Gene Symbol | GMFG |
Entrez Gene ID | 9535 |
Full Name | glia maturation factor gamma |
Synonyms | GMF-GAMMA |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » GMFG cDNA ORF clone
Gene Symbol | GMFG |
Entrez Gene ID | 9535 |
Full Name | glia maturation factor gamma |
Synonyms | GMF-GAMMA |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001301008.1 | NP_001287937.1 | glia maturation factor gamma isoform 2 |
NM_004877.3 | NP_004868.1 | glia maturation factor gamma isoform 1 |
NM_004877.4 | NP_004868.1 | glia maturation factor gamma isoform 1 |
NM_001301008.2 | NP_001287937.1 | glia maturation factor gamma isoform 2 |
Mus musculus (house mouse) | Gmfg | NP_071307.1 |
Canis lupus familiaris (dog) | GMFG | XP_853348.2 |
Homo sapiens (human) | GMFG | NP_004868.1 |
Bos taurus (cattle) | GMFG | NP_001019708.1 |
Caenorhabditis elegans (roundworm) | Y50D7A.10 | NP_871652.2 |
Xenopus tropicalis (tropical clawed frog) | gmfg | NP_001025651.1 |
Pan troglodytes (chimpanzee) | GMFG | XP_512648.2 |
Rattus norvegicus (Norway rat) | Gmfg | NP_851605.1 |
Mus musculus (house mouse) | Gm9835 | XP_006505279.1 |
Danio rerio (zebrafish) | gmfg | NP_001035136.1 |
Expression of glia maturation factor ? is associated with colorectal cancer metastasis and its downregulation suppresses colorectal cancer cell migration and invasion in vitro.
Wang H, Chen Z, Chang H, Mu X, Deng W, Yuan Z, Yao F, Liu Y, Mai R, Wu B
Oncology reports37(2)929-936(2017 Feb)
Glia Maturation Factor-? Regulates Monocyte Migration through Modulation of ?1-Integrin.
Aerbajinai W, Liu L, Zhu J, Kumkhaek C, Chin K, Rodgers GP
The Journal of biological chemistry291(16)8549-64(2016 Apr)
Glia maturation factor-? phosphorylation at Tyr-104 regulates actin dynamics and contraction in human airway smooth muscle.
Wang T, Cleary RA, Wang R, Tang DD
American journal of respiratory cell and molecular biology51(5)652-9(2014 Nov)
Glia maturation factor (GMF) interacts with Arp2/3 complex in a nucleotide state-dependent manner.
Boczkowska M, Rebowski G, Dominguez R
The Journal of biological chemistry288(36)25683-8(2013 Sep)
Glia maturation factor-? negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages.
Aerbajinai W, Lee K, Chin K, Rodgers GP
Journal of immunology (Baltimore, Md. : 1950)190(12)6093-103(2013 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
High GMF-GAMMA expression is associated with colorectal cancer metastasis.
Title: Expression of glia maturation factor ? is associated with colorectal cancer metastasis and its downregulation suppresses colorectal cancer cell migration and invasion in vitro.
These results indicate that the effects of GMFG on monocyte migration and adhesion probably occur through preventing ubiquitin-mediated proteasome degradation of alpha5beta1-integrin and facilitating effective beta1-integrin recycling back to the plasma membrane.
Title: Glia Maturation Factor-? Regulates Monocyte Migration through Modulation of ?1-Integrin.
In this study, knockdown of GMF-gamma by RNA interference enhanced actin polymerization and contraction in human airway smooth muscle (HASM) cells and tissues without affecting myosin phosphorylation.
Title: Glia maturation factor-? phosphorylation at Tyr-104 regulates actin dynamics and contraction in human airway smooth muscle.
Together, the results suggest that GMFG functions by a mechanism similar to that of other ADF/cofilin family members, displaying a preference for ADP-Arp2/3 complex and undergoing inhibition by phosphorylation of a serine residue near the N terminus.
Title: Glia maturation factor (GMF) interacts with Arp2/3 complex in a nucleotide state-dependent manner.
our findings suggest that GMFG functions as a negative regulator of TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages
Title: Glia maturation factor-? negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages.
The following GMFG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GMFG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu04667 | |
Clone ID Related Accession (Same CDS sequence) | NM_004877.3 , NM_004877.4 | |
Accession Version | NM_004877.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | glia maturation factor gamma isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF974742.1, BC080180.1 and AA648706.1. On Jul 18, 2014 this sequence version replaced NM_004877.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.609773.1, BF974742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159764 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCTGACT CCCTGGTGGT GTGCGAGGTA GACCCAGAGC TAACAGAAAA GCTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_004868.1 |
CDS | 111..539 |
Translation |
Target ORF information:
Target ORF information:
|
NM_004877.3 |
1 | ATGTCTGACT CCCTGGTGGT GTGCGAGGTA GACCCAGAGC TAACAGAAAA GCTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu04667 | |
Clone ID Related Accession (Same CDS sequence) | NM_004877.3 , NM_004877.4 | |
Accession Version | NM_004877.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Homo sapiens(human) | |
Product | glia maturation factor gamma isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF974742.1 and BC080180.1. On Nov 22, 2018 this sequence version replaced NM_004877.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF974742.1, BU687769.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159764 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000597595.6/ ENSP00000472249.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGTCTGACT CCCTGGTGGT GTGCGAGGTA GACCCAGAGC TAACAGAAAA GCTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_004868.1 |
CDS | 68..496 |
Translation |
Target ORF information:
Target ORF information:
|
NM_004877.4 |
1 | ATGTCTGACT CCCTGGTGGT GTGCGAGGTA GACCCAGAGC TAACAGAAAA GCTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu52637 | |
Clone ID Related Accession (Same CDS sequence) | NM_001301008.1 , NM_001301008.2 | |
Accession Version | NM_001301008.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-29 | |
Organism | Homo sapiens(human) | |
Product | glia maturation factor gamma isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF974742.1, AV714415.1, BC080180.1 and AA648706.1. On Jul 18, 2014 this sequence version replaced XM_005259440.2. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.481468.1, AV714415.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGTGGTGC TGGAGGAAGA ATTTCAGAAC ATTTCCCCAG AGGAGCTCAA AATGGAGTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001287937.1 |
CDS | 137..442 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001301008.1 |
1 | ATGGTGGTGC TGGAGGAAGA ATTTCAGAAC ATTTCCCCAG AGGAGCTCAA AATGGAGTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu52637 | |
Clone ID Related Accession (Same CDS sequence) | NM_001301008.1 , NM_001301008.2 | |
Accession Version | NM_001301008.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | glia maturation factor gamma isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF974742.1, AV714415.1 and BC080180.1. On May 31, 2019 this sequence version replaced NM_001301008.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.481468.1, AV714415.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGTGGTGC TGGAGGAAGA ATTTCAGAAC ATTTCCCCAG AGGAGCTCAA AATGGAGTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001287937.1 |
CDS | 94..399 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001301008.2 |
1 | ATGGTGGTGC TGGAGGAAGA ATTTCAGAAC ATTTCCCCAG AGGAGCTCAA AATGGAGTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Expression of glia maturation factor ? is associated with colorectal cancer metastasis and its downregulation suppresses colorectal cancer cell migration and invasion in vitro. |
Glia Maturation Factor-? Regulates Monocyte Migration through Modulation of ?1-Integrin. |
Glia maturation factor-? phosphorylation at Tyr-104 regulates actin dynamics and contraction in human airway smooth muscle. |
Glia maturation factor (GMF) interacts with Arp2/3 complex in a nucleotide state-dependent manner. |
Glia maturation factor-? negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages. |