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UQCRH cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol UQCRH
Entrez Gene ID 7388
Full Name ubiquinol-cytochrome c reductase hinge protein
Synonyms QCR6,UQCR8
General protein information
Preferred Names

ubiquinol-cytochrome c reductase hinge protein

Names

cytochrome b-c1 complex subunit 6, mitochondrial
complex III subunit 6
cytochrome c1 non-heme 11 kDa protein
mitochondrial hinge protein
ubiquinol-cytochrome c reductase complex 11 kDa protein
ubiquinol-cytochrome c reductase, complex III subunit VIII
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

1

1p33
Disorder MIM:

613844


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001297566.1 NP_001284495.1 cytochrome b-c1 complex subunit 6, mitochondrial isoform 3 precursor
NM_001297565.1 NP_001284494.1 cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor
NM_001297565.2 NP_001284494.1 cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor
NM_006004.3 NP_005995.2 cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor
NM_006004.4 NP_005995.2 cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor
NM_001297566.2 NP_001284495.1 cytochrome b-c1 complex subunit 6, mitochondrial isoform 3 precursor

Pathways from BioSystems


Homologies


Homo sapiens (human) UQCRH NP_005995.2
Mus musculus (house mouse) Gm9763 XP_006521701.1
Gallus gallus (chicken) UQCRH NP_001264602.1
Danio rerio (zebrafish) uqcrh NP_001032185.1
Xenopus tropicalis (tropical clawed frog) LOC100492979 XP_002931521.2
Canis lupus familiaris (dog) UQCRH XP_005629093.1
UQCRH NP_001029373.1
UQCRH XP_001107675.2
Pan troglodytes (chimpanzee) UQCRH XP_001160739.1
Bos taurus (cattle) UQCRH NP_001029917.1

Gene Ontology


Bibliography

Related articles in PubMed

The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma.
Park ER, Kim SB, Lee JS, Kim YH, Lee DH, Cho EH, Park SH, Han CJ, Kim BY, Choi DW, Yoo YD, Yu A, Lee JW, Jang JJ, Park YN, Suh KS, Lee KH
Cancer medicine6(4)749-760(2017 Apr)

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Zhao X, Le?n IR, Bak S, Mogensen M, Wrzesinski K, H?jlund K, Jensen ON
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)

UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines.
Modena P, Testi MA, Facchinetti F, Mezzanzanica D, Radice MT, Pilotti S, Sozzi G
Oncogene22(29)4586-93(2003 Jul)

Elevated expression of the human mitochondrial hinge protein gene in cancer.
Liu AY, Bradner RC
Cancer research53(11)2460-5(1993 Jun)

An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein.
Ohta S, Goto K, Arai H, Kagawa Y
FEBS letters226(1)171-5(1987 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that UQCRH is overexpressed in hepatocellular carcinoma.
Title: The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

These data provide preliminary evidence of the inactivation of UQCRH gene in cancer either by structural rearrangements or epigenetic mechanisms.
Title: UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines.

The following UQCRH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UQCRH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu28762 NM_006004.4
Latest version!		 Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$49.50-$69.30
$99.00
OHu28776 NM_001297565.2
Latest version!		 Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $69.30
$99.00
OHu28763 NM_001297566.2
Latest version!		 Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 3, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $69.30
$99.00
View Old Accession Versions >>
OHu28776 NM_001297565.1 Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $69.30
$99.00
OHu28762 NM_006004.3 Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$49.50-$69.30
$99.00
OHu28763 NM_001297566.1 Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 3, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $69.30
$99.00
Hide Old Accession Versions >>

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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu28762
Clone ID Related Accession (Same CDS sequence) NM_006004.3 , NM_006004.4
Accession Version NM_006004.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 276bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-11-12
Organism Homo sapiens(human)
Product cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL122001.32, BP366403.1, BC001934.1 and AA526171.1. On Jul 3, 2014 this sequence version replaced NM_006004.2. Transcript Variant: This variant (1) encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: AA526171.1, BM809148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGAGGAA 
GAGGAAGAGG AGGAATTAGT GGATCCCCTA ACAACAGTGA GAGAGCAATG CGAGCAGTTG 
GAGAAATGTG TAAAGGCCCG GGAGCGGCTA GAGCTCTGTG ATGAGCGTGT ATCCTCTCGA 
TCACATACAG AAGAGGATTG CACGGAGGAG CTCTTTGACT TCTTGCATGC GAGGGACCAT 
TGCGTGGCCC ACAAACTCTT TAACAACTTG AAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005995.2
CDS155..430
Translation

Target ORF information:

RefSeq Version NM_006004.3
Organism Homo sapiens(human)
Definition Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_006004.3

ORF Insert Sequence:

