Gene Symbol
SMS
Entrez Gene ID
6611
Full Name
spermine synthase
Synonyms
MRSR,SPMSY,SRS,SpS
General protein information
Preferred Namesspermine synthase
Namesspermine synthase spermidine aminopropyltransferase
Gene Type
protein-coding
Organism
Homo sapiens(human)
Genome
Chromosome: X
Map Location: Xp22.11
Summary
This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].
Disorder MIM:
300105
Disorder Html:
Mental retardation, X-linked, Snyder-Robinson type, 309583 (3)
Homo sapiens (human)
SMS
NP_004586.2
Pan troglodytes (chimpanzee)
SMS
XP_001142843.3
SMS
XP_001086702.2
Gallus gallus (chicken)
SMS
NP_001025974.1
Canis lupus familiaris (dog)
SMS
XP_537978.3
Drosophila melanogaster (fruit fly)
CG4300
NP_729798.1
Anopheles gambiae (African malaria mosquito)
AgaP_AGAP005325
XP_315341.4
Mus musculus (house mouse)
Sms
NP_033240.3
Mus musculus (house mouse)
Gm14680
XP_001473484.1
Rattus norvegicus (Norway rat)
Sms
NP_001029071.1
Xenopus tropicalis (tropical clawed frog)
sms
NP_001245351.1
Bos taurus (cattle)
SMS
NP_001030548.1
Danio rerio (zebrafish)
sms
NP_571831.1
Related articles in PubMed
Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase.
Peng Y, Norris J, Schwartz C, Alexov E International journal of molecular sciences17(1)(2016 Jan)
A Y328C missense mutation in spermine synthase causes a mild form of Snyder-Robinson syndrome.
Zhang Z, Norris J, Kalscheuer V, Wood T, Wang L, Schwartz C, Alexov E, Van Esch H Human molecular genetics22(18)3789-97(2013 Sep)
Enhancing human spermine synthase activity by engineered mutations.
Zhang Z, Zheng Y, Petukh M, Pegg A, Ikeguchi Y, Alexov E PLoS computational biology9(2)e1002924(2013)
A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome.
Becerra-Solano LE, Butler J, Castañeda-Cisneros G, McCloskey DE, Wang X, Pegg AE, Schwartz CE, Sánchez-Corona J, García-Ortiz JE American journal of medical genetics. Part A149A(3)328-35(2009 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following SMS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+ /C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID
OHu53952
Clone ID Related Accession (Same CDS sequence)
XM_005274582.2
, XM_011545568.2
Accession Version
XM_005274582.2 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 999bp)
Protein sequence
SNP
Vector
pcDNA3.1-C-(k)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-12-05
Organism
Homo sapiens(human)
Product
spermine synthase isoform X3
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process
On Jun 6, 2016 this sequence version replaced XM_005274582.1.
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Updated annotation
Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205
Annotation Version :: 109.20191205
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 8.3
Annotation Method :: Best-placed RefSeq; propagated RefSeq model
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG TGGGTATTTT ACACTGTTTG GAAGAAAGCT AAACCCTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
XP_005274639.1
CDS 421..1419
Translation
Target ORF information:
RefSeq Version XM_005274582.2
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant X3, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
XM_005274582.2
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG TGGGTATTTT ACACTGTTTG GAAGAAAGCT AAACCCTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu53952
Clone ID Related Accession (Same CDS sequence)
XM_005274582.2
, XM_011545568.2
Accession Version
XM_011545568.2 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 999bp)
Protein sequence
SNP
Vector
pcDNA3.1-C-(k)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-12-05
Organism
Homo sapiens(human)
Product
spermine synthase isoform X3
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process
On Jun 6, 2016 this sequence version replaced XM_011545568.1.
