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SLC45A2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SLC45A2
Entrez Gene ID 51151
Full Name solute carrier family 45 member 2
Synonyms 1A1,AIM1,MATP,OCA4,SHEP5
General protein information
Preferred Names

solute carrier family 45 member 2

Names

membrane-associated transporter protein
melanoma antigen AIM1
protein AIM-1
underwhite

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

5

5p13.2

Summary This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Disorder MIM:

606202

Disorder Html: Oculocutaneous albinism, type IV, 606574 (3); [Skin/hair/eye

mRNA and Protein(s)

mRNA Protein Name
NM_001297417.2 NP_001284346.2 membrane-associated transporter protein isoform c
NM_016180.4 NP_057264.3 membrane-associated transporter protein isoform a
NM_001012509.3 NP_001012527.1 membrane-associated transporter protein isoform b



Homo sapiens (human) SLC45A2 NP_057264.3
Pan troglodytes (chimpanzee) SLC45A2 XP_526962.2
Xenopus tropicalis (tropical clawed frog) slc45a2 NP_001011335.1
Gallus gallus (chicken) SLC45A2 NP_001076833.1
Danio rerio (zebrafish) slc45a2 NP_001103847.1
Canis lupus familiaris (dog) SLC45A2 NP_001033036.1
Rattus norvegicus (Norway rat) Slc45a2 NP_001101123.1
Bos taurus (cattle) SLC45A2 XP_002696433.2
Mus musculus (house mouse) Slc45a2 NP_444307.1
Macaca mulatta (rhesus monkey) SLC45A2 XP_002804382.1


Related articles in PubMed

Mutational spectrum of the TYR and SLC45A2 genes in Pakistani families with oculocutaneous albinism, and potential founder effect of missense substitution (p.Arg77Gln) of tyrosinase.
Shah SA, Raheem N, Daud S, Mubeen J, Shaikh AA, Baloch AH, Nadeem A, Tayyab M, Babar ME, Ahmad J
Clinical and experimental dermatology40(7)774-80(2015 Oct)

Investigating polymorphisms in membrane-associated transporter protein SLC45A2, using sucrose transporters as a model.
Reinders A, Ward JM
Molecular medicine reports12(1)1393-8(2015 Jul)

Membrane-Associated Transporter Protein (MATP) Regulates Melanosomal pH and Influences Tyrosinase Activity.
Bin BH, Bhin J, Yang SH, Shin M, Nam YJ, Choi DH, Shin DW, Lee AY, Hwang D, Cho EG, Lee TR
PloS one10(6)e0129273(2015)

The interplay between natural selection and susceptibility to melanoma on allele 374F of SLC45A2 gene in a South European population.
López S, García O, Yurrebaso I, Flores C, Acosta-Herrera M, Chen H, Gardeazabal J, Careaga JM, Boyano MD, Sánchez A, Ratón-Nieto JA, Sevilla A, Smith-Zubiaga I, de Galdeano AG, Martinez-Cadenas C, Izagirre N, de la Rúa C, Alonso S
PloS one9(8)e104367(2014)

High-resolution array-CGH in patients with oculocutaneous albinism identifies new deletions of the TYR, OCA2, and SLC45A2 genes and a complex rearrangement of the OCA2 gene.
Morice-Picard F, Lasseaux E, Cailley D, Gros A, Toutain J, Plaisant C, Simon D, François S, Gilbert-Dussardier B, Kaplan J, Rooryck C, Lacombe D, Arveiler B
Pigment cell & melanoma research27(1)59-71(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

All affected members showed a novel heterozygous variant, c.208T>C (p.Y70H), in the SLC45A2 gene, which supported a diagnosis of OCA4.
Title: A Japanese Family With Autosomal Dominant Oculocutaneous Albinism Type 4.

Mutation in MATP gene expression is associated with Oculocutaneous albinism type IV.
Title: Mutational Analysis on Membrane Associated Transporter Protein (MATP) and Their Structural Consequences in Oculocutaeous Albinism Type 4 (OCA4)-A Molecular Dynamics Approach.

