PDCL3 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | PDCL3 |
| Entrez Gene ID | 79031 |
| Full Name | phosducin like 3 |
| Synonyms | HTPHLP,PHLP2A,PHLP3,VIAF,VIAF1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_024065.4 | NP_076970.1 | phosducin-like protein 3 |
| XM_017004890.1 | XP_016860379.1 | phosducin-like protein 3 isoform X1 |
| NM_024065.5 | NP_076970.1 | phosducin-like protein 3 |
| Oryza sativa (rice) | Os01g0184800 | NP_001042236.1 |
| Canis lupus familiaris (dog) | PDCL3 | XP_531782.1 |
| Arabidopsis thaliana (thale cress) | AT5G14240 | NP_196928.1 |
| Pan troglodytes (chimpanzee) | PDCL3 | XP_525834.2 |
| Gallus gallus (chicken) | PDCL3 | NP_001025983.1 |
| Drosophila melanogaster (fruit fly) | viaf | NP_524032.2 |
| Schizosaccharomyces pombe (fission yeast) | SPBC2A9.09 | NP_596219.1 |
| Xenopus tropicalis (tropical clawed frog) | pdcl3 | NP_001011382.1 |
| Homo sapiens (human) | PDCL3 | NP_076970.1 |
| LOC707924 | XP_001097346.1 | |
| Bos taurus (cattle) | PDCL3 | NP_001069113.1 |
| Mus musculus (house mouse) | Pdcl3 | NP_081126.2 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010477 | XP_311467.3 |
| Saccharomyces cerevisiae (baker's yeast) | PLP2 | NP_014924.3 |
| Neurospora crassa | NCU00617 | XP_965757.1 |
| Rattus norvegicus (Norway rat) | Pdcl3 | NP_001020880.1 |
| Danio rerio (zebrafish) | pdcl3 | NP_991284.1 |
| Kluyveromyces lactis | KLLA0C06952g | XP_452508.1 |
| Eremothecium gossypii | AGOS_AFR552C | NP_986099.2 |
| Magnaporthe oryzae (rice blast fungus) | MGG_17944 | XP_003720863.1 |
Related articles in PubMed
Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein Hsp90.
Krzemie?-Ojak ?, G?ral A, Joachimiak E, Filipek A, Fabczak H
Journal of cellular biochemistry118(2)420-429(2017 Feb)
Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.
Herold C, Hooli BV, Mullin K, Liu T, Roehr JT, Mattheisen M, Parrado AR, Bertram L, Lange C, Tanzi RE
Molecular psychiatry21(11)1608-1612(2016 Nov)
Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis.
Srinivasan S, Chitalia V, Meyer RD, Hartsough E, Mehta M, Harrold I, Anderson N, Feng H, Smith LE, Jiang Y, Costello CE, Rahimi N
Angiogenesis18(4)449-62(2015 Oct)
Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2.
Srinivasan S, Meyer RD, Lugo R, Rahimi N
The Journal of biological chemistry288(32)23171-81(2013 Aug)
Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression.
Stirling PC, Srayko M, Takhar KS, Pozniakovsky A, Hyman AA, Leroux MR
Molecular biology of the cell18(6)2336-45(2007 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
results have shown that PhLP2A interacts with Hsp90 and exhibits molecular chaperone activity toward denatured proteins.
Title: Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein Hsp90.
family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG, OSBPL6, and PDCL3 that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG, rs1347297 in the gene OSBPL6, and rs1513625 near PDCL3. In addition, rs72953347 in OSBPL6 and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).
Title: Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.
The data provide new insights for the chaperone function of PDCL3 in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 expression and its effect on VEGFR-2.
Title: Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis.
data provide strong evidence for the role of PDCL3 in angiogenesis and establishes the molecular mechanism by which it regulates VEGFR-2 expression and function.
Title: Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2.
Data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2.
Title: Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression.
The following PDCL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDCL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu31692 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_024065.4 , NM_024065.5 | |
| Accession Version | NM_024065.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-11-11 | |
| Organism | Homo sapiens(human) | |
| Product | phosducin-like protein 3 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI820064.1, BC001021.2 and AI741007.1. On Dec 19, 2007 this sequence version replaced NM_024065.3. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.115369.1, ERR279835.10130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCAGGACC CCAACGCAGA CACTGAATGG AATGACATCT TACGCAAAAA GGGTATCTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_076970.1 |
| CDS | 113..832 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_024065.4 |
ORF Insert Sequence:
1 | ATGCAGGACC CCAACGCAGA CACTGAATGG AATGACATCT TACGCAAAAA GGGTATCTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu31692 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_024065.4 , NM_024065.5 | |
| Accession Version | NM_024065.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-01 | |
| Organism | Homo sapiens(human) | |
| Product | phosducin-like protein 3 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC001021.2 and AI741007.1. On Nov 22, 2018 this sequence version replaced NM_024065.4. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.215273.1, SRR3476690.166917.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000264254.11/ ENSP00000264254.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGCAGGACC CCAACGCAGA CACTGAATGG AATGACATCT TACGCAAAAA GGGTATCTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_076970.1 |
| CDS | 76..795 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_024065.5 |
ORF Insert Sequence:
1 | ATGCAGGACC CCAACGCAGA CACTGAATGG AATGACATCT TACGCAAAAA GGGTATCTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu89896 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017004890.1 | |
| Accession Version | XM_017004890.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-06-12 | |
| Organism | Homo sapiens(human) | |
| Product | phosducin-like protein 3 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END## | |
1 | ATGACTTTGG AAGAGCTGGA GGATCATGAA GACGAGTTTA ATGAGGAGGA TGAACGTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_016860379.1 |
| CDS | 392..961 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017004890.1 |
ORF Insert Sequence:
1 | ATGACTTTGG AAGAGCTGGA GGATCATGAA GACGAGTTTA ATGAGGAGGA TGAACGTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein Hsp90. |
|
Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3. |
|
Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. |
|
Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2. |
|
Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. |