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RDH11 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol RDH11
Entrez Gene ID 51109
Full Name retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Synonyms ARSDR1,CGI82,HCBP12,MDT1,PSDR1,RALR1,RDJCSS,SCALD,SDR7C1
General protein information
Preferred Names

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

Names

retinol dehydrogenase 11
HCV core-binding protein HCBP12
androgen-regulated short-chain dehydrogenase/reductase 1
prostate short-chain dehydrogenase reductase 1
retinal reductase 1
short chain dehydrogenase/reductase family 7C, member 1
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

14

14q24.1
Summary The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011].
Disorder MIM:

607849

Disorder Html: ?Retinal dystrophy, juvenile cataracts, and short stature syndrome, 616108 (3)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_016026.3 NP_057110.3 retinol dehydrogenase 11 isoform 1 precursor
NM_001252650.1 NP_001239579.1 retinol dehydrogenase 11 isoform 2 precursor
NM_001252650.2 NP_001239579.1 retinol dehydrogenase 11 isoform 2 precursor
NM_016026.4 NP_057110.3 retinol dehydrogenase 11 isoform 1 precursor

Pathways from BioSystems


Homologies


Homo sapiens (human) RDH11 NP_057110.3
RDH11 XP_001107838.1
Canis lupus familiaris (dog) RDH11 XP_854354.2
Mus musculus (house mouse) Rdh11 NP_067532.2
Caenorhabditis elegans (roundworm) dhs-22 NP_506570.1
Pan troglodytes (chimpanzee) RDH11 XP_003314453.1
Bos taurus (cattle) RDH11 XP_005212137.1
Drosophila melanogaster (fruit fly) CG30495 NP_724589.2
Arabidopsis thaliana (thale cress) AT2G37540 NP_181290.1
Arabidopsis thaliana (thale cress) AT5G02540 NP_568102.1
Rattus norvegicus (Norway rat) Rdh11 NP_001012193.1
Oryza sativa (rice) Os01g0151700 NP_001042042.1
Drosophila melanogaster (fruit fly) CG2070 NP_610308.2
Drosophila melanogaster (fruit fly) CG2064 NP_610310.2
Drosophila melanogaster (fruit fly) CG2065 NP_610309.1

Gene Ontology


Bibliography

Related articles in PubMed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells.
Kummalue T, Inoue T, Miura Y, Narusawa M, Inoue H, Komatsu N, Wanachiwanawin W, Sugiyama D, Tani K
Experimental hematology43(5)414-423.e1(2015 May)

Structure of the N-terminal segment of human retinol dehydrogenase 11 and its preferential lipid binding using model membranes.
Lhor M, M?thot M, Horchani H, Salesse C
Biochimica et biophysica acta1848(3)878-85(2015 Mar)

New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11.
Xie YA, Lee W, Cai C, Gambin T, N?upuu K, Sujirakul T, Ayuso C, Jhangiani S, Muzny D, Boerwinkle E, Gibbs R, Greenstein VC, Lupski JR, Tsang SH, Allikmets R
Human molecular genetics23(21)5774-80(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that ribosomal protein L11 (RPL11)-expressing cells proliferated more rapidly than the ribosomal protein L11 (RPL11)-expressing cells.
Title: Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells.

Data suggest that membrane anchoring of retinol dehydrogenase 11 (RDH11) is likely driven by its N-terminal segment.
Title: Structure of the N-terminal segment of human retinol dehydrogenase 11 and its preferential lipid binding using model membranes.

deleterious mutations in RDH11, an important enzyme for vision-related and systemic retinoic acid metabolism, cause a new syndrome with RP.
Title: New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11.

RDH11 localizes to photoreceptor inner segments [review]
Title: Photoreceptor retinol dehydrogenases. An attempt to characterize the function of Rdh11.

Expression pattern and high catalytic efficiency of RalR1 are consistent with the hypothesis that RalR1 contributes to the reduction of retinal in various human tissues.
Title: Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines.

The following RDH11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RDH11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu07203 NM_016026.4
Latest version!		 Homo sapiens retinol dehydrogenase 11 (RDH11), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $154.50-$216.30
$309.00
OHu01616 NM_001252650.2
Latest version!		 Homo sapiens retinol dehydrogenase 11 (RDH11), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
View Old Accession Versions >>
OHu01616 NM_001252650.1 Homo sapiens retinol dehydrogenase 11 (RDH11), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu07203 NM_016026.3 Homo sapiens retinol dehydrogenase 11 (all-trans/9-cis/11-cis) (RDH11), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $154.50-$216.30
$309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu07203
Clone ID Related Accession (Same CDS sequence) NM_016026.3 , NM_016026.4
Accession Version NM_016026.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 957bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-10-01
Organism Homo sapiens(human)
Product retinol dehydrogenase 11 isoform 1 precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC355364.1, BC011727.2 and AF167438.1. This sequence is a reference standard in the RefSeqGene project. On Feb 2, 2008 this sequence version replaced NM_016026.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF167438.1, ERR279831.7502.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGTTGAGC TCATGTTCCC GCTGTTGCTC CTCCTTCTGC CCTTCCTTCT GTATATGGCT 
GCGCCCCAAA TCAGGAAAAT GCTGTCCAGT GGGGTGTGTA CATCAACTGT TCAGCTTCCT 
GGGAAAGTAG TTGTGGTCAC AGGAGCTAAT ACAGGTATCG GGAAGGAGAC AGCCAAAGAG 
CTGGCTCAGA GAGGAGCTCG AGTATATTTA GCTTGCCGGG ATGTGGAAAA GGGGGAATTG 
GTGGCCAAAG AGATCCAGAC CACGACAGGG AACCAGCAGG TGTTGGTGCG GAAACTGGAC 
CTGTCTGATA CTAAGTCTAT TCGAGCTTTT GCTAAGGGCT TCTTAGCTGA GGAAAAGCAC 
CTCCACGTTT TGATCAACAA TGCAGGAGTG ATGATGTGTC CGTACTCGAA GACAGCAGAT 
GGCTTTGAGA TGCACATAGG AGTCAACCAC TTGGGTCACT TCCTCCTAAC CCATCTGCTG 
CTAGAGAAAC TAAAGGAATC AGCCCCATCA AGGATAGTAA ATGTGTCTTC CCTCGCACAT 
CACCTGGGAA GGATCCACTT CCATAACCTG CAGGGCGAGA AATTCTACAA TGCAGGCCTG 
GCCTACTGTC ACAGCAAGCT AGCCAACATC CTCTTCACCC AGGAACTGGC CCGGAGACTA 
AAAGGCTCTG GCGTTACGAC GTATTCTGTA CACCCTGGCA CAGTCCAATC TGAACTGGTT 
CGGCACTCAT CTTTCATGAG ATGGATGTGG TGGCTTTTCT CCTTTTTCAT CAAGACTCCT 
CAGCAGGGAG CCCAGACCAG CCTGCACTGT GCCTTAACAG AAGGTCTTGA GATTCTAAGT 
GGGAATCATT TCAGTGACTG TCATGTGGCA TGGGTCTCTG CCCAAGCTCG TAATGAGACT 
ATAGCAAGGC GGCTGTGGGA CGTCAGTTGT GACCTGCTGG GCCTCCCAAT AGACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057110.3
CDS91..1047
Translation

Target ORF information:

RefSeq Version NM_016026.3
Organism Homo sapiens(human)
Definition Homo sapiens retinol dehydrogenase 11 (all-trans/9-cis/11-cis) (RDH11), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_016026.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGTTGAGC TCATGTTCCC GCTGTTGCTC CTCCTTCTGC CCTTCCTTCT GTATATGGCT 
GCGCCCCAAA TCAGGAAAAT GCTGTCCAGT GGGGTGTGTA CATCAACTGT TCAGCTTCCT 
GGGAAAGTAG TTGTGGTCAC AGGAGCTAAT ACAGGTATCG GGAAGGAGAC AGCCAAAGAG 
CTGGCTCAGA GAGGAGCTCG AGTATATTTA GCTTGCCGGG ATGTGGAAAA GGGGGAATTG 
GTGGCCAAAG AGATCCAGAC CACGACAGGG AACCAGCAGG TGTTGGTGCG GAAACTGGAC 
CTGTCTGATA CTAAGTCTAT TCGAGCTTTT GCTAAGGGCT TCTTAGCTGA GGAAAAGCAC 
CTCCACGTTT TGATCAACAA TGCAGGAGTG ATGATGTGTC CGTACTCGAA GACAGCAGAT 
GGCTTTGAGA TGCACATAGG AGTCAACCAC TTGGGTCACT TCCTCCTAAC CCATCTGCTG 
CTAGAGAAAC TAAAGGAATC AGCCCCATCA AGGATAGTAA ATGTGTCTTC CCTCGCACAT 
CACCTGGGAA GGATCCACTT CCATAACCTG CAGGGCGAGA AATTCTACAA TGCAGGCCTG 
GCCTACTGTC ACAGCAAGCT AGCCAACATC CTCTTCACCC AGGAACTGGC CCGGAGACTA 
AAAGGCTCTG GCGTTACGAC GTATTCTGTA CACCCTGGCA CAGTCCAATC TGAACTGGTT 
CGGCACTCAT CTTTCATGAG ATGGATGTGG TGGCTTTTCT CCTTTTTCAT CAAGACTCCT 
CAGCAGGGAG CCCAGACCAG CCTGCACTGT GCCTTAACAG AAGGTCTTGA GATTCTAAGT 
GGGAATCATT TCAGTGACTG TCATGTGGCA TGGGTCTCTG CCCAAGCTCG TAATGAGACT 
ATAGCAAGGC GGCTGTGGGA CGTCAGTTGT GACCTGCTGG GCCTCCCAAT AGACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu07203
Clone ID Related Accession (Same CDS sequence) NM_016026.3 , NM_016026.4
Accession Version NM_016026.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 957bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-29
Organism Homo sapiens(human)
Product retinol dehydrogenase 11 isoform 1 precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC355364.1, BC011727.2 and AF167438.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_016026.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF167438.1, SRR5189658.217098.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381346.9/ ENSP00000370750.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGTTGAGC TCATGTTCCC GCTGTTGCTC CTCCTTCTGC CCTTCCTTCT GTATATGGCT 
GCGCCCCAAA TCAGGAAAAT GCTGTCCAGT GGGGTGTGTA CATCAACTGT TCAGCTTCCT 
GGGAAAGTAG TTGTGGTCAC AGGAGCTAAT ACAGGTATCG GGAAGGAGAC AGCCAAAGAG 
CTGGCTCAGA GAGGAGCTCG AGTATATTTA GCTTGCCGGG ATGTGGAAAA GGGGGAATTG 
GTGGCCAAAG AGATCCAGAC CACGACAGGG AACCAGCAGG TGTTGGTGCG GAAACTGGAC 
CTGTCTGATA CTAAGTCTAT TCGAGCTTTT GCTAAGGGCT TCTTAGCTGA GGAAAAGCAC 
CTCCACGTTT TGATCAACAA TGCAGGAGTG ATGATGTGTC CGTACTCGAA GACAGCAGAT 
GGCTTTGAGA TGCACATAGG AGTCAACCAC TTGGGTCACT TCCTCCTAAC CCATCTGCTG 
CTAGAGAAAC TAAAGGAATC AGCCCCATCA AGGATAGTAA ATGTGTCTTC CCTCGCACAT 
CACCTGGGAA GGATCCACTT CCATAACCTG CAGGGCGAGA AATTCTACAA TGCAGGCCTG 
GCCTACTGTC ACAGCAAGCT AGCCAACATC CTCTTCACCC AGGAACTGGC CCGGAGACTA 
AAAGGCTCTG GCGTTACGAC GTATTCTGTA CACCCTGGCA CAGTCCAATC TGAACTGGTT 
CGGCACTCAT CTTTCATGAG ATGGATGTGG TGGCTTTTCT CCTTTTTCAT CAAGACTCCT 
CAGCAGGGAG CCCAGACCAG CCTGCACTGT GCCTTAACAG AAGGTCTTGA GATTCTAAGT 
GGGAATCATT TCAGTGACTG TCATGTGGCA TGGGTCTCTG CCCAAGCTCG TAATGAGACT 
ATAGCAAGGC GGCTGTGGGA CGTCAGTTGT GACCTGCTGG GCCTCCCAAT AGACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057110.3
CDS62..1018
Translation

Target ORF information:

RefSeq Version NM_016026.4
Organism Homo sapiens(human)
Definition Homo sapiens retinol dehydrogenase 11 (RDH11), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_016026.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGTTGAGC TCATGTTCCC GCTGTTGCTC CTCCTTCTGC CCTTCCTTCT GTATATGGCT 
GCGCCCCAAA TCAGGAAAAT GCTGTCCAGT GGGGTGTGTA CATCAACTGT TCAGCTTCCT 
GGGAAAGTAG TTGTGGTCAC AGGAGCTAAT ACAGGTATCG GGAAGGAGAC AGCCAAAGAG 
CTGGCTCAGA GAGGAGCTCG AGTATATTTA GCTTGCCGGG ATGTGGAAAA GGGGGAATTG 
GTGGCCAAAG AGATCCAGAC CACGACAGGG AACCAGCAGG TGTTGGTGCG GAAACTGGAC 
CTGTCTGATA CTAAGTCTAT TCGAGCTTTT GCTAAGGGCT TCTTAGCTGA GGAAAAGCAC 
CTCCACGTTT TGATCAACAA TGCAGGAGTG ATGATGTGTC CGTACTCGAA GACAGCAGAT 
GGCTTTGAGA TGCACATAGG AGTCAACCAC TTGGGTCACT TCCTCCTAAC CCATCTGCTG 
CTAGAGAAAC TAAAGGAATC AGCCCCATCA AGGATAGTAA ATGTGTCTTC CCTCGCACAT 
CACCTGGGAA GGATCCACTT CCATAACCTG CAGGGCGAGA AATTCTACAA TGCAGGCCTG 
GCCTACTGTC ACAGCAAGCT AGCCAACATC CTCTTCACCC AGGAACTGGC CCGGAGACTA 
AAAGGCTCTG GCGTTACGAC GTATTCTGTA CACCCTGGCA CAGTCCAATC TGAACTGGTT 
CGGCACTCAT CTTTCATGAG ATGGATGTGG TGGCTTTTCT CCTTTTTCAT CAAGACTCCT 
CAGCAGGGAG CCCAGACCAG CCTGCACTGT GCCTTAACAG AAGGTCTTGA GATTCTAAGT 
GGGAATCATT TCAGTGACTG TCATGTGGCA TGGGTCTCTG CCCAAGCTCG TAATGAGACT 
ATAGCAAGGC GGCTGTGGGA CGTCAGTTGT GACCTGCTGG GCCTCCCAAT AGACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu01616
Clone ID Related Accession (Same CDS sequence) NM_001252650.1 , NM_001252650.2
Accession Version NM_001252650.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 747bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-06-02
Organism Homo sapiens(human)
Product retinol dehydrogenase 11 isoform 2 precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC355364.1, AK293355.1, AL049779.6 and AI382141.1. Transcript Variant: This variant (2) lacks an alternate in-frame coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.92976.1, SRR1660803.246323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGTTGAGC TCATGTTCCC GCTGTTGCTC CTCCTTCTGC CCTTCCTTCT GTATATGGCT 
GCGCCCCAAA TCAGGAAAAT GCTGTCCAGT GGGGTGTGTA CATCAACTGT TCAGCTTCCT 
GGGAAAGTAG TTGTGGTCAC AGGAGCTAAT ACAGGTATCG GGAAGGAGAC AGCCAAAGAG 
CTGGCTCAGA GAGGAGCTCG AGTATATTTA GCTTGCCGGG ATGTGGAAAA GGGGGAATTG 
GTGGCCAAAG AGATCCAGAC CACGACAGGG AACCAGCAGG TGTTGGTGCG GAAACTGGAC 
CTGTCTGATA CTAAGTCTAT TCGAGCTTTT GCTAAGGGCT TCTTAGCTGA GGAAAAGCAC 
CTCCACGTTT TGATCAACAA TGCAGGAGTG ATGATGTGTC CGTACTCGAA GACAGCAGAT 
GGCTTTGAGA TGCACATAGG AGTCAACCAC TTGGGCTCTG GCGTTACGAC GTATTCTGTA 
CACCCTGGCA CAGTCCAATC TGAACTGGTT CGGCACTCAT CTTTCATGAG ATGGATGTGG 
TGGCTTTTCT CCTTTTTCAT CAAGACTCCT CAGCAGGGAG CCCAGACCAG CCTGCACTGT 
GCCTTAACAG AAGGTCTTGA GATTCTAAGT GGGAATCATT TCAGTGACTG TCATGTGGCA 
TGGGTCTCTG CCCAAGCTCG TAATGAGACT ATAGCAAGGC GGCTGTGGGA CGTCAGTTGT 
GACCTGCTGG GCCTCCCAAT AGACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001239579.1
CDS91..837
Translation

Target ORF information:

RefSeq Version NM_001252650.1
Organism Homo sapiens(human)
Definition Homo sapiens retinol dehydrogenase 11 (RDH11), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001252650.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGTTGAGC TCATGTTCCC GCTGTTGCTC CTCCTTCTGC CCTTCCTTCT GTATATGGCT 
GCGCCCCAAA TCAGGAAAAT GCTGTCCAGT GGGGTGTGTA CATCAACTGT TCAGCTTCCT 
GGGAAAGTAG TTGTGGTCAC AGGAGCTAAT ACAGGTATCG GGAAGGAGAC AGCCAAAGAG 
CTGGCTCAGA GAGGAGCTCG AGTATATTTA GCTTGCCGGG ATGTGGAAAA GGGGGAATTG 
GTGGCCAAAG AGATCCAGAC CACGACAGGG AACCAGCAGG TGTTGGTGCG GAAACTGGAC 
CTGTCTGATA CTAAGTCTAT TCGAGCTTTT GCTAAGGGCT TCTTAGCTGA GGAAAAGCAC 
CTCCACGTTT TGATCAACAA TGCAGGAGTG ATGATGTGTC CGTACTCGAA GACAGCAGAT 
GGCTTTGAGA TGCACATAGG AGTCAACCAC TTGGGCTCTG GCGTTACGAC GTATTCTGTA 
CACCCTGGCA CAGTCCAATC TGAACTGGTT CGGCACTCAT CTTTCATGAG ATGGATGTGG 
TGGCTTTTCT CCTTTTTCAT CAAGACTCCT CAGCAGGGAG CCCAGACCAG CCTGCACTGT 
GCCTTAACAG AAGGTCTTGA GATTCTAAGT GGGAATCATT TCAGTGACTG TCATGTGGCA 
TGGGTCTCTG CCCAAGCTCG TAATGAGACT ATAGCAAGGC GGCTGTGGGA CGTCAGTTGT 
GACCTGCTGG GCCTCCCAAT AGACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu01616
Clone ID Related Accession (Same CDS sequence) NM_001252650.1 , NM_001252650.2
Accession Version NM_001252650.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 747bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-05-30
Organism Homo sapiens(human)
Product retinol dehydrogenase 11 isoform 2 precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC355364.1, AK293355.1, AL049779.6 and AI382141.1. On May 31, 2019 this sequence version replaced NM_001252650.1. Transcript Variant: This variant (2) lacks an alternate in-frame coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.284710.1, SRR1660805.92976.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGTTGAGC TCATGTTCCC GCTGTTGCTC CTCCTTCTGC CCTTCCTTCT GTATATGGCT 
GCGCCCCAAA TCAGGAAAAT GCTGTCCAGT GGGGTGTGTA CATCAACTGT TCAGCTTCCT 
GGGAAAGTAG TTGTGGTCAC AGGAGCTAAT ACAGGTATCG GGAAGGAGAC AGCCAAAGAG 
CTGGCTCAGA GAGGAGCTCG AGTATATTTA GCTTGCCGGG ATGTGGAAAA GGGGGAATTG 
GTGGCCAAAG AGATCCAGAC CACGACAGGG AACCAGCAGG TGTTGGTGCG GAAACTGGAC 
CTGTCTGATA CTAAGTCTAT TCGAGCTTTT GCTAAGGGCT TCTTAGCTGA GGAAAAGCAC 
CTCCACGTTT TGATCAACAA TGCAGGAGTG ATGATGTGTC CGTACTCGAA GACAGCAGAT 
GGCTTTGAGA TGCACATAGG AGTCAACCAC TTGGGCTCTG GCGTTACGAC GTATTCTGTA 
CACCCTGGCA CAGTCCAATC TGAACTGGTT CGGCACTCAT CTTTCATGAG ATGGATGTGG 
TGGCTTTTCT CCTTTTTCAT CAAGACTCCT CAGCAGGGAG CCCAGACCAG CCTGCACTGT 
GCCTTAACAG AAGGTCTTGA GATTCTAAGT GGGAATCATT TCAGTGACTG TCATGTGGCA 
TGGGTCTCTG CCCAAGCTCG TAATGAGACT ATAGCAAGGC GGCTGTGGGA CGTCAGTTGT 
GACCTGCTGG GCCTCCCAAT AGACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001239579.1
CDS62..808
Translation

Target ORF information:

RefSeq Version NM_001252650.2
Organism Homo sapiens(human)
Definition Homo sapiens retinol dehydrogenase 11 (RDH11), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001252650.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGTTGAGC TCATGTTCCC GCTGTTGCTC CTCCTTCTGC CCTTCCTTCT GTATATGGCT 
GCGCCCCAAA TCAGGAAAAT GCTGTCCAGT GGGGTGTGTA CATCAACTGT TCAGCTTCCT 
GGGAAAGTAG TTGTGGTCAC AGGAGCTAAT ACAGGTATCG GGAAGGAGAC AGCCAAAGAG 
CTGGCTCAGA GAGGAGCTCG AGTATATTTA GCTTGCCGGG ATGTGGAAAA GGGGGAATTG 
GTGGCCAAAG AGATCCAGAC CACGACAGGG AACCAGCAGG TGTTGGTGCG GAAACTGGAC 
CTGTCTGATA CTAAGTCTAT TCGAGCTTTT GCTAAGGGCT TCTTAGCTGA GGAAAAGCAC 
CTCCACGTTT TGATCAACAA TGCAGGAGTG ATGATGTGTC CGTACTCGAA GACAGCAGAT 
GGCTTTGAGA TGCACATAGG AGTCAACCAC TTGGGCTCTG GCGTTACGAC GTATTCTGTA 
CACCCTGGCA CAGTCCAATC TGAACTGGTT CGGCACTCAT CTTTCATGAG ATGGATGTGG 
TGGCTTTTCT CCTTTTTCAT CAAGACTCCT CAGCAGGGAG CCCAGACCAG CCTGCACTGT 
GCCTTAACAG AAGGTCTTGA GATTCTAAGT GGGAATCATT TCAGTGACTG TCATGTGGCA 
TGGGTCTCTG CCCAAGCTCG TAATGAGACT ATAGCAAGGC GGCTGTGGGA CGTCAGTTGT 
GACCTGCTGG GCCTCCCAAT AGACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M


book

Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells.
Experimental hematology43(5)414-423.e1(2015 May)
Kummalue T,Inoue T,Miura Y,Narusawa M,Inoue H,Komatsu N,Wanachiwanawin W,Sugiyama D,Tani K


book

Structure of the N-terminal segment of human retinol dehydrogenase 11 and its preferential lipid binding using model membranes.
Biochimica et biophysica acta1848(3)878-85(2015 Mar)
Lhor M,M?thot M,Horchani H,Salesse C


book

New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11.
Human molecular genetics23(21)5774-80(2014 Nov)
Xie YA,Lee W,Cai C,Gambin T,N?upuu K,Sujirakul T,Ayuso C,Jhangiani S,Muzny D,Boerwinkle E,Gibbs R,Greenstein VC,Lupski JR,Tsang SH,Allikmets R