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CSRP3 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol CSRP3
Entrez Gene ID 8048
Full Name cysteine and glycine rich protein 3
Synonyms CLP,CMD1M,CMH12,CRP3,LMO4,MLP
General protein information
Preferred Names

cysteine and glycine rich protein 3

Names

cysteine and glycine-rich protein 3
LIM domain only 4
cardiac LIM domain protein
cysteine and glycine-rich protein 3 (cardiac LIM protein)
muscle lim protein isoform

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

11

11p15.1

Summary This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:

600824

Disorder Html: Cardiomyopathy, dilated, 1M, 607482 (3); Cardiomyopathy,

mRNA and Protein(s)

mRNA Protein Name
NM_003476.4 NP_003467.1 cysteine and glycine-rich protein 3



Mus musculus (house mouse) Csrp3 NP_001185770.1
Drosophila melanogaster (fruit fly) Mlp60A NP_001137750.1
Rattus norvegicus (Norway rat) Csrp3 NP_476485.1
Gallus gallus (chicken) CSRP3 NP_001186415.1
Xenopus tropicalis (tropical clawed frog) csrp3 NP_001006836.1
Homo sapiens (human) CSRP3 NP_003467.1
Pan troglodytes (chimpanzee) CSRP3 XP_528813.2
Canis lupus familiaris (dog) CSRP3 XP_852328.1
Bos taurus (cattle) CSRP3 NP_001019860.1
Danio rerio (zebrafish) csrp3 NP_001006026.1
Macaca mulatta (rhesus monkey) CSRP3 XP_001095430.1


Related articles in PubMed

Human muscle LIM protein dimerizes along the actin cytoskeleton and cross-links actin filaments.
Hoffmann C, Moreau F, Moes M, Luthold C, Dieterle M, Goretti E, Neumann K, Steinmetz A, Thomas C
Molecular and cellular biology34(16)3053-65(2014 Aug)

Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.
Vafiadaki E, Arvanitis DA, Papalouka V, Terzis G, Roumeliotis TI, Spengos K, Garbis SD, Manta P, Kranias EG, Sanoudou D
The FEBS journal281(14)3261-79(2014 Jul)

KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells.
Shi HJ, Wen JK, Miao SB, Liu Y, Zheng B
Molecular and cellular biochemistry367(1-2)185-94(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MLP contributes to the maintenance of cardiomyocyte cytoarchitecture by a mechanism involving its self-association and actin filament cross-linking.
Title: Human muscle LIM protein dimerizes along the actin cytoskeleton and cross-links actin filaments.

study reports the discovery of an alternative splice variant of muscle lim protein encoded by the CSRP3 gene, designated as MLP-b, showing distinct expression in neuromuscular disease and direct roles in actin dynamics and muscle differentiation
Title: Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.

KLF5 reverses hhLIM function from anti-proliferation to pro-proliferation through its interaction with hhLIM on the cyclin E promoter.
Title: KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of genetic testing. (HuGE Navigator)
Title: A novel custom resequencing array for dilated cardiomyopathy.

