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Tob1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Tob1
Entrez Gene ID 170842
Full Name transducer of ErbB-2.1
General protein information
Preferred Names

transducer of ErbB-2.1

Names

protein Tob1
transducer of ERBB2, 1
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

10

10q26
Summary human homolog is an antiproliferative protein involved in the negative regulation of osteoblast and T cell proliferation [RGD, Feb 2006].

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_133317.2 NP_579851.2 protein Tob1

Pathways from BioSystems


Homologies


Mus musculus (house mouse) Tob1 NP_033453.2
Rattus norvegicus (Norway rat) Tob1 NP_579851.2
Xenopus tropicalis (tropical clawed frog) tob1 NP_001016611.1
Homo sapiens (human) TOB1 NP_001230806.1
Danio rerio (zebrafish) tob1b NP_998139.1
Pan troglodytes (chimpanzee) TOB1 XP_523795.3
LOC706873 XP_001095282.1
Canis lupus familiaris (dog) TOB1 XP_005624733.1
Danio rerio (zebrafish) tob1a NP_938177.1
Bos taurus (cattle) TOB1 NP_001070543.2
Gallus gallus (chicken) TOB1 NP_001001467.1

Gene Ontology


Bibliography

Related articles in PubMed

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
Doidge R, Mittal S, Aslam A, Winkler GS
PloS one7(12)e51331(2012)

Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.
Hosoda N, Funakoshi Y, Hirasawa M, Yamagishi R, Asano Y, Miyagawa R, Ogami K, Tsujimoto M, Hoshino S
The EMBO journal30(7)1311-23(2011 Apr)

Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T, Kawamura-Tsuzuku J, Takahasi K, Yamamoto T, Inagaki F
The Journal of biological chemistry284(19)13244-55(2009 May)

Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.
Miyasaka T, Morita M, Ito K, Suzuki T, Fukuda H, Takeda S, Inoue J, Semba K, Yamamoto T
Cancer science99(4)755-61(2008 Apr)

The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory.
Jin M, Wang XM, Tu Y, Zhang XH, Gao X, Guo N, Xie Z, Zhao G, Jing N, Li BM, Yu L
Neuroscience131(3)647-59(2005)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Tob1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tob1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa42836 NM_133317.2
Latest version!		 Rattus norvegicus transducer of ErbB-2.1 (Tob1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $188.30
$269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa42836
Clone ID Related Accession (Same CDS sequence) NM_133317.2
Accession Version NM_133317.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1101bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-16
Organism Rattus norvegicus(Norway rat)
Product protein Tob1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07030334.1. On Nov 23, 2005 this sequence version replaced NM_133317.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: AF349723.1 [ECO:0000345] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCAGCTTG AAATTCAAGT AGCACTAAAT TTTATTATTT CCTATTTGTA CAATAAGCTT 
CCCAGGAