ATAD3A cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | ATAD3A |
| Entrez Gene ID | 55210 |
| Full Name | ATPase family, AAA domain containing 3A |
| Synonyms | HAYOS |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a ubiquitously expressed mitochondrial membrane protein that contributes to mitochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabolism. This gene is a member of the ATPase family AAA-domain containing 3 gene family which, in humans, includes two other paralogs. Naturally occurring mutations in this gene are associated with distinct neurological syndromes including Harel-Yoon syndrome. High-level expression of this gene is associated with poor survival in breast cancer patients. A homozygous knockout of the orthologous gene in mice results in embryonic lethality at day 7.5 due to growth retardation and defective development of the trophoblast lineage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]. |
| Disorder MIM: | |
| Disorder Html: | Harel-Yoon syndrome, 617183 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001170536.1 | NP_001164007.1 | ATPase family AAA domain-containing protein 3A isoform 3 |
| NM_018188.5 | NP_060658.3 | ATPase family AAA domain-containing protein 3A isoform 1 |
| XM_024448098.1 | XP_024303866.1 | ATPase family AAA domain-containing protein 3A isoform X1 |
| NM_018188.4 | NP_060658.3 | ATPase family AAA domain-containing protein 3A isoform 1 |
| NM_001170536.2 | NP_001164007.1 | ATPase family AAA domain-containing protein 3A isoform 3 |
| XM_017001628.1 | XP_016857117.1 | ATPase family AAA domain-containing protein 3A isoform X1 |
| NM_001170535.2 | NP_001164006.1 | ATPase family AAA domain-containing protein 3A isoform 2 |
| NM_001170535.1 | NP_001164006.1 | ATPase family AAA domain-containing protein 3A isoform 2 |
| NM_001170535.3 | NP_001164006.1 | ATPase family AAA domain-containing protein 3A isoform 2 |
| Homo sapiens (human) | ATAD3A | NP_001164006.1 |
| Oryza sativa (rice) | Os02g0697600 | NP_001047821.1 |
| Xenopus tropicalis (tropical clawed frog) | atad3a | NP_998849.1 |
| Bos taurus (cattle) | ATAD3A | NP_001098932.1 |
| Danio rerio (zebrafish) | atad3b | NP_991266.1 |
| Pan troglodytes (chimpanzee) | ATAD3B | XP_003307806.1 |
| Mus musculus (house mouse) | Atad3a | NP_849534.2 |
| Gallus gallus (chicken) | ATAD3A | XP_004947462.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001792 | XP_321276.4 |
| Arabidopsis thaliana (thale cress) | AT5G16930 | NP_197195.2 |
| Canis lupus familiaris (dog) | ATAD3B | XP_536708.2 |
| Rattus norvegicus (Norway rat) | Atad3a | NP_001030094.1 |
| Drosophila melanogaster (fruit fly) | bor | NP_524996.1 |
| Caenorhabditis elegans (roundworm) | atad-3 | NP_496210.2 |
| Arabidopsis thaliana (thale cress) | AT3G03060 | NP_186956.2 |
Related articles in PubMed
ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.
Desai R, Frazier AE, Durigon R, Patel H, Jones AW, Dalla Rosa I, Lake NJ, Compton AG, Mountford HS, Tucker EJ, Mitchell ALR, Jackson D, Sesay A, Di Re M, van den Heuvel LP, Burke D, Francis D, Lunke S, McGillivray G, Mandelstam S, Mochel F, Keren B, Jardel C, Turner AM, Ian Andrews P, Smeitink J, Spelbrink JN, Heales SJ, Kohda M, Ohtake A, Murayama K, Okazaki Y, Lomb?s A, Holt IJ, Thorburn DR, Spinazzola A
Brain : a journal of neurology140(6)1595-1610(2017 Jun)
ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia.
Cooper HM, Yang Y, Ylikallio E, Khairullin R, Woldegebriel R, Lin KL, Euro L, Palin E, Wolf A, Trokovic R, Isohanni P, Kaakkola S, Auranen M, L?nnqvist T, Wanrooij S, Tyynismaa H
Human molecular genetics26(8)1432-1443(2017 04)
Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes.
Harel T, Yoon WH, Garone C, Gu S, Coban-Akdemir Z, Eldomery MK, Posey JE, Jhangiani SN, Rosenfeld JA, Cho MT, Fox S, Withers M, Brooks SM, Chiang T, Duraine L, Erdin S, Yuan B, Shao Y, Moussallem E, Lamperti C, Donati MA, Smith JD, McLaughlin HM, Eng CM, Walkiewicz M, Xia F, Pippucci T, Magini P, Seri M, Zeviani M, Hirano M, Hunter JV, Srour M, Zanigni S, Lewis RA, Muzny DM, Lotze TE, Boerwinkle E, , , Gibbs RA, Hickey SE, Graham BH, Yang Y, Buhas D, Martin DM, Potocki L, Graziano C, Bellen HJ, Lupski JR
American journal of human genetics99(4)831-845(2016 Oct)
Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein.
Teng Y, Ren X, Li H, Shull A, Kim J, Cowell JK
Oncogene35(3)333-43(2016 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
ATAD3A region deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.
Title: ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.
Mutations in ATAD3A can thus be dominantly inherited and underlie variable neurological phenotypes, including hereditary spastic paraplegia with intrafamiliar variability. This finding extends the group of mitochondrial inner membrane AAA proteins associated with spasticity.