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Updated annotation
Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205
Annotation Version :: 109.20191205
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 8.3
Annotation Method :: Best-placed RefSeq; propagated RefSeq model
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG TGGGTATTTT ACACTGTTTG GAAGAAAGCT AAACCCTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
XP_011543870.1
CDS 215..1213
Translation
Target ORF information:
RefSeq Version XM_011545568.2
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant X4, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
XM_011545568.2
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG TGGGTATTTT ACACTGTTTG GAAGAAAGCT AAACCCTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu99436
Clone ID Related Accession (Same CDS sequence)
XM_017029753.1
, XM_017029753.2
Accession Version
XM_017029753.1
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1110bp)
Protein sequence
SNP
Vector
pcDNA3.1-C-(k)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2016-06-05
Organism
Homo sapiens(human)
Product
spermine synthase isoform X1
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Full annotation
Annotation Version :: Homo sapiens Annotation Release 108
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 7.0
Annotation Method :: Best-placed RefSeq; Gnomon
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 ATGGCAGCAG CACGGCACAG CACGCTCGAC TTCATGCTCG GCGCCAAAGC TGATGGTGAG ACCATTCTAA AAGGCCTCCA GTCCATTTTC CAGGAGCAGG GGATGGCGGA GTCGGTGCAC ACCTGGCAGG ACCATGGCTA TTTAGCAACC TACACAAACA AGAACGGCAG CTTTGCCAAT TTGAGAATTT ACCCACATGG ATTGGTGTTG CTGGACCTTC AGAGTTATGA TGGTGATGCG CAAGGCAAAG AAGAGATCGA CAGTATTTTG AACAAAGTAG AGGAAAGAAT GAAAGAATTG AGTCAGGACA GTACTGGGCG GGTGAAACGA TTACCACCCA TAGTGCGAGG AGGAGCCATC GACAGATACT GGCCCACCGC CGACGGGCGC CTGGTTGAAT ATGACATAGA TGAAGTGGTA TATGACGAAG ATTCACCTTA TCAAAATATA AAAATTCTAC ACTCGAAGCA GTTTGGAAAT ATTCTCATCC TTAGTGGGGA TGTTAATTTG GCAGAGAGTG ATTTGGCATA TACCCGGGCC ATCATGGGCA GTGGCAAAGA AGATTACACT GGCAAAGATG TACTCATTCT GGGAGGTGGA GACGGAGGCA TATTGTGTGA AATAGTCAAA CTAAAACCAA AGATGGTCAC TATGGTAGAG ATTGACCAAA TGGTGATTGA TGGGTGTAAG AAATACATGC GAAAAACGTG TGGCGATGTC TTAGACAATC TTAAAGGAGA CTGCTATCAG GTTCTAATAG AAGACTGTAT CCCGGTACTG AAGAGGTACG CCAAAGAAGG GAGAGAATTT GATTATGTGA TTAATGATTT GACAGCTGTT CCAATCTCCA CGTCTCCAGA AGAAGATTCC ACATGGGAGT TTCTCAGACT GATTCTTGAC CTCTCAATGA AAGTGTTGAA ACAGGATGGG AAATATTTTA CACAGGGGAA CTGTGTCAAT CTGACAGAAG CACTGTCGCT CTATGAAGAA CAGCTGGGGC GCCTGTATTG TCCTGTGGAA TTTTCAAAGG AGATCGTCTG TGTCCCTTCA TACTTGGAAT TGTATCCTTT GACCGTGACA TTCTGTTGCC AGATCAAAGC ACCCAAGTAA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
XP_016885242.1
CDS 93..1202
Translation
Target ORF information:
RefSeq Version XM_017029753.1
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant X1, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
XM_017029753.1
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 ATGGCAGCAG CACGGCACAG CACGCTCGAC TTCATGCTCG GCGCCAAAGC TGATGGTGAG ACCATTCTAA AAGGCCTCCA GTCCATTTTC CAGGAGCAGG GGATGGCGGA GTCGGTGCAC ACCTGGCAGG ACCATGGCTA TTTAGCAACC TACACAAACA AGAACGGCAG CTTTGCCAAT TTGAGAATTT ACCCACATGG ATTGGTGTTG CTGGACCTTC AGAGTTATGA TGGTGATGCG CAAGGCAAAG AAGAGATCGA CAGTATTTTG AACAAAGTAG AGGAAAGAAT GAAAGAATTG AGTCAGGACA GTACTGGGCG GGTGAAACGA TTACCACCCA TAGTGCGAGG AGGAGCCATC GACAGATACT GGCCCACCGC CGACGGGCGC CTGGTTGAAT ATGACATAGA TGAAGTGGTA TATGACGAAG ATTCACCTTA TCAAAATATA AAAATTCTAC ACTCGAAGCA GTTTGGAAAT ATTCTCATCC TTAGTGGGGA TGTTAATTTG GCAGAGAGTG ATTTGGCATA TACCCGGGCC ATCATGGGCA GTGGCAAAGA AGATTACACT GGCAAAGATG TACTCATTCT GGGAGGTGGA GACGGAGGCA TATTGTGTGA AATAGTCAAA CTAAAACCAA AGATGGTCAC TATGGTAGAG ATTGACCAAA TGGTGATTGA TGGGTGTAAG AAATACATGC GAAAAACGTG TGGCGATGTC TTAGACAATC TTAAAGGAGA CTGCTATCAG GTTCTAATAG AAGACTGTAT CCCGGTACTG AAGAGGTACG CCAAAGAAGG GAGAGAATTT GATTATGTGA TTAATGATTT GACAGCTGTT CCAATCTCCA CGTCTCCAGA AGAAGATTCC ACATGGGAGT TTCTCAGACT GATTCTTGAC CTCTCAATGA AAGTGTTGAA ACAGGATGGG AAATATTTTA CACAGGGGAA CTGTGTCAAT CTGACAGAAG CACTGTCGCT CTATGAAGAA CAGCTGGGGC GCCTGTATTG TCCTGTGGAA TTTTCAAAGG AGATCGTCTG TGTCCCTTCA TACTTGGAAT TGTATCCTTT GACCGTGACA TTCTGTTGCC AGATCAAAGC ACCCAAGTAA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu99436
Clone ID Related Accession (Same CDS sequence)
XM_017029753.1
, XM_017029753.2
Accession Version
XM_017029753.2 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1110bp)
Protein sequence
SNP
Vector
pcDNA3.1-C-(k)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-12-05
Organism
Homo sapiens(human)
Product
spermine synthase isoform X1
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process
On Mar 26, 2018 this sequence version replaced XM_017029753.1.