Our analysis revealed 10 sun-exposure-dependent gene expression quantitative trait loci (se-eQTLs), including genes involved in skin pigmentation (SLC45A2) and epidermal differentiation (RASSF9).
Title: Local Adaptation of Sun-Exposure-Dependent Gene Expression Regulation in Human Skin.

The results indicated that the D93N mutation causes OCA4 as a result of loss of MATP transport activity, and that the F374 allele confers significantly lower transport activity than L374.
Title: Investigating polymorphisms in membrane-associated transporter protein SLC45A2, using sucrose transporters as a model.

The reduction of tyrosinase activity associated with the knockdown of MATP.
Title: Membrane-Associated Transporter Protein (MATP) Regulates Melanosomal pH and Influences Tyrosinase Activity.

The following SLC45A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC45A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu67717 NM_016180.4
Latest version!
Homo sapiens solute carrier family 45 member 2 (SLC45A2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $314.30
$449.00
OHu67718 NM_001012509.3
Latest version!
Homo sapiens solute carrier family 45 member 2 (SLC45A2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $265.30
$379.00
OHu67719 NM_001297417.2
Latest version!
Homo sapiens solute carrier family 45 member 2 (SLC45A2), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00

ORF Online Only Promotion

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2-4 Clone 40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu67717
Clone ID Related Accession (Same CDS sequence) NM_016180.4
Accession Version NM_016180.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1593bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-08-28
Organism Homo sapiens(Human)
Product membrane-associated transporter protein isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ677785.1, AF172849.1, AC139777.3 and BU166522.1. This sequence is a reference standard in the RefSeqGene project. On Dec 6, 2014 this sequence version replaced NM_016180.3. Transcript Variant: This variant (1) encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF172849.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGGTAGCA ACAGTGGGCA GGCTGGCCGC CACATCTATA AATCCCTAGC TGATGATGGC 
