×

PPIB cDNA ORF clone, Homo sapiens (human)

Gene Symbol PPIB
Entrez Gene ID 5479
Full Name peptidylprolyl isomerase B (cyclophilin B)
Synonyms CYP-S1, CYPB, HEL-S-39, OI9, SCYLP
General protein information
Preferred Names
peptidyl-prolyl cis-trans isomerase B
Names
peptidyl-prolyl cis-trans isomerase B
PPIase B
rotamase B
S-cyclophilin
cyclophilin-like protein
NP_000933.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q21-q22

Summary The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]. lac of sum
Disorder MIM:

123841

Disorder Html: Osteogenesis imperfecta, type IX, 259440 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000942 NP_000933 peptidyl-prolyl cis-trans isomerase B precursor



Homo sapiens (human) PPIB NP_000933.1
Pan troglodytes (chimpanzee) PPIB XP_003952716.1
Macaca mulatta (Rhesus monkey) PPIB XP_001106590.1
Canis lupus familiaris (dog) PPIB XP_852389.1
Bos taurus (cattle) PPIB NP_776577.1
Mus musculus (house mouse) Ppib NP_035279.2
Rattus norvegicus (Norway rat) Ppib NP_071981.1
Gallus gallus (chicken) PPIB NP_990792.1
Danio rerio (zebrafish) ppib NP_998184.1
Drosophila melanogaster (fruit fly) CG2852 NP_611695.1
Caenorhabditis elegans cyn-6 NP_497257.1
Caenorhabditis elegans cyn-5 NP_493624.1
Arabidopsis thaliana (thale cress) CYP20-2 NP_001190299.1
Xenopus (Silurana) tropicalis (western clawed frog) ppib NP_001017063.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PPIB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPIB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19649
NM_000942 Homo sapiens peptidylprolyl isomerase B (cyclophilin B) (PPIB), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19649
Clone ID Related Accession (Same CDS sequence) NM_000942
Accession Version NM_000942.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 651bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product peptidyl-prolyl cis-trans isomerase B precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ931949.1, BC008848.2 and BC001125.2. This sequence is a reference standard in the RefSeqGene project. On Mar 2, 2004 this sequence version replaced gi:34147592. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001125.2, BC008848.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGCTGCGCC TCTCCGAACG CAACATGAAG GTGCTCCTTG CCGCCGCCCT CATCGCGGGG 
TCCGTCTTCT TCCTGCTGCT GCCGGGACCT TCTGCGGCCG ATGAGAAGAA GAAGGGGCCC
AAAGTCACCG TCAAGGTGTA TTTTGACCTA CGAATTGGAG ATGAAGATGT AGGCCGGGTG
ATCTTTGGTC TCTTCGGAAA GACTGTTCCA AAAACAGTGG ATAATTTTGT GGCCTTAGCT
ACAGGAGAGA AAGGATTTGG CTACAAAAAC AGCAAATTCC ATCGTGTAAT CAAGGACTTC
ATGATCCAGG GCGGAGACTT CACCAGGGGA GATGGCACAG GAGGAAAGAG CATCTACGGT
GAGCGCTTCC CCGATGAGAA CTTCAAACTG AAGCACTACG GGCCTGGCTG GGTGAGCATG
GCCAACGCAG GCAAAGACAC CAACGGCTCC CAGTTCTTCA TCACGACAGT CAAGACAGCC
TGGCTAGATG GCAAGCATGT GGTGTTTGGC AAAGTTCTAG AGGGCATGGA GGTGGTGCGG
AAGGTGGAGA GCACCAAGAC AGACAGCCGG GATAAACCCC TGAAGGATGT GATCATCGCA
GACTGCGGCA AGATCGAGGT GGAGAAGCCC TTTGCCATCG CCAAGGAGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000933.1
CDS170..820
Misc Feature(1)302..778(+)
Misc Feature(2)449..652(+)
Misc Feature(3)773..775(+)
Misc Feature(4)806..817(+)
Exon (1)1..304
Gene:PPIB
Gene Synonym:
Exon (2)305..418
Gene:PPIB
Gene Synonym:
Exon (3)419..512
Gene:PPIB
Gene Synonym:
Exon (4)513..697
Gene:PPIB
Gene Synonym:
Exon (5)698..1028
Gene:PPIB
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000942
Organism Homo sapiens (human)
Definition Homo sapiens peptidylprolyl isomerase B (cyclophilin B) (PPIB), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000942

