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SMS cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol SMS
Entrez Gene ID 6611
Full Name spermine synthase
Synonyms MRSR,SPMSY,SRS,SpS
General protein information
Preferred Names

spermine synthase

Names

spermine synthase
spermidine aminopropyltransferase
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

X

Xp22.11
Summary This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].
Disorder MIM:

300105

Disorder Html: Mental retardation, X-linked, Snyder-Robinson type, 309583 (3)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_004595.5 NP_004586.2 spermine synthase isoform 1
XM_005274582.2 XP_005274639.1 spermine synthase isoform X3
XM_017029753.1 XP_016885242.1 spermine synthase isoform X1
XM_017029753.2 XP_016885242.1 spermine synthase isoform X1
XM_017029755.1 XP_016885244.1 spermine synthase isoform X2
XM_011545568.2 XP_011543870.1 spermine synthase isoform X3

Pathways from BioSystems


Homologies


Homo sapiens (human) SMS NP_004586.2
Pan troglodytes (chimpanzee) SMS XP_001142843.3
SMS XP_001086702.2
Gallus gallus (chicken) SMS NP_001025974.1
Canis lupus familiaris (dog) SMS XP_537978.3
Drosophila melanogaster (fruit fly) CG4300 NP_729798.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP005325 XP_315341.4
Mus musculus (house mouse) Sms NP_033240.3
Mus musculus (house mouse) Gm14680 XP_001473484.1
Rattus norvegicus (Norway rat) Sms NP_001029071.1
Xenopus tropicalis (tropical clawed frog) sms NP_001245351.1
Bos taurus (cattle) SMS NP_001030548.1
Danio rerio (zebrafish) sms NP_571831.1

Gene Ontology


Bibliography

Related articles in PubMed

Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase.
Peng Y, Norris J, Schwartz C, Alexov E
International journal of molecular sciences17(1)(2016 Jan)

A Y328C missense mutation in spermine synthase causes a mild form of Snyder-Robinson syndrome.
Zhang Z, Norris J, Kalscheuer V, Wood T, Wang L, Schwartz C, Alexov E, Van Esch H
Human molecular genetics22(18)3789-97(2013 Sep)

Enhancing human spermine synthase activity by engineered mutations.
Zhang Z, Zheng Y, Petukh M, Pegg A, Ikeguchi Y, Alexov E
PLoS computational biology9(2)e1002924(2013)

A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome.
Becerra-Solano LE, Butler J, Castañeda-Cisneros G, McCloskey DE, Wang X, Pegg AE, Schwartz CE, Sánchez-Corona J, García-Ortiz JE
American journal of medical genetics. Part A149A(3)328-35(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Missense mutations causing Snyder-Robinson Syndrome resulting in dysfunctional spermine synthase cause the destabilization of the protein.
Title: Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase.

Results show that p.Y328C, a missense mutation in SMS is responsible for the patients having a mild form of Snyder-Robinson syndrome.
Title: A Y328C missense mutation in spermine synthase causes a mild form of Snyder-Robinson syndrome.

This observation is used to demonstrate, computationally and experimentally, that a particular condition, Snyder-Robinson syndrome caused by the G56S spermine synthase mutation, might be ameliorated by small molecule binding.
Title: A rational free energy-based approach to understanding and targeting disease-causing missense mutations.

Studied human spermine synthase activity by engineered mutations.
Title: Enhancing human spermine synthase activity by engineered mutations.

spermine synthase activity and the resulting elevation of the spermine:spermidine ratio does not alter susceptibility to tumor development initiated by c-Ha-Ras mutation or Apc loss
Title: Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.

