NEUROD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NEUROD1
Entrez Gene ID	4760
Full Name	neuronal differentiation 1
Synonyms	BETA2,BHF-1,MODY6,NEUROD,bHLHa3
General protein information	Preferred Names neuronal differentiation 1 Names neurogenic differentiation factor 1 basic helix-loop-helix transcription factor beta-cell E-box transactivator 2 class A basic helix-loop-helix protein 3 neurogenic helix-loop-helix protein NEUROD
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.3
Summary	This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008].
Disorder MIM:	601724
Disorder Html:	{Diabetes mellitus, noninsulin-dependent}, 125853 (3); Maturity-onset diabetes of the young 6, 606394 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002500.4	NP_002491.2	neurogenic differentiation factor 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NEUROD1	XP_001158946.1
Rattus norvegicus (Norway rat)	Neurod1	NP_062091.1
Homo sapiens (human)	NEUROD1	NP_002491.2
Bos taurus (cattle)	NEUROD1	NP_001096758.1
Xenopus tropicalis (tropical clawed frog)	neurod1	NP_001090868.1
Canis lupus familiaris (dog)	NEUROD1	XP_005640434.1
Danio rerio (zebrafish)	neurod	NP_571053.1
Mus musculus (house mouse)	Neurod1	NP_035024.1
	NEUROD1	XP_001101116.1
Gallus gallus (chicken)	NEUROD1	NP_990251.1

Gene Ontology
Bibliography

Related articles in PubMed

NEUROD1-deficient diabetes (MODY6): Identification of the first cases in Japanese and the clinical features.
Horikawa Y, Enya M, Mabe H, Fukushima K, Takubo N, Ohashi M, Ikeda F, Hashimoto KI, Watada H, Takeda J
Pediatric diabetes(2017 Jun)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest the EGR1-miR-30a-5p-NEUROD1 axis might serve as a promising biomarker for diagnosis and treatment monitoring for schizophrenic patients in acute psychotic state. EGR1 and miR-30a-5p were remarkably downregulated, whereas NEUROD1 was significantly upregulated in PBMNCs from patients in acute psychotic state.
Title: The early growth response protein 1-miR-30a-5p-neurogenic differentiation factor 1 axis as a novel biomarker for schizophrenia diagnosis and treatment monitoring.

Mutation in NEUROD1 gene is associated with Maturity Onset Diabetes of the Young.
Title: Comprehensive Maturity Onset Diabetes of the Young (MODY) Gene Screening in Pregnant Women with Diabetes in India.

the importance of the oligomeric state of CtBP for coactivation of NeuroD1-dependent transcription, was investigated.
Title: Oligomeric form of C-terminal-binding protein coactivates NeuroD1-mediated transcription.

NeuroD1 seemed not sufficient to induce and maintain neuronal differentiation. Induction of neuronal differentiation by overexpression of Neurog1 initiated important steps for the development of glutamatergic neurons such as the spiral ganglion neurons
Title: Induction of neuronal-like phenotype in human mesenchymal stem cells by overexpression of Neurogenin1 and treatment with neurotrophins.

Study reports a family with autosomal dominant diabetes related to a new NEUROD1 mutation, one of very few meeting Maturity Onset Diabetes of the Young criteria.
Title: A family with the Arg103Pro mutation in the NEUROD1 gene detected by next-generation sequencing - Clinical characteristics of mutation carriers.

The following NEUROD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NEUROD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu22879	NM_002500.4 Latest version!	Homo sapiens neuronal differentiation 1 (NEUROD1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NEUROD1 ( NM_002500.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002491.2 Homo sapiens neuronal differentiation 1 (NEUROD1), transcript variant 1, mRNA.

