Gene Symbol | USP50 |
Entrez Gene ID | 373509 |
Full Name | ubiquitin specific peptidase 50 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
ORF » Species Summary » Homo sapiens » USP50 cDNA ORF clone
Gene Symbol | USP50 |
Entrez Gene ID | 373509 |
Full Name | ubiquitin specific peptidase 50 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_011521528.1 | XP_011519830.1 | inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X1 |
NM_203494.4 | NP_987090.2 | inactive ubiquitin carboxyl-terminal hydrolase 50 |
NM_203494.5 | NP_987090.2 | inactive ubiquitin carboxyl-terminal hydrolase 50 |
LOC716718 | XP_001107612.2 | |
Rattus norvegicus (Norway rat) | Usp50 | XP_003749615.1 |
Pan troglodytes (chimpanzee) | USP50 | XP_003952700.1 |
Canis lupus familiaris (dog) | LOC608487 | XP_850913.1 |
Homo sapiens (human) | USP50 | NP_987090.2 |
Bos taurus (cattle) | USP50 | NP_001073699.2 |
Mus musculus (house mouse) | Usp50 | NP_083439.2 |
Induction of deubiquitinating enzyme USP50 during erythropoiesis and its potential role in the regulation of Ku70 stability.
Cai J, Wei J, Schrott V, Zhao J, Bullock G, Zhao Y
Journal of investigative medicine : the official publication of the American Federation for Clinical Research66(1)1-6(2018 Jan)
The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.
Lee JY, Seo D, You J, Chung S, Park JS, Lee JH, Jung SM, Lee YS, Park SH
FEBS letters591(3)479-490(2017 02)
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, D?rr M, M?ller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC, Isaacs A, Newhouse SJ, Evans DS, Post WS, Waggott D, Lyytik?inen LP, Hicks AA, Eisele L, Ellinghaus D, Hayward C, Navarro P, Ulivi S, Tanaka T, Tester DJ, Chatel S, Gustafsson S, Kumari M, Morris RW, Naluai ?T, Padmanabhan S, Kluttig A, Strohmer B, Panayiotou AG, Torres M, Knoflach M, Hubacek JA, Slowikowski K, Raychaudhuri S, Kumar RD, Harris TB, Launer LJ, Shuldiner AR, Alonso A, Bader JS, Ehret G, Huang H, Kao WH, Strait JB, Macfarlane PW, Brown M, Caulfield MJ, Samani NJ, Kronenberg F, Willeit J, , , Smith JG, Greiser KH, Meyer Zu Schwabedissen H, Werdan K, Carella M, Zelante L, Heckbert SR, Psaty BM, Rotter JI, Kolcic I, Pola?ek O, Wright AF, Griffin M, Daly MJ, , Arnar DO, H?lm H, Thorsteinsdottir U, , Denny JC, Roden DM, Zuvich RL, Emilsson V, Plump AS, Larson MG, O'Donnell CJ, Yin X, Bobbo M, D'Adamo AP, Iorio A, Sinagra G, Carracedo A, Cummings SR, Nalls MA, Jula A, Kontula KK, Marjamaa A, Oikarinen L, Perola M, Porthan K, Erbel R, Hoffmann P, J?ckel KH, K?lsch H, N?then MM, , den Hoed M, Loos RJ, Thelle DS, Gieger C, Meitinger T, Perz S, Peters A, Prucha H, Sinner MF, Waldenberger M, de Boer RA, Franke L, van der Vleuten PA, Beckmann BM, Martens E, Bardai A, Hofman N, Wilde AA, Behr ER, Dalageorgou C, Giudicessi JR, Medeiros-Domingo A, Barc J, Kyndt F, Probst V, Ghidoni A, Insolia R, Hamilton RM, Scherer SW, Brandimarto J, Margulies K, Moravec CE, del Greco M F, Fuchsberger C, O'Connell JR, Lee WK, Watt GC, Campbell H, Wild SH, El Mokhtari NE, Frey N, Asselbergs FW, Mateo Leach I, Navis G, van den Berg MP, van Veldhuisen DJ, Kellis M, Krijthe BP, Franco OH, Hofman A, Kors JA, Uitterlinden AG, Witteman JC, Kedenko L, Lamina C, Oostra BA, Abecasis GR, Lakatta EG, Mulas A, Orr? M, Schlessinger D, Uda M, Markus MR, V?lker U, Snieder H, Spector TD, ?rnl?v J, Lind L, Sundstr?m J, Syv?nen AC, Kivimaki M, K?h?nen M, Mononen N, Raitakari OT, Viikari JS, Adamkova V, Kiechl S, Brion M, Nicolaides AN, Paulweber B, Haerting J, Dominiczak AF, Nyberg F, Whincup PH, Hingorani AD, Schott JJ, Bezzina CR, Ingelsson E, Ferrucci L, Gasparini P, Wilson JF, Rudan I, Franke A, M?hleisen TW, Pramstaller PP, Lehtim?ki TJ, Paterson AD, Parsa A, Liu Y, van Duijn CM, Siscovick DS, Gudnason V, Jamshidi Y, Salomaa V, Felix SB, Sanna S, Ritchie MD, Stricker BH, Stefansson K, Boyer LA, Cappola TP, Olsen JV, Lage K, Schwartz PJ, K??b S, Chakravarti A, Ackerman MJ, Pfeufer A, de Bakker PI, Newton-Cheh C
Nature genetics46(8)826-36(2014 Aug)
A screen for deubiquitinating enzymes involved in the G?/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.