The following CSRP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSRP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu21723 NM_003476.4
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Homo sapiens cysteine and glycine rich protein 3 (CSRP3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21723
Clone ID Related Accession (Same CDS sequence) NM_003476.4
Accession Version NM_003476.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 585bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-12
Organism Homo sapiens(Human)
Product cysteine and glycine-rich protein 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC024010.1, AC009652.14, AJ711422.1 and AA192614.1. On or before Aug 31, 2013 this sequence version replaced XM_005253152.1, NM_001127656.1, NM_003476.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024010.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2155550, SAMN03267760 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGCCAAACT GGGGCGGAGG CGCAAAATGT GGAGCCTGTG AAAAGACCGT CTACCATGCA 
GAAGAAATCC AGTGCAATGG AAGGAGTTTC CACAAGACGT GTTTCCACTG CATGGCCTGC
AGGAAGGCTC TTGACAGCAC GACAGTCGCG GCTCATGAGT CGGAGATCTA CTGCAAGGTG
TGCTATGGGC GCAGATATGG CCCCAAAGGG ATCGGGTATG GACAAGGCGC TGGCTGTCTC
AGCACAGACA CGGGCGAGCA TCTCGGCCTG CAGTTCCAAC AGTCCCCAAA GCCGGCACGC
TCAGTTACCA CCAGCAACCC TTCCAAATTC ACTGCGAAGT TTGGAGAGTC CGAGAAGTGC
CCTCGATGTG GCAAGTCAGT CTATGCTGCT GAGAAGGTTA TGGGAGGTGG CAAGCCTTGG
CACAAGACCT GTTTCCGCTG TGCCATCTGT GGGAAGAGTC TGGAGTCCAC AAATGTCACT
GACAAAGATG GGGAACTTTA TTGCAAAGTT TGCTATGCCA AAAATTTTGG CCCCACGGGT
ATTGGGTTTG GAGGCCTTAC ACAACAAGTG GAAAAGAAAG AATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003467.1
CDS240..824
Misc Feature(1)93..95
Misc Feature(2)264..425
Misc Feature(3)order(267..269,276..278,330..332,339..341,348..350,357..359,411..413,420..422)
Misc Feature(4)429..446
Misc Feature(5)522..524
Misc Feature(6)597..758
Misc Feature(7)order(597..599,606..608,660..662,669..671,678..680,687..689,741..743,750..752)
Misc Feature(8)696..698
Exon (1)1..122
Exon (2)123..211
Exon (3)212..351
Exon (4)352..520
Exon (5)521..653
Exon (6)654..747
Exon (7)748..1464
Translation

Target ORF information:

RefSeq Version NM_003476.4
Organism Homo sapiens(Human)
Definition Homo sapiens cysteine and glycine rich protein 3 (CSRP3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003476.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGCCAAACT GGGGCGGAGG CGCAAAATGT GGAGCCTGTG AAAAGACCGT CTACCATGCA 
GAAGAAATCC AGTGCAATGG AAGGAGTTTC CACAAGACGT GTTTCCACTG CATGGCCTGC
AGGAAGGCTC TTGACAGCAC GACAGTCGCG GCTCATGAGT CGGAGATCTA CTGCAAGGTG
TGCTATGGGC GCAGATATGG CCCCAAAGGG ATCGGGTATG GACAAGGCGC TGGCTGTCTC
AGCACAGACA CGGGCGAGCA TCTCGGCCTG CAGTTCCAAC AGTCCCCAAA GCCGGCACGC
TCAGTTACCA CCAGCAACCC TTCCAAATTC ACTGCGAAGT TTGGAGAGTC CGAGAAGTGC
CCTCGATGTG GCAAGTCAGT CTATGCTGCT GAGAAGGTTA TGGGAGGTGG CAAGCCTTGG
CACAAGACCT GTTTCCGCTG TGCCATCTGT GGGAAGAGTC TGGAGTCCAC AAATGTCACT
GACAAAGATG GGGAACTTTA TTGCAAAGTT TGCTATGCCA AAAATTTTGG CCCCACGGGT
ATTGGGTTTG GAGGCCTTAC ACAACAAGTG GAAAAGAAAG AATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Human muscle LIM protein dimerizes along the actin cytoskeleton and cross-links actin filaments.
Molecular and cellular biology34(16)3053-65(2014 Aug)
Hoffmann C,Moreau F,Moes M,Luthold C,Dieterle M,Goretti E,Neumann K,Steinmetz A,Thomas C


book

Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.
The FEBS journal281(14)3261-79(2014 Jul)
Vafiadaki E,Arvanitis DA,Papalouka V,Terzis G,Roumeliotis TI,Spengos K,Garbis SD,Manta P,Kranias EG,Sanoudou D


book

KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells.
Molecular and cellular biochemistry367(1-2)185-94(2012 Aug)
Shi HJ,Wen JK,Miao SB,Liu Y,Zheng B


 
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