CD3D cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD3D
Entrez Gene ID	915
Full Name	CD3d molecule
Synonyms	CD3-DELTA,IMD19,T3D
General protein information	Preferred Names CD3d molecule Names T-cell surface glycoprotein CD3 delta chain CD3 antigen, delta subunit CD3 delta CD3d antigen, delta polypeptide (TiT3 complex) CD3d molecule, delta (CD3-TCR complex) OKT3, delta chain T-cell receptor T3 delta chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009].
Disorder MIM:	186790
Disorder Html:	Immunodeficiency 19, 615617 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001040651.2	NP_001035741.1	T-cell surface glycoprotein CD3 delta chain isoform B precursor
XM_017018543.1	XP_016874032.1	T-cell surface glycoprotein CD3 delta chain isoform X1
NM_000732.4	NP_000723.1	T-cell surface glycoprotein CD3 delta chain isoform A precursor
NM_001040651.1	NP_001035741.1	T-cell surface glycoprotein CD3 delta chain isoform B precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CD3D	NP_000723.1
	CD3D	XP_001097302.1
Xenopus tropicalis (tropical clawed frog)	cd3g	NP_001135555.1
Bos taurus (cattle)	CD3D	NP_001029205.1
Rattus norvegicus (Norway rat)	Cd3d	NP_037301.1
Mus musculus (house mouse)	Cd3d	NP_038515.3
Gallus gallus (chicken)	CD3D	NP_990843.1
Pan troglodytes (chimpanzee)	CD3D	XP_508789.2
Canis lupus familiaris (dog)	CD3D	XP_536556.1

Gene Ontology
Bibliography

Related articles in PubMed

Balanced secretion of anti-CEA ? anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity.
M?lgaard K, Compte M, Nu?ez-Prado N, Harwood SL, Sanz L, Alvarez-Vallina L
Gene therapy24(4)208-214(2017 Apr)

CD3D and PRKCQ work together to discriminate between B-cell and T-cell acute lymphoblastic leukemia.
Ma D, Zhong S, Liu X, Mai H, Mai G, Xu C, Zhou F
Computers in biology and medicine7716-22(2016 10)

Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma.
Li X, Peng J, Pang Y, Yu S, Yu X, Chen P, Wang W, Han W, Zhang J, Yin Y, Zhang Y
Scientific reports514757(2015 Oct)

Identification of the Docking Site for CD3 on the T Cell Receptor ? Chain by Solution NMR.
He Y, Rangarajan S, Kerzic M, Luo M, Chen Y, Wang Q, Yin Y, Workman CJ, Vignali KM, Vignali DA, Mariuzza RA, Orban J
The Journal of biological chemistry290(32)19796-805(2015 Aug)

Molecular architecture of the ?? T cell receptor-CD3 complex.
Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC
Proceedings of the National Academy of Sciences of the United States of America111(49)17576-81(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we demonstrate that the incorporation of a 2A self-processing peptide derived from foot-and-mouth disease virus conveying co-translational cleavage into a two-chain anti-CD3 x anti-CEA diabody gene enables near-equimolar expression of diabody chains 1 and 2, and thus increases the final amount of assembled diabody.
Title: Balanced secretion of anti-CEA ? anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity.

PCR and transcriptome analysis suggest that the genes CD3D and PKRCQ together can be used as a model for differentiating between B-cell and T-cell acute lymphoblastic leukemia.
Title: CD3D and PRKCQ work together to discriminate between B-cell and T-cell acute lymphoblastic leukemia.

A FOXP3(+)CD3(+)CD56(+)-expressed T-cell population with immunosuppressive function and reduced patient survival has been identified in cancer tissues of human hepatocellular carcinoma.
Title: Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma.

The docking site for CD3 subunits on the T Cell receptor beta chain has been identified by solution NMR.
Title: Identification of the Docking Site for CD3 on the T Cell Receptor ? Chain by Solution NMR.

analysis of the molecular organization of the TCR-CD3 complex
Title: Molecular architecture of the ?? T cell receptor-CD3 complex.

The following CD3D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD3D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18375	NM_000732.4 Latest version!	Homo sapiens CD3d molecule (CD3D), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18375	XM_017018543.1 Latest version!	Homo sapiens CD3d molecule (CD3D), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu05021	NM_001040651.2 Latest version!	Homo sapiens CD3d molecule (CD3D), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu05021	NM_001040651.1	Homo sapiens CD3d molecule (CD3D), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD3D ( NM_000732.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000723.1 Homo sapiens CD3d molecule (CD3D), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18375
Clone ID Related Accession (Same CDS sequence)	XM_017018543.1 , NM_000732.4
Accession Version	NM_000732.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 delta chain isoform A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070321.1. This sequence is a reference standard in the RefSeqGene project. On May 18, 2006 this sequence version replaced NM_000732.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070321.1, BI907465.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142670, SAMEA2146236 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAACATA GCACGTTTCT CTCTGGCCTG GTACTGGCTA CCCTTCTCTC GCAAGTGAGC 
CCCTTCAAGA TACCTATAGA GGAACTTGAG GACAGAGTGT TTGTGAATTG CAATACCAGC 
ATCACATGGG TAGAGGGAAC GGTGGGAACA CTGCTCTCAG ACATTACAAG ACTGGACCTG 
GGAAAACGCA TCCTGGACCC ACGAGGAATA TATAGGTGTA ATGGGACAGA TATATACAAG 
GACAAAGAAT CTACCGTGCA AGTTCATTAT CGAATGTGCC AGAGCTGTGT GGAGCTGGAT 
CCAGCCACCG TGGCTGGCAT CATTGTCACT GATGTCATTG CCACTCTGCT CCTTGCTTTG 
GGAGTCTTCT GCTTTGCTGG ACATGAGACT GGAAGGCTGT CTGGGGCTGC CGACACACAA 
GCTCTGTTGA GGAATGACCA GGTCTATCAG CCCCTCCGAG ATCGAGATGA TGCTCAGTAC 
AGCCACCTTG GAGGAAACTG GGCTCGGAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000723.1
CDS	138..653
Translation	MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK

Target ORF information:

RefSeq Version	NM_000732.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CD3d molecule (CD3D), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000732.4

ORF Insert Sequence:

ATGGAACATA GCACGTTTCT CTCTGGCCTG GTACTGGCTA CCCTTCTCTC GCAAGTGAGC 
CCCTTCAAGA TACCTATAGA GGAACTTGAG GACAGAGTGT TTGTGAATTG CAATACCAGC 
ATCACATGGG TAGAGGGAAC GGTGGGAACA CTGCTCTCAG ACATTACAAG ACTGGACCTG 
GGAAAACGCA TCCTGGACCC ACGAGGAATA TATAGGTGTA ATGGGACAGA TATATACAAG 
GACAAAGAAT CTACCGTGCA AGTTCATTAT CGAATGTGCC AGAGCTGTGT GGAGCTGGAT 
CCAGCCACCG TGGCTGGCAT CATTGTCACT GATGTCATTG CCACTCTGCT CCTTGCTTTG 
GGAGTCTTCT GCTTTGCTGG ACATGAGACT GGAAGGCTGT CTGGGGCTGC CGACACACAA 
GCTCTGTTGA GGAATGACCA GGTCTATCAG CCCCTCCGAG ATCGAGATGA TGCTCAGTAC 
AGCCACCTTG GAGGAAACTG GGCTCGGAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD3D ( XM_017018543.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016874032.1 Homo sapiens CD3d molecule (CD3D), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu18375
Clone ID Related Accession (Same CDS sequence)	XM_017018543.1 , NM_000732.4
Accession Version	XM_017018543.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 delta chain isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAACATA GCACGTTTCT CTCTGGCCTG GTACTGGCTA CCCTTCTCTC GCAAGTGAGC 
CCCTTCAAGA TACCTATAGA GGAACTTGAG GACAGAGTGT TTGTGAATTG CAATACCAGC 
ATCACATGGG TAGAGGGAAC GGTGGGAACA CTGCTCTCAG ACATTACAAG ACTGGACCTG 
GGAAAACGCA TCCTGGACCC ACGAGGAATA TATAGGTGTA ATGGGACAGA TATATACAAG 
GACAAAGAAT CTACCGTGCA AGTTCATTAT CGAATGTGCC AGAGCTGTGT GGAGCTGGAT 
CCAGCCACCG TGGCTGGCAT CATTGTCACT GATGTCATTG CCACTCTGCT CCTTGCTTTG 
GGAGTCTTCT GCTTTGCTGG ACATGAGACT GGAAGGCTGT CTGGGGCTGC CGACACACAA 
GCTCTGTTGA GGAATGACCA GGTCTATCAG CCCCTCCGAG ATCGAGATGA TGCTCAGTAC 
AGCCACCTTG GAGGAAACTG GGCTCGGAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016874032.1
CDS	1038..1553
Translation	MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK

Target ORF information:

RefSeq Version	XM_017018543.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CD3d molecule (CD3D), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017018543.1

ORF Insert Sequence:

ATGGAACATA GCACGTTTCT CTCTGGCCTG GTACTGGCTA CCCTTCTCTC GCAAGTGAGC 
CCCTTCAAGA TACCTATAGA GGAACTTGAG GACAGAGTGT TTGTGAATTG CAATACCAGC 
ATCACATGGG TAGAGGGAAC GGTGGGAACA CTGCTCTCAG ACATTACAAG ACTGGACCTG 
GGAAAACGCA TCCTGGACCC ACGAGGAATA TATAGGTGTA ATGGGACAGA TATATACAAG 
GACAAAGAAT CTACCGTGCA AGTTCATTAT CGAATGTGCC AGAGCTGTGT GGAGCTGGAT 
CCAGCCACCG TGGCTGGCAT CATTGTCACT GATGTCATTG CCACTCTGCT CCTTGCTTTG 
GGAGTCTTCT GCTTTGCTGG ACATGAGACT GGAAGGCTGT CTGGGGCTGC CGACACACAA 
GCTCTGTTGA GGAATGACCA GGTCTATCAG CCCCTCCGAG ATCGAGATGA TGCTCAGTAC 
AGCCACCTTG GAGGAAACTG GGCTCGGAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD3D ( NM_001040651.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035741.1 Homo sapiens CD3d molecule (CD3D), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05021
Clone ID Related Accession (Same CDS sequence)	NM_001040651.2 , NM_001040651.1
Accession Version	NM_001040651.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 delta chain isoform B precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070321.1, CD014058.1 and AP001582.4. On Jun 2, 2019 this sequence version replaced NM_001040651.1. Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded protein (B) is shorter and lacks the transmembrane domain, compared to isoform A. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD014058.1, AI219691.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2146236, SAMEA2150385 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAACATA GCACGTTTCT CTCTGGCCTG GTACTGGCTA CCCTTCTCTC GCAAGTGAGC 
CCCTTCAAGA TACCTATAGA GGAACTTGAG GACAGAGTGT TTGTGAATTG CAATACCAGC 
ATCACATGGG TAGAGGGAAC GGTGGGAACA CTGCTCTCAG ACATTACAAG ACTGGACCTG 
GGAAAACGCA TCCTGGACCC ACGAGGAATA TATAGGTGTA ATGGGACAGA TATATACAAG 
GACAAAGAAT CTACCGTGCA AGTTCATTAT CGAACTGCCG ACACACAAGC TCTGTTGAGG 
AATGACCAGG TCTATCAGCC CCTCCGAGAT CGAGATGATG CTCAGTACAG CCACCTTGGA 
GGAAACTGGG CTCGGAACAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035741.1
CDS	99..482
Translation	MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRTADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK

Target ORF information:

RefSeq Version	NM_001040651.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD3d molecule (CD3D), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040651.2

ORF Insert Sequence:

ATGGAACATA GCACGTTTCT CTCTGGCCTG GTACTGGCTA CCCTTCTCTC GCAAGTGAGC 
CCCTTCAAGA TACCTATAGA GGAACTTGAG GACAGAGTGT TTGTGAATTG CAATACCAGC 
ATCACATGGG TAGAGGGAAC GGTGGGAACA CTGCTCTCAG ACATTACAAG ACTGGACCTG 
GGAAAACGCA TCCTGGACCC ACGAGGAATA TATAGGTGTA ATGGGACAGA TATATACAAG 
GACAAAGAAT CTACCGTGCA AGTTCATTAT CGAACTGCCG ACACACAAGC TCTGTTGAGG 
AATGACCAGG TCTATCAGCC CCTCCGAGAT CGAGATGATG CTCAGTACAG CCACCTTGGA 
GGAAACTGGG CTCGGAACAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD3D ( NM_001040651.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035741.1 Homo sapiens CD3d molecule (CD3D), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05021
Clone ID Related Accession (Same CDS sequence)	NM_001040651.2 , NM_001040651.1
Accession Version	NM_001040651.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 delta chain isoform B precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070321.1 and CD014058.1. Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded protein (B) is shorter and lacks the transmembrane domain, compared to isoform A. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD014058.1, AI219691.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2146236, SAMEA2150385 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAACATA GCACGTTTCT CTCTGGCCTG GTACTGGCTA CCCTTCTCTC GCAAGTGAGC 
CCCTTCAAGA TACCTATAGA GGAACTTGAG GACAGAGTGT TTGTGAATTG CAATACCAGC 
ATCACATGGG TAGAGGGAAC GGTGGGAACA CTGCTCTCAG ACATTACAAG ACTGGACCTG 
GGAAAACGCA TCCTGGACCC ACGAGGAATA TATAGGTGTA ATGGGACAGA TATATACAAG 
GACAAAGAAT CTACCGTGCA AGTTCATTAT CGAACTGCCG ACACACAAGC TCTGTTGAGG 
AATGACCAGG TCTATCAGCC CCTCCGAGAT CGAGATGATG CTCAGTACAG CCACCTTGGA 
GGAAACTGGG CTCGGAACAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035741.1
CDS	138..521
Translation	MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRTADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK

Target ORF information:

RefSeq Version	NM_001040651.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CD3d molecule (CD3D), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040651.1

ORF Insert Sequence:

ATGGAACATA GCACGTTTCT CTCTGGCCTG GTACTGGCTA CCCTTCTCTC GCAAGTGAGC 
CCCTTCAAGA TACCTATAGA GGAACTTGAG GACAGAGTGT TTGTGAATTG CAATACCAGC 
ATCACATGGG TAGAGGGAAC GGTGGGAACA CTGCTCTCAG ACATTACAAG ACTGGACCTG 
GGAAAACGCA TCCTGGACCC ACGAGGAATA TATAGGTGTA ATGGGACAGA TATATACAAG 
GACAAAGAAT CTACCGTGCA AGTTCATTAT CGAACTGCCG ACACACAAGC TCTGTTGAGG 
AATGACCAGG TCTATCAGCC CCTCCGAGAT CGAGATGATG CTCAGTACAG CCACCTTGGA 
GGAAACTGGG CTCGGAACAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Balanced secretion of anti-CEA ? anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity.
Gene therapy24(4)208-214(2017 Apr)
M?lgaard K,Compte M,Nu?ez-Prado N,Harwood SL,Sanz L,Alvarez-Vallina L

CD3D and PRKCQ work together to discriminate between B-cell and T-cell acute lymphoblastic leukemia.
Computers in biology and medicine7716-22(2016 10)
Ma D,Zhong S,Liu X,Mai H,Mai G,Xu C,Zhou F

Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma.
Scientific reports514757(2015 Oct)
Li X,Peng J,Pang Y,Yu S,Yu X,Chen P,Wang W,Han W,Zhang J,Yin Y,Zhang Y

Identification of the Docking Site for CD3 on the T Cell Receptor ? Chain by Solution NMR.
The Journal of biological chemistry290(32)19796-805(2015 Aug)
He Y,Rangarajan S,Kerzic M,Luo M,Chen Y,Wang Q,Yin Y,Workman CJ,Vignali KM,Vignali DA,Mariuzza RA,Orban J

Molecular architecture of the ?? T cell receptor-CD3 complex.
Proceedings of the National Academy of Sciences of the United States of America111(49)17576-81(2014 Dec)
Birnbaum ME,Berry R,Hsiao YS,Chen Z,Shingu-Vazquez MA,Yu X,Waghray D,Fischer S,McCluskey J,Rossjohn J,Walz T,Garcia KC

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CD3D cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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