×

NBN cDNA ORF clone, Homo sapiens(Human)

Gene Symbol NBN
Entrez Gene ID 4683
Full Name nibrin
Synonyms AT-V1,AT-V2,ATV,NBS,NBS1,P95
General protein information
Preferred Names

nibrin

Names

nibrin
Nijmegen breakage syndrome 1 (nibrin)
cell cycle regulatory protein p95
p95 protein of the MRE11/RAD50 complex

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

8

8q21.3

Summary Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008].
Disorder MIM:

602667

Disorder Html: Nijmegen breakage syndrome, 251260 (3); Leukemia, acute

mRNA and Protein(s)

mRNA Protein Name
NM_002485.4 NP_002476.2 nibrin isoform 1
XM_017013461.1 XP_016868950.1 nibrin isoform X3
XM_011517046.1 XP_011515348.1 nibrin isoform X2
XM_017013462.1 XP_016868951.1 nibrin isoform X3
NM_001024688.2 NP_001019859.1 nibrin isoform 2
XM_017013460.1 XP_016868949.1 nibrin isoform X3
XM_011517045.1 XP_011515347.1 nibrin isoform X1



Danio rerio (zebrafish) nbn NP_001014819.1
Mus musculus (house mouse) Nbn NP_038780.3
Bos taurus (cattle) NBN NP_001069305.2
Gallus gallus (chicken) NBN NP_989668.1
Homo sapiens (human) NBN NP_002476.2
Pan troglodytes (chimpanzee) NBN XP_519851.3
Canis lupus familiaris (dog) NBN XP_005638161.1
Xenopus tropicalis (tropical clawed frog) nbn XP_004915210.1
Rattus norvegicus (Norway rat) Nbn NP_620228.1
Macaca mulatta (rhesus monkey) NBN XP_001085033.1


Related articles in PubMed

A balance between elongation and trimming regulates telomere stability in stem cells.
Rivera T, Haggblom C, Cosconati S, Karlseder J
Nature structural & molecular biology24(1)30-39(2017 Jan)

High Expression of MRE11-RAD50-NBS1 Is Associated with Poor Prognosis and Chemoresistance in Gastric Cancer.
Altan B, Yokobori T, Ide M, Bai T, Yanoma T, Kimura A, Kogure N, Suzuki M, Bao P, Mochiki E, Ogata K, Handa T, Kaira K, Nishiyama M, Asao T, Oyama T, Kuwano H
Anticancer research36(10)5237-5247(2016 10)

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response.
Staples CJ, Barone G, Myers KN, Ganesh A, Gibbs-Seymour I, Patil AA, Beveridge RD, Daye C, Beniston R, Maslen S, Ahel I, Skehel JM, Collis SJ
Cell reports16(10)2565-75(2016 Sep)

The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths.
Takeda S, Hoa NN, Sasanuma H
Journal of radiation research57 Suppl 1i25-i32(2016 Aug)

The c.657del5 variant in the NBN gene predisposes to pancreatic cancer.
Borecka M, Zemankova P, Lhota F, Soukupova J, Kleiblova P, Vocka M, Soucek P, Ticha I, Kleibl Z, Janatova M
Gene587(2)169-72(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer
Title: Contribution of Double-strand Break Repair Gene Nijmegen Breakage Syndrome 1 Genotypes, Gender Difference and Smoking Status to Taiwanese Lung Cancer.

The results illuminate the important role of Nbs1 and CtIP in determining the substrates and consequences of human Mre11/Rad50 nuclease activities on protein-DNA lesions.
Title: Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts.

The high expression of MRE11-RAD50-NBS1 complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer
Title: High Expression of MRE11-RAD50-NBS1 Is Associated with Poor Prognosis and Chemoresistance in Gastric Cancer.

The Nbs1 homologs that promote herpes simplex virus 1 infection also interact with the herpes simplex virus 1 ICP0 protein.
Title: An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates.

surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination
Title: The Slavic NBN Founder Mutation: A Role for Reproductive Fitness?

The following NBN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NBN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25559 NM_002485.4
Latest version!
Homo sapiens nibrin (NBN), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu42449 NM_001024688.2
Latest version!
Homo sapiens nibrin (NBN), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $391.30
$559.00
OHu42449 XM_011517045.1
Latest version!
Homo sapiens nibrin (NBN), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $391.30
$559.00
OHu59212 XM_011517046.1
Latest version!
Homo sapiens nibrin (NBN), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu98013 XM_017013461.1
Latest version!
Homo sapiens nibrin (NBN), transcript variant X4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu98013 XM_017013460.1
Latest version!
Homo sapiens nibrin (NBN), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu98013 XM_017013462.1
Latest version!
Homo sapiens nibrin (NBN), transcript variant X5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25559
Clone ID Related Accession (Same CDS sequence) NM_002485.4
Accession Version NM_002485.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2265bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-30
Organism Homo sapiens(Human)
Product nibrin isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX640816.1, BC071590.1 and BC040519.1. This sequence is a reference standard in the RefSeqGene project. On Jun 9, 2005 this sequence version replaced NM_002485.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.171681.1, SRR1803614.280240.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGTGGAAAC TGCTGCCCGC CGCGGGCCCG GCAGGAGGAG AACCATACAG ACTTTTGACT 
GGCGTTGAGT ACGTTGTTGG AAGGAAAAAC TGTGCCATTC TGATTGAAAA TGATCAGTCG
ATCAGCCGAA ATCATGCTGT GTTAACTGCT AACTTTTCTG TAACCAACCT GAGTCAAACA
GATGAAATCC CTGTATTGAC ATTAAAAGAT AATTCTAAGT ATGGTACCTT TGTTAATGAG
GAAAAAATGC AGAATGGCTT TTCCCGAACT TTGAAGTCGG GGGATGGTAT TACTTTTGGA
GTGTTTGGAA GTAAATTCAG AATAGAGTAT GAGCCTTTGG TTGCATGCTC TTCTTGTTTA
GATGTCTCTG GGAAAACTGC TTTAAATCAA GCTATATTGC AACTTGGAGG ATTTACTGTA
AACAATTGGA CAGAAGAATG CACTCACCTT GTCATGGTAT CAGTGAAAGT TACCATTAAA
ACAATATGTG CACTCATTTG TGGACGTCCA ATTGTAAAGC CAGAATATTT TACTGAATTC
CTGAAAGCAG TTGAGTCCAA GAAGCAGCCT CCACAAATTG AAAGTTTTTA CCCACCTCTT
GATGAACCAT CTATTGGAAG TAAAAATGTT GATCTGTCAG GACGGCAGGA AAGAAAACAA
ATCTTCAAAG GGAAAACATT TATATTTTTG AATGCCAAAC AGCATAAGAA ATTGAGTTCC
GCAGTTGTCT TTGGAGGTGG GGAAGCTAGG TTGATAACAG AAGAGAATGA AGAAGAACAT
AATTTCTTTT TGGCTCCGGG AACGTGTGTT GTTGATACAG GAATAACAAA CTCACAGACC
TTAATTCCTG ACTGTCAGAA GAAATGGATT CAGTCAATAA TGGATATGCT CCAAAGGCAA
GGTCTTAGAC CTATTCCTGA AGCAGAAATT GGATTGGCGG TGATTTTCAT GACTACAAAG
AATTACTGTG ATCCTCAGGG CCATCCCAGT ACAGGATTAA AGACAACAAC TCCAGGACCA
AGCCTTTCAC AAGGCGTGTC AGTTGATGAA AAACTAATGC CAAGCGCCCC AGTGAACACT
ACAACATACG TAGCTGACAC AGAATCAGAG CAAGCAGATA CATGGGATTT GAGTGAAAGG
CCAAAAGAAA TCAAAGTCTC CAAAATGGAA CAAAAATTCA GAATGCTTTC ACAAGATGCA
CCCACTGTAA AGGAGTCCTG CAAAACAAGC TCTAATAATA ATAGTATGGT ATCAAATACT
TTGGCTAAGA TGAGAATCCC AAACTATCAG CTTTCACCAA CTAAATTGCC AAGTATAAAT
AAAAGTAAAG ATAGGGCTTC TCAGCAGCAG CAGACCAACT CCATCAGAAA CTACTTTCAG
CCGTCTACCA AAAAAAGGGA AAGGGATGAA GAAAATCAAG AAATGTCTTC ATGCAAATCA
GCAAGAATAG AAACGTCTTG TTCTCTTTTA GAACAAACAC AACCTGCTAC ACCCTCATTG
TGGAAAAATA AGGAGCAGCA TCTATCTGAG AATGAGCCTG TGGACACAAA CTCAGACAAT
AACTTATTTA CAGATACAGA TTTAAAATCT ATTGTGAAAA ATTCTGCCAG TAAATCTCAT
GCTGCAGAAA AGCTAAGATC AAATAAAAAA AGGGAAATGG ATGATGTGGC CATAGAAGAT
GAAGTATTGG AACAGTTATT CAAGGACACA AAACCAGAGT TAGAAATTGA TGTGAAAGTT
CAAAAACAGG AGGAAGATGT CAATGTTAGA AAAAGGCCAA GGATGGATAT AGAAACAAAT
GACACTTTCA GTGATGAAGC AGTACCAGAA AGTAGCAAAA TATCTCAAGA AAATGAAATT
GGGAAGAAAC GTGAACTCAA GGAAGACTCA CTATGGTCAG CTAAAGAAAT ATCTAACAAT
GACAAACTTC AGGATGATAG TGAGATGCTT CCAAAAAAGC TGTTATTGAC TGAATTTAGA
TCACTGGTGA TTAAAAACTC TACTTCCAGA AATCCATCTG GCATAAATGA TGATTATGGT
CAACTAAAAA ATTTCAAGAA ATTCAAAAAG GTCACATATC CTGGAGCAGG AAAACTTCCA
CACATCATTG GAGGATCAGA TCTAATAGCT CATCATGCTC GAAAGAATAC AGAACTAGAA
GAGTGGCTAA GGCAGGAAAT GGAGGTACAA AATCAACATG CAAAAGAAGA GTCTCTTGCT
GATGATCTTT TTAGATACAA TCCTTATTTA AAAAGGAGAA GATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002476.2
CDS111..2375
Misc Feature(1)96..98
Misc Feature(2)111..437
Misc Feature(3)order(192..194,228..230,234..239,327..335)
Misc Feature(4)441..1094
Misc Feature(5)450..656
Misc Feature(6)order(486..488,498..500,507..509,516..518,522..524)
Misc Feature(7)order(636..638,648..650)
Misc Feature(8)756..1085
Misc Feature(9)771..1316
Misc Feature(10)942..944
Misc Feature(11)942..944
Misc Feature(12)1119..1121
Misc Feature(13)1137..1139
Misc Feature(14)1137..1139
Misc Feature(15)1149..1151
Misc Feature(16)1299..1301
Misc Feature(17)1299..1301
Misc Feature(18)1314..1316
Misc Feature(19)1395..1397
Misc Feature(20)1404..1406
Misc Feature(21)1404..1406
Misc Feature(22)1491..1511
Misc Feature(23)1635..1637
Misc Feature(24)1662..1664
Misc Feature(25)1953..1955
Misc Feature(26)2127..2129
Misc Feature(27)2157..2345
Misc Feature(28)2316..2339
Exon (1)1..147
Exon (2)148..281
Exon (3)282..430
Exon (4)431..590
Exon (5)591..694
Exon (6)695..812
Exon (7)813..1006
Exon (8)1007..1104
Exon (9)1105..1234
Exon (10)1235..1507
Exon (11)1508..1955
Exon (12)1956..2024
Exon (13)2025..2180
Exon (14)2181..2294
Exon (15)2295..2344
Exon (16)2345..4621
Translation