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Updated annotation
Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205
Annotation Version :: 109.20191205
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 8.3
Annotation Method :: Best-placed RefSeq; propagated RefSeq model
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 ATGGCAGCAG CACGGCACAG CACGCTCGAC TTCATGCTCG GCGCCAAAGC TGATGGTGAG ACCATTCTAA AAGGCCTCCA GTCCATTTTC CAGGAGCAGG GGATGGCGGA GTCGGTGCAC ACCTGGCAGG ACCATGGCTA TTTAGCAACC TACACAAACA AGAACGGCAG CTTTGCCAAT TTGAGAATTT ACCCACATGG ATTGGTGTTG CTGGACCTTC AGAGTTATGA TGGTGATGCG CAAGGCAAAG AAGAGATCGA CAGTATTTTG AACAAAGTAG AGGAAAGAAT GAAAGAATTG AGTCAGGACA GTACTGGGCG GGTGAAACGA TTACCACCCA TAGTGCGAGG AGGAGCCATC GACAGATACT GGCCCACCGC CGACGGGCGC CTGGTTGAAT ATGACATAGA TGAAGTGGTA TATGACGAAG ATTCACCTTA TCAAAATATA AAAATTCTAC ACTCGAAGCA GTTTGGAAAT ATTCTCATCC TTAGTGGGGA TGTTAATTTG GCAGAGAGTG ATTTGGCATA TACCCGGGCC ATCATGGGCA GTGGCAAAGA AGATTACACT GGCAAAGATG TACTCATTCT GGGAGGTGGA GACGGAGGCA TATTGTGTGA AATAGTCAAA CTAAAACCAA AGATGGTCAC TATGGTAGAG ATTGACCAAA TGGTGATTGA TGGGTGTAAG AAATACATGC GAAAAACGTG TGGCGATGTC TTAGACAATC TTAAAGGAGA CTGCTATCAG GTTCTAATAG AAGACTGTAT CCCGGTACTG AAGAGGTACG CCAAAGAAGG GAGAGAATTT GATTATGTGA TTAATGATTT GACAGCTGTT CCAATCTCCA CGTCTCCAGA AGAAGATTCC ACATGGGAGT TTCTCAGACT GATTCTTGAC CTCTCAATGA AAGTGTTGAA ACAGGATGGG AAATATTTTA CACAGGGGAA CTGTGTCAAT CTGACAGAAG CACTGTCGCT CTATGAAGAA CAGCTGGGGC GCCTGTATTG TCCTGTGGAA TTTTCAAAGG AGATCGTCTG TGTCCCTTCA TACTTGGAAT TGTATCCTTT GACCGTGACA TTCTGTTGCC AGATCAAAGC ACCCAAGTAA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
XP_016885242.1
CDS 96..1205
Translation
Target ORF information:
RefSeq Version XM_017029753.2
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant X1, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
XM_017029753.2
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 ATGGCAGCAG CACGGCACAG CACGCTCGAC TTCATGCTCG GCGCCAAAGC TGATGGTGAG ACCATTCTAA AAGGCCTCCA GTCCATTTTC CAGGAGCAGG GGATGGCGGA GTCGGTGCAC ACCTGGCAGG ACCATGGCTA TTTAGCAACC TACACAAACA AGAACGGCAG CTTTGCCAAT TTGAGAATTT ACCCACATGG ATTGGTGTTG CTGGACCTTC AGAGTTATGA TGGTGATGCG CAAGGCAAAG AAGAGATCGA CAGTATTTTG AACAAAGTAG AGGAAAGAAT GAAAGAATTG AGTCAGGACA GTACTGGGCG GGTGAAACGA TTACCACCCA TAGTGCGAGG AGGAGCCATC GACAGATACT GGCCCACCGC CGACGGGCGC CTGGTTGAAT ATGACATAGA TGAAGTGGTA TATGACGAAG ATTCACCTTA TCAAAATATA AAAATTCTAC ACTCGAAGCA GTTTGGAAAT ATTCTCATCC TTAGTGGGGA TGTTAATTTG GCAGAGAGTG ATTTGGCATA TACCCGGGCC ATCATGGGCA GTGGCAAAGA AGATTACACT GGCAAAGATG TACTCATTCT GGGAGGTGGA GACGGAGGCA TATTGTGTGA AATAGTCAAA CTAAAACCAA AGATGGTCAC TATGGTAGAG ATTGACCAAA TGGTGATTGA TGGGTGTAAG AAATACATGC GAAAAACGTG TGGCGATGTC TTAGACAATC TTAAAGGAGA CTGCTATCAG GTTCTAATAG AAGACTGTAT CCCGGTACTG AAGAGGTACG CCAAAGAAGG GAGAGAATTT GATTATGTGA TTAATGATTT GACAGCTGTT CCAATCTCCA CGTCTCCAGA AGAAGATTCC ACATGGGAGT TTCTCAGACT GATTCTTGAC CTCTCAATGA AAGTGTTGAA ACAGGATGGG AAATATTTTA CACAGGGGAA CTGTGTCAAT CTGACAGAAG CACTGTCGCT CTATGAAGAA CAGCTGGGGC GCCTGTATTG TCCTGTGGAA TTTTCAAAGG AGATCGTCTG TGTCCCTTCA TACTTGGAAT TGTATCCTTT GACCGTGACA TTCTGTTGCC AGATCAAAGC ACCCAAGTAA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu99437
