Gene Symbol | EXOSC5 |
Entrez Gene ID | 56915 |
Full Name | exosome component 5 |
Synonyms | RRP41B,RRP46,Rrp46p,hRrp46p,p12B |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » EXOSC5 cDNA ORF clone
gRNAs
Gene Symbol | EXOSC5 |
Entrez Gene ID | 56915 |
Full Name | exosome component 5 |
Synonyms | RRP41B,RRP46,Rrp46p,hRrp46p,p12B |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_020158.4 | NP_064543.3 | exosome complex component RRP46 |
NM_020158.3 | NP_064543.3 | exosome complex component RRP46 |
Pan troglodytes (chimpanzee) | EXOSC5 | XP_001152170.1 |
EXOSC5 | XP_001102687.2 | |
Gallus gallus (chicken) | EXOSC5 | XP_003643513.1 |
Oryza sativa (rice) | Os03g0854200 | NP_001051936.1 |
Xenopus tropicalis (tropical clawed frog) | exosc5 | XP_002939437.2 |
Mus musculus (house mouse) | Exosc5 | NP_613052.1 |
Danio rerio (zebrafish) | exosc5 | NP_001038817.2 |
Eremothecium gossypii | AGOS_AAR035C | NP_982576.2 |
Arabidopsis thaliana (thale cress) | AT3G46210 | NP_001030818.1 |
Homo sapiens (human) | EXOSC5 | NP_064543.3 |
Canis lupus familiaris (dog) | EXOSC5 | XP_852838.1 |
Rattus norvegicus (Norway rat) | Exosc5 | NP_001100963.2 |
Drosophila melanogaster (fruit fly) | Rrp46 | NP_650001.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002177 | XP_308011.5 |
Caenorhabditis elegans (roundworm) | crn-5 | NP_496284.1 |
Bos taurus (cattle) | EXOSC5 | XP_005219175.1 |
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)
Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.
Wasmuth EV, Januszyk K, Lima CD
Nature511(7510)435-9(2014 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Further, subcellular co-localization assay showed that the two proteins could co-localize in the cytoplasm of K562 cells, but WT1/CML28 complexes were not detected by using immunoprecipitation.
Title: Interaction of human genes WT1 and CML28 in leukemic cells.
Results suggest that Rrp46 forms a homodimer separately from exosome complexes and, depending on species, is a structural component of the machinery that cleaves DNA during apoptosis.
Title: Structural and biochemical characterization of CRN-5 and Rrp46: an exosome component participating in apoptotic DNA degradation.
rAAV/CML28-transduced DCs vaccine may serve as a feasible approach for the treatment of CML28-associated cancers.
Title: Activation of cytotoxic T lymphocytes against CML28-bearing tumors by dendritic cells transduced with a recombinant adeno-associated virus encoding the CML28 gene.
These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs.
Title: Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector.
Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
Title: Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
The following EXOSC5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EXOSC5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu03225![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_020158.4 , NM_020158.3 | |
Accession Version | NM_020158.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-25 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component RRP46 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC011462.4 and AF281134.1. On Nov 23, 2018 this sequence version replaced NM_020158.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF285785.1, SRR5189658.209245.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000221233.9/ ENSP00000221233.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGAGGAGG AGACGCATAC TGACGCCAAA ATCCGTGCTG AAAATGGAAC AGGGTCCAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_064543.3 |
CDS | 32..739 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGAGG AGACGCATAC TGACGCCAAA ATCCGTGCTG AAAATGGAAC AGGGTCCAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu03225![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_020158.4 , NM_020158.3 | |
Accession Version | NM_020158.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-30 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component RRP46 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF281134.1 and BU683254.1. On May 14, 2004 this sequence version replaced NM_020158.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF281134.1, BC107696.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGAGGAGG AGACGCATAC TGACGCCAAA ATCCGTGCTG AAAATGGAAC AGGGTCCAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_064543.3 |
CDS | 24..731 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGAGG AGACGCATAC TGACGCCAAA ATCCGTGCTG AAAATGGAAC AGGGTCCAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Architecture of the human interactome defines protein communities and disease networks. |
Pooled-matrix protein interaction screens using Barcode Fusion Genetics. |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. |
Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. |