Gene Symbol | Cngb3 |
Entrez Gene ID | 30952 |
Full Name | cyclic nucleotide gated channel beta 3 |
Synonyms | CCNC2,CNG6,Cngbeta2 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Cngb3 cDNA ORF clone
gRNAs
Gene Symbol | Cngb3 |
Entrez Gene ID | 30952 |
Full Name | cyclic nucleotide gated channel beta 3 |
Synonyms | CCNC2,CNG6,Cngbeta2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_013927.2 | NP_038955.1 | cyclic nucleotide-gated cation channel beta-3 |
Pan troglodytes (chimpanzee) | CNGB3 | XP_519846.2 |
Homo sapiens (human) | CNGB3 | NP_061971.3 |
CNGB3 | XP_001083646.1 | |
Bos taurus (cattle) | CNGB3 | XP_002692873.2 |
Danio rerio (zebrafish) | cngb3 | XP_691142.4 |
Canis lupus familiaris (dog) | CNGB3 | NP_001003030.1 |
Rattus norvegicus (Norway rat) | Cngb3 | NP_001258167.1 |
Danio rerio (zebrafish) | LOC562466 | XP_690937.4 |
Xenopus tropicalis (tropical clawed frog) | cngb3 | XP_002939202.2 |
Mus musculus (house mouse) | Cngb3 | NP_038955.1 |
Gallus gallus (chicken) | CNGB3 | XP_425928.4 |
Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration.
Ma H, Yang F, Butler MR, Belcher J, Redmond TM, Placzek AT, Scanlan TS, Ding XQ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(8)3425-3438(2017 Aug)
Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration.
Yang F, Ma H, Belcher J, Butler MR, Redmond TM, Boye SL, Hauswirth WW, Ding XQ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(12)4313-4325(2016 12)
The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility.
Ding XQ, Thapa A, Ma H, Xu J, Elliott MH, Rodgers KK, Smith ML, Wang JS, Pittler SJ, Kefalov VJ
The Journal of biological chemistry291(16)8721-34(2016 Apr)
Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia.
Marangoni D, Vijayasarathy C, Bush RA, Wei LL, Wen R, Sieving PA
Investigative ophthalmology & visual science56(11)6810-22(2015 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CNGB3 regulates cone light response kinetics and the channel structural flexibility.
Title: The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility.
This work investigated the functional modulation of cone CNG channel by exploring the channel-interacting proteins.
Title: Exploration of cone cyclic nucleotide-gated channel-interacting proteins using affinity purification and mass spectrometry.
Cone CNG channel is a heterotetrameric complex likely at a stoichiometry of three CNGA3 and one CNGB3.
Title: Biochemical characterization of cone cyclic nucleotide-gated (CNG) channel using the infrared fluorescence detection system.
RDS does not interact with the cone CNG.
Title: RDS in cones does not interact with the beta subunit of the cyclic nucleotide gated channel.
The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry
Title: The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry.
The following Cngb3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cngb3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu20015 | |
Clone ID Related Accession (Same CDS sequence) | NM_013927.2 | |
Accession Version | NM_013927.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2085bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-09 | |
Organism | Mus musculus(house mouse) | |
Product | cyclic nucleotide-gated cation channel beta-3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX001053.7, AL772281.7, BX640400.4 and AL683894.6. On Nov 17, 2006 this sequence version replaced NM_013927.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ243572.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01164138, SAMN01164141 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGTTAAAAT CACTGACAGT AAAATTCAAC AAAGTGAATC CCATGGAAGG GAGAATGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_038955.1 |
CDS | 84..2168 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGTTAAAAT CACTGACAGT AAAATTCAAC AAAGTGAATC CCATGGAAGG GAGAATGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration. |
Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration. |
The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility. |
Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia. |