LMAN1L cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | LMAN1L |
| Entrez Gene ID | 79748 |
| Full Name | lectin, mannose binding 1 like |
| Synonyms | ERGIC-53L,ERGL |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_021819.2 | NP_068591.2 | protein ERGIC-53-like precursor |
| NM_021819.3 | NP_068591.2 | protein ERGIC-53-like precursor |
| Pan troglodytes (chimpanzee) | LMAN1L | XP_003952751.1 |
| Homo sapiens (human) | LMAN1L | NP_068591.2 |
| Canis lupus familiaris (dog) | LMAN1L | XP_005638684.1 |
| Mus musculus (house mouse) | Lman1l | NP_954692.2 |
| LOC709457 | XP_001097975.2 | |
| Bos taurus (cattle) | LMAN1L | XP_002696725.3 |
| Rattus norvegicus (Norway rat) | Lman1l | NP_001012483.1 |
Related articles in PubMed
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO
Journal of proteome research16(8)3083-3091(2017 Aug)
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, Bennett SN, Berndt SI, Boerwinkle E, Chanock S, Chatterjee N, Couper D, Curhan G, Heiss G, Hu FB, Hunter DJ, Jacobs K, Jensen MK, Kraft P, Landi MT, Nettleton JA, Purdue MP, Rajaraman P, Rimm EB, Rose LM, Rothman N, Silverman D, Stolzenberg-Solomon R, Subar A, Yeager M, Chasman DI, van Dam RM, Caporaso NE
PLoS genetics7(4)e1002033(2011 Apr)
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes and immunity11(3)232-8(2010 Apr)
Genome-wide association study identifies eight loci associated with blood pressure.
Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, , Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, D?ring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syv?nen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, D?rr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, V?lker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, V?lzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB
Nature genetics41(6)666-76(2009 Jun)
Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin.
Nyfeler B, Reiterer V, Wendeler MW, Stefan E, Zhang B, Michnick SW, Hauri HP
The Journal of cell biology180(4)705-12(2008 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Binding of ERGIC-53 to sugar is enhanced by its interaction with MCFD2, and defects in this interaction in factor V and VIII deeficient patients may be the cause for reduced secretion of factors V and VIII.
Title: The sugar-binding ability of ERGIC-53 is enhanced by its interaction with MCFD2.
The results reveal ERGIC-53 to be an intracellular transport receptor of alpha1-AT and provide direct evidence for active receptor-mediated ER export of a soluble secretory protein in higher eukaryotes
Title: Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin.
ERGIC-53 provides a platform that receives micro(2)L(2) subunits from the BiP-dependent checkpoint, assisting polymerization. In this process, ERp44 couples thiol-dependent assembly and quality control.
Title: Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis.
The following LMAN1L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LMAN1L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu03743 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_021819.2 , NM_021819.3 | |
| Accession Version | NM_021819.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-16 | |
| Organism | Homo sapiens(human) | |
| Product | protein ERGIC-53-like precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358724.1 and AF303398.1. This sequence is a reference standard in the RefSeqGene project. On Sep 15, 2005 this sequence version replaced NM_021819.1. ##Evidence-Data-START## Transcript exon combination :: AF303398.1, AK291819.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCCGGCGG TCAGTGGTCC AGGTCCCTTA TTCTGCCTTC TCCTCCTGCT CCTGGACCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_068591.2 |
| CDS | 3..1583 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_021819.2 |
ORF Insert Sequence:
1 | ATGCCGGCGG TCAGTGGTCC AGGTCCCTTA TTCTGCCTTC TCCTCCTGCT CCTGGACCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu03743 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_021819.2 , NM_021819.3 | |
| Accession Version | NM_021819.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-25 | |
| Organism | Homo sapiens(human) | |
| Product | protein ERGIC-53-like precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091230.23, AY358724.1 and AF303398.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_021819.2. ##Evidence-Data-START## Transcript exon combination :: AK291819.1, AF303398.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000309664.10/ ENSP00000310431.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCCGGCGG TCAGTGGTCC AGGTCCCTTA TTCTGCCTTC TCCTCCTGCT CCTGGACCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_068591.2 |
| CDS | 21..1601 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_021819.3 |
ORF Insert Sequence:
1 | ATGCCGGCGG TCAGTGGTCC AGGTCCCTTA TTCTGCCTTC TCCTCCTGCT CCTGGACCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. |
|
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. |
|
New genetic associations detected in a host response study to hepatitis B vaccine. |
|
Genome-wide association study identifies eight loci associated with blood pressure. |
|
Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin. |