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SNRPA cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol SNRPA
Entrez Gene ID 6626
Full Name small nuclear ribonucleoprotein polypeptide A
Synonyms Mud1,U1-A,U1A
General protein information
Preferred Names

small nuclear ribonucleoprotein polypeptide A

Names

U1 small nuclear ribonucleoprotein A
U1 small nuclear RNP-specific A
U1 snRNP A
U1 snRNP-specific protein A
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

19

19q13.2
Summary The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010].
Disorder MIM:

182285


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_004596.4 NP_004587.1 U1 small nuclear ribonucleoprotein A
NM_004596.5 NP_004587.1 U1 small nuclear ribonucleoprotein A

Pathways from BioSystems


Homologies


Canis lupus familiaris (dog) SNRPA XP_533663.2
Anopheles gambiae (African malaria mosquito) AgaP_AGAP011637 XP_320869.2
Oryza sativa (rice) Os05g0154800 NP_001054685.1
Bos taurus (cattle) SNRPA NP_001039504.1
Homo sapiens (human) SNRPA NP_004587.1
Rattus norvegicus (Norway rat) Snrpa NP_001008304.1
Danio rerio (zebrafish) snrpa NP_955965.1
Caenorhabditis elegans (roundworm) rnp-2 NP_500504.1
Schizosaccharomyces pombe (fission yeast) usp102 NP_596424.1
Pan troglodytes (chimpanzee) SNRPA XP_512674.2
SNRPA XP_001098504.1
Drosophila melanogaster (fruit fly) snf NP_511045.1
Neurospora crassa NCU08034 XP_962704.1
Magnaporthe oryzae (rice blast fungus) MGG_07085 XP_003715274.1
Arabidopsis thaliana (thale cress) U1A NP_182280.1
Xenopus tropicalis (tropical clawed frog) snrpa NP_001016784.1

Gene Ontology


Bibliography

Related articles in PubMed

Small Nuclear Ribonucleoprotein Polypeptide A-Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation.
Qiu F, Fu Y, Lu C, Feng Y, Wang Q, Huo Z, Jia X, Chen C, Chen S, Xu A
Journal of immunology (Baltimore, Md. : 1950)199(9)3106-3115(2017 Nov)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

p65 activation triggered by TCR signaling could promote SNRPA transcription and 3' UTR shortening of STAT5B. Thus we propose that the alternative polyadenylation switching of STAT5B induced by TCR activation is mediated by SNRPA.
Title: Small Nuclear Ribonucleoprotein Polypeptide A-Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation.

a new mechanism for regulating SMN levels and provides new insight into the roles of U1A in 3' processing of mRNAs.
Title: U1A regulates 3' processing of the survival motor neuron mRNA.

structural analysis of U1A protein-stem loop 2 RNA recognition
Title: U1A protein-stem loop 2 RNA recognition: prediction of structural differences from protein mutations.

study shows that the yellow fever virus (YFV) NS5 protein is able to interact with U1A, a protein involved in splicing and polyadenylation; a region between amino acids 368 and 448 was identified as the site of interaction of the NS5 protein with U1A
Title: The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus.

An analysis of the kinetic data suggests three phases of U1A-SL2 RNA complex dissociation with time scales of approximately 100 mus, approximately 50 ms, and approximately 2 s. We propose that the first step of dissociation is a fast rearrangement of the complex to form a loosely bound complex.
Title: Multistep kinetics of the U1A-SL2 RNA complex dissociation.