Aressy B, Jullien D, Cazales M, Marcellin M, Bugler B, Burlet-Schiltz O, Ducommun B
Cell cycle (Georgetown, Tex.)9(18)3815-22(2010 Sep)
A genomic analysis of rat proteases and protease inhibitors.
Puente XS, L?pez-Ot?n C
Genome research14(4)609-22(2004 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
the deubiquitinating enzyme USP50 binds to the ASC protein and subsequently regulates the inflammasome signaling pathway.
Title: The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.
USP50 may act through a HSP90-dependent mechanism to counteract CDC25B mitotic inducing activity and prevent Wee1 degradation.
Title: A screen for deubiquitinating enzymes involved in the G?/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The following USP50 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the USP50 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu10720 | |
Clone ID Related Accession (Same CDS sequence) | XM_011521528.1 , NM_203494.4 , NM_203494.5 | |
Accession Version | NM_203494.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-09-21 | |
Organism | Homo sapiens(human) | |
Product | inactive ubiquitin carboxyl-terminal hydrolase 50 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC012170.6. On Mar 20, 2010 this sequence version replaced NM_203494.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACTTCTC AGCCGTCTCT CCCTGCAGAT GACTTCGATA TCTACCACGT CCTTGCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_987090.2 |
CDS | 181..1185 |
Translation |
Target ORF information:
Target ORF information:
|
NM_203494.4 |
1 | ATGACTTCTC AGCCGTCTCT CCCTGCAGAT GACTTCGATA TCTACCACGT CCTTGCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10720 | |
Clone ID Related Accession (Same CDS sequence) | XM_011521528.1 , NM_203494.4 , NM_203494.5 | |
Accession Version | NM_203494.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-24 | |
Organism | Homo sapiens(human) | |
Product | inactive ubiquitin carboxyl-terminal hydrolase 50 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC012170.6. On May 17, 2019 this sequence version replaced NM_203494.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000532404.6/ ENSP00000434676.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACTTCTC AGCCGTCTCT CCCTGCAGAT GACTTCGATA TCTACCACGT CCTTGCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_987090.2 |
CDS | 142..1146 |
Translation |
Target ORF information:
Target ORF information:
|
NM_203494.5 |
1 | ATGACTTCTC AGCCGTCTCT CCCTGCAGAT GACTTCGATA TCTACCACGT CCTTGCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10720 | |
Clone ID Related Accession (Same CDS sequence) | XM_011521528.1 , NM_203494.4 , NM_203494.5 | |
Accession Version | XM_011521528.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X1 | |
Comment |
1 | ATGACTTCTC AGCCGTCTCT CCCTGCAGAT GACTTCGATA TCTACCACGT CCTTGCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011519830.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011521528.1 |
1 | ATGACTTCTC AGCCGTCTCT CCCTGCAGAT GACTTCGATA TCTACCACGT CCTTGCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Induction of deubiquitinating enzyme USP50 during erythropoiesis and its potential role in the regulation of Ku70 stability. |
The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein. |
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. |
A screen for deubiquitinating enzymes involved in the G?/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability. |
A genomic analysis of rat proteases and protease inhibitors. |