1
61
121
181
241
ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGAGGAA 
GAGGAAGAGG AGGAATTAGT GGATCCCCTA ACAACAGTGA GAGAGCAATG CGAGCAGTTG 
GAGAAATGTG TAAAGGCCCG GGAGCGGCTA GAGCTCTGTG ATGAGCGTGT ATCCTCTCGA 
TCACATACAG AAGAGGATTG CACGGAGGAG CTCTTTGACT TCTTGCATGC GAGGGACCAT 
TGCGTGGCCC ACAAACTCTT TAACAACTTG AAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu28762
Clone ID Related Accession (Same CDS sequence) NM_006004.3 , NM_006004.4
Accession Version NM_006004.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 276bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Homo sapiens(human)
Product cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP366403.1 and BC001934.1. On Nov 23, 2018 this sequence version replaced NM_006004.3. Transcript Variant: This variant (1) encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: AL583587.3, BG033879.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000311672.10/ ENSP00000309565.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGAGGAA 
GAGGAAGAGG AGGAATTAGT GGATCCCCTA ACAACAGTGA GAGAGCAATG CGAGCAGTTG 
GAGAAATGTG TAAAGGCCCG GGAGCGGCTA GAGCTCTGTG ATGAGCGTGT ATCCTCTCGA 
TCACATACAG AAGAGGATTG CACGGAGGAG CTCTTTGACT TCTTGCATGC GAGGGACCAT 
TGCGTGGCCC ACAAACTCTT TAACAACTTG AAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005995.2
CDS70..345
Translation

Target ORF information:

RefSeq Version NM_006004.4
Organism Homo sapiens(human)
Definition Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_006004.4

ORF Insert Sequence:

1
61
121
181
241
ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGAGGAA 
GAGGAAGAGG AGGAATTAGT GGATCCCCTA ACAACAGTGA GAGAGCAATG CGAGCAGTTG 
GAGAAATGTG TAAAGGCCCG GGAGCGGCTA GAGCTCTGTG ATGAGCGTGT ATCCTCTCGA 
TCACATACAG AAGAGGATTG CACGGAGGAG CTCTTTGACT TCTTGCATGC GAGGGACCAT 
TGCGTGGCCC ACAAACTCTT TAACAACTTG AAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu28776
Clone ID Related Accession (Same CDS sequence) NM_001297565.1 , NM_001297565.2
Accession Version NM_001297565.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 258bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-23
Organism Homo sapiens(human)
Product cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL122001.32, BP366403.1, BC093060.1 and AA526171.1. Transcript Variant: This variant (2) contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BI561295.1, SRR1163658.208653.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
ATGGGAGACC GCATTCTGCC ATTTCTGGCG GCAGTGTGGC TCTGCCAGCT GGCCTTCTGC 
ACGGATCCCC TAACAACAGT GAGAGAGCAA TGCGAGCAGT TGGAGAAATG TGTAAAGGCC 
CGGGAGCGGC TAGAGCTCTG TGATGAGCGT GTATCCTCTC GATCACATAC AGAAGAGGAT 
TGCACGGAGG AGCTCTTTGA CTTCTTGCAT GCGAGGGACC ATTGCGTGGC CCACAAACTC 
TTTAACAACT TGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001284494.1
CDS321..578
Translation

Target ORF information:

RefSeq Version NM_001297565.1
Organism Homo sapiens(human)
Definition Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001297565.1

ORF Insert Sequence:

1
61
121
181
241
ATGGGAGACC GCATTCTGCC ATTTCTGGCG GCAGTGTGGC TCTGCCAGCT GGCCTTCTGC 
ACGGATCCCC TAACAACAGT GAGAGAGCAA TGCGAGCAGT TGGAGAAATG TGTAAAGGCC 
CGGGAGCGGC TAGAGCTCTG TGATGAGCGT GTATCCTCTC GATCACATAC AGAAGAGGAT 
TGCACGGAGG AGCTCTTTGA CTTCTTGCAT GCGAGGGACC ATTGCGTGGC CCACAAACTC 
TTTAACAACT TGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu28776
Clone ID Related Accession (Same CDS sequence) NM_001297565.1 , NM_001297565.2
Accession Version NM_001297565.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 258bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Homo sapiens(human)
Product cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC093060.1 and AA526171.1. On May 31, 2019 this sequence version replaced NM_001297565.1. Transcript Variant: This variant (2) contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BI546614.1, BI548467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
ATGGGAGACC GCATTCTGCC ATTTCTGGCG GCAGTGTGGC TCTGCCAGCT GGCCTTCTGC 
ACGGATCCCC TAACAACAGT GAGAGAGCAA TGCGAGCAGT TGGAGAAATG TGTAAAGGCC 
CGGGAGCGGC TAGAGCTCTG TGATGAGCGT GTATCCTCTC GATCACATAC AGAAGAGGAT 
TGCACGGAGG AGCTCTTTGA CTTCTTGCAT GCGAGGGACC ATTGCGTGGC CCACAAACTC 
TTTAACAACT TGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001284494.1
CDS236..493
Translation