Target ORF information:

RefSeq Version NM_002485.4
Organism Homo sapiens(Human)
Definition Homo sapiens nibrin (NBN), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002485.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGTGGAAAC TGCTGCCCGC CGCGGGCCCG GCAGGAGGAG AACCATACAG ACTTTTGACT 
GGCGTTGAGT ACGTTGTTGG AAGGAAAAAC TGTGCCATTC TGATTGAAAA TGATCAGTCG
ATCAGCCGAA ATCATGCTGT GTTAACTGCT AACTTTTCTG TAACCAACCT GAGTCAAACA
GATGAAATCC CTGTATTGAC ATTAAAAGAT AATTCTAAGT ATGGTACCTT TGTTAATGAG
GAAAAAATGC AGAATGGCTT TTCCCGAACT TTGAAGTCGG GGGATGGTAT TACTTTTGGA
GTGTTTGGAA GTAAATTCAG AATAGAGTAT GAGCCTTTGG TTGCATGCTC TTCTTGTTTA
GATGTCTCTG GGAAAACTGC TTTAAATCAA GCTATATTGC AACTTGGAGG ATTTACTGTA
AACAATTGGA CAGAAGAATG CACTCACCTT GTCATGGTAT CAGTGAAAGT TACCATTAAA
ACAATATGTG CACTCATTTG TGGACGTCCA ATTGTAAAGC CAGAATATTT TACTGAATTC
CTGAAAGCAG TTGAGTCCAA GAAGCAGCCT CCACAAATTG AAAGTTTTTA CCCACCTCTT
GATGAACCAT CTATTGGAAG TAAAAATGTT GATCTGTCAG GACGGCAGGA AAGAAAACAA
ATCTTCAAAG GGAAAACATT TATATTTTTG AATGCCAAAC AGCATAAGAA ATTGAGTTCC
GCAGTTGTCT TTGGAGGTGG GGAAGCTAGG TTGATAACAG AAGAGAATGA AGAAGAACAT
AATTTCTTTT TGGCTCCGGG AACGTGTGTT GTTGATACAG GAATAACAAA CTCACAGACC
TTAATTCCTG ACTGTCAGAA GAAATGGATT CAGTCAATAA TGGATATGCT CCAAAGGCAA
GGTCTTAGAC CTATTCCTGA AGCAGAAATT GGATTGGCGG TGATTTTCAT GACTACAAAG
AATTACTGTG ATCCTCAGGG CCATCCCAGT ACAGGATTAA AGACAACAAC TCCAGGACCA
AGCCTTTCAC AAGGCGTGTC AGTTGATGAA AAACTAATGC CAAGCGCCCC AGTGAACACT
ACAACATACG TAGCTGACAC AGAATCAGAG CAAGCAGATA CATGGGATTT GAGTGAAAGG
CCAAAAGAAA TCAAAGTCTC CAAAATGGAA CAAAAATTCA GAATGCTTTC ACAAGATGCA
CCCACTGTAA AGGAGTCCTG CAAAACAAGC TCTAATAATA ATAGTATGGT ATCAAATACT
TTGGCTAAGA TGAGAATCCC AAACTATCAG CTTTCACCAA CTAAATTGCC AAGTATAAAT
AAAAGTAAAG ATAGGGCTTC TCAGCAGCAG CAGACCAACT CCATCAGAAA CTACTTTCAG
CCGTCTACCA AAAAAAGGGA AAGGGATGAA GAAAATCAAG AAATGTCTTC ATGCAAATCA
GCAAGAATAG AAACGTCTTG TTCTCTTTTA GAACAAACAC AACCTGCTAC ACCCTCATTG
TGGAAAAATA AGGAGCAGCA TCTATCTGAG AATGAGCCTG TGGACACAAA CTCAGACAAT
AACTTATTTA CAGATACAGA TTTAAAATCT ATTGTGAAAA ATTCTGCCAG TAAATCTCAT
GCTGCAGAAA AGCTAAGATC AAATAAAAAA AGGGAAATGG ATGATGTGGC CATAGAAGAT
GAAGTATTGG AACAGTTATT CAAGGACACA AAACCAGAGT TAGAAATTGA TGTGAAAGTT
CAAAAACAGG AGGAAGATGT CAATGTTAGA AAAAGGCCAA GGATGGATAT AGAAACAAAT
GACACTTTCA GTGATGAAGC AGTACCAGAA AGTAGCAAAA TATCTCAAGA AAATGAAATT
GGGAAGAAAC GTGAACTCAA GGAAGACTCA CTATGGTCAG CTAAAGAAAT ATCTAACAAT
GACAAACTTC AGGATGATAG TGAGATGCTT CCAAAAAAGC TGTTATTGAC TGAATTTAGA
TCACTGGTGA TTAAAAACTC TACTTCCAGA AATCCATCTG GCATAAATGA TGATTATGGT
CAACTAAAAA ATTTCAAGAA ATTCAAAAAG GTCACATATC CTGGAGCAGG AAAACTTCCA
CACATCATTG GAGGATCAGA TCTAATAGCT CATCATGCTC GAAAGAATAC AGAACTAGAA
GAGTGGCTAA GGCAGGAAAT GGAGGTACAA AATCAACATG CAAAAGAAGA GTCTCTTGCT
GATGATCTTT TTAGATACAA TCCTTATTTA AAAAGGAGAA GATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu42449
Clone ID Related Accession (Same CDS sequence) NM_001024688.2 , XM_011517045.1
Accession Version NM_001024688.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2019bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-30
Organism Homo sapiens(Human)
Product nibrin isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA634817.1, BC040519.1, BC136802.1 and BX640816.1. On or before Apr 2, 2015 this sequence version replaced XM_005250923.2, NM_001024688.1. Transcript Variant: This variant (2) has an additional exon in the 5' region, as compared to variant 1. This results in translation initiation from a downstream AUG codon and an isoform (2) with a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.78761.1, BC040519.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGCAGAATG GCTTTTCCCG AACTTTGAAG TCGGGGGATG GTATTACTTT TGGAGTGTTT 
GGAAGTAAAT TCAGAATAGA GTATGAGCCT TTGGTTGCAT GCTCTTCTTG TTTAGATGTC
TCTGGGAAAA CTGCTTTAAA TCAAGCTATA TTGCAACTTG GAGGATTTAC TGTAAACAAT
TGGACAGAAG AATGCACTCA CCTTGTCATG GTATCAGTGA AAGTTACCAT TAAAACAATA
TGTGCACTCA TTTGTGGACG TCCAATTGTA AAGCCAGAAT ATTTTACTGA ATTCCTGAAA
GCAGTTGAGT CCAAGAAGCA GCCTCCACAA ATTGAAAGTT TTTACCCACC TCTTGATGAA
CCATCTATTG GAAGTAAAAA TGTTGATCTG TCAGGACGGC AGGAAAGAAA ACAAATCTTC
AAAGGGAAAA CATTTATATT TTTGAATGCC AAACAGCATA AGAAATTGAG TTCCGCAGTT
GTCTTTGGAG GTGGGGAAGC TAGGTTGATA ACAGAAGAGA ATGAAGAAGA ACATAATTTC
TTTTTGGCTC CGGGAACGTG TGTTGTTGAT ACAGGAATAA CAAACTCACA GACCTTAATT
CCTGACTGTC AGAAGAAATG GATTCAGTCA ATAATGGATA TGCTCCAAAG GCAAGGTCTT
AGACCTATTC CTGAAGCAGA AATTGGATTG GCGGTGATTT TCATGACTAC AAAGAATTAC
TGTGATCCTC AGGGCCATCC CAGTACAGGA TTAAAGACAA CAACTCCAGG ACCAAGCCTT
TCACAAGGCG TGTCAGTTGA TGAAAAACTA ATGCCAAGCG CCCCAGTGAA CACTACAACA
TACGTAGCTG ACACAGAATC AGAGCAAGCA GATACATGGG ATTTGAGTGA AAGGCCAAAA
GAAATCAAAG TCTCCAAAAT GGAACAAAAA TTCAGAATGC TTTCACAAGA TGCACCCACT
GTAAAGGAGT CCTGCAAAAC AAGCTCTAAT AATAATAGTA TGGTATCAAA TACTTTGGCT
AAGATGAGAA TCCCAAACTA TCAGCTTTCA CCAACTAAAT TGCCAAGTAT AAATAAAAGT
AAAGATAGGG CTTCTCAGCA GCAGCAGACC AACTCCATCA GAAACTACTT TCAGCCGTCT
ACCAAAAAAA GGGAAAGGGA TGAAGAAAAT CAAGAAATGT CTTCATGCAA ATCAGCAAGA
ATAGAAACGT CTTGTTCTCT TTTAGAACAA ACACAACCTG CTACACCCTC ATTGTGGAAA
AATAAGGAGC AGCATCTATC TGAGAATGAG CCTGTGGACA CAAACTCAGA CAATAACTTA
TTTACAGATA CAGATTTAAA ATCTATTGTG AAAAATTCTG CCAGTAAATC TCATGCTGCA
GAAAAGCTAA GATCAAATAA AAAAAGGGAA ATGGATGATG TGGCCATAGA AGATGAAGTA
TTGGAACAGT TATTCAAGGA CACAAAACCA GAGTTAGAAA TTGATGTGAA AGTTCAAAAA
CAGGAGGAAG ATGTCAATGT TAGAAAAAGG CCAAGGATGG ATATAGAAAC AAATGACACT
TTCAGTGATG AAGCAGTACC AGAAAGTAGC AAAATATCTC AAGAAAATGA AATTGGGAAG
AAACGTGAAC TCAAGGAAGA CTCACTATGG TCAGCTAAAG AAATATCTAA CAATGACAAA
CTTCAGGATG ATAGTGAGAT GCTTCCAAAA AAGCTGTTAT TGACTGAATT TAGATCACTG
GTGATTAAAA ACTCTACTTC CAGAAATCCA TCTGGCATAA ATGATGATTA TGGTCAACTA
AAAAATTTCA AGAAATTCAA AAAGGTCACA TATCCTGGAG CAGGAAAACT TCCACACATC
ATTGGAGGAT CAGATCTAAT AGCTCATCAT GCTCGAAAGA ATACAGAACT AGAAGAGTGG
CTAAGGCAGG AAATGGAGGT ACAAAATCAA CATGCAAAAG AAGAGTCTCT TGCTGATGAT
CTTTTTAGAT ACAATCCTTA TTTAAAAAGG AGAAGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001019859.1
CDS460..2478
Misc Feature(1)313..315
Misc Feature(2)553..759
Misc Feature(3)order(589..591,601..603,610..612,619..621,625..627)
Misc Feature(4)order(739..741,751..753)
Misc Feature(5)859..1188
Misc Feature(6)1045..1047
Misc Feature(7)1240..1242
Misc Feature(8)1402..1404
Misc Feature(9)1498..1500
Misc Feature(10)1507..1509
Misc Feature(11)2260..2448
Exon (1)1..200
Exon (2)201..334
Exon (3)335..384
Exon (4)385..533
Exon (5)534..693
Exon (6)694..797
Exon (7)798..915
Exon (8)916..1109
Exon (9)1110..1207
Exon (10)1208..1337
Exon (11)1338..1610
Exon (12)1611..2058
Exon (13)2059..2127
Exon (14)2128..2283
Exon (15)2284..2397
Exon (16)2398..2447
Exon (17)2448..4724
Translation

Target ORF information:

RefSeq Version NM_001024688.2
Organism Homo sapiens(Human)
Definition Homo sapiens nibrin (NBN), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001024688.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGCAGAATG GCTTTTCCCG AACTTTGAAG TCGGGGGATG GTATTACTTT TGGAGTGTTT 
GGAAGTAAAT TCAGAATAGA GTATGAGCCT TTGGTTGCAT GCTCTTCTTG TTTAGATGTC
TCTGGGAAAA CTGCTTTAAA TCAAGCTATA TTGCAACTTG GAGGATTTAC TGTAAACAAT
TGGACAGAAG AATGCACTCA CCTTGTCATG GTATCAGTGA AAGTTACCAT TAAAACAATA
TGTGCACTCA TTTGTGGACG TCCAATTGTA AAGCCAGAAT ATTTTACTGA ATTCCTGAAA
GCAGTTGAGT CCAAGAAGCA GCCTCCACAA ATTGAAAGTT TTTACCCACC TCTTGATGAA
CCATCTATTG GAAGTAAAAA TGTTGATCTG TCAGGACGGC AGGAAAGAAA ACAAATCTTC
AAAGGGAAAA CATTTATATT TTTGAATGCC AAACAGCATA AGAAATTGAG TTCCGCAGTT
GTCTTTGGAG GTGGGGAAGC TAGGTTGATA ACAGAAGAGA ATGAAGAAGA ACATAATTTC
TTTTTGGCTC CGGGAACGTG TGTTGTTGAT ACAGGAATAA CAAACTCACA GACCTTAATT
CCTGACTGTC AGAAGAAATG GATTCAGTCA ATAATGGATA TGCTCCAAAG GCAAGGTCTT
AGACCTATTC CTGAAGCAGA AATTGGATTG GCGGTGATTT TCATGACTAC AAAGAATTAC
TGTGATCCTC AGGGCCATCC CAGTACAGGA TTAAAGACAA CAACTCCAGG ACCAAGCCTT
TCACAAGGCG TGTCAGTTGA TGAAAAACTA ATGCCAAGCG CCCCAGTGAA CACTACAACA
TACGTAGCTG ACACAGAATC AGAGCAAGCA GATACATGGG ATTTGAGTGA AAGGCCAAAA
GAAATCAAAG TCTCCAAAAT GGAACAAAAA TTCAGAATGC TTTCACAAGA TGCACCCACT
GTAAAGGAGT CCTGCAAAAC AAGCTCTAAT AATAATAGTA TGGTATCAAA TACTTTGGCT
AAGATGAGAA TCCCAAACTA TCAGCTTTCA CCAACTAAAT TGCCAAGTAT AAATAAAAGT
AAAGATAGGG CTTCTCAGCA GCAGCAGACC AACTCCATCA GAAACTACTT TCAGCCGTCT
ACCAAAAAAA GGGAAAGGGA TGAAGAAAAT CAAGAAATGT CTTCATGCAA ATCAGCAAGA
ATAGAAACGT CTTGTTCTCT TTTAGAACAA ACACAACCTG CTACACCCTC ATTGTGGAAA
AATAAGGAGC AGCATCTATC TGAGAATGAG CCTGTGGACA CAAACTCAGA CAATAACTTA
TTTACAGATA CAGATTTAAA ATCTATTGTG AAAAATTCTG CCAGTAAATC TCATGCTGCA
GAAAAGCTAA GATCAAATAA AAAAAGGGAA ATGGATGATG TGGCCATAGA AGATGAAGTA
TTGGAACAGT TATTCAAGGA CACAAAACCA GAGTTAGAAA TTGATGTGAA AGTTCAAAAA
CAGGAGGAAG ATGTCAATGT TAGAAAAAGG CCAAGGATGG ATATAGAAAC AAATGACACT
TTCAGTGATG AAGCAGTACC AGAAAGTAGC AAAATATCTC AAGAAAATGA AATTGGGAAG
AAACGTGAAC TCAAGGAAGA CTCACTATGG TCAGCTAAAG AAATATCTAA CAATGACAAA
CTTCAGGATG ATAGTGAGAT GCTTCCAAAA AAGCTGTTAT TGACTGAATT TAGATCACTG
GTGATTAAAA ACTCTACTTC CAGAAATCCA TCTGGCATAA ATGATGATTA TGGTCAACTA
AAAAATTTCA AGAAATTCAA AAAGGTCACA TATCCTGGAG CAGGAAAACT TCCACACATC
ATTGGAGGAT CAGATCTAAT AGCTCATCAT GCTCGAAAGA ATACAGAACT AGAAGAGTGG
CTAAGGCAGG AAATGGAGGT ACAAAATCAA CATGCAAAAG AAGAGTCTCT TGCTGATGAT
CTTTTTAGAT ACAATCCTTA TTTAAAAAGG AGAAGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu42449
Clone ID Related Accession (Same CDS sequence) NM_001024688.2 , XM_011517045.1
Accession Version XM_011517045.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2019bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product nibrin isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGCAGAATG GCTTTTCCCG AACTTTGAAG TCGGGGGATG GTATTACTTT TGGAGTGTTT 
GGAAGTAAAT TCAGAATAGA GTATGAGCCT TTGGTTGCAT GCTCTTCTTG TTTAGATGTC
TCTGGGAAAA CTGCTTTAAA TCAAGCTATA TTGCAACTTG GAGGATTTAC TGTAAACAAT
TGGACAGAAG AATGCACTCA CCTTGTCATG GTATCAGTGA AAGTTACCAT TAAAACAATA
TGTGCACTCA TTTGTGGACG TCCAATTGTA AAGCCAGAAT ATTTTACTGA ATTCCTGAAA
GCAGTTGAGT CCAAGAAGCA GCCTCCACAA ATTGAAAGTT TTTACCCACC TCTTGATGAA
CCATCTATTG GAAGTAAAAA TGTTGATCTG TCAGGACGGC AGGAAAGAAA ACAAATCTTC
AAAGGGAAAA CATTTATATT TTTGAATGCC AAACAGCATA AGAAATTGAG TTCCGCAGTT
GTCTTTGGAG GTGGGGAAGC TAGGTTGATA ACAGAAGAGA ATGAAGAAGA ACATAATTTC
TTTTTGGCTC CGGGAACGTG TGTTGTTGAT ACAGGAATAA CAAACTCACA GACCTTAATT
CCTGACTGTC AGAAGAAATG GATTCAGTCA ATAATGGATA TGCTCCAAAG GCAAGGTCTT
AGACCTATTC CTGAAGCAGA AATTGGATTG GCGGTGATTT TCATGACTAC AAAGAATTAC
TGTGATCCTC AGGGCCATCC CAGTACAGGA TTAAAGACAA CAACTCCAGG ACCAAGCCTT
TCACAAGGCG TGTCAGTTGA TGAAAAACTA ATGCCAAGCG CCCCAGTGAA CACTACAACA
TACGTAGCTG ACACAGAATC AGAGCAAGCA GATACATGGG ATTTGAGTGA AAGGCCAAAA
GAAATCAAAG TCTCCAAAAT GGAACAAAAA TTCAGAATGC TTTCACAAGA TGCACCCACT
GTAAAGGAGT CCTGCAAAAC AAGCTCTAAT AATAATAGTA TGGTATCAAA TACTTTGGCT
AAGATGAGAA TCCCAAACTA TCAGCTTTCA CCAACTAAAT TGCCAAGTAT AAATAAAAGT
AAAGATAGGG CTTCTCAGCA GCAGCAGACC AACTCCATCA GAAACTACTT TCAGCCGTCT
ACCAAAAAAA GGGAAAGGGA TGAAGAAAAT CAAGAAATGT CTTCATGCAA ATCAGCAAGA
ATAGAAACGT CTTGTTCTCT TTTAGAACAA ACACAACCTG CTACACCCTC ATTGTGGAAA
AATAAGGAGC AGCATCTATC TGAGAATGAG CCTGTGGACA CAAACTCAGA CAATAACTTA
TTTACAGATA CAGATTTAAA ATCTATTGTG AAAAATTCTG CCAGTAAATC TCATGCTGCA
GAAAAGCTAA GATCAAATAA AAAAAGGGAA ATGGATGATG TGGCCATAGA AGATGAAGTA
TTGGAACAGT TATTCAAGGA CACAAAACCA GAGTTAGAAA TTGATGTGAA AGTTCAAAAA
CAGGAGGAAG ATGTCAATGT TAGAAAAAGG CCAAGGATGG ATATAGAAAC AAATGACACT
TTCAGTGATG AAGCAGTACC AGAAAGTAGC AAAATATCTC AAGAAAATGA AATTGGGAAG
AAACGTGAAC TCAAGGAAGA CTCACTATGG TCAGCTAAAG AAATATCTAA CAATGACAAA
CTTCAGGATG ATAGTGAGAT GCTTCCAAAA AAGCTGTTAT TGACTGAATT TAGATCACTG
GTGATTAAAA ACTCTACTTC CAGAAATCCA TCTGGCATAA ATGATGATTA TGGTCAACTA
AAAAATTTCA AGAAATTCAA AAAGGTCACA TATCCTGGAG CAGGAAAACT TCCACACATC
ATTGGAGGAT CAGATCTAAT AGCTCATCAT GCTCGAAAGA ATACAGAACT AGAAGAGTGG
CTAAGGCAGG AAATGGAGGT ACAAAATCAA CATGCAAAAG AAGAGTCTCT TGCTGATGAT
CTTTTTAGAT ACAATCCTTA TTTAAAAAGG AGAAGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011515347.1
CDS290..2308
Misc Feature(1)383..589
Misc Feature(2)order(419..421,431..433,440..442,449..451,455..457)
Misc Feature(3)order(569..571,581..583)
Misc Feature(4)689..1018
Misc Feature(5)2090..2278
Translation

Target ORF information:

