Gene Symbol | UQCRH |
Entrez Gene ID | 7388 |
Full Name | ubiquinol-cytochrome c reductase hinge protein |
Synonyms | QCR6,UQCR8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » UQCRH cDNA ORF clone
gRNAs
Gene Symbol | UQCRH |
Entrez Gene ID | 7388 |
Full Name | ubiquinol-cytochrome c reductase hinge protein |
Synonyms | QCR6,UQCR8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001297566.1 | NP_001284495.1 | cytochrome b-c1 complex subunit 6, mitochondrial isoform 3 precursor |
NM_001297565.1 | NP_001284494.1 | cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor |
NM_001297565.2 | NP_001284494.1 | cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor |
NM_006004.3 | NP_005995.2 | cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor |
NM_006004.4 | NP_005995.2 | cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor |
NM_001297566.2 | NP_001284495.1 | cytochrome b-c1 complex subunit 6, mitochondrial isoform 3 precursor |
Homo sapiens (human) | UQCRH | NP_005995.2 |
Mus musculus (house mouse) | Gm9763 | XP_006521701.1 |
Gallus gallus (chicken) | UQCRH | NP_001264602.1 |
Danio rerio (zebrafish) | uqcrh | NP_001032185.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100492979 | XP_002931521.2 |
Canis lupus familiaris (dog) | UQCRH | XP_005629093.1 |
UQCRH | NP_001029373.1 | |
UQCRH | XP_001107675.2 | |
Pan troglodytes (chimpanzee) | UQCRH | XP_001160739.1 |
Bos taurus (cattle) | UQCRH | NP_001029917.1 |
The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma.
Park ER, Kim SB, Lee JS, Kim YH, Lee DH, Cho EH, Park SH, Han CJ, Kim BY, Choi DW, Yoo YD, Yu A, Lee JW, Jang JJ, Park YN, Suh KS, Lee KH
Cancer medicine6(4)749-760(2017 Apr)
Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Zhao X, Le?n IR, Bak S, Mogensen M, Wrzesinski K, H?jlund K, Jensen ON
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)
UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines.
Modena P, Testi MA, Facchinetti F, Mezzanzanica D, Radice MT, Pilotti S, Sozzi G
Oncogene22(29)4586-93(2003 Jul)
Elevated expression of the human mitochondrial hinge protein gene in cancer.
Liu AY, Bradner RC
Cancer research53(11)2460-5(1993 Jun)
An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein.
Ohta S, Goto K, Arai H, Kagawa Y
FEBS letters226(1)171-5(1987 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results show that UQCRH is overexpressed in hepatocellular carcinoma.
Title: The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
These data provide preliminary evidence of the inactivation of UQCRH gene in cancer either by structural rearrangements or epigenetic mechanisms.
Title: UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines.
The following UQCRH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UQCRH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu28762![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_006004.3 , NM_006004.4 | |
Accession Version | NM_006004.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-11-12 | |
Organism | Homo sapiens(human) | |
Product | cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL122001.32, BP366403.1, BC001934.1 and AA526171.1. On Jul 3, 2014 this sequence version replaced NM_006004.2. Transcript Variant: This variant (1) encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: AA526171.1, BM809148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_005995.2 |
CDS | 155..430 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28762![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_006004.3 , NM_006004.4 | |
Accession Version | NM_006004.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Homo sapiens(human) | |
Product | cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP366403.1 and BC001934.1. On Nov 23, 2018 this sequence version replaced NM_006004.3. Transcript Variant: This variant (1) encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: AL583587.3, BG033879.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000311672.10/ ENSP00000309565.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_005995.2 |
CDS | 70..345 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28776 | |
Clone ID Related Accession (Same CDS sequence) | NM_001297565.1 , NM_001297565.2 | |
Accession Version | NM_001297565.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-23 | |
Organism | Homo sapiens(human) | |
Product | cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL122001.32, BP366403.1, BC093060.1 and AA526171.1. Transcript Variant: This variant (2) contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BI561295.1, SRR1163658.208653.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGAGACC GCATTCTGCC ATTTCTGGCG GCAGTGTGGC TCTGCCAGCT GGCCTTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001284494.1 |
CDS | 321..578 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGAGACC GCATTCTGCC ATTTCTGGCG GCAGTGTGGC TCTGCCAGCT GGCCTTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28776 | |
Clone ID Related Accession (Same CDS sequence) | NM_001297565.1 , NM_001297565.2 | |
Accession Version | NM_001297565.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Homo sapiens(human) | |
Product | cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC093060.1 and AA526171.1. On May 31, 2019 this sequence version replaced NM_001297565.1. Transcript Variant: This variant (2) contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BI546614.1, BI548467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGAGACC GCATTCTGCC ATTTCTGGCG GCAGTGTGGC TCTGCCAGCT GGCCTTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001284494.1 |
CDS | 236..493 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGAGACC GCATTCTGCC ATTTCTGGCG GCAGTGTGGC TCTGCCAGCT GGCCTTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28763 | |
Clone ID Related Accession (Same CDS sequence) | NM_001297566.1 , NM_001297566.2 | |
Accession Version | NM_001297566.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-23 | |
Organism | Homo sapiens(human) | |
Product | cytochrome b-c1 complex subunit 6, mitochondrial isoform 3 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL122001.32, BP366403.1, BG472687.1 and AA526171.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.145008.1, BG472687.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGATCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001284495.1 |
CDS | 155..403 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGATCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28763 | |
Clone ID Related Accession (Same CDS sequence) | NM_001297566.1 , NM_001297566.2 | |
Accession Version | NM_001297566.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Homo sapiens(human) | |
Product | cytochrome b-c1 complex subunit 6, mitochondrial isoform 3 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP366403.1, BG472687.1 and AA526171.1. On Jun 1, 2019 this sequence version replaced NM_001297566.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.431823.1, BG472687.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGATCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001284495.1 |
CDS | 70..318 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGACTGG AGGACGAGCA AAAGATGCTT ACCGAATCCG GAGATCCTGA GGAGGATCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma. |
Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. |
UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines. |
Elevated expression of the human mitochondrial hinge protein gene in cancer. |
An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein. |