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CloneID	OHu22879
Clone ID Related Accession (Same CDS sequence)	NM_002500.4
Accession Version	NM_002500.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	neurogenic differentiation factor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC013733.10 and BC009046.1. This sequence is a reference standard in the RefSeqGene project. On Mar 14, 2012 this sequence version replaced NM_002500.3. Transcript Variant: This variant (1) represents the protein-coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.42423.1, D82347.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCAAAT CGTACAGCGA GAGTGGGCTG ATGGGCGAGC CTCAGCCCCA AGGTCCTCCA 
AGCTGGACAG ACGAGTGTCT CAGTTCTCAG GACGAGGAGC ACGAGGCAGA CAAGAAGGAG 
GACGACCTCG AAGCCATGAA CGCAGAGGAG GACTCACTGA GGAACGGGGG AGAGGAGGAG 
GACGAAGATG AGGACCTGGA AGAGGAGGAA GAAGAGGAAG AGGAGGATGA CGATCAAAAG 
CCCAAGAGAC GCGGCCCCAA AAAGAAGAAG ATGACTAAGG CTCGCCTGGA GCGTTTTAAA 
TTGAGACGCA TGAAGGCTAA CGCCCGGGAG CGGAACCGCA TGCACGGACT GAACGCGGCG 
CTAGACAACC TGCGCAAGGT GGTGCCTTGC TATTCTAAGA CGCAGAAGCT GTCCAAAATC 
GAGACTCTGC GCTTGGCCAA GAACTACATC TGGGCTCTGT CGGAGATCCT GCGCTCAGGC 
AAAAGCCCAG ACCTGGTCTC CTTCGTTCAG ACGCTTTGCA AGGGCTTATC CCAACCCACC 
ACCAACCTGG TTGCGGGCTG CCTGCAACTC AATCCTCGGA CTTTTCTGCC TGAGCAGAAC 
CAGGACATGC CCCCCCACCT GCCGACGGCC AGCGCTTCCT TCCCTGTACA CCCCTACTCC 
TACCAGTCGC CTGGGCTGCC CAGTCCGCCT TACGGTACCA TGGACAGCTC CCATGTCTTC 
CACGTTAAGC CTCCGCCGCA CGCCTACAGC GCAGCGCTGG AGCCCTTCTT TGAAAGCCCT 
CTGACTGATT GCACCAGCCC TTCCTTTGAT GGACCCCTCA GCCCGCCGCT CAGCATCAAT 
GGCAACTTCT CTTTCAAACA CGAACCGTCC GCCGAGTTTG AGAAAAATTA TGCCTTTACC 
ATGCACTATC CTGCAGCGAC ACTGGCAGGG GCCCAAAGCC ACGGATCAAT CTTCTCAGGC 
ACCGCTGCCC CTCGCTGCGA GATCCCCATA GACAATATTA TGTCCTTCGA TAGCCATTCA 
CATCATGAGC GAGTCATGAG TGCCCAGCTC AATGCCATAT TTCATGATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002491.2
CDS	248..1318
Translation	MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDDLEAMNAEEDSLRNGGEEEDEDEDLEEEEEEEEEDDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNQDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSAEFEKNYAFTMHYPAATLAGAQSHGSIFSGTAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD

Target ORF information:

RefSeq Version	NM_002500.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal differentiation 1 (NEUROD1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002500.4

ORF Insert Sequence:

ATGACCAAAT CGTACAGCGA GAGTGGGCTG ATGGGCGAGC CTCAGCCCCA AGGTCCTCCA 
AGCTGGACAG ACGAGTGTCT CAGTTCTCAG GACGAGGAGC ACGAGGCAGA CAAGAAGGAG 
GACGACCTCG AAGCCATGAA CGCAGAGGAG GACTCACTGA GGAACGGGGG AGAGGAGGAG 
GACGAAGATG AGGACCTGGA AGAGGAGGAA GAAGAGGAAG AGGAGGATGA CGATCAAAAG 
CCCAAGAGAC GCGGCCCCAA AAAGAAGAAG ATGACTAAGG CTCGCCTGGA GCGTTTTAAA 
TTGAGACGCA TGAAGGCTAA CGCCCGGGAG CGGAACCGCA TGCACGGACT GAACGCGGCG 
CTAGACAACC TGCGCAAGGT GGTGCCTTGC TATTCTAAGA CGCAGAAGCT GTCCAAAATC 
GAGACTCTGC GCTTGGCCAA GAACTACATC TGGGCTCTGT CGGAGATCCT GCGCTCAGGC 
AAAAGCCCAG ACCTGGTCTC CTTCGTTCAG ACGCTTTGCA AGGGCTTATC CCAACCCACC 
ACCAACCTGG TTGCGGGCTG CCTGCAACTC AATCCTCGGA CTTTTCTGCC TGAGCAGAAC 
CAGGACATGC CCCCCCACCT GCCGACGGCC AGCGCTTCCT TCCCTGTACA CCCCTACTCC 
TACCAGTCGC CTGGGCTGCC CAGTCCGCCT TACGGTACCA TGGACAGCTC CCATGTCTTC 
CACGTTAAGC CTCCGCCGCA CGCCTACAGC GCAGCGCTGG AGCCCTTCTT TGAAAGCCCT 
CTGACTGATT GCACCAGCCC TTCCTTTGAT GGACCCCTCA GCCCGCCGCT CAGCATCAAT 
GGCAACTTCT CTTTCAAACA CGAACCGTCC GCCGAGTTTG AGAAAAATTA TGCCTTTACC 
ATGCACTATC CTGCAGCGAC ACTGGCAGGG GCCCAAAGCC ACGGATCAAT CTTCTCAGGC 
ACCGCTGCCC CTCGCTGCGA GATCCCCATA GACAATATTA TGTCCTTCGA TAGCCATTCA 
CATCATGAGC GAGTCATGAG TGCCCAGCTC AATGCCATAT TTCATGATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NEUROD1-deficient diabetes (MODY6): Identification of the first cases in Japanese and the clinical features.
Pediatric diabetes(2017 Jun)
Horikawa Y,Enya M,Mabe H,Fukushima K,Takubo N,Ohashi M,Ikeda F,Hashimoto KI,Watada H,Takeda J

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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NEUROD1 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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