Grap2 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Grap2 |
| Entrez Gene ID | 17444 |
| Full Name | GRB2-related adaptor protein 2 |
| Synonyms | GRAP-2,GRB2L,GRBLG,GRID,Gads,GrbX,Grf40,GrpL,Mona,P38 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001289442.1 | NP_001276371.1 | GRB2-related adaptor protein 2 |
| NM_010815.3 | NP_034945.1 | GRB2-related adaptor protein 2 |
| Rattus norvegicus (Norway rat) | Grap2 | NP_001030116.1 |
| Gallus gallus (chicken) | GRAP2 | XP_004937789.1 |
| Danio rerio (zebrafish) | grap2b | NP_956972.1 |
| Canis lupus familiaris (dog) | GRAP2 | XP_005625915.1 |
| Mus musculus (house mouse) | Grap2 | NP_034945.1 |
| Xenopus tropicalis (tropical clawed frog) | grap2 | XP_002933793.1 |
| Homo sapiens (human) | GRAP2 | NP_004801.1 |
| GRAP2 | XP_001100458.2 | |
| Bos taurus (cattle) | GRAP2 | NP_001179489.1 |
| Danio rerio (zebrafish) | grap2a | NP_001017756.1 |
| Pan troglodytes (chimpanzee) | GRAP2 | XP_001166508.1 |
Related articles in PubMed
Expression of GADS enhances FLT3-induced mitogenic signaling.
Chougule RA, Cordero E, Moharram SA, Pietras K, R?nnstrand L, Kazi JU
Oncotarget7(12)14112-24(2016 Mar)
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.
Dufner A, Kisser A, Niendorf S, Basters A, Reissig S, Sch?nle A, Aichem A, Kurz T, Schlosser A, Yablonski D, Groettrup M, Buch T, Waisman A, Schamel WW, Prinz M, Knobeloch KP
Nature immunology16(9)950-60(2015 Sep)
The combined loss of Gads and CD127 reveals a novel function of Gads prior to TCR? expression.
Xiong J, Parker BL, Yankee TM
Immunologic research60(1)77-84(2014 Oct)
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, L?hdesm?ki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B
Nature immunology15(4)384-392(2014 Apr)
Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia.
Gillis LC, Berry DM, Minden MD, McGlade CJ, Barber DL
Leukemia27(8)1666-76(2013 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
High GADS expression is associated with neoplasms.
Title: Expression of GADS enhances FLT3-induced mitogenic signaling.
The combined loss of Gads and CD127 reveals a novel function of Gads prior to T cell receptor beta expression
Title: The combined loss of Gads and CD127 reveals a novel function of Gads prior to TCR? expression.
GADS mediates lymphoid disease downstream of BCR-ABL through the recruitment of specific signaling intermediates.
Title: Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia.
Data show that the primary function of Gads is to regulate the sensitivity of the TCR to Ag ligation.
Title: Gads regulates the expansion phase of CD8+ T cell-mediated immunity.
Gads plays a key role in linking the adapter LAT to SLP-76 in response to weak activation of GPVI and CLEC-2 whereas LAT is required for full activation over a wider range of agonist concentrations.
Title: Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.
The following Grap2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Grap2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu14074 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001289442.1 , NM_010815.3 | |
| Accession Version | NM_001289442.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-19 | |
| Organism | Mus musculus(house mouse) | |
| Product | GRB2-related adaptor protein 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC052496.1 and AC147041.3. On Jan 22, 2014 this sequence version replaced XM_006520559.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC052496.1, AK156939.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGAAGCCA CTGCCAAGTT TGATTTCATG GCCTCAGGTG AGGACGAACT GAGCTTTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001276371.1 |
| CDS | 160..1128 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001289442.1 |
ORF Insert Sequence:
1 | ATGGAAGCCA CTGCCAAGTT TGATTTCATG GCCTCAGGTG AGGACGAACT GAGCTTTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu14074 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001289442.1 , NM_010815.3 | |
| Accession Version | NM_010815.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-19 | |
| Organism | Mus musculus(house mouse) | |
| Product | GRB2-related adaptor protein 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC147041.3. On Jan 22, 2014 this sequence version replaced NM_010815.2. Transcript Variant: This variant (1) represents the longer variant. Variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF055465.1, AK156939.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGAAGCCA CTGCCAAGTT TGATTTCATG GCCTCAGGTG AGGACGAACT GAGCTTTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_034945.1 |
| CDS | 255..1223 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_010815.3 |
ORF Insert Sequence:
1 | ATGGAAGCCA CTGCCAAGTT TGATTTCATG GCCTCAGGTG AGGACGAACT GAGCTTTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Expression of GADS enhances FLT3-induced mitogenic signaling. |
|
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. |
|
The combined loss of Gads and CD127 reveals a novel function of Gads prior to TCR? expression. |
|
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. |
|
Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia. |