The following SMS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu21210 NM_004595.5
Latest version!		 Homo sapiens spermine synthase (SMS), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$49.50-$69.30
$99.00
OHu53952 XM_005274582.2
Latest version!		 Homo sapiens spermine synthase (SMS), transcript variant X3, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $139.30
$199.00
OHu53952 XM_011545568.2
Latest version!		 Homo sapiens spermine synthase (SMS), transcript variant X4, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $139.30
$199.00
OHu99436 XM_017029753.2
Latest version!		 Homo sapiens spermine synthase (SMS), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 9-11 $223.30
$319.00
OHu99437 XM_017029755.1
Latest version!		 Homo sapiens spermine synthase (SMS), transcript variant X6, mRNA. pcDNA3.1-C-(k)DYK or customized vector 9-11 $223.30
$319.00
View Old Accession Versions >>
OHu99436 XM_017029753.1 Homo sapiens spermine synthase (SMS), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 9-11 $223.30
$319.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu21210
Clone ID Related Accession (Same CDS sequence) NM_004595.5
Accession Version NM_004595.5 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1101bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-21
Organism Homo sapiens(human)
Product spermine synthase isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U73023.1, AD001528.1 and BC009898.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004595.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1167824.1, SRR1660809.231072.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000404933.7/ ENSP00000385746.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
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421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCAGCAG CACGGCACAG CACGCTCGAC TTCATGCTCG GCGCCAAAGC TGATGGTGAG 
ACCATTCTAA AAGGCCTCCA GTCCATTTTC CAGGAGCAGG GGATGGCGGA GTCGGTGCAC 
ACCTGGCAGG ACCATGGCTA TTTAGCAACC TACACAAACA AGAACGGCAG CTTTGCCAAT 
TTGAGAATTT ACCCACATGG ATTGGTGTTG CTGGACCTTC AGAGTTATGA TGGTGATGCG 
CAAGGCAAAG AAGAGATCGA CAGTATTTTG AACAAAGTAG AGGAAAGAAT GAAAGAATTG 
AGTCAGGACA GTACTGGGCG GGTGAAACGA TTACCACCCA TAGTGCGAGG AGGAGCCATC 
GACAGATACT GGCCCACCGC CGACGGGCGC CTGGTTGAAT ATGACATAGA TGAAGTGGTA 
TATGACGAAG ATTCACCTTA TCAAAATATA AAAATTCTAC ACTCGAAGCA GTTTGGAAAT 
ATTCTCATCC TTAGTGGGGA TGTTAATTTG GCAGAGAGTG ATTTGGCATA TACCCGGGCC 
ATCATGGGCA GTGGCAAAGA AGATTACACT GGCAAAGATG TACTCATTCT GGGAGGTGGA 
GACGGAGGCA TATTGTGTGA AATAGTCAAA CTAAAACCAA AGATGGTCAC TATGGTAGAG 
ATTGACCAAA TGGTGATTGA TGGGTGTAAG AAATACATGC GAAAAACGTG TGGCGATGTC 
TTAGACAATC TTAAAGGAGA CTGCTATCAG GTTCTAATAG AAGACTGTAT CCCGGTACTG 
AAGAGGTACG CCAAAGAAGG GAGAGAATTT GATTATGTGA TTAATGATTT GACAGCTGTT 
CCAATCTCCA CGTCTCCAGA AGAAGATTCC ACATGGGAGT TTCTCAGACT GATTCTTGAC 
CTCTCAATGA AAGTGTTGAA ACAGGATGGG AAATATTTTA CACAGGGGAA CTGTGTCAAT 
CTGACAGAAG CACTGTCGCT CTATGAAGAA CAGCTGGGGC GCCTGTATTG TCCTGTGGAA 
TTTTCAAAGG AGATCGTCTG TGTCCCTTCA TACTTGGAAT TGTGGGTATT TTACACTGTT 
TGGAAGAAAG CTAAACCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004586.2
CDS117..1217
Translation

Target ORF information:

RefSeq Version NM_004595.5
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004595.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCAGCAG CACGGCACAG CACGCTCGAC TTCATGCTCG GCGCCAAAGC TGATGGTGAG 
ACCATTCTAA AAGGCCTCCA GTCCATTTTC CAGGAGCAGG GGATGGCGGA GTCGGTGCAC 
ACCTGGCAGG ACCATGGCTA TTTAGCAACC TACACAAACA AGAACGGCAG CTTTGCCAAT 
TTGAGAATTT ACCCACATGG ATTGGTGTTG CTGGACCTTC AGAGTTATGA TGGTGATGCG 
CAAGGCAAAG AAGAGATCGA CAGTATTTTG AACAAAGTAG AGGAAAGAAT GAAAGAATTG 
AGTCAGGACA GTACTGGGCG GGTGAAACGA TTACCACCCA TAGTGCGAGG AGGAGCCATC 
GACAGATACT GGCCCACCGC CGACGGGCGC CTGGTTGAAT ATGACATAGA TGAAGTGGTA 
TATGACGAAG ATTCACCTTA TCAAAATATA AAAATTCTAC ACTCGAAGCA GTTTGGAAAT 
ATTCTCATCC TTAGTGGGGA TGTTAATTTG GCAGAGAGTG ATTTGGCATA TACCCGGGCC 
ATCATGGGCA GTGGCAAAGA AGATTACACT GGCAAAGATG TACTCATTCT GGGAGGTGGA 
GACGGAGGCA TATTGTGTGA AATAGTCAAA CTAAAACCAA AGATGGTCAC TATGGTAGAG 
ATTGACCAAA TGGTGATTGA TGGGTGTAAG AAATACATGC GAAAAACGTG TGGCGATGTC 
TTAGACAATC TTAAAGGAGA CTGCTATCAG GTTCTAATAG AAGACTGTAT CCCGGTACTG 
AAGAGGTACG CCAAAGAAGG GAGAGAATTT GATTATGTGA TTAATGATTT GACAGCTGTT 
CCAATCTCCA CGTCTCCAGA AGAAGATTCC ACATGGGAGT TTCTCAGACT GATTCTTGAC 
CTCTCAATGA AAGTGTTGAA ACAGGATGGG AAATATTTTA CACAGGGGAA CTGTGTCAAT 
CTGACAGAAG CACTGTCGCT CTATGAAGAA CAGCTGGGGC GCCTGTATTG TCCTGTGGAA 
TTTTCAAAGG AGATCGTCTG TGTCCCTTCA TACTTGGAAT TGTGGGTATT TTACACTGTT 
TGGAAGAAAG CTAAACCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu53952
Clone ID Related Accession (Same CDS sequence) XM_005274582.2 , XM_011545568.2
Accession Version XM_005274582.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 999bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product spermine synthase isoform X3
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005274582.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

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721
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961
ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG 
AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG 
AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG 
GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA 
GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT 
GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC 
TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT 
TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA 
CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG 
ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA 
AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA 
GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT 
AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT 
CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA 
CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC 
CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG 
TGGGTATTTT ACACTGTTTG GAAGAAAGCT AAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005274639.1
CDS421..1419
Translation

Target ORF information:

RefSeq Version XM_005274582.2
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005274582.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG 
AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG 
AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG 
GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA 
GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT 
GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC 
TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT 
TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA 
CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG 
ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA 
AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA 
GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT 
AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT 
CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA 
CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC 
CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG 
TGGGTATTTT ACACTGTTTG GAAGAAAGCT AAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu53952
Clone ID Related Accession (Same CDS sequence) XM_005274582.2 , XM_011545568.2
Accession Version XM_011545568.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 999bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product spermine synthase isoform X3
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011545568.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG 
AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG 
AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG 
GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA 
GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT 
GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC 
TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT 
TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA 
CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG 
ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA 
AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA 
GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT 
AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT 
CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA 
CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC 
CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG 
TGGGTATTTT ACACTGTTTG GAAGAAAGCT AAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011543870.1
CDS215..1213
Translation

Target ORF information:

RefSeq Version XM_011545568.2
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011545568.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG 
AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG 
AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG 
GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA 
GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT 
GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC 
TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT 
TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA 
CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG 
ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA 
AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA 
GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT 
AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT 
CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA 
CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC 
CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG 
TGGGTATTTT ACACTGTTTG GAAGAAAGCT AAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu99436
Clone ID Related Accession (Same CDS sequence) XM_017029753.1 , XM_017029753.2
Accession Version XM_017029753.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1110bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product spermine synthase isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCAGCAG CACGGCACAG CACGCTCGAC TTCATGCTCG GCGCCAAAGC TGATGGTGAG 
ACCATTCTAA AAGGCCTCCA GTCCATTTTC CAGGAGCAGG GGATGGCGGA GTCGGTGCAC 
ACCTGGCAGG ACCATGGCTA TTTAGCAACC TACACAAACA AGAACGGCAG CTTTGCCAAT 
TTGAGAATTT ACCCACATGG ATTGGTGTTG CTGGACCTTC AGAGTTATGA TGGTGATGCG 
CAAGGCAAAG AAGAGATCGA CAGTATTTTG AACAAAGTAG AGGAAAGAAT GAAAGAATTG 
AGTCAGGACA GTACTGGGCG GGTGAAACGA TTACCACCCA TAGTGCGAGG AGGAGCCATC 
GACAGATACT GGCCCACCGC CGACGGGCGC CTGGTTGAAT ATGACATAGA TGAAGTGGTA 
TATGACGAAG ATTCACCTTA TCAAAATATA AAAATTCTAC ACTCGAAGCA GTTTGGAAAT 
ATTCTCATCC TTAGTGGGGA TGTTAATTTG GCAGAGAGTG ATTTGGCATA TACCCGGGCC 
ATCATGGGCA GTGGCAAAGA AGATTACACT GGCAAAGATG TACTCATTCT GGGAGGTGGA 
GACGGAGGCA TATTGTGTGA AATAGTCAAA CTAAAACCAA AGATGGTCAC TATGGTAGAG 
ATTGACCAAA TGGTGATTGA TGGGTGTAAG AAATACATGC GAAAAACGTG TGGCGATGTC 
TTAGACAATC TTAAAGGAGA CTGCTATCAG GTTCTAATAG AAGACTGTAT CCCGGTACTG 
AAGAGGTACG CCAAAGAAGG GAGAGAATTT GATTATGTGA TTAATGATTT GACAGCTGTT 
CCAATCTCCA CGTCTCCAGA AGAAGATTCC ACATGGGAGT TTCTCAGACT GATTCTTGAC 
CTCTCAATGA AAGTGTTGAA ACAGGATGGG AAATATTTTA CACAGGGGAA CTGTGTCAAT 
CTGACAGAAG CACTGTCGCT CTATGAAGAA CAGCTGGGGC GCCTGTATTG TCCTGTGGAA 
TTTTCAAAGG AGATCGTCTG TGTCCCTTCA TACTTGGAAT TGTATCCTTT GACCGTGACA 
TTCTGTTGCC AGATCAAAGC ACCCAAGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016885242.1
CDS93..1202
Translation

Target ORF information:

RefSeq Version XM_017029753.1
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017029753.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCAGCAG CACGGCACAG CACGCTCGAC TTCATGCTCG GCGCCAAAGC TGATGGTGAG 
ACCATTCTAA AAGGCCTCCA GTCCATTTTC CAGGAGCAGG GGATGGCGGA GTCGGTGCAC 
ACCTGGCAGG ACCATGGCTA TTTAGCAACC TACACAAACA AGAACGGCAG CTTTGCCAAT 
TTGAGAATTT ACCCACATGG ATTGGTGTTG CTGGACCTTC AGAGTTATGA TGGTGATGCG 
CAAGGCAAAG AAGAGATCGA CAGTATTTTG AACAAAGTAG AGGAAAGAAT GAAAGAATTG 
AGTCAGGACA GTACTGGGCG GGTGAAACGA TTACCACCCA TAGTGCGAGG AGGAGCCATC 
GACAGATACT GGCCCACCGC CGACGGGCGC CTGGTTGAAT ATGACATAGA TGAAGTGGTA 
TATGACGAAG ATTCACCTTA TCAAAATATA AAAATTCTAC ACTCGAAGCA GTTTGGAAAT 
ATTCTCATCC TTAGTGGGGA TGTTAATTTG GCAGAGAGTG ATTTGGCATA TACCCGGGCC 
ATCATGGGCA GTGGCAAAGA AGATTACACT GGCAAAGATG TACTCATTCT GGGAGGTGGA 
GACGGAGGCA TATTGTGTGA AATAGTCAAA CTAAAACCAA AGATGGTCAC TATGGTAGAG 
ATTGACCAAA TGGTGATTGA TGGGTGTAAG AAATACATGC GAAAAACGTG TGGCGATGTC 
TTAGACAATC TTAAAGGAGA CTGCTATCAG GTTCTAATAG AAGACTGTAT CCCGGTACTG 
AAGAGGTACG CCAAAGAAGG GAGAGAATTT GATTATGTGA TTAATGATTT GACAGCTGTT 
CCAATCTCCA CGTCTCCAGA AGAAGATTCC ACATGGGAGT TTCTCAGACT GATTCTTGAC 
CTCTCAATGA AAGTGTTGAA ACAGGATGGG AAATATTTTA CACAGGGGAA CTGTGTCAAT 
CTGACAGAAG CACTGTCGCT CTATGAAGAA CAGCTGGGGC GCCTGTATTG TCCTGTGGAA 
TTTTCAAAGG AGATCGTCTG TGTCCCTTCA TACTTGGAAT TGTATCCTTT GACCGTGACA 
TTCTGTTGCC AGATCAAAGC ACCCAAGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu99436
Clone ID Related Accession (Same CDS sequence) XM_017029753.1 , XM_017029753.2
Accession Version XM_017029753.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1110bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product spermine synthase isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017029753.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCAGCAG CACGGCACAG CACGCTCGAC TTCATGCTCG GCGCCAAAGC TGATGGTGAG 
ACCATTCTAA AAGGCCTCCA GTCCATTTTC CAGGAGCAGG GGATGGCGGA GTCGGTGCAC 
ACCTGGCAGG ACCATGGCTA TTTAGCAACC TACACAAACA AGAACGGCAG CTTTGCCAAT 
TTGAGAATTT ACCCACATGG ATTGGTGTTG CTGGACCTTC AGAGTTATGA TGGTGATGCG 
CAAGGCAAAG AAGAGATCGA CAGTATTTTG AACAAAGTAG AGGAAAGAAT GAAAGAATTG 
AGTCAGGACA GTACTGGGCG GGTGAAACGA TTACCACCCA TAGTGCGAGG AGGAGCCATC 
GACAGATACT GGCCCACCGC CGACGGGCGC CTGGTTGAAT ATGACATAGA TGAAGTGGTA 
TATGACGAAG ATTCACCTTA TCAAAATATA AAAATTCTAC ACTCGAAGCA GTTTGGAAAT 
ATTCTCATCC TTAGTGGGGA TGTTAATTTG GCAGAGAGTG ATTTGGCATA TACCCGGGCC 
ATCATGGGCA GTGGCAAAGA AGATTACACT GGCAAAGATG TACTCATTCT GGGAGGTGGA 
GACGGAGGCA TATTGTGTGA AATAGTCAAA CTAAAACCAA AGATGGTCAC TATGGTAGAG 
ATTGACCAAA TGGTGATTGA TGGGTGTAAG AAATACATGC GAAAAACGTG TGGCGATGTC 
TTAGACAATC TTAAAGGAGA CTGCTATCAG GTTCTAATAG AAGACTGTAT CCCGGTACTG 
AAGAGGTACG CCAAAGAAGG GAGAGAATTT GATTATGTGA TTAATGATTT GACAGCTGTT 
CCAATCTCCA CGTCTCCAGA AGAAGATTCC ACATGGGAGT TTCTCAGACT GATTCTTGAC 
CTCTCAATGA AAGTGTTGAA ACAGGATGGG AAATATTTTA CACAGGGGAA CTGTGTCAAT 
CTGACAGAAG CACTGTCGCT CTATGAAGAA CAGCTGGGGC GCCTGTATTG TCCTGTGGAA 
TTTTCAAAGG AGATCGTCTG TGTCCCTTCA TACTTGGAAT TGTATCCTTT GACCGTGACA 
TTCTGTTGCC AGATCAAAGC ACCCAAGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016885242.1
CDS96..1205
Translation

Target ORF information:

RefSeq Version XM_017029753.2
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017029753.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCAGCAG CACGGCACAG CACGCTCGAC TTCATGCTCG GCGCCAAAGC TGATGGTGAG 
ACCATTCTAA AAGGCCTCCA GTCCATTTTC CAGGAGCAGG GGATGGCGGA GTCGGTGCAC 
ACCTGGCAGG ACCATGGCTA TTTAGCAACC TACACAAACA AGAACGGCAG CTTTGCCAAT 
TTGAGAATTT ACCCACATGG ATTGGTGTTG CTGGACCTTC AGAGTTATGA TGGTGATGCG 
CAAGGCAAAG AAGAGATCGA CAGTATTTTG AACAAAGTAG AGGAAAGAAT GAAAGAATTG 
AGTCAGGACA GTACTGGGCG GGTGAAACGA TTACCACCCA TAGTGCGAGG AGGAGCCATC 
GACAGATACT GGCCCACCGC CGACGGGCGC CTGGTTGAAT ATGACATAGA TGAAGTGGTA 
TATGACGAAG ATTCACCTTA TCAAAATATA AAAATTCTAC ACTCGAAGCA GTTTGGAAAT 
ATTCTCATCC TTAGTGGGGA TGTTAATTTG GCAGAGAGTG ATTTGGCATA TACCCGGGCC 
ATCATGGGCA GTGGCAAAGA AGATTACACT GGCAAAGATG TACTCATTCT GGGAGGTGGA 
GACGGAGGCA TATTGTGTGA AATAGTCAAA CTAAAACCAA AGATGGTCAC TATGGTAGAG 
ATTGACCAAA TGGTGATTGA TGGGTGTAAG AAATACATGC GAAAAACGTG TGGCGATGTC 
TTAGACAATC TTAAAGGAGA CTGCTATCAG GTTCTAATAG AAGACTGTAT CCCGGTACTG 
AAGAGGTACG CCAAAGAAGG GAGAGAATTT GATTATGTGA TTAATGATTT GACAGCTGTT 
CCAATCTCCA CGTCTCCAGA AGAAGATTCC ACATGGGAGT TTCTCAGACT GATTCTTGAC 
CTCTCAATGA AAGTGTTGAA ACAGGATGGG AAATATTTTA CACAGGGGAA CTGTGTCAAT 
CTGACAGAAG CACTGTCGCT CTATGAAGAA CAGCTGGGGC GCCTGTATTG TCCTGTGGAA 
TTTTCAAAGG AGATCGTCTG TGTCCCTTCA TACTTGGAAT TGTATCCTTT GACCGTGACA 
TTCTGTTGCC AGATCAAAGC ACCCAAGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu99437
Clone ID Related Accession (Same CDS sequence) XM_017029755.1
Accession Version XM_017029755.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1008bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product spermine synthase isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG 
AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG 
AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG 
GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA 
GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT 
GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC 
TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT 
TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA 
CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG 
ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA 
AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA 
GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT 
AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT 
CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA 
CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC 
CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG 
TATCCTTTGA CCGTGACATT CTGTTGCCAG ATCAAAGCAC CCAAGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016885244.1
CDS253..1260
Translation

Target ORF information:

RefSeq Version XM_017029755.1
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant X6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017029755.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG 
AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG 
AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG 
GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA 
GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT 
GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC 
TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT 
TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA 
CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG 
ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA 
AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA 
GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT 
AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT 
CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA 
CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC 
CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG 
TATCCTTTGA CCGTGACATT CTGTTGCCAG ATCAAAGCAC CCAAGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase.
International journal of molecular sciences17(1)(2016 Jan)
Peng Y,Norris J,Schwartz C,Alexov E


book

A Y328C missense mutation in spermine synthase causes a mild form of Snyder-Robinson syndrome.
Human molecular genetics22(18)3789-97(2013 Sep)
Zhang Z,Norris J,Kalscheuer V,Wood T,Wang L,Schwartz C,Alexov E,Van Esch H


book

Enhancing human spermine synthase activity by engineered mutations.
PLoS computational biology9(2)e1002924(2013)
Zhang Z,Zheng Y,Petukh M,Pegg A,Ikeguchi Y,Alexov E


book

A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome.
American journal of medical genetics. Part A149A(3)328-35(2009 Mar)
Becerra-Solano LE,Butler J,Castañeda-Cisneros G,McCloskey DE,Wang X,Pegg AE,Schwartz CE,Sánchez-Corona J,García-Ortiz JE