Hspb8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hspb8
Entrez Gene ID	113906
Full Name	heat shock protein family B (small) member 8
Synonyms	Cryac,Hsp22
General protein information	Preferred Names heat shock protein family B (small) member 8 Names heat shock protein beta-8 alpha-crystallin C chain crystallin, alpha C heat shock 22kDa protein 8 heat shock protein 8 heat shock protein B8 small stress protein-like protein HSP22
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q16
Summary	human homolog binds Hsp27 and may play a role in muscle function and integrity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053612.2	NP_446064.1	heat shock protein beta-8

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	hspb8	NP_001094427.2
Homo sapiens (human)	HSPB8	NP_055180.1
Pan troglodytes (chimpanzee)	HSPB8	XP_509417.1
Canis lupus familiaris (dog)	HSPB8	NP_001003029.1
Xenopus tropicalis (tropical clawed frog)	hspb8	NP_001005658.1
Mus musculus (house mouse)	Hspb8	NP_109629.1
Gallus gallus (chicken)	HSPB8	XP_415280.1
Bos taurus (cattle)	HSPB8	NP_001014955.1
	HSPB8	NP_001028109.1
Rattus norvegicus (Norway rat)	Hspb8	NP_446064.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of heat shock protein B8 decreases osteogenic differentiation potential of dental pulp stem cells during in vitro proliferation.
Flanagan M, Li C, Dietrich MA, Richard M, Yao S
Cell proliferation(2017 Dec)

Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.
Echaniz-Laguna A, Geuens T, Petiot P, P?r?on Y, Adriaenssens E, Haidar M, Capponi S, Maisonobe T, Fournier E, Dubourg O, Degos B, Salachas F, Lenglet T, Eymard B, Delmont E, Pouget J, Juntas Morales R, Goizet C, Latour P, Timmerman V, Stojkovic T
Human mutation38(5)556-568(2017 May)

HSPB8 Promotes the Fusion of Autophagosome and Lysosome during Autophagy in Diabetic Neurons.
Li XC, Hu QK, Chen L, Liu SY, Su S, Tao H, Zhang LN, Sun T, He LJ
International journal of medical sciences14(13)1335-1341(2017)

HSPB8 and the Cochaperone BAG3 Are Highly Expressed During the Synthetic Phase of Rat Myometrium Programming During Pregnancy.
Marsh NM, Wareham A, White BG, Miskiewicz EI, Landry J, MacPhee DJ
Biology of reproduction92(5)131(2015 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HSPB8 and BAG3 are highly expressed during the synthetic phase of myometrial differentiation marked by initiation of uterine distension and myometrial hypertrophy.
Title: HSPB8 and the Cochaperone BAG3 Are Highly Expressed During the Synthetic Phase of Rat Myometrium Programming During Pregnancy.

Changes were observed in small heat shock proteins HSPB1, HSPB5 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats
Title: Changes in small heat shock proteins HSPB1, HSPB5 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats.

chaperone-like activity of HspB8
Title: The chaperone-like activity of rat HspB8/Hsp22 and dynamic molecular transition related to oligomeric architectures in vitro.

CryAB-amyloid oligomer formation is interrupted by HSP22
Title: Interruption of CryAB-amyloid oligomer formation by HSP22.

The following Hspb8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hspb8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10082	NM_053612.2 Latest version!	Rattus norvegicus heat shock protein family B (small) member 8 (Hspb8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hspb8 ( NM_053612.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446064.1 Rattus norvegicus heat shock protein family B (small) member 8 (Hspb8), mRNA.

