequence) XM_011529234.2
Accession Version XM_011529234.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 444bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product inosine triphosphate pyrophosphatase isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011529234.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGGAAACAGT
TGGCTAACAG CTCCTGAGGC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011527536.1
CDS476..919
Misc Feature(1)503..>889
Misc Feature(2)order(605..613,713..718,725..727,734..736,743..745)
Translation

Target ORF information:

RefSeq Version XM_011529234.2
Organism Homo sapiens(Human)
Definition Homo sapiens inosine triphosphatase (ITPA), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011529234.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGGAAACAGT
TGGCTAACAG CTCCTGAGGC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

High Prevalence of ITPA Alleles Associated with Ribavirin-Induced Hemolytic Anemia Among Mexican Population.
Annals of hepatology16(2)221-229(2017 March-April)
Gonzalez-Aldaco K,Rebello Pinho JO,Panduro A,Martinez-Lopez E,Gleyzer K,Fierro N,Roman S


book

TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects.
Advances in medical sciences61(1)135-40(2016 Mar)
Steponaitiene R,Kupcinskas J,Survilaite S,Varkalaite G,Jonaitis L,Kiudelis G,Denapiene G,Valantinas J,Skieceviciene J,Kupcinskas L


book

Rapidity and Severity of Hemoglobin Decreasing Associated with Erythrocyte Inosine Triphosphatase Activity and ATP Concentration during Chronic Hepatitis C Treatment.
Biological & pharmaceutical bulletin39(4)615-9(2016)
Tanaka Y,Tamura Y,Yokomori H,Komiyama T


book

Role of ITPA gene polymorphism in ribavirin-induced anemia and thrombocytopenia in Egyptian patients with chronic hepatitis C.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology35(1)7-13(2016 Jan)
Nemr N,Kishk R,Mandour M


book

DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency.
Journal of human genetics47(11)620-2(2002)
Cao H,Hegele RA


 
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