SNRPA cDNA ORF clone, Homo sapiens(human)
Gene Symbol | SNRPA |
Entrez Gene ID | 6626 |
Full Name | small nuclear ribonucleoprotein polypeptide A |
Synonyms | Mud1,U1-A,U1A |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_004596.4 | NP_004587.1 | U1 small nuclear ribonucleoprotein A |
NM_004596.5 | NP_004587.1 | U1 small nuclear ribonucleoprotein A |

Canis lupus familiaris (dog) | SNRPA | XP_533663.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP011637 | XP_320869.2 |
Oryza sativa (rice) | Os05g0154800 | NP_001054685.1 |
Bos taurus (cattle) | SNRPA | NP_001039504.1 |
Homo sapiens (human) | SNRPA | NP_004587.1 |
Rattus norvegicus (Norway rat) | Snrpa | NP_001008304.1 |
Danio rerio (zebrafish) | snrpa | NP_955965.1 |
Caenorhabditis elegans (roundworm) | rnp-2 | NP_500504.1 |
Schizosaccharomyces pombe (fission yeast) | usp102 | NP_596424.1 |
Pan troglodytes (chimpanzee) | SNRPA | XP_512674.2 |
SNRPA | XP_001098504.1 | |
Drosophila melanogaster (fruit fly) | snf | NP_511045.1 |
Neurospora crassa | NCU08034 | XP_962704.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_07085 | XP_003715274.1 |
Arabidopsis thaliana (thale cress) | U1A | NP_182280.1 |
Xenopus tropicalis (tropical clawed frog) | snrpa | NP_001016784.1 |

Related articles in PubMed
Small Nuclear Ribonucleoprotein Polypeptide A-Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation.
Qiu F, Fu Y, Lu C, Feng Y, Wang Q, Huo Z, Jia X, Chen C, Chen S, Xu A
Journal of immunology (Baltimore, Md. : 1950)199(9)3106-3115(2017 Nov)
An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
p65 activation triggered by TCR signaling could promote SNRPA transcription and 3' UTR shortening of STAT5B. Thus we propose that the alternative polyadenylation switching of STAT5B induced by TCR activation is mediated by SNRPA.
Title: Small Nuclear Ribonucleoprotein Polypeptide A-Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation.
a new mechanism for regulating SMN levels and provides new insight into the roles of U1A in 3' processing of mRNAs.
Title: U1A regulates 3' processing of the survival motor neuron mRNA.
structural analysis of U1A protein-stem loop 2 RNA recognition
Title: U1A protein-stem loop 2 RNA recognition: prediction of structural differences from protein mutations.
study shows that the yellow fever virus (YFV) NS5 protein is able to interact with U1A, a protein involved in splicing and polyadenylation; a region between amino acids 368 and 448 was identified as the site of interaction of the NS5 protein with U1A
Title: The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus.
An analysis of the kinetic data suggests three phases of U1A-SL2 RNA complex dissociation with time scales of approximately 100 mus, approximately 50 ms, and approximately 2 s. We propose that the first step of dissociation is a fast rearrangement of the complex to form a loosely bound complex.
Title: Multistep kinetics of the U1A-SL2 RNA complex dissociation.
The following SNRPA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNRPA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu15951![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_004596.4 , NM_004596.5 | |
Accession Version | NM_004596.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-11-02 | |
Organism | Homo sapiens(human) | |
Product | U1 small nuclear ribonucleoprotein A | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN286572.1, BC000405.2, AC020945.6 and BQ002918.1. On Apr 28, 2010 this sequence version replaced NM_004596.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000405.2, SRR1163655.27760.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCAGTTC CCGAGACCCG CCCTAACCAC ACTATTTATA TCAACAACCT CAATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_004587.1 |
CDS | 556..1404 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGGCAGTTC CCGAGACCCG CCCTAACCAC ACTATTTATA TCAACAACCT CAATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15951![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_004596.4 , NM_004596.5 | |
Accession Version | NM_004596.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-09 | |
Organism | Homo sapiens(human) | |
Product | U1 small nuclear ribonucleoprotein A | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000405.2 and AC020945.6. On Nov 23, 2018 this sequence version replaced NM_004596.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000405.2, SRR1163657.318416.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000243563.8/ ENSP00000243563.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCAGTTC CCGAGACCCG CCCTAACCAC ACTATTTATA TCAACAACCT CAATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_004587.1 |
CDS | 207..1055 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCAGTTC CCGAGACCCG CCCTAACCAC ACTATTTATA TCAACAACCT CAATGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Small Nuclear Ribonucleoprotein Polypeptide A-Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation. |
![]() |
An inter-species protein-protein interaction network across vast evolutionary distance. |
![]() |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. |