The following SNRPA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNRPA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu15951 NM_004596.5
Latest version!		 Homo sapiens small nuclear ribonucleoprotein polypeptide A (SNRPA), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
View Old Accession Versions >>
OHu15951 NM_004596.4 Homo sapiens small nuclear ribonucleoprotein polypeptide A (SNRPA), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu15951
Clone ID Related Accession (Same CDS sequence) NM_004596.4 , NM_004596.5
Accession Version NM_004596.4 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 849bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-11-02
Organism Homo sapiens(human)
Product U1 small nuclear ribonucleoprotein A
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN286572.1, BC000405.2, AC020945.6 and BQ002918.1. On Apr 28, 2010 this sequence version replaced NM_004596.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000405.2, SRR1163655.27760.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGTTC CCGAGACCCG CCCTAACCAC ACTATTTATA TCAACAACCT CAATGAGAAG 
ATCAAGAAGG ATGAGCTAAA AAAGTCCCTG TACGCCATCT TCTCCCAGTT TGGCCAGATC 
CTGGATATCC TGGTATCACG GAGCCTGAAG ATGAGGGGCC AGGCCTTTGT CATCTTCAAG 
GAGGTCAGCA GCGCCACCAA CGCCCTGCGC TCCATGCAGG GTTTCCCTTT CTATGACAAA 
CCTATGCGTA TCCAGTATGC CAAGACCGAC TCAGATATCA TTGCCAAGAT GAAAGGCACC 
TTCGTGGAGC GGGACCGCAA GCGGGAGAAG AGGAAGCCCA AGAGCCAGGA GACCCCGGCC 
ACCAAGAAGG CTGTGCAAGG CGGGGGAGCC ACCCCCGTGG TGGGGGCTGT CCAGGGGCCT 
GTCCCGGGCA TGCCGCCGAT GACTCAGGCG CCCCGCATTA TGCACCACAT GCCGGGCCAG 
CCGCCCTACA TGCCGCCCCC TGGTATGATC CCCCCGCCAG GCCTTGCACC TGGCCAGATC 
CCACCAGGGG CCATGCCCCC GCAGCAGCTT ATGCCAGGAC AGATGCCCCC TGCCCAGCCT 
CTTTCTGAGA ATCCACCGAA TCACATCTTG TTCCTCACCA ACCTGCCAGA GGAGACCAAC 
GAGCTCATGC TGTCCATGCT TTTCAATCAG TTCCCTGGCT TCAAGGAGGT CCGTCTGGTA 
CCCGGGCGGC ATGACATCGC CTTCGTGGAG TTTGACAATG AGGTACAGGC AGGGGCAGCT 
CGCGATGCCC TGCAGGGCTT TAAGATCACG CAGAACAACG CCATGAAGAT CTCCTTTGCC 
AAGAAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004587.1
CDS556..1404
Translation

Target ORF information:

RefSeq Version NM_004596.4
Organism Homo sapiens(human)
Definition Homo sapiens small nuclear ribonucleoprotein polypeptide A (SNRPA), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004596.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGTTC CCGAGACCCG CCCTAACCAC ACTATTTATA TCAACAACCT CAATGAGAAG 
ATCAAGAAGG ATGAGCTAAA AAAGTCCCTG TACGCCATCT TCTCCCAGTT TGGCCAGATC 
CTGGATATCC TGGTATCACG GAGCCTGAAG ATGAGGGGCC AGGCCTTTGT CATCTTCAAG 
GAGGTCAGCA GCGCCACCAA CGCCCTGCGC TCCATGCAGG GTTTCCCTTT CTATGACAAA 
CCTATGCGTA TCCAGTATGC CAAGACCGAC TCAGATATCA TTGCCAAGAT GAAAGGCACC 
TTCGTGGAGC GGGACCGCAA GCGGGAGAAG AGGAAGCCCA AGAGCCAGGA GACCCCGGCC 
ACCAAGAAGG CTGTGCAAGG CGGGGGAGCC ACCCCCGTGG TGGGGGCTGT CCAGGGGCCT 
GTCCCGGGCA TGCCGCCGAT GACTCAGGCG CCCCGCATTA TGCACCACAT GCCGGGCCAG 
CCGCCCTACA TGCCGCCCCC TGGTATGATC CCCCCGCCAG GCCTTGCACC TGGCCAGATC 
CCACCAGGGG CCATGCCCCC GCAGCAGCTT ATGCCAGGAC AGATGCCCCC TGCCCAGCCT 
CTTTCTGAGA ATCCACCGAA TCACATCTTG TTCCTCACCA ACCTGCCAGA GGAGACCAAC 
GAGCTCATGC TGTCCATGCT TTTCAATCAG TTCCCTGGCT TCAAGGAGGT CCGTCTGGTA 
CCCGGGCGGC ATGACATCGC CTTCGTGGAG TTTGACAATG AGGTACAGGC AGGGGCAGCT 
CGCGATGCCC TGCAGGGCTT TAAGATCACG CAGAACAACG CCATGAAGAT CTCCTTTGCC 
AAGAAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15951
Clone ID Related Accession (Same CDS sequence) NM_004596.4 , NM_004596.5
Accession Version NM_004596.5 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 849bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-09
Organism Homo sapiens(human)
Product U1 small nuclear ribonucleoprotein A
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000405.2 and AC020945.6. On Nov 23, 2018 this sequence version replaced NM_004596.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000405.2, SRR1163657.318416.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000243563.8/ ENSP00000243563.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGTTC CCGAGACCCG CCCTAACCAC ACTATTTATA TCAACAACCT CAATGAGAAG 
ATCAAGAAGG ATGAGCTAAA AAAGTCCCTG TACGCCATCT TCTCCCAGTT TGGCCAGATC 
CTGGATATCC TGGTATCACG GAGCCTGAAG ATGAGGGGCC AGGCCTTTGT CATCTTCAAG 
GAGGTCAGCA GCGCCACCAA CGCCCTGCGC TCCATGCAGG GTTTCCCTTT CTATGACAAA 
CCTATGCGTA TCCAGTATGC CAAGACCGAC TCAGATATCA TTGCCAAGAT GAAAGGCACC 
TTCGTGGAGC GGGACCGCAA GCGGGAGAAG AGGAAGCCCA AGAGCCAGGA GACCCCGGCC 
ACCAAGAAGG CTGTGCAAGG CGGGGGAGCC ACCCCCGTGG TGGGGGCTGT CCAGGGGCCT 
GTCCCGGGCA TGCCGCCGAT GACTCAGGCG CCCCGCATTA TGCACCACAT GCCGGGCCAG 
CCGCCCTACA TGCCGCCCCC TGGTATGATC CCCCCGCCAG GCCTTGCACC TGGCCAGATC 
CCACCAGGGG CCATGCCCCC GCAGCAGCTT ATGCCAGGAC AGATGCCCCC TGCCCAGCCT 
CTTTCTGAGA ATCCACCGAA TCACATCTTG TTCCTCACCA ACCTGCCAGA GGAGACCAAC 
GAGCTCATGC TGTCCATGCT TTTCAATCAG TTCCCTGGCT TCAAGGAGGT CCGTCTGGTA 
CCCGGGCGGC ATGACATCGC CTTCGTGGAG TTTGACAATG AGGTACAGGC AGGGGCAGCT 
CGCGATGCCC TGCAGGGCTT TAAGATCACG CAGAACAACG CCATGAAGAT CTCCTTTGCC 
AAGAAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004587.1
CDS207..1055
Translation

Target ORF information:

RefSeq Version NM_004596.5
Organism Homo sapiens(human)
Definition Homo sapiens small nuclear ribonucleoprotein polypeptide A (SNRPA), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004596.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGTTC CCGAGACCCG CCCTAACCAC ACTATTTATA TCAACAACCT CAATGAGAAG 
ATCAAGAAGG ATGAGCTAAA AAAGTCCCTG TACGCCATCT TCTCCCAGTT TGGCCAGATC 
CTGGATATCC TGGTATCACG GAGCCTGAAG ATGAGGGGCC AGGCCTTTGT CATCTTCAAG 
GAGGTCAGCA GCGCCACCAA CGCCCTGCGC TCCATGCAGG GTTTCCCTTT CTATGACAAA 
CCTATGCGTA TCCAGTATGC CAAGACCGAC TCAGATATCA TTGCCAAGAT GAAAGGCACC 
TTCGTGGAGC GGGACCGCAA GCGGGAGAAG AGGAAGCCCA AGAGCCAGGA GACCCCGGCC 
ACCAAGAAGG CTGTGCAAGG CGGGGGAGCC ACCCCCGTGG TGGGGGCTGT CCAGGGGCCT 
GTCCCGGGCA TGCCGCCGAT GACTCAGGCG CCCCGCATTA TGCACCACAT GCCGGGCCAG 
CCGCCCTACA TGCCGCCCCC TGGTATGATC CCCCCGCCAG GCCTTGCACC TGGCCAGATC 
CCACCAGGGG CCATGCCCCC GCAGCAGCTT ATGCCAGGAC AGATGCCCCC TGCCCAGCCT 
CTTTCTGAGA ATCCACCGAA TCACATCTTG TTCCTCACCA ACCTGCCAGA GGAGACCAAC 
GAGCTCATGC TGTCCATGCT TTTCAATCAG TTCCCTGGCT TCAAGGAGGT CCGTCTGGTA 
CCCGGGCGGC ATGACATCGC CTTCGTGGAG TTTGACAATG AGGTACAGGC AGGGGCAGCT 
CGCGATGCCC TGCAGGGCTT TAAGATCACG CAGAACAACG CCATGAAGAT CTCCTTTGCC 
AAGAAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Small Nuclear Ribonucleoprotein Polypeptide A-Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)199(9)3106-3115(2017 Nov)
Qiu F,Fu Y,Lu C,Feng Y,Wang Q,Huo Z,Jia X,Chen C,Chen S,Xu A


book

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M


book

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M