Clone ID Related Accession (Same CDS sequence)
XM_017029755.1
Accession Version
XM_017029755.1 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1008bp)
Protein sequence
SNP
Vector
pcDNA3.1-C-(k)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-12-05
Organism
Homo sapiens(human)
Product
spermine synthase isoform X2
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Updated annotation
Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205
Annotation Version :: 109.20191205
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 8.3
Annotation Method :: Best-placed RefSeq; propagated RefSeq model
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG TATCCTTTGA CCGTGACATT CTGTTGCCAG ATCAAAGCAC CCAAGTAA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
XP_016885244.1
CDS 253..1260
Translation
Target ORF information:
RefSeq Version XM_017029755.1
Organism Homo sapiens(human)
Definition Homo sapiens spermine synthase (SMS), transcript variant X6, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
XM_017029755.1
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 ATGGCGGAGT CGGTGCACAC CTGGCAGGAC CATGGCTATT TAGCAACCTA CACAAACAAG AACGGCAGCT TTGCCAATTT GAGAATTTAC CCACATGGAT TGGTGTTGCT GGACCTTCAG AGTTATGATG GTGATGCGCA AGGCAAAGAA GAGATCGACA GTATTTTGAA CAAAGTAGAG GAAAGAATGA AAGAATTGAG TCAGGACAGT ACTGGGCGGG TGAAACGATT ACCACCCATA GTGCGAGGAG GAGCCATCGA CAGATACTGG CCCACCGCCG ACGGGCGCCT GGTTGAATAT GACATAGATG AAGTGGTATA TGACGAAGAT TCACCTTATC AAAATATAAA AATTCTACAC TCGAAGCAGT TTGGAAATAT TCTCATCCTT AGTGGGGATG TTAATTTGGC AGAGAGTGAT TTGGCATATA CCCGGGCCAT CATGGGCAGT GGCAAAGAAG ATTACACTGG CAAAGATGTA CTCATTCTGG GAGGTGGAGA CGGAGGCATA TTGTGTGAAA TAGTCAAACT AAAACCAAAG ATGGTCACTA TGGTAGAGAT TGACCAAATG GTGATTGATG GGTGTAAGAA ATACATGCGA AAAACGTGTG GCGATGTCTT AGACAATCTT AAAGGAGACT GCTATCAGGT TCTAATAGAA GACTGTATCC CGGTACTGAA GAGGTACGCC AAAGAAGGGA GAGAATTTGA TTATGTGATT AATGATTTGA CAGCTGTTCC AATCTCCACG TCTCCAGAAG AAGATTCCAC ATGGGAGTTT CTCAGACTGA TTCTTGACCT CTCAATGAAA GTGTTGAAAC AGGATGGGAA ATATTTTACA CAGGGGAACT GTGTCAATCT GACAGAAGCA CTGTCGCTCT ATGAAGAACA GCTGGGGCGC CTGTATTGTC CTGTGGAATT TTCAAAGGAG ATCGTCTGTG TCCCTTCATA CTTGGAATTG TATCCTTTGA CCGTGACATT CTGTTGCCAG ATCAAAGCAC CCAAGTAA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome.
American journal of medical genetics. Part A149A(3)328-35(2009 Mar)
Becerra-Solano LE,Butler J,Castañeda-Cisneros G,McCloskey DE,Wang X,Pegg AE,Schwartz CE,Sánchez-Corona J,García-Ortiz JE