Gene Symbol | Dclre1b |
Entrez Gene ID | 140917 |
Full Name | DNA cross-link repair 1B |
Synonyms | AI452214,Apollo,SNMIB,mSNM1B |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Dclre1b cDNA ORF clone
gRNAs
Gene Symbol | Dclre1b |
Entrez Gene ID | 140917 |
Full Name | DNA cross-link repair 1B |
Synonyms | AI452214,Apollo,SNMIB,mSNM1B |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001025312.1 | NP_001020483.1 | 5' exonuclease Apollo isoform b |
NM_133865.2 | NP_598626.2 | 5' exonuclease Apollo isoform a |
Danio rerio (zebrafish) | dclre1b | NP_001070751.1 |
Canis lupus familiaris (dog) | DCLRE1B | XP_848274.1 |
Rattus norvegicus (Norway rat) | Dclre1b | NP_001020858.1 |
Gallus gallus (chicken) | DCLRE1B | NP_001026671.2 |
Arabidopsis thaliana (thale cress) | AT1G27410 | NP_174061.1 |
Pan troglodytes (chimpanzee) | DCLRE1B | XP_524804.1 |
Xenopus tropicalis (tropical clawed frog) | dclre1b | XP_002932166.1 |
DCLRE1B | XP_001110949.1 | |
Bos taurus (cattle) | DCLRE1B | XP_002686220.1 |
Oryza sativa (rice) | Os01g0783400 | NP_001044453.2 |
Homo sapiens (human) | DCLRE1B | NP_073747.1 |
Mus musculus (house mouse) | Dclre1b | NP_598626.2 |
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
Wu P, Takai H, de Lange T
Cell150(1)39-52(2012 Jul)
The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.
Akhter S, Lam YC, Chang S, Legerski RJ
Aging cell9(6)1047-56(2010 Dec)
Apollo contributes to G overhang maintenance and protects leading-end telomeres.
Wu P, van Overbeek M, Rooney S, de Lange T
Molecular cell39(4)606-17(2010 Aug)
SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.
Lam YC, Akhter S, Gu P, Ye J, Poulet A, Giraud-Panis MJ, Bailey SM, Gilson E, Legerski RJ, Chang S
The EMBO journal29(13)2230-41(2010 Jul)
SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.
Akhter S, Legerski RJ
Biochemical and biophysical research communications377(1)236-41(2008 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Study documents the combinatorial action of Apollo, POT1b, CST, and the 5' exonuclease Exo1 in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
Title: Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development
Title: The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.
TRF2-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM signaling, and protecting leading-end telomeres from fusion.
Title: Apollo contributes to G overhang maintenance and protects leading-end telomeres.
Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.
Title: SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.
The following Dclre1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dclre1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu10288 | |
Clone ID Related Accession (Same CDS sequence) | NM_133865.2 | |
Accession Version | NM_133865.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1626bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | 5' exonuclease Apollo isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA548899.1, AK049115.1, AK084347.1 and BC067017.1. On Jul 13, 2005 this sequence version replaced NM_133865.1. ##Evidence-Data-START## Transcript exon combination :: AK137495.1, AK134324.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAACGGGG TCGTAATCCC CCAAACGCCC ATTGCTGTGG ACTTTTGGAG CCTGCGCCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_598626.2 |
CDS | 300..1925 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGAACGGGG TCGTAATCCC CCAAACGCCC ATTGCTGTGG ACTTTTGGAG CCTGCGCCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu12093 | |
Clone ID Related Accession (Same CDS sequence) | NM_001025312.1 | |
Accession Version | NM_001025312.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-19 | |
Organism | Mus musculus(house mouse) | |
Product | 5' exonuclease Apollo isoform b | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ559794.1, BC067017.1 and CA317555.1. ##Evidence-Data-START## Transcript exon combination :: BC067017.1, AK084347.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCTGAAGG AACCTGCTCT GATACTGGGG AAACAGATTC ATACTTTGTA TCTAGACAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001020483.1 |
CDS | 512..1759 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGAAGG AACCTGCTCT GATACTGGGG AAACAGATTC ATACTTTGTA TCTAGACAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST. |
The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development. |
Apollo contributes to G overhang maintenance and protects leading-end telomeres. |
SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. |
SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. |