CCCTTTGACT CTGTGGAGCC GCCTAAAAGA CCCACCAGCA GACTCATCAT GCACAGCATG
GCCATGTTCG GAAGAGAGTT CTGCTACGCG GTGGAGGCAG CGTATGTGAC CCCAGTCCTG
CTCAGCGTAG GTCTGCCCAG CAGCCTGTAC AGCATTGTGT GGTTCCTCAG CCCCATCCTG
GGATTCCTGC TGCAGCCCGT GGTCGGATCG GCCAGCGACC ACTGCCGGTC CAGGTGGGGC
CGCCGGAGAC CCTACATCCT CACCCTGGGA GTCATGATGC TCGTGGGCAT GGCTCTGTAC
CTCAATGGGG CTACTGTTGT AGCAGCTTTG ATTGCTAACC CAAGGAGGAA GCTGGTTTGG
GCCATAAGTG TCACCATGAT AGGTGTCGTT CTCTTTGATT TTGCTGCCGA CTTCATTGAT
GGGCCCATCA AAGCCTACTT ATTTGATGTC TGCTCCCATC AGGACAAGGA GAAGGGCCTC
CACTACCATG CCCTCTTCAC AGGTTTTGGA GGTGCCCTGG GTTACCTTTT GGGTGCTATA
GACTGGGCCC ATCTGGAGCT GGGAAGACTG TTGGGTACAG AATTCCAGGT CATGTTCTTC
TTCTCTGCAT TGGTGCTCAC TTTGTGTTTT ACTGTTCATC TGTGCAGTAT CTCTGAAGCC
CCACTTACAG AGGTTGCAAA GGGCATTCCC CCACAGCAAA CCCCTCAGGA CCCTCCATTG
TCATCAGATG GAATGTACGA GTATGGTTCT ATCGAGAAAG TTAAAAATGG TTACGTAAAT
CCAGAGCTGG CAATGCAGGG AGCAAAAAAC AAAAATCATG CTGAACAGAC TCGCAGGGCA
ATGACATTAA AGTCACTGCT GAGAGCACTG GTGAACATGC CTCCTCACTA CCGCTACCTT
TGCATCAGCC ACCTCATTGG ATGGACAGCC TTCCTGTCCA ACATGCTGTT CTTCACAGAT
TTCATGGGCC AGATTGTGTA CCGCGGGGAT CCCTATAGTG CACACAACTC CACAGAGTTT
CTCATCTACG AAAGAGGAGT CGAGGTTGGA TGTTGGGGCT TCTGCATCAA CTCCGTGTTT
TCCTCACTTT ATTCTTACTT TCAGAAAGTT TTGGTATCCT ACATTGGATT AAAGGGTCTT
TACTTCACGG GATATTTGCT GTTTGGCCTG GGGACGGGAT TTATTGGGCT CTTCCCGAAT
GTCTACTCCA CCCTGGTCCT GTGCAGCCTG TTTGGTGTAA TGTCCAGCAC CCTGTACACT
GTGCCCTTTA ACCTCATTAC TGAGTACCAC CGCGAGGAAG AAAAGGAGAG GCAGCAGGCC
CCAGGAGGGG ACCCAGACAA CAGCGTGAGA GGGAAGGGCA TGGACTGCGC CACCCTCACA
TGCATGGTGC AGCTGGCTCA GATCCTGGTC GGAGGTGGCC TGGGCTTTCT GGTCAACACA
GCCGGGACCG TTGTCGTCGT GGTGATCACA GCGTCTGCGG TGGCACTGAT AGGCTGTTGC
TTTGTCGCTC TCTTTGTTAG ATATGTGGAT TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057264.3
CDS93..1685
Misc Feature(1)<192..788
Misc Feature(2)198..1664
Misc Feature(3)231..293
Misc Feature(4)297..359
Misc Feature(5)423..485
Misc Feature(6)507..569
Misc Feature(7)645..707
Misc Feature(8)741..803
Misc Feature(9)1047..1109
Misc Feature(10)1191..1253
Misc Feature(11)1287..1349
Misc Feature(12)1368..1430
Misc Feature(13)1524..1586
Misc Feature(14)1605..1667
Exon (1)1..477
Exon (2)478..654
Exon (3)655..980
Exon (4)981..1124
Exon (5)1125..1248
Exon (6)1249..1460
Exon (7)1461..1717
Translation