RefSeq Version XM_011517045.1
Organism Homo sapiens(Human)
Definition Homo sapiens nibrin (NBN), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011517045.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGCAGAATG GCTTTTCCCG AACTTTGAAG TCGGGGGATG GTATTACTTT TGGAGTGTTT 
GGAAGTAAAT TCAGAATAGA GTATGAGCCT TTGGTTGCAT GCTCTTCTTG TTTAGATGTC
TCTGGGAAAA CTGCTTTAAA TCAAGCTATA TTGCAACTTG GAGGATTTAC TGTAAACAAT
TGGACAGAAG AATGCACTCA CCTTGTCATG GTATCAGTGA AAGTTACCAT TAAAACAATA
TGTGCACTCA TTTGTGGACG TCCAATTGTA AAGCCAGAAT ATTTTACTGA ATTCCTGAAA
GCAGTTGAGT CCAAGAAGCA GCCTCCACAA ATTGAAAGTT TTTACCCACC TCTTGATGAA
CCATCTATTG GAAGTAAAAA TGTTGATCTG TCAGGACGGC AGGAAAGAAA ACAAATCTTC
AAAGGGAAAA CATTTATATT TTTGAATGCC AAACAGCATA AGAAATTGAG TTCCGCAGTT
GTCTTTGGAG GTGGGGAAGC TAGGTTGATA ACAGAAGAGA ATGAAGAAGA ACATAATTTC
TTTTTGGCTC CGGGAACGTG TGTTGTTGAT ACAGGAATAA CAAACTCACA GACCTTAATT
CCTGACTGTC AGAAGAAATG GATTCAGTCA ATAATGGATA TGCTCCAAAG GCAAGGTCTT
AGACCTATTC CTGAAGCAGA AATTGGATTG GCGGTGATTT TCATGACTAC AAAGAATTAC
TGTGATCCTC AGGGCCATCC CAGTACAGGA TTAAAGACAA CAACTCCAGG ACCAAGCCTT
TCACAAGGCG TGTCAGTTGA TGAAAAACTA ATGCCAAGCG CCCCAGTGAA CACTACAACA
TACGTAGCTG ACACAGAATC AGAGCAAGCA GATACATGGG ATTTGAGTGA AAGGCCAAAA
GAAATCAAAG TCTCCAAAAT GGAACAAAAA TTCAGAATGC TTTCACAAGA TGCACCCACT
GTAAAGGAGT CCTGCAAAAC AAGCTCTAAT AATAATAGTA TGGTATCAAA TACTTTGGCT
AAGATGAGAA TCCCAAACTA TCAGCTTTCA CCAACTAAAT TGCCAAGTAT AAATAAAAGT
AAAGATAGGG CTTCTCAGCA GCAGCAGACC AACTCCATCA GAAACTACTT TCAGCCGTCT
ACCAAAAAAA GGGAAAGGGA TGAAGAAAAT CAAGAAATGT CTTCATGCAA ATCAGCAAGA
ATAGAAACGT CTTGTTCTCT TTTAGAACAA ACACAACCTG CTACACCCTC ATTGTGGAAA
AATAAGGAGC AGCATCTATC TGAGAATGAG CCTGTGGACA CAAACTCAGA CAATAACTTA
TTTACAGATA CAGATTTAAA ATCTATTGTG AAAAATTCTG CCAGTAAATC TCATGCTGCA
GAAAAGCTAA GATCAAATAA AAAAAGGGAA ATGGATGATG TGGCCATAGA AGATGAAGTA
TTGGAACAGT TATTCAAGGA CACAAAACCA GAGTTAGAAA TTGATGTGAA AGTTCAAAAA
CAGGAGGAAG ATGTCAATGT TAGAAAAAGG CCAAGGATGG ATATAGAAAC AAATGACACT
TTCAGTGATG AAGCAGTACC AGAAAGTAGC AAAATATCTC AAGAAAATGA AATTGGGAAG
AAACGTGAAC TCAAGGAAGA CTCACTATGG TCAGCTAAAG AAATATCTAA CAATGACAAA
CTTCAGGATG ATAGTGAGAT GCTTCCAAAA AAGCTGTTAT TGACTGAATT TAGATCACTG
GTGATTAAAA ACTCTACTTC CAGAAATCCA TCTGGCATAA ATGATGATTA TGGTCAACTA
AAAAATTTCA AGAAATTCAA AAAGGTCACA TATCCTGGAG CAGGAAAACT TCCACACATC
ATTGGAGGAT CAGATCTAAT AGCTCATCAT GCTCGAAAGA ATACAGAACT AGAAGAGTGG
CTAAGGCAGG AAATGGAGGT ACAAAATCAA CATGCAAAAG AAGAGTCTCT TGCTGATGAT
CTTTTTAGAT ACAATCCTTA TTTAAAAAGG AGAAGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu59212
Clone ID Related Accession (Same CDS sequence) XM_011517046.1
Accession Version XM_011517046.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1410bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product nibrin isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTGGAAAC TGCTGCCCGC CGCGGGCCCG GCAGGAGGAG AACCATACAG ACTTTTGACT 
GGCGTTGAGT ACGTTGTTGG AAGGAAAAAC TGTGCCATTC TGATTGAAAA TGATCAGTCG
ATCAGCCGAA ATCATGCTGT GTTAACTGCT AACTTTTCTG TAACCAACCT GAGTCAAACA
GATGAAATCC CTGTATTGAC ATTAAAAGAT AATTCTAAGT ATGGTACCTT TGTTAATGAG
GAAAAAATGC AGAATGGCTT TTCCCGAACT TTGAAGTCGG GGGATGGTAT TACTTTTGGA
GTGTTTGGAA GTAAATTCAG AATAGAGTAT GAGCCTTTGG TTGCATGCTC TTCTTGTTTA
GATGTCTCTG GGAAAACTGC TTTAAATCAA GCTATATTGC AACTTGGAGG ATTTACTGTA
AACAATTGGA CAGAAGAATG CACTCACCTT GTCATGGTAT CAGTGAAAGT TACCATTAAA
ACAATATGTG CACTCATTTG TGGACGTCCA ATTGTAAAGC CAGAATATTT TACTGAATTC
CTGAAAGCAG TTGAGTCCAA GAAGCAGCCT CCACAAATTG AAAGTTTTTA CCCACCTCTT
GATGAACCAT CTATTGGAAG TAAAAATGTT GATCTGTCAG GACGGCAGGA AAGAAAACAA
ATCTTCAAAG GGAAAACATT TATATTTTTG AATGCCAAAC AGCATAAGAA ATTGAGTTCC
GCAGTTGTCT TTGGAGGTGG GGAAGCTAGG TTGATAACAG AAGAGAATGA AGAAGAACAT
AATTTCTTTT TGGCTCCGGG AACGTGTGTT GTTGATACAG GAATAACAAA CTCACAGACC
TTAATTCCTG ACTGTCAGAA GAAATGGATT CAGTCAATAA TGGATATGCT CCAAAGGCAA
GGTCTTAGAC CTATTCCTGA AGCAGAAATT GGATTGGCGG TGATTTTCAT GACTACAAAG
AATTACTGTG ATCCTCAGGG CCATCCCAGT ACAGGATTAA AGACAACAAC TCCAGGACCA
AGCCTTTCAC AAGGCGTGTC AGTTGATGAA AAACTAATGC CAAGCGCCCC AGTGAACACT
ACAACATACG TAGCTGACAC AGAATCAGAG CAAGCAGATA CATGGGATTT GAGTGAAAGG
CCAAAAGAAA TCAAAGTCTC CAAAATGGAA CAAAAATTCA GAATGCTTTC ACAAGATGCA
CCCACTGTAA AGGAGTCCTG CAAAACAAGC TCTAATAATA ATAGTATGGT ATCAAATACT
TTGGCTAAGA TGAGAATCCC AAACTATCAG CTTTCACCAA CTAAATTGCC AAGTATAAAT
AAAAGTAAAG ATAGGGCTTC TCAGCAGCAG CAGACCAACT CCATCAGAAA CTACTTTCAG
CCGTCTACCA AAAAAAAGGG AAAGGGATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011515348.1
CDS138..1547
Misc Feature(1)138..464
Misc Feature(2)order(219..221,255..257,261..266,354..362)
Misc Feature(3)477..683
Misc Feature(4)order(513..515,525..527,534..536,543..545,549..551)
Misc Feature(5)order(663..665,675..677)
Misc Feature(6)783..1112
Translation

