Gene Symbol | Adh5 |
Entrez Gene ID | 11532 |
Full Name | alcohol dehydrogenase 5 (class III), chi polypeptide |
Synonyms | Adh-5,Adh3,GSNOR |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Adh5 cDNA ORF clone
gRNAs
Gene Symbol | Adh5 |
Entrez Gene ID | 11532 |
Full Name | alcohol dehydrogenase 5 (class III), chi polypeptide |
Synonyms | Adh-5,Adh3,GSNOR |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001288578.1 | NP_001275507.1 | alcohol dehydrogenase class-3 isoform 2 |
NM_007410.3 | NP_031436.2 | alcohol dehydrogenase class-3 isoform 1 |
Bos taurus (cattle) | ADH5 | NP_001029421.1 |
Eremothecium gossypii | AGOS_ACL148C | NP_983256.1 |
Schizosaccharomyces pombe (fission yeast) | SPCC13B11.04c | NP_588247.1 |
Xenopus tropicalis (tropical clawed frog) | adh5 | NP_001011502.1 |
Canis lupus familiaris (dog) | ADH5 | NP_001239084.1 |
Saccharomyces cerevisiae (baker's yeast) | SFA1 | NP_010113.1 |
Kluyveromyces lactis | KLLA0D12342g | XP_453612.1 |
Oryza sativa (rice) | Os02g0815500 | NP_001048503.1 |
Homo sapiens (human) | ADH5 | NP_000662.3 |
Pan troglodytes (chimpanzee) | ADH5 | XP_001166206.1 |
Mus musculus (house mouse) | Adh5 | NP_031436.2 |
Rattus norvegicus (Norway rat) | Adh5 | NP_001119592.1 |
Gallus gallus (chicken) | ADH5 | NP_001026323.1 |
Caenorhabditis elegans (roundworm) | H24K24.3 | NP_001024016.1 |
Caenorhabditis elegans (roundworm) | Y50D4C.2 | NP_503357.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_06011 | XP_003711858.1 |
LOC697703 | XP_001088376.1 | |
Danio rerio (zebrafish) | adh5 | NP_571924.2 |
Drosophila melanogaster (fruit fly) | Fdh | NP_524310.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010499 | XP_314472.4 |
Neurospora crassa | NCU06652 | XP_960697.1 |
Arabidopsis thaliana (thale cress) | HOT5 | NP_199207.1 |
Qian Q, Zhang Z, Orwig A, Chen S, Ding WX, Xu Y, Kunz RC, Lind NRL, Stamler JS, Yang L
Diabetes67(2)193-207(2018 Feb)
Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKII?.
Zhang Y, Wu K, Su W, Zhang DF, Wang P, Qiao X, Yao Q, Yuan Z, Yao YG, Liu G, Zhang C, Liu L, Chen C
The Journal of neuroscience : the official journal of the Society for Neuroscience37(40)9741-9758(2017 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Increased GSNOR expression during aging decreases S-nitrosation of CaMKIIalpha and reduces CaMKIIalpha synaptosomal accumulation.
Title: Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKII?.
GSNOR may act as a "brake" on skeletal muscle contractile performance under physiological conditions by modulating nitrosylation/denitrosylation balance.
Title: GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity.
Report inhibition of GSNOR activity by nebivolol leading to accumulation of nitrosothiols in cells, and this is associated with an enhanced vasodilation by S-nitrosoglutathione.
Title: Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor: A New Mechanism of Action.
Results show that ADH5 removes endogenous formaldehyde to prevent DNA adducts, and protects with FANCD2, hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage.
Title: Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.
The following Adh5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adh5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu19827 | |
Clone ID Related Accession (Same CDS sequence) | NM_001288578.1 | |
Accession Version | NM_001288578.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Mus musculus(house mouse) | |
Product | alcohol dehydrogenase class-3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF172597.1 and AK076507.1. Transcript Variant: This variant (2) has an alternate 5' exon, which results in translation intiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AK002790.1, SRR1660817.434017.1 [ECO:0000331] ##Evidence-Data-END## |
1 | ATGCCAGATG GGACTAGCAG ATTTACCTGC AAAGGAAAGT CTGTTTTTCA CTTCATGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001275507.1 |
CDS | 438..1196 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCAGATG GGACTAGCAG ATTTACCTGC AAAGGAAAGT CTGTTTTTCA CTTCATGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23236 | |
Clone ID Related Accession (Same CDS sequence) | NM_007410.3 | |
Accession Version | NM_007410.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Mus musculus(house mouse) | |
Product | alcohol dehydrogenase class-3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY125542.1 and AK076507.1. On Dec 21, 2013 this sequence version replaced NM_007410.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK076507.1, AK159803.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGAACC AGGTGATCAG GTGTAAGGCT GCAGTCGCCT GGGAGGCGGG AAAGCCTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_031436.2 |
CDS | 90..1214 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGCGAACC AGGTGATCAG GTGTAAGGCT GCAGTCGCCT GGGAGGCGGG AAAGCCTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
|
Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKII?. |