Title: ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia.
identification of a recurrent de novo ATAD3A c.1582C>T (p.Arg528Trp) variant by whole-exome sequencing in five unrelated individuals with a core phenotype of global developmental delay, hypotonia, optic atrophy, axonal neuropathy, and hypertrophic cardiomyopathy
Title: Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes.
stabilization of WASF3 function occurs through its interaction with ATAD3A and GRP78, which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles
Title: Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein.
These results demonstrate that ATAD3-mediated mitochondrial membrane formation participates in the optimal transfer of cholesterol from the endoplasmic reticulum into mitochondria.
Title: Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3.
The following ATAD3A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATAD3A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu20158 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001170535.2 , NM_001170535.1 , NM_001170535.3 | |
| Accession Version | NM_001170535.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1761bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-25 | |
| Organism | Homo sapiens(human) | |
| Product | ATPase family AAA domain-containing protein 3A isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA206969.1, BC014101.2, AK001571.1 and BC011814.2. On Feb 12, 2017 this sequence version replaced NM_001170535.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011814.2, BC014101.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 17210950, 18639545; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001164006.1 |
| CDS | 127..1887 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001170535.2 |
ORF Insert Sequence:
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20158 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001170535.2 , NM_001170535.1 , NM_001170535.3 | |
| Accession Version | NM_001170535.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1761bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-03-14 | |
| Organism | Homo sapiens(Human) | |
| Product | ATPase family AAA domain-containing protein 3A isoform 2 | |
| Comment | ||
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001164006.1 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001170535.1 |
ORF Insert Sequence:
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20158 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001170535.2 , NM_001170535.1 , NM_001170535.3 | |
| Accession Version | NM_001170535.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1761bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-25 | |
| Organism | Homo sapiens(human) | |
| Product | ATPase family AAA domain-containing protein 3A isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA206969.1, BC014101.2, AK001571.1 and BC011814.2. On May 17, 2019 this sequence version replaced NM_001170535.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014101.2, SRR1163658.208765.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 17210950, 18639545; reported by MitoCarta MANE Ensembl match :: ENST00000378756.8/ ENSP00000368031.3 RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001164006.1 |
| CDS | 108..1868 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001170535.3 |
ORF Insert Sequence:
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20192 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001170536.1 , NM_001170536.2 | |
| Accession Version | NM_001170536.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-03-14 | |
| Organism | Homo sapiens(Human) | |
| Product | ATPase family AAA domain-containing protein 3A isoform 3 | |
| Comment | ||
1 | ATGCAGGAGC AGACGCTGCA GTTGGAGCAA CAGTCCAAGC TCAAAGAGTA TGAGGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001164007.1 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001170536.1 |
ORF Insert Sequence:
1 | ATGCAGGAGC AGACGCTGCA GTTGGAGCAA CAGTCCAAGC TCAAAGAGTA TGAGGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20192 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001170536.1 , NM_001170536.2 | |
| Accession Version | NM_001170536.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-05 | |
| Organism | Homo sapiens(human) | |
| Product | ATPase family AAA domain-containing protein 3A isoform 3 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK056099.1, BC014101.2, AK001571.1 and BC011814.2. On Feb 12, 2017 this sequence version replaced NM_001170536.1. Transcript Variant: This variant (3) has multiple differences in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK056099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 17210950, 18639545; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCAGGAGC AGACGCTGCA GTTGGAGCAA CAGTCCAAGC TCAAAGAGTA TGAGGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001164007.1 |
| CDS | 194..1717 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001170536.2 |
ORF Insert Sequence:
1 | ATGCAGGAGC AGACGCTGCA GTTGGAGCAA CAGTCCAAGC TCAAAGAGTA TGAGGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20198 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_018188.5 , NM_018188.4 | |
| Accession Version | NM_018188.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1905bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-21 | |
| Organism | Homo sapiens(human) | |
| Product | ATPase family AAA domain-containing protein 3A isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA206969.1, AK091144.1, BC014101.2, AK001571.1 and BC011814.2. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_018188.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK091144.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820687, SAMN03465411 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 17210950, 18639545; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_060658.3 |
| CDS | 108..2012 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_018188.5 |
ORF Insert Sequence:
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20198 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_018188.5 , NM_018188.4 | |
| Accession Version | NM_018188.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1905bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-24 | |
| Organism | Homo sapiens(human) | |
| Product | ATPase family AAA domain-containing protein 3A isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA206969.1, AK091144.1, BC014101.2, AK001571.1 and BC011814.2. This sequence is a reference standard in the RefSeqGene project. On Feb 12, 2017 this sequence version replaced NM_018188.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK091144.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820687, SAMN03465411 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 17210950, 18639545; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_060658.3 |
| CDS | 127..2031 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_018188.4 |
ORF Insert Sequence:
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu105087 | |
| Clone ID Related Accession (Same CDS sequence) | XM_024448098.1 | |
| Accession Version | XM_024448098.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1839bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | ATPase family AAA domain-containing protein 3A isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_024303866.1 |
| CDS | 127..1965 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_024448098.1 |
ORF Insert Sequence:
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu90176 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017001628.1 | |
| Accession Version | XM_017001628.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1452bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-05 | |
| Organism | Homo sapiens(human) | |
| Product | ATPase family AAA domain-containing protein 3A isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_016857117.1 |
| CDS | 127..1578 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017001628.1 |
ORF Insert Sequence:
1 | ATGTCGTGGC TCTTCGGCAT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism. |
|
ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia. |
|
Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes. |
|
Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein. |