Target ORF information:

RefSeq Version XM_011517046.1
Organism Homo sapiens(Human)
Definition Homo sapiens nibrin (NBN), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011517046.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTGGAAAC TGCTGCCCGC CGCGGGCCCG GCAGGAGGAG AACCATACAG ACTTTTGACT 
GGCGTTGAGT ACGTTGTTGG AAGGAAAAAC TGTGCCATTC TGATTGAAAA TGATCAGTCG
ATCAGCCGAA ATCATGCTGT GTTAACTGCT AACTTTTCTG TAACCAACCT GAGTCAAACA
GATGAAATCC CTGTATTGAC ATTAAAAGAT AATTCTAAGT ATGGTACCTT TGTTAATGAG
GAAAAAATGC AGAATGGCTT TTCCCGAACT TTGAAGTCGG GGGATGGTAT TACTTTTGGA
GTGTTTGGAA GTAAATTCAG AATAGAGTAT GAGCCTTTGG TTGCATGCTC TTCTTGTTTA
GATGTCTCTG GGAAAACTGC TTTAAATCAA GCTATATTGC AACTTGGAGG ATTTACTGTA
AACAATTGGA CAGAAGAATG CACTCACCTT GTCATGGTAT CAGTGAAAGT TACCATTAAA
ACAATATGTG CACTCATTTG TGGACGTCCA ATTGTAAAGC CAGAATATTT TACTGAATTC
CTGAAAGCAG TTGAGTCCAA GAAGCAGCCT CCACAAATTG AAAGTTTTTA CCCACCTCTT
GATGAACCAT CTATTGGAAG TAAAAATGTT GATCTGTCAG GACGGCAGGA AAGAAAACAA
ATCTTCAAAG GGAAAACATT TATATTTTTG AATGCCAAAC AGCATAAGAA ATTGAGTTCC
GCAGTTGTCT TTGGAGGTGG GGAAGCTAGG TTGATAACAG AAGAGAATGA AGAAGAACAT
AATTTCTTTT TGGCTCCGGG AACGTGTGTT GTTGATACAG GAATAACAAA CTCACAGACC
TTAATTCCTG ACTGTCAGAA GAAATGGATT CAGTCAATAA TGGATATGCT CCAAAGGCAA
GGTCTTAGAC CTATTCCTGA AGCAGAAATT GGATTGGCGG TGATTTTCAT GACTACAAAG
AATTACTGTG ATCCTCAGGG CCATCCCAGT ACAGGATTAA AGACAACAAC TCCAGGACCA
AGCCTTTCAC AAGGCGTGTC AGTTGATGAA AAACTAATGC CAAGCGCCCC AGTGAACACT
ACAACATACG TAGCTGACAC AGAATCAGAG CAAGCAGATA CATGGGATTT GAGTGAAAGG
CCAAAAGAAA TCAAAGTCTC CAAAATGGAA CAAAAATTCA GAATGCTTTC ACAAGATGCA
CCCACTGTAA AGGAGTCCTG CAAAACAAGC TCTAATAATA ATAGTATGGT ATCAAATACT
TTGGCTAAGA TGAGAATCCC AAACTATCAG CTTTCACCAA CTAAATTGCC AAGTATAAAT
AAAAGTAAAG ATAGGGCTTC TCAGCAGCAG CAGACCAACT CCATCAGAAA CTACTTTCAG
CCGTCTACCA AAAAAAAGGG AAAGGGATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu98013
Clone ID Related Accession (Same CDS sequence) XM_017013461.1 , XM_017013462.1 , XM_017013460.1
Accession Version XM_017013461.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1386bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product nibrin isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGATATGC TCCAAAGGCA AGGTCTTAGA CCTATTCCTG AAGCAGAAAT TGGATTGGCG 
GTGATTTTCA TGACTACAAA GAATTACTGT GATCCTCAGG GCCATCCCAG TACAGGATTA
AAGACAACAA CTCCAGGACC AAGCCTTTCA CAAGGCGTGT CAGTTGATGA AAAACTAATG
CCAAGCGCCC CAGTGAACAC TACAACATAC GTAGCTGACA CAGAATCAGA GCAAGCAGAT
ACATGGGATT TGAGTGAAAG GCCAAAAGAA ATCAAAGTCT CCAAAATGGA ACAAAAATTC
AGAATGCTTT CACAAGATGC ACCCACTGTA AAGGAGTCCT GCAAAACAAG CTCTAATAAT
AATAGTATGG TATCAAATAC TTTGGCTAAG ATGAGAATCC CAAACTATCA GCTTTCACCA
ACTAAATTGC CAAGTATAAA TAAAAGTAAA GATAGGGCTT CTCAGCAGCA GCAGACCAAC
TCCATCAGAA ACTACTTTCA GCCGTCTACC AAAAAAAGGG AAAGGGATGA AGAAAATCAA
GAAATGTCTT CATGCAAATC AGCAAGAATA GAAACGTCTT GTTCTCTTTT AGAACAAACA
CAACCTGCTA CACCCTCATT GTGGAAAAAT AAGGAGCAGC ATCTATCTGA GAATGAGCCT
GTGGACACAA ACTCAGACAA TAACTTATTT ACAGATACAG ATTTAAAATC TATTGTGAAA
AATTCTGCCA GTAAATCTCA TGCTGCAGAA AAGCTAAGAT CAAATAAAAA AAGGGAAATG
GATGATGTGG CCATAGAAGA TGAAGTATTG GAACAGTTAT TCAAGGACAC AAAACCAGAG
TTAGAAATTG ATGTGAAAGT TCAAAAACAG GAGGAAGATG TCAATGTTAG AAAAAGGCCA
AGGATGGATA TAGAAACAAA TGACACTTTC AGTGATGAAG CAGTACCAGA AAGTAGCAAA
ATATCTCAAG AAAATGAAAT TGGGAAGAAA CGTGAACTCA AGGAAGACTC ACTATGGTCA
GCTAAAGAAA TATCTAACAA TGACAAACTT CAGGATGATA GTGAGATGCT TCCAAAAAAG
CTGTTATTGA CTGAATTTAG ATCACTGGTG ATTAAAAACT CTACTTCCAG AAATCCATCT
GGCATAAATG ATGATTATGG TCAACTAAAA AATTTCAAGA AATTCAAAAA GGTCACATAT
CCTGGAGCAG GAAAACTTCC ACACATCATT GGAGGATCAG ATCTAATAGC TCATCATGCT
CGAAAGAATA CAGAACTAGA AGAGTGGCTA AGGCAGGAAA TGGAGGTACA AAATCAACAT
GCAAAAGAAG AGTCTCTTGC TGATGATCTT TTTAGATACA ATCCTTATTT AAAAAGGAGA
AGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016868950.1
CDS813..2198
Translation

Target ORF information:

