Gene Symbol | Dusp9 |
Entrez Gene ID | 75590 |
Full Name | dual specificity phosphatase 9 |
Synonyms | Dusp4,Mpk4,Pyst3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Dusp9 cDNA ORF clone
gRNAs
Gene Symbol | Dusp9 |
Entrez Gene ID | 75590 |
Full Name | dual specificity phosphatase 9 |
Synonyms | Dusp4,Mpk4,Pyst3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006528333.1 | XP_006528396.1 | dual specificity protein phosphatase 9 isoform X2 |
NM_029352.3 | NP_083628.3 | dual specificity protein phosphatase 9 |
XM_006528331.1 | XP_006528394.1 | dual specificity protein phosphatase 9 isoform X1 |
Homo sapiens (human) | DUSP9 | NP_001386.1 |
DUSP9 | XP_001084096.1 | |
Canis lupus familiaris (dog) | DUSP9 | XP_549360.4 |
Bos taurus (cattle) | DUSP9 | NP_001179956.1 |
Rattus norvegicus (Norway rat) | Dusp9 | NP_001033062.1 |
Mus musculus (house mouse) | Dusp9 | NP_083628.3 |
Xenopus tropicalis (tropical clawed frog) | LOC100493388 | XP_002935558.1 |
DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.
Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, Park PJ, Gygi SP, Meissner A, Hochedlinger K
Cell stem cell20(5)706-719.e7(2017 May)
Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-? Production.
Niedzielska M, Raffi FA, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt UK, Wirtz S, Sparwasser T, Hochrein H, Figdor CG, Keyse SM, Lang R
Journal of immunology (Baltimore, Md. : 1950)195(4)1753-62(2015 Aug)
Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development.
Finelli MJ, Murphy KJ, Chen L, Zou H
Cell reports3(5)1592-606(2013 May)
BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells.
Li Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG
Cell stem cell10(2)171-82(2012 Feb)
Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.
Dickinson RJ, Delavaine L, Cejudo-Mar?n R, Stewart G, Staples CJ, Didmon MP, Trinidad AG, Alonso A, Pulido R, Keyse SM
The Journal of biological chemistry286(44)38018-26(2011 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
we have identified in this study the MAPK phosphatase Dusp9 as selectively expressed in mouse pDCs.
Title: Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-? Production.
these findings identify DUSP9 as a critical mediator of BMP signaling to control appropriate ERK activity critical for ESC fate determination.
Title: BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells.
DUSP9/MKP-4 is a bona fide target of PKA signaling and attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK signaling through both ERK1/2 and p38alpha in vivo
Title: Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.
Dusp9 has a protective effect against the development of insulin resistance through its ability to dephosphorylate and inactivate crucial mediators of stress-induced insulin resistance, such as ERK and JNK
Title: Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
Data show that Dusp9 transcripts is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development.
Title: Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development.
The following Dusp9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dusp9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu06858 | |
Clone ID Related Accession (Same CDS sequence) | NM_029352.3 | |
Accession Version | NM_029352.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-26 | |
Organism | Mus musculus(house mouse) | |
Product | dual specificity protein phosphatase 9 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY316312.1. On Jul 13, 2003 this sequence version replaced NM_029352.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC100309.1, AY316312.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGAGTC TGAGTCGGTC ATGCCTGTGG CTGCGTCAGG AGCTGTCGTC CCCGCGCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_083628.3 |
CDS | 237..1595 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGAGTC TGAGTCGGTC ATGCCTGTGG CTGCGTCAGG AGCTGTCGTC CCCGCGCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu56399 | |
Clone ID Related Accession (Same CDS sequence) | XM_006528331.1 | |
Accession Version | XM_006528331.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | dual specificity protein phosphatase 9 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGAGTC TGAGTCGGTC ATGCCTGTGG CTGCGTCAGG AGCTGTCGTC CCCGCGCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006528394.1 |
CDS | 289..1611 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGAGTC TGAGTCGGTC ATGCCTGTGG CTGCGTCAGG AGCTGTCGTC CCCGCGCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu56400 | |
Clone ID Related Accession (Same CDS sequence) | XM_006528333.1 | |
Accession Version | XM_006528333.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | dual specificity protein phosphatase 9 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGAGTC TGAGTCGGTC ATGCCTGTGG CTGCGTCAGG AGCTGTCGTC CCCGCGCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006528396.1 |
CDS | 289..1599 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGAGTC TGAGTCGGTC ATGCCTGTGG CTGCGTCAGG AGCTGTCGTC CCCGCGCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells. |
Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-? Production. |
Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. |
BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. |
Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways. |