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGCTGCGCC TCTCCGAACG CAACATGAAG GTGCTCCTTG CCGCCGCCCT CATCGCGGGG 
TCCGTCTTCT TCCTGCTGCT GCCGGGACCT TCTGCGGCCG ATGAGAAGAA GAAGGGGCCC
AAAGTCACCG TCAAGGTGTA TTTTGACCTA CGAATTGGAG ATGAAGATGT AGGCCGGGTG
ATCTTTGGTC TCTTCGGAAA GACTGTTCCA AAAACAGTGG ATAATTTTGT GGCCTTAGCT
ACAGGAGAGA AAGGATTTGG CTACAAAAAC AGCAAATTCC ATCGTGTAAT CAAGGACTTC
ATGATCCAGG GCGGAGACTT CACCAGGGGA GATGGCACAG GAGGAAAGAG CATCTACGGT
GAGCGCTTCC CCGATGAGAA CTTCAAACTG AAGCACTACG GGCCTGGCTG GGTGAGCATG
GCCAACGCAG GCAAAGACAC CAACGGCTCC CAGTTCTTCA TCACGACAGT CAAGACAGCC
TGGCTAGATG GCAAGCATGT GGTGTTTGGC AAAGTTCTAG AGGGCATGGA GGTGGTGCGG
AAGGTGGAGA GCACCAAGAC AGACAGCCGG GATAAACCCC TGAAGGATGT GATCATCGCA
GACTGCGGCA AGATCGAGGT GGAGAAGCCC TTTGCCATCG CCAAGGAGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells
Cancer Res. 74 (2), 484-496 (2014)
Choi JW, Schroeder MA, Sarkaria JN and Bram RJ.


book

An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro
J. Biol. Chem. 288 (44), 31437-31446 (2013)
Ishikawa Y and Bachinger HP.


book

Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat)
J. Biol. Chem. 287 (53), 44361-44371 (2012)
Hershko K, Simhadri VL, Blaisdell A, Hunt RC, Newell J, Tseng SC, Hershko AY, Choi JW, Sauna ZE, Wu A, Bram RJ, Komar AA and Kimchi-Sarfaty C.


book

Cyclophilin B attenuates the expression of TNF-alpha in lipopolysaccharide-stimulated macrophages through the induction of B cell lymphoma-3
J. Immunol. 189 (4), 2023-2032 (2012)
Marcant A, Denys A, Melchior A, Martinez P, Deligny A, Carpentier M and Allain F.


book

Release of overexpressed CypB activates ERK signaling through CD147 binding for hepatoma cell resistance to oxidative stress
Apoptosis 17 (8), 784-796 (2012)
Kim K, Kim H, Jeong K, Jung MH, Hahn BS, Yoon KS, Jin BK, Jahng GH, Kang I, Ha J and Choe W.


book

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes
Electrophoresis 13 (12), 960-969 (1992)
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE and Vandekerckhove J.


book

s-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin
J. Cell Biol. 116 (1), 113-125 (1992)
Arber S, Krause KH and Caroni P.


book

Somatic cell mapping of the human cyclophilin B gene (PPIB) to chromosome 15
Cytogenet. Cell Genet. 60 (3-4), 219-221 (1992)
Peddada LB, McPherson JD, Law R, Wasmuth JJ, Youderian P and Deans RJ.


book

An endoplasmic reticulum-specific cyclophilin
Mol. Cell. Biol. 11 (7), 3484-3491 (1991)
Hasel KW, Glass JR, Godbout M and Sutcliffe JG.


book

Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence
Proc. Natl. Acad. Sci. U.S.A. 88 (5), 1903-1907 (1991)
Price ER, Zydowsky LD, Jin MJ, Baker CH, McKeon FD and Walsh CT.


 
*
*
*
*