Price & Availability↑

CloneID	ORa10082
Clone ID Related Accession (Same CDS sequence)	NM_053612.2
Accession Version	NM_053612.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Rattus norvegicus(Norway rat)
Product	heat shock protein beta-8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061748.1. On Oct 17, 2004 this sequence version replaced NM_053612.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061748.1, FQ148790.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGACG GGCAATTGCC TTTCCCGTGC TCCTACCCAA GCCGCTTGCG CCGAGACCCC 
TTTCGGGACT CACCGCTCTC TTCCCGCCTG CTGGACGATG GCTTTGGCAT GGACCCCTTC 
CCAGACGACT TGACAGCCCC TTGGCCCGAG TGGGCTTTGC CTCGGCTCTC CTCTGCCTGG 
CCTGGAACCC TAAGGTCTGG CATGGTACCC CGAGGGCCTA CAGCCACAGC CAGGTTTGGG 
GTACCTGCTG AGGGTAGGAA CCCCCCACCC TTCCCTGGGG AGCCCTGGAA AGTGTGTGTC 
AATGTGCACA GCTTCAAGCC GGAAGAACTG ATGGTAAAGA CCAAGGATGG ATACGTGGAA 
GTGTCAGGGA AGCACGAAGA GAAGCAGCAA GAAGGTGGGA TTGTCTCCAA GAACTTCACC 
AAGAAAATAC AGCTTCCTGC AGAAGTGGAT CCAGTGACTG TATTTGCCTC ACTTTCTCCA 
GAGGGTCTGC TCATCATTGA GGCTCCCCAG GTCCCTCCTT ACTCACCCTT TGGAGAGAGC 
AGCTTTAACA ACGAGCTTCC TCAAGACAAC CAGGAAGTCA CCTGCTCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446064.1
CDS	361..951
Translation	MADGQLPFPCSYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTAPWPEWALPRLSSAWPGTLRSGMVPRGPTATARFGVPAEGRNPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSPFGESSFNNELPQDNQEVTCS

Target ORF information:

RefSeq Version	NM_053612.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heat shock protein family B (small) member 8 (Hspb8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053612.2

ORF Insert Sequence:

ATGGCTGACG GGCAATTGCC TTTCCCGTGC TCCTACCCAA GCCGCTTGCG CCGAGACCCC 
TTTCGGGACT CACCGCTCTC TTCCCGCCTG CTGGACGATG GCTTTGGCAT GGACCCCTTC 
CCAGACGACT TGACAGCCCC TTGGCCCGAG TGGGCTTTGC CTCGGCTCTC CTCTGCCTGG 
CCTGGAACCC TAAGGTCTGG CATGGTACCC CGAGGGCCTA CAGCCACAGC CAGGTTTGGG 
GTACCTGCTG AGGGTAGGAA CCCCCCACCC TTCCCTGGGG AGCCCTGGAA AGTGTGTGTC 
AATGTGCACA GCTTCAAGCC GGAAGAACTG ATGGTAAAGA CCAAGGATGG ATACGTGGAA 
GTGTCAGGGA AGCACGAAGA GAAGCAGCAA GAAGGTGGGA TTGTCTCCAA GAACTTCACC 
AAGAAAATAC AGCTTCCTGC AGAAGTGGAT CCAGTGACTG TATTTGCCTC ACTTTCTCCA 
GAGGGTCTGC TCATCATTGA GGCTCCCCAG GTCCCTCCTT ACTCACCCTT TGGAGAGAGC 
AGCTTTAACA ACGAGCTTCC TCAAGACAAC CAGGAAGTCA CCTGCTCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of heat shock protein B8 decreases osteogenic differentiation potential of dental pulp stem cells during in vitro proliferation.
Cell proliferation(2017 Dec)
Flanagan M,Li C,Dietrich MA,Richard M,Yao S

Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.
Human mutation38(5)556-568(2017 May)
Echaniz-Laguna A,Geuens T,Petiot P,P?r?on Y,Adriaenssens E,Haidar M,Capponi S,Maisonobe T,Fournier E,Dubourg O,Degos B,Salachas F,Lenglet T,Eymard B,Delmont E,Pouget J,Juntas Morales R,Goizet C,Latour P,Timmerman V,Stojkovic T

HSPB8 Promotes the Fusion of Autophagosome and Lysosome during Autophagy in Diabetic Neurons.
International journal of medical sciences14(13)1335-1341(2017)
Li XC,Hu QK,Chen L,Liu SY,Su S,Tao H,Zhang LN,Sun T,He LJ

HSPB8 and the Cochaperone BAG3 Are Highly Expressed During the Synthetic Phase of Rat Myometrium Programming During Pregnancy.
Biology of reproduction92(5)131(2015 May)
Marsh NM,Wareham A,White BG,Miskiewicz EI,Landry J,MacPhee DJ

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Hspb8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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