Target ORF information:

RefSeq Version NM_001297565.2
Organism Homo sapiens(human)
Definition Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001297565.2

ORF Insert Sequence:

1
61
121
181
241
ATGGGAGACC GCATTCTGCC ATTTCTGGCG GCAGTGTGGC TCTGCCAGCT GGCCTTCTGC 
ACGGATCCCC TAACAACAGT GAGAGAGCAA TGCGAGCAGT TGGAGAAATG TGTAAAGGCC 
CGGGAGCGGC TAGAGCTCTG TGATGAGCGT GTATCCTCTC GATCACATAC AGAAGAGGAT 
TGCACGGAGG AGCTCTTTGA CTTCTTGCAT GCGAGGGACC ATTGCGTGGC CCACAAACTC 
TTTAACAACT TGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu28763
Clone ID Related Accession (Same CDS sequence) NM_001297566.1 , NM_001297566.2
Accession Version NM_001297566.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 249bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-23
Organism Homo sapiens(human)
Product cytochrome b-c1 complex subunit 6, mitochondrial isoform 3 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL122001.32, BP366403.1, BG472687.1 and AA526171.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.145008.1, BG472687.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGATCCC 
CTAACAACAG TGAGAGAGCA ATGCGAGCAG TTGGAGAAAT GTGTAAAGGC CCGGGAGCGG 
CTAGAGCTCT GTGATGAGCG TGTATCCTCT CGATCACATA CAGAAGAGGA TTGCACGGAG 
GAGCTCTTTG ACTTCTTGCA TGCGAGGGAC CATTGCGTGG CCCACAAACT CTTTAACAAC 
TTGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001284495.1
CDS155..403
Translation

Target ORF information:

RefSeq Version NM_001297566.1
Organism Homo sapiens(human)
Definition Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001297566.1

ORF Insert Sequence:

1
61
121
181
241
ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGATCCC 
CTAACAACAG TGAGAGAGCA ATGCGAGCAG TTGGAGAAAT GTGTAAAGGC CCGGGAGCGG 
CTAGAGCTCT GTGATGAGCG TGTATCCTCT CGATCACATA CAGAAGAGGA TTGCACGGAG 
GAGCTCTTTG ACTTCTTGCA TGCGAGGGAC CATTGCGTGG CCCACAAACT CTTTAACAAC 
TTGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu28763
Clone ID Related Accession (Same CDS sequence) NM_001297566.1 , NM_001297566.2
Accession Version NM_001297566.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 249bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Homo sapiens(human)
Product cytochrome b-c1 complex subunit 6, mitochondrial isoform 3 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP366403.1, BG472687.1 and AA526171.1. On Jun 1, 2019 this sequence version replaced NM_001297566.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.431823.1, BG472687.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGATCCC 
CTAACAACAG TGAGAGAGCA ATGCGAGCAG TTGGAGAAAT GTGTAAAGGC CCGGGAGCGG 
CTAGAGCTCT GTGATGAGCG TGTATCCTCT CGATCACATA CAGAAGAGGA TTGCACGGAG 
GAGCTCTTTG ACTTCTTGCA TGCGAGGGAC CATTGCGTGG CCCACAAACT CTTTAACAAC 
TTGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001284495.1
CDS70..318
Translation

Target ORF information:

RefSeq Version NM_001297566.2
Organism Homo sapiens(human)
Definition Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001297566.2

ORF Insert Sequence:

1
61
121
181
241
ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGATCCC 
CTAACAACAG TGAGAGAGCA ATGCGAGCAG TTGGAGAAAT GTGTAAAGGC CCGGGAGCGG 
CTAGAGCTCT GTGATGAGCG TGTATCCTCT CGATCACATA CAGAAGAGGA TTGCACGGAG 
GAGCTCTTTG ACTTCTTGCA TGCGAGGGAC CATTGCGTGG CCCACAAACT CTTTAACAAC 
TTGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma.
Cancer medicine6(4)749-760(2017 Apr)
Park ER,Kim SB,Lee JS,Kim YH,Lee DH,Cho EH,Park SH,Han CJ,Kim BY,Choi DW,Yoo YD,Yu A,Lee JW,Jang JJ,Park YN,Suh KS,Lee KH


book

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)
Zhao X,Le?n IR,Bak S,Mogensen M,Wrzesinski K,H?jlund K,Jensen ON


book

UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines.
Oncogene22(29)4586-93(2003 Jul)
Modena P,Testi MA,Facchinetti F,Mezzanzanica D,Radice MT,Pilotti S,Sozzi G


book

Elevated expression of the human mitochondrial hinge protein gene in cancer.
Cancer research53(11)2460-5(1993 Jun)
Liu AY,Bradner RC


book

An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein.
FEBS letters226(1)171-5(1987 Dec)
Ohta S,Goto K,Arai H,Kagawa Y