The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009].
Molecular architecture of the ?? T cell receptor-CD3 complex.
Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC Proceedings of the National Academy of Sciences of the United States of America111(49)17576-81(2014 Dec)
The following CD3D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD3D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
T-cell surface glycoprotein CD3 delta chain isoform A precursor
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070321.1. This sequence is a reference standard in the RefSeqGene project. On May 18, 2006 this sequence version replaced NM_000732.3.
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC070321.1, BI907465.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA2142670, SAMEA2146236 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression, longest protein
##RefSeq-Attributes-END##
COMPLETENESS: full length.
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Full annotation
Annotation Version :: Homo sapiens Annotation Release 108
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 7.0
Annotation Method :: Best-placed RefSeq; Gnomon
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
T-cell surface glycoprotein CD3 delta chain isoform B precursor
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070321.1, CD014058.1 and AP001582.4. On Jun 2, 2019 this sequence version replaced NM_001040651.1.
Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded protein (B) is shorter and lacks the transmembrane domain, compared to isoform A.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: CD014058.1, AI219691.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA2146236, SAMEA2150385 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
T-cell surface glycoprotein CD3 delta chain isoform B precursor
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070321.1 and CD014058.1.
Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded protein (B) is shorter and lacks the transmembrane domain, compared to isoform A.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: CD014058.1, AI219691.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA2146236, SAMEA2150385 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
Molecular architecture of the ?? T cell receptor-CD3 complex.
Proceedings of the National Academy of Sciences of the United States of America111(49)17576-81(2014 Dec)
Birnbaum ME,Berry R,Hsiao YS,Chen Z,Shingu-Vazquez MA,Yu X,Waghray D,Fischer S,McCluskey J,Rossjohn J,Walz T,Garcia KC
User Manual
NM_000732.4