RefSeq Version XM_017013461.1
Organism Homo sapiens(Human)
Definition Homo sapiens nibrin (NBN), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017013461.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGATATGC TCCAAAGGCA AGGTCTTAGA CCTATTCCTG AAGCAGAAAT TGGATTGGCG 
GTGATTTTCA TGACTACAAA GAATTACTGT GATCCTCAGG GCCATCCCAG TACAGGATTA
AAGACAACAA CTCCAGGACC AAGCCTTTCA CAAGGCGTGT CAGTTGATGA AAAACTAATG
CCAAGCGCCC CAGTGAACAC TACAACATAC GTAGCTGACA CAGAATCAGA GCAAGCAGAT
ACATGGGATT TGAGTGAAAG GCCAAAAGAA ATCAAAGTCT CCAAAATGGA ACAAAAATTC
AGAATGCTTT CACAAGATGC ACCCACTGTA AAGGAGTCCT GCAAAACAAG CTCTAATAAT
AATAGTATGG TATCAAATAC TTTGGCTAAG ATGAGAATCC CAAACTATCA GCTTTCACCA
ACTAAATTGC CAAGTATAAA TAAAAGTAAA GATAGGGCTT CTCAGCAGCA GCAGACCAAC
TCCATCAGAA ACTACTTTCA GCCGTCTACC AAAAAAAGGG AAAGGGATGA AGAAAATCAA
GAAATGTCTT CATGCAAATC AGCAAGAATA GAAACGTCTT GTTCTCTTTT AGAACAAACA
CAACCTGCTA CACCCTCATT GTGGAAAAAT AAGGAGCAGC ATCTATCTGA GAATGAGCCT
GTGGACACAA ACTCAGACAA TAACTTATTT ACAGATACAG ATTTAAAATC TATTGTGAAA
AATTCTGCCA GTAAATCTCA TGCTGCAGAA AAGCTAAGAT CAAATAAAAA AAGGGAAATG
GATGATGTGG CCATAGAAGA TGAAGTATTG GAACAGTTAT TCAAGGACAC AAAACCAGAG
TTAGAAATTG ATGTGAAAGT TCAAAAACAG GAGGAAGATG TCAATGTTAG AAAAAGGCCA
AGGATGGATA TAGAAACAAA TGACACTTTC AGTGATGAAG CAGTACCAGA AAGTAGCAAA
ATATCTCAAG AAAATGAAAT TGGGAAGAAA CGTGAACTCA AGGAAGACTC ACTATGGTCA
GCTAAAGAAA TATCTAACAA TGACAAACTT CAGGATGATA GTGAGATGCT TCCAAAAAAG
CTGTTATTGA CTGAATTTAG ATCACTGGTG ATTAAAAACT CTACTTCCAG AAATCCATCT
GGCATAAATG ATGATTATGG TCAACTAAAA AATTTCAAGA AATTCAAAAA GGTCACATAT
CCTGGAGCAG GAAAACTTCC ACACATCATT GGAGGATCAG ATCTAATAGC TCATCATGCT
CGAAAGAATA CAGAACTAGA AGAGTGGCTA AGGCAGGAAA TGGAGGTACA AAATCAACAT
GCAAAAGAAG AGTCTCTTGC TGATGATCTT TTTAGATACA ATCCTTATTT AAAAAGGAGA
AGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu98013
Clone ID Related Accession (Same CDS sequence) XM_017013461.1 , XM_017013462.1 , XM_017013460.1
Accession Version XM_017013462.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1386bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product nibrin isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGATATGC TCCAAAGGCA AGGTCTTAGA CCTATTCCTG AAGCAGAAAT TGGATTGGCG 
GTGATTTTCA TGACTACAAA GAATTACTGT GATCCTCAGG GCCATCCCAG TACAGGATTA
AAGACAACAA CTCCAGGACC AAGCCTTTCA CAAGGCGTGT CAGTTGATGA AAAACTAATG
CCAAGCGCCC CAGTGAACAC TACAACATAC GTAGCTGACA CAGAATCAGA GCAAGCAGAT
ACATGGGATT TGAGTGAAAG GCCAAAAGAA ATCAAAGTCT CCAAAATGGA ACAAAAATTC
AGAATGCTTT CACAAGATGC ACCCACTGTA AAGGAGTCCT GCAAAACAAG CTCTAATAAT
AATAGTATGG TATCAAATAC TTTGGCTAAG ATGAGAATCC CAAACTATCA GCTTTCACCA
ACTAAATTGC CAAGTATAAA TAAAAGTAAA GATAGGGCTT CTCAGCAGCA GCAGACCAAC
TCCATCAGAA ACTACTTTCA GCCGTCTACC AAAAAAAGGG AAAGGGATGA AGAAAATCAA
GAAATGTCTT CATGCAAATC AGCAAGAATA GAAACGTCTT GTTCTCTTTT AGAACAAACA
CAACCTGCTA CACCCTCATT GTGGAAAAAT AAGGAGCAGC ATCTATCTGA GAATGAGCCT
GTGGACACAA ACTCAGACAA TAACTTATTT ACAGATACAG ATTTAAAATC TATTGTGAAA
AATTCTGCCA GTAAATCTCA TGCTGCAGAA AAGCTAAGAT CAAATAAAAA AAGGGAAATG
GATGATGTGG CCATAGAAGA TGAAGTATTG GAACAGTTAT TCAAGGACAC AAAACCAGAG
TTAGAAATTG ATGTGAAAGT TCAAAAACAG GAGGAAGATG TCAATGTTAG AAAAAGGCCA
AGGATGGATA TAGAAACAAA TGACACTTTC AGTGATGAAG CAGTACCAGA AAGTAGCAAA
ATATCTCAAG AAAATGAAAT TGGGAAGAAA CGTGAACTCA AGGAAGACTC ACTATGGTCA
GCTAAAGAAA TATCTAACAA TGACAAACTT CAGGATGATA GTGAGATGCT TCCAAAAAAG
CTGTTATTGA CTGAATTTAG ATCACTGGTG ATTAAAAACT CTACTTCCAG AAATCCATCT
GGCATAAATG ATGATTATGG TCAACTAAAA AATTTCAAGA AATTCAAAAA GGTCACATAT
CCTGGAGCAG GAAAACTTCC ACACATCATT GGAGGATCAG ATCTAATAGC TCATCATGCT
CGAAAGAATA CAGAACTAGA AGAGTGGCTA AGGCAGGAAA TGGAGGTACA AAATCAACAT
GCAAAAGAAG AGTCTCTTGC TGATGATCTT TTTAGATACA ATCCTTATTT AAAAAGGAGA
AGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016868951.1
CDS998..2383
Translation

Target ORF information:

RefSeq Version XM_017013462.1
Organism Homo sapiens(Human)
Definition Homo sapiens nibrin (NBN), transcript variant X5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017013462.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGATATGC TCCAAAGGCA AGGTCTTAGA CCTATTCCTG AAGCAGAAAT TGGATTGGCG 
GTGATTTTCA TGACTACAAA GAATTACTGT GATCCTCAGG GCCATCCCAG TACAGGATTA
AAGACAACAA CTCCAGGACC AAGCCTTTCA CAAGGCGTGT CAGTTGATGA AAAACTAATG
CCAAGCGCCC CAGTGAACAC TACAACATAC GTAGCTGACA CAGAATCAGA GCAAGCAGAT
ACATGGGATT TGAGTGAAAG GCCAAAAGAA ATCAAAGTCT CCAAAATGGA ACAAAAATTC
AGAATGCTTT CACAAGATGC ACCCACTGTA AAGGAGTCCT GCAAAACAAG CTCTAATAAT
AATAGTATGG TATCAAATAC TTTGGCTAAG ATGAGAATCC CAAACTATCA GCTTTCACCA
ACTAAATTGC CAAGTATAAA TAAAAGTAAA GATAGGGCTT CTCAGCAGCA GCAGACCAAC
TCCATCAGAA ACTACTTTCA GCCGTCTACC AAAAAAAGGG AAAGGGATGA AGAAAATCAA
GAAATGTCTT CATGCAAATC AGCAAGAATA GAAACGTCTT GTTCTCTTTT AGAACAAACA
CAACCTGCTA CACCCTCATT GTGGAAAAAT AAGGAGCAGC ATCTATCTGA GAATGAGCCT
GTGGACACAA ACTCAGACAA TAACTTATTT ACAGATACAG ATTTAAAATC TATTGTGAAA
AATTCTGCCA GTAAATCTCA TGCTGCAGAA AAGCTAAGAT CAAATAAAAA AAGGGAAATG
GATGATGTGG CCATAGAAGA TGAAGTATTG GAACAGTTAT TCAAGGACAC AAAACCAGAG
TTAGAAATTG ATGTGAAAGT TCAAAAACAG GAGGAAGATG TCAATGTTAG AAAAAGGCCA
AGGATGGATA TAGAAACAAA TGACACTTTC AGTGATGAAG CAGTACCAGA AAGTAGCAAA
ATATCTCAAG AAAATGAAAT TGGGAAGAAA CGTGAACTCA AGGAAGACTC ACTATGGTCA
GCTAAAGAAA TATCTAACAA TGACAAACTT CAGGATGATA GTGAGATGCT TCCAAAAAAG
CTGTTATTGA CTGAATTTAG ATCACTGGTG ATTAAAAACT CTACTTCCAG AAATCCATCT
GGCATAAATG ATGATTATGG TCAACTAAAA AATTTCAAGA AATTCAAAAA GGTCACATAT
CCTGGAGCAG GAAAACTTCC ACACATCATT GGAGGATCAG ATCTAATAGC TCATCATGCT
CGAAAGAATA CAGAACTAGA AGAGTGGCTA AGGCAGGAAA TGGAGGTACA AAATCAACAT
GCAAAAGAAG AGTCTCTTGC TGATGATCTT TTTAGATACA ATCCTTATTT AAAAAGGAGA
AGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu98013
Clone ID Related Accession (Same CDS sequence) XM_017013461.1 , XM_017013462.1 , XM_017013460.1
Accession Version XM_017013460.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1386bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product nibrin isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGATATGC TCCAAAGGCA AGGTCTTAGA CCTATTCCTG AAGCAGAAAT TGGATTGGCG 
GTGATTTTCA TGACTACAAA GAATTACTGT GATCCTCAGG GCCATCCCAG TACAGGATTA
AAGACAACAA CTCCAGGACC AAGCCTTTCA CAAGGCGTGT CAGTTGATGA AAAACTAATG
CCAAGCGCCC CAGTGAACAC TACAACATAC GTAGCTGACA CAGAATCAGA GCAAGCAGAT
ACATGGGATT TGAGTGAAAG GCCAAAAGAA ATCAAAGTCT CCAAAATGGA ACAAAAATTC
AGAATGCTTT CACAAGATGC ACCCACTGTA AAGGAGTCCT GCAAAACAAG CTCTAATAAT
AATAGTATGG TATCAAATAC TTTGGCTAAG ATGAGAATCC CAAACTATCA GCTTTCACCA
ACTAAATTGC CAAGTATAAA TAAAAGTAAA GATAGGGCTT CTCAGCAGCA GCAGACCAAC
TCCATCAGAA ACTACTTTCA GCCGTCTACC AAAAAAAGGG AAAGGGATGA AGAAAATCAA
GAAATGTCTT CATGCAAATC AGCAAGAATA GAAACGTCTT GTTCTCTTTT AGAACAAACA
CAACCTGCTA CACCCTCATT GTGGAAAAAT AAGGAGCAGC ATCTATCTGA GAATGAGCCT
GTGGACACAA ACTCAGACAA TAACTTATTT ACAGATACAG ATTTAAAATC TATTGTGAAA
AATTCTGCCA GTAAATCTCA TGCTGCAGAA AAGCTAAGAT CAAATAAAAA AAGGGAAATG
GATGATGTGG CCATAGAAGA TGAAGTATTG GAACAGTTAT TCAAGGACAC AAAACCAGAG
TTAGAAATTG ATGTGAAAGT TCAAAAACAG GAGGAAGATG TCAATGTTAG AAAAAGGCCA
AGGATGGATA TAGAAACAAA TGACACTTTC AGTGATGAAG CAGTACCAGA AAGTAGCAAA
ATATCTCAAG AAAATGAAAT TGGGAAGAAA CGTGAACTCA AGGAAGACTC ACTATGGTCA
GCTAAAGAAA TATCTAACAA TGACAAACTT CAGGATGATA GTGAGATGCT TCCAAAAAAG
CTGTTATTGA CTGAATTTAG ATCACTGGTG ATTAAAAACT CTACTTCCAG AAATCCATCT
GGCATAAATG ATGATTATGG TCAACTAAAA AATTTCAAGA AATTCAAAAA GGTCACATAT
CCTGGAGCAG GAAAACTTCC ACACATCATT GGAGGATCAG ATCTAATAGC TCATCATGCT
CGAAAGAATA CAGAACTAGA AGAGTGGCTA AGGCAGGAAA TGGAGGTACA AAATCAACAT
GCAAAAGAAG AGTCTCTTGC TGATGATCTT TTTAGATACA ATCCTTATTT AAAAAGGAGA
AGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016868949.1
CDS1074..2459
Translation

Target ORF information:

RefSeq Version XM_017013460.1
Organism Homo sapiens(Human)
Definition Homo sapiens nibrin (NBN), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017013460.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGATATGC TCCAAAGGCA AGGTCTTAGA CCTATTCCTG AAGCAGAAAT TGGATTGGCG 
GTGATTTTCA TGACTACAAA GAATTACTGT GATCCTCAGG GCCATCCCAG TACAGGATTA
AAGACAACAA CTCCAGGACC AAGCCTTTCA CAAGGCGTGT CAGTTGATGA AAAACTAATG
CCAAGCGCCC CAGTGAACAC TACAACATAC GTAGCTGACA CAGAATCAGA GCAAGCAGAT
ACATGGGATT TGAGTGAAAG GCCAAAAGAA ATCAAAGTCT CCAAAATGGA ACAAAAATTC
AGAATGCTTT CACAAGATGC ACCCACTGTA AAGGAGTCCT GCAAAACAAG CTCTAATAAT
AATAGTATGG TATCAAATAC TTTGGCTAAG ATGAGAATCC CAAACTATCA GCTTTCACCA
ACTAAATTGC CAAGTATAAA TAAAAGTAAA GATAGGGCTT CTCAGCAGCA GCAGACCAAC
TCCATCAGAA ACTACTTTCA GCCGTCTACC AAAAAAAGGG AAAGGGATGA AGAAAATCAA
GAAATGTCTT CATGCAAATC AGCAAGAATA GAAACGTCTT GTTCTCTTTT AGAACAAACA
CAACCTGCTA CACCCTCATT GTGGAAAAAT AAGGAGCAGC ATCTATCTGA GAATGAGCCT
GTGGACACAA ACTCAGACAA TAACTTATTT ACAGATACAG ATTTAAAATC TATTGTGAAA
AATTCTGCCA GTAAATCTCA TGCTGCAGAA AAGCTAAGAT CAAATAAAAA AAGGGAAATG
GATGATGTGG CCATAGAAGA TGAAGTATTG GAACAGTTAT TCAAGGACAC AAAACCAGAG
TTAGAAATTG ATGTGAAAGT TCAAAAACAG GAGGAAGATG TCAATGTTAG AAAAAGGCCA
AGGATGGATA TAGAAACAAA TGACACTTTC AGTGATGAAG CAGTACCAGA AAGTAGCAAA
ATATCTCAAG AAAATGAAAT TGGGAAGAAA CGTGAACTCA AGGAAGACTC ACTATGGTCA
GCTAAAGAAA TATCTAACAA TGACAAACTT CAGGATGATA GTGAGATGCT TCCAAAAAAG
CTGTTATTGA CTGAATTTAG ATCACTGGTG ATTAAAAACT CTACTTCCAG AAATCCATCT
GGCATAAATG ATGATTATGG TCAACTAAAA AATTTCAAGA AATTCAAAAA GGTCACATAT
CCTGGAGCAG GAAAACTTCC ACACATCATT GGAGGATCAG ATCTAATAGC TCATCATGCT
CGAAAGAATA CAGAACTAGA AGAGTGGCTA AGGCAGGAAA TGGAGGTACA AAATCAACAT
GCAAAAGAAG AGTCTCTTGC TGATGATCTT TTTAGATACA ATCCTTATTT AAAAAGGAGA
AGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A balance between elongation and trimming regulates telomere stability in stem cells.
Nature structural & molecular biology24(1)30-39(2017 Jan)
Rivera T,Haggblom C,Cosconati S,Karlseder J


book

High Expression of MRE11-RAD50-NBS1 Is Associated with Poor Prognosis and Chemoresistance in Gastric Cancer.
Anticancer research36(10)5237-5247(2016 10)
Altan B,Yokobori T,Ide M,Bai T,Yanoma T,Kimura A,Kogure N,Suzuki M,Bao P,Mochiki E,Ogata K,Handa T,Kaira K,Nishiyama M,Asao T,Oyama T,Kuwano H


book

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response.
Cell reports16(10)2565-75(2016 Sep)
Staples CJ,Barone G,Myers KN,Ganesh A,Gibbs-Seymour I,Patil AA,Beveridge RD,Daye C,Beniston R,Maslen S,Ahel I,Skehel JM,Collis SJ


book

The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths.
Journal of radiation research57 Suppl 1i25-i32(2016 Aug)
Takeda S,Hoa NN,Sasanuma H


book

The c.657del5 variant in the NBN gene predisposes to pancreatic cancer.
Gene587(2)169-72(2016 Aug)
Borecka M,Zemankova P,Lhota F,Soukupova J,Kleiblova P,Vocka M,Soucek P,Ticha I,Kleibl Z,Janatova M


 
*
*
*
*