Gene Symbol | Jph2 |
Entrez Gene ID | 59091 |
Full Name | junctophilin 2 |
Synonyms | 1110002E14Rik,JP-2,Jp2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Jph2 cDNA ORF clone
gRNAs
Gene Symbol | Jph2 |
Entrez Gene ID | 59091 |
Full Name | junctophilin 2 |
Synonyms | 1110002E14Rik,JP-2,Jp2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006499972.2 | XP_006500035.1 | junctophilin-2 isoform X1 |
NM_021566.2 | NP_067541.1 | junctophilin-2 |
NM_001205076.1 | NP_001192005.1 | junctophilin-2 |
Xenopus tropicalis (tropical clawed frog) | jph2 | XP_002933232.1 |
Bos taurus (cattle) | JPH2 | XP_002692371.3 |
Rattus norvegicus (Norway rat) | Jph2 | NP_001033063.1 |
Gallus gallus (chicken) | JPH2 | XP_001234186.3 |
JPH2 | XP_001083346.1 | |
Mus musculus (house mouse) | Jph2 | NP_001192005.1 |
Homo sapiens (human) | JPH2 | NP_065166.2 |
Pan troglodytes (chimpanzee) | JPH2 | XP_525332.2 |
Danio rerio (zebrafish) | jph2 | NP_001082833.1 |
Functional interaction of Junctophilin 2 with small- conductance Ca
Fan HK, Luo TX, Zhao WD, Mu YH, Yang Y, Guo WJ, Tu HY, Zhang Q
Acta physiologica (Oxford, England)(2017 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This molecular rearrangement is compatible with direct inhibition of RyR opening by junctophilin-2 to intrinsically stabilise the Ca(2+) signalling properties of the junction and thus the contractile function of the cell.
Title: Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes.
These results suggested that NCX1 may play an important role in the proper spatial distribution of LTCC and JP2 in T-tubules in the context of pressure-overloading.
Title: Effects of induced Na
Junctophilin-2 is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 truncations.
Title: Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.
overexpression of JP2 provided significantly protective benefits after pressure overload
Title: Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress.
Our data identify a mechanistic link between microtubule densification and T-tubule remodeling and reveal microtubule-mediated JP2 redistribution as a novel mechanism for T-tubule disruption, loss of excitation-contraction coupling, and heart failure.
Title: Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.
The following Jph2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jph2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu02759 | |
Clone ID Related Accession (Same CDS sequence) | XM_006499972.2 , NM_021566.2 , NM_001205076.1 | |
Accession Version | NM_021566.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | junctophilin-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL589876.11 and AB024447.1. On Mar 23, 2011 this sequence version replaced NM_021566.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB024447.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGCGGGG GCCGCTTTGA CTTTGATGAT GGCGGGGCGT ATTGTGGGGG CTGGGAAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_067541.1 |
CDS | 448..2538 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGAGCGGGG GCCGCTTTGA CTTTGATGAT GGCGGGGCGT ATTGTGGGGG CTGGGAAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02759 | |
Clone ID Related Accession (Same CDS sequence) | XM_006499972.2 , NM_021566.2 , NM_001205076.1 | |
Accession Version | NM_001205076.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | junctophilin-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL589876.11. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK157145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGCGGGG GCCGCTTTGA CTTTGATGAT GGCGGGGCGT ATTGTGGGGG CTGGGAAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001192005.1 |
CDS | 368..2458 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGCGGGG GCCGCTTTGA CTTTGATGAT GGCGGGGCGT ATTGTGGGGG CTGGGAAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02759 | |
Clone ID Related Accession (Same CDS sequence) | XM_006499972.2 , NM_021566.2 , NM_001205076.1 | |
Accession Version | XM_006499972.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | junctophilin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006499972.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCGGGG GCCGCTTTGA CTTTGATGAT GGCGGGGCGT ATTGTGGGGG CTGGGAAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006500035.1 |
CDS | 524..2614 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGCGGGG GCCGCTTTGA CTTTGATGAT GGCGGGGCGT ATTGTGGGGG CTGGGAAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Functional interaction of Junctophilin 2 with small- conductance Ca |
A nanoscale view of junctophilin-2 and ryanodine receptors. |