Target ORF information:

RefSeq Version NM_016180.4
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier family 45 member 2 (SLC45A2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_016180.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGGTAGCA ACAGTGGGCA GGCTGGCCGC CACATCTATA AATCCCTAGC TGATGATGGC 
CCCTTTGACT CTGTGGAGCC GCCTAAAAGA CCCACCAGCA GACTCATCAT GCACAGCATG
GCCATGTTCG GAAGAGAGTT CTGCTACGCG GTGGAGGCAG CGTATGTGAC CCCAGTCCTG
CTCAGCGTAG GTCTGCCCAG CAGCCTGTAC AGCATTGTGT GGTTCCTCAG CCCCATCCTG
GGATTCCTGC TGCAGCCCGT GGTCGGATCG GCCAGCGACC ACTGCCGGTC CAGGTGGGGC
CGCCGGAGAC CCTACATCCT CACCCTGGGA GTCATGATGC TCGTGGGCAT GGCTCTGTAC
CTCAATGGGG CTACTGTTGT AGCAGCTTTG ATTGCTAACC CAAGGAGGAA GCTGGTTTGG
GCCATAAGTG TCACCATGAT AGGTGTCGTT CTCTTTGATT TTGCTGCCGA CTTCATTGAT
GGGCCCATCA AAGCCTACTT ATTTGATGTC TGCTCCCATC AGGACAAGGA GAAGGGCCTC
CACTACCATG CCCTCTTCAC AGGTTTTGGA GGTGCCCTGG GTTACCTTTT GGGTGCTATA
GACTGGGCCC ATCTGGAGCT GGGAAGACTG TTGGGTACAG AATTCCAGGT CATGTTCTTC
TTCTCTGCAT TGGTGCTCAC TTTGTGTTTT ACTGTTCATC TGTGCAGTAT CTCTGAAGCC
CCACTTACAG AGGTTGCAAA GGGCATTCCC CCACAGCAAA CCCCTCAGGA CCCTCCATTG
TCATCAGATG GAATGTACGA GTATGGTTCT ATCGAGAAAG TTAAAAATGG TTACGTAAAT
CCAGAGCTGG CAATGCAGGG AGCAAAAAAC AAAAATCATG CTGAACAGAC TCGCAGGGCA
ATGACATTAA AGTCACTGCT GAGAGCACTG GTGAACATGC CTCCTCACTA CCGCTACCTT
TGCATCAGCC ACCTCATTGG ATGGACAGCC TTCCTGTCCA ACATGCTGTT CTTCACAGAT
TTCATGGGCC AGATTGTGTA CCGCGGGGAT CCCTATAGTG CACACAACTC CACAGAGTTT
CTCATCTACG AAAGAGGAGT CGAGGTTGGA TGTTGGGGCT TCTGCATCAA CTCCGTGTTT
TCCTCACTTT ATTCTTACTT TCAGAAAGTT TTGGTATCCT ACATTGGATT AAAGGGTCTT
TACTTCACGG GATATTTGCT GTTTGGCCTG GGGACGGGAT TTATTGGGCT CTTCCCGAAT
GTCTACTCCA CCCTGGTCCT GTGCAGCCTG TTTGGTGTAA TGTCCAGCAC CCTGTACACT
GTGCCCTTTA ACCTCATTAC TGAGTACCAC CGCGAGGAAG AAAAGGAGAG GCAGCAGGCC
CCAGGAGGGG ACCCAGACAA CAGCGTGAGA GGGAAGGGCA TGGACTGCGC CACCCTCACA
TGCATGGTGC AGCTGGCTCA GATCCTGGTC GGAGGTGGCC TGGGCTTTCT GGTCAACACA
GCCGGGACCG TTGTCGTCGT GGTGATCACA GCGTCTGCGG TGGCACTGAT AGGCTGTTGC
TTTGTCGCTC TCTTTGTTAG ATATGTGGAT TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu67718
Clone ID Related Accession (Same CDS sequence) NM_001012509.3
Accession Version NM_001012509.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1383bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-08-28
Organism Homo sapiens(Human)
Product membrane-associated transporter protein isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ677785.1, BC064405.1 and AC139777.3. On Dec 6, 2014 this sequence version replaced NM_001012509.2. Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064405.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGGTAGCA ACAGTGGGCA GGCTGGCCGC CACATCTATA AATCCCTAGC TGATGATGGC 
CCCTTTGACT CTGTGGAGCC GCCTAAAAGA CCCACCAGCA GACTCATCAT GCACAGCATG
GCCATGTTCG GAAGAGAGTT CTGCTACGCG GTGGAGGCAG CGTATGTGAC CCCAGTCCTG
CTCAGCGTAG GTCTGCCCAG CAGCCTGTAC AGCATTGTGT GGTTCCTCAG CCCCATCCTG
GGATTCCTGC TGCAGCCCGT GGTCGGATCG GCCAGCGACC ACTGCCGGTC CAGGTGGGGC
CGCCGGAGAC CCTACATCCT CACCCTGGGA GTCATGATGC TCGTGGGCAT GGCTCTGTAC
CTCAATGGGG CTACTGTTGT AGCAGCTTTG ATTGCTAACC CAAGGAGGAA GCTGGTTTGG
GCCATAAGTG TCACCATGAT AGGTGTCGTT CTCTTTGATT TTGCTGCCGA CTTCATTGAT
GGGCCCATCA AAGCCTACTT ATTTGATGTC TGCTCCCATC AGGACAAGGA GAAGGGCCTC
CACTACCATG CCCTCTTCAC AGGTTTTGGA GGTGCCCTGG GTTACCTTTT GGGTGCTATA
GACTGGGCCC ATCTGGAGCT GGGAAGACTG TTGGGTACAG AATTCCAGGT CATGTTCTTC
TTCTCTGCAT TGGTGCTCAC TTTGTGTTTT ACTGTTCATC TGTGCAGTAT CTCTGAAGCC
CCACTTACAG AGGTTGCAAA GGGCATTCCC CCACAGCAAA CCCCTCAGGA CCCTCCATTG
TCATCAGATG GAATGTACGA GTATGGTTCT ATCGAGAAAG TTAAAAATGG TTACGTAAAT
CCAGAGCTGG CAATGCAGGG AGCAAAAAAC AAAAATCATG CTGAACAGAC TCGCAGGGCA
ATGACATTAA AGTCACTGCT GAGAGCACTG GTGAACATGC CTCCTCACTA CCGCTACCTT
TGCATCAGCC ACCTCATTGG ATGGACAGCC TTCCTGTCCA ACATGCTGTT CTTCACAGAT
TTCATGGGCC AGATTGTGTA CCGCGGGGAT CCCTATAGTG CACACAACTC CACAGAGTTT
CTCATCTACG AAAGAGGAGT CGAGGTTGGA TGTTGGGGCT TCTGCATCAA CTCCGTGTTT
TCCTCACTTT ATTCTTACTT TCAGAAAGTT TTGGTATCCT ACATTGGATT AAAGGGTCTT
TACTTCACGG GATATTTGCT GTTTGGCCTG GGGACGGGAT TTATTGGGCT CTTCCCGAAT
GTCTACTCCA CCCTGGTCCT GTGCAGCCTG TTTGGTGTAA TGTCCAGCAC CCTGTACACT
GTGCCCTTTA ACCTCATTAC TGAGTACCAC CGCGAGGAAG AAAAGGAGGT GTGCTGTCAT
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001012527.1
CDS93..1475
Misc Feature(1)183..1439
Misc Feature(2)<192..788
Misc Feature(3)231..293
Misc Feature(4)297..359
Misc Feature(5)423..485
Misc Feature(6)507..569
Misc Feature(7)645..707
Misc Feature(8)741..803
Misc Feature(9)1047..1109
Misc Feature(10)1191..1253
Misc Feature(11)1287..1349
Misc Feature(12)1368..1430
Exon (1)1..477
Exon (2)478..654
Exon (3)655..980
Exon (4)981..1124
Exon (5)1125..1248
Exon (6)1249..2757
Translation

Target ORF information:

RefSeq Version NM_001012509.3
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier family 45 member 2 (SLC45A2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001012509.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGGTAGCA ACAGTGGGCA GGCTGGCCGC CACATCTATA AATCCCTAGC TGATGATGGC 
CCCTTTGACT CTGTGGAGCC GCCTAAAAGA CCCACCAGCA GACTCATCAT GCACAGCATG
GCCATGTTCG GAAGAGAGTT CTGCTACGCG GTGGAGGCAG CGTATGTGAC CCCAGTCCTG
CTCAGCGTAG GTCTGCCCAG CAGCCTGTAC AGCATTGTGT GGTTCCTCAG CCCCATCCTG
GGATTCCTGC TGCAGCCCGT GGTCGGATCG GCCAGCGACC ACTGCCGGTC CAGGTGGGGC
CGCCGGAGAC CCTACATCCT CACCCTGGGA GTCATGATGC TCGTGGGCAT GGCTCTGTAC
CTCAATGGGG CTACTGTTGT AGCAGCTTTG ATTGCTAACC CAAGGAGGAA GCTGGTTTGG
GCCATAAGTG TCACCATGAT AGGTGTCGTT CTCTTTGATT TTGCTGCCGA CTTCATTGAT
GGGCCCATCA AAGCCTACTT ATTTGATGTC TGCTCCCATC AGGACAAGGA GAAGGGCCTC
CACTACCATG CCCTCTTCAC AGGTTTTGGA GGTGCCCTGG GTTACCTTTT GGGTGCTATA
GACTGGGCCC ATCTGGAGCT GGGAAGACTG TTGGGTACAG AATTCCAGGT CATGTTCTTC
TTCTCTGCAT TGGTGCTCAC TTTGTGTTTT ACTGTTCATC TGTGCAGTAT CTCTGAAGCC
CCACTTACAG AGGTTGCAAA GGGCATTCCC CCACAGCAAA CCCCTCAGGA CCCTCCATTG
TCATCAGATG GAATGTACGA GTATGGTTCT ATCGAGAAAG TTAAAAATGG TTACGTAAAT
CCAGAGCTGG CAATGCAGGG AGCAAAAAAC AAAAATCATG CTGAACAGAC TCGCAGGGCA
ATGACATTAA AGTCACTGCT GAGAGCACTG GTGAACATGC CTCCTCACTA CCGCTACCTT
TGCATCAGCC ACCTCATTGG ATGGACAGCC TTCCTGTCCA ACATGCTGTT CTTCACAGAT
TTCATGGGCC AGATTGTGTA CCGCGGGGAT CCCTATAGTG CACACAACTC CACAGAGTTT
CTCATCTACG AAAGAGGAGT CGAGGTTGGA TGTTGGGGCT TCTGCATCAA CTCCGTGTTT
TCCTCACTTT ATTCTTACTT TCAGAAAGTT TTGGTATCCT ACATTGGATT AAAGGGTCTT
TACTTCACGG GATATTTGCT GTTTGGCCTG GGGACGGGAT TTATTGGGCT CTTCCCGAAT
GTCTACTCCA CCCTGGTCCT GTGCAGCCTG TTTGGTGTAA TGTCCAGCAC CCTGTACACT
GTGCCCTTTA ACCTCATTAC TGAGTACCAC CGCGAGGAAG AAAAGGAGGT GTGCTGTCAT
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu67719
Clone ID Related Accession (Same CDS sequence) NM_001297417.2
Accession Version NM_001297417.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 732bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-08-28
Organism Homo sapiens(Human)
Product membrane-associated transporter protein isoform c
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ677785.1, BC003597.1 and AC139777.3. On Dec 6, 2014 this sequence version replaced NM_001297417.1. Transcript Variant: This variant (3) has multiple differences, which result in a translational frameshift and an earlier translation termination as well as a novel 3' UTR, compared to variant 1. The resulting isoform (c) is shorter and has a distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003597.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGGTAGCA ACAGTGGGCA GGCTGGCCGC CACATCTATA AATCCCTAGC TGATGATGGC 
CCCTTTGACT CTGTGGAGCC GCCTAAAAGA CCCACCAGCA GACTCATCAT GCACAGCATG
GCCATGTTCG GAAGAGAGTT CTGCTACGCG GTGGAGGCAG CGTATGTGAC CCCAGTCCTG
CTCAGCGTAG GTCTGCCCAG CAGCCTGTAC AGCATTGTGT GGTTCCTCAG CCCCATCCTG
GGATTCCTGC TGCAGCCCGT GGTCGGATCG GCCAGCGACC ACTGCCGGTC CAGGTGGGGC
CGCCGGAGAC CCTACATCCT CACCCTGGGA GTCATGATGC TCGTGGGCAT GGCTCTGTAC
CTCAATGGGG CTACTGTTGT AGCAGCTTTG ATTGCTAACC CAAGGAGGAA GCTGGTTTGG
GCCATAAGTG TCACCATGAT AGGTGTCGTT CTCTTTGATT TTGCTGCCGA CTTCATTGAT
GGGCCCATCA AAGCCTACTT ATTTGATGTC TGCTCCCATC AGGACAAGGA GAAGGGCCTC
CACTACCATG CCCTCTTCAC AGACTCGCAG GGCAATGACA TTAAAGTCAC TGCTGAGAGC
ACTGGTGAAC ATGCCTCCTC ACTACCGCTA CCTTTGCATC AGCCACCTCA TTGGATGGAC
AGCCTTCCTG TCCAACATGC TGTTCTTCAC AGATTTCATG GGCCAGATTG TGTACCGCGG
GGATCCCTAT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001284346.2
CDS93..824
Misc Feature(1)<192..563
Misc Feature(2)231..293
Misc Feature(3)297..359
Misc Feature(4)423..485
Misc Feature(5)507..569
Exon (1)1..477
Exon (2)478..654
Exon (3)655..798
Exon (4)799..1071
Translation

Target ORF information:

RefSeq Version NM_001297417.2
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier family 45 member 2 (SLC45A2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001297417.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGGTAGCA ACAGTGGGCA GGCTGGCCGC CACATCTATA AATCCCTAGC TGATGATGGC 
CCCTTTGACT CTGTGGAGCC GCCTAAAAGA CCCACCAGCA GACTCATCAT GCACAGCATG
GCCATGTTCG GAAGAGAGTT CTGCTACGCG GTGGAGGCAG CGTATGTGAC CCCAGTCCTG
CTCAGCGTAG GTCTGCCCAG CAGCCTGTAC AGCATTGTGT GGTTCCTCAG CCCCATCCTG
GGATTCCTGC TGCAGCCCGT GGTCGGATCG GCCAGCGACC ACTGCCGGTC CAGGTGGGGC
CGCCGGAGAC CCTACATCCT CACCCTGGGA GTCATGATGC TCGTGGGCAT GGCTCTGTAC
CTCAATGGGG CTACTGTTGT AGCAGCTTTG ATTGCTAACC CAAGGAGGAA GCTGGTTTGG
GCCATAAGTG TCACCATGAT AGGTGTCGTT CTCTTTGATT TTGCTGCCGA CTTCATTGAT
GGGCCCATCA AAGCCTACTT ATTTGATGTC TGCTCCCATC AGGACAAGGA GAAGGGCCTC
CACTACCATG CCCTCTTCAC AGACTCGCAG GGCAATGACA TTAAAGTCAC TGCTGAGAGC
ACTGGTGAAC ATGCCTCCTC ACTACCGCTA CCTTTGCATC AGCCACCTCA TTGGATGGAC
AGCCTTCCTG TCCAACATGC TGTTCTTCAC AGATTTCATG GGCCAGATTG TGTACCGCGG
GGATCCCTAT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Mutational spectrum of the TYR and SLC45A2 genes in Pakistani families with oculocutaneous albinism, and potential founder effect of missense substitution (p.Arg77Gln) of tyrosinase.
Clinical and experimental dermatology40(7)774-80(2015 Oct)
Shah SA,Raheem N,Daud S,Mubeen J,Shaikh AA,Baloch AH,Nadeem A,Tayyab M,Babar ME,Ahmad J


book

Investigating polymorphisms in membrane-associated transporter protein SLC45A2, using sucrose transporters as a model.
Molecular medicine reports12(1)1393-8(2015 Jul)
Reinders A,Ward JM


book

Membrane-Associated Transporter Protein (MATP) Regulates Melanosomal pH and Influences Tyrosinase Activity.
PloS one10(6)e0129273(2015)
Bin BH,Bhin J,Yang SH,Shin M,Nam YJ,Choi DH,Shin DW,Lee AY,Hwang D,Cho EG,Lee TR


book

The interplay between natural selection and susceptibility to melanoma on allele 374F of SLC45A2 gene in a South European population.
PloS one9(8)e104367(2014)
López S,García O,Yurrebaso I,Flores C,Acosta-Herrera M,Chen H,Gardeazabal J,Careaga JM,Boyano MD,Sánchez A,Ratón-Nieto JA,Sevilla A,Smith-Zubiaga I,de Galdeano AG,Martinez-Cadenas C,Izagirre N,de la Rúa C,Alonso S


book

High-resolution array-CGH in patients with oculocutaneous albinism identifies new deletions of the TYR, OCA2, and SLC45A2 genes and a complex rearrangement of the OCA2 gene.
Pigment cell & melanoma research27(1)59-71(2014 Jan)
Morice-Picard F,Lasseaux E,Cailley D,Gros A,Toutain J,Plaisant C,Simon D,François S,Gilbert-Dussardier B,Kaplan J,Rooryck C,Lacombe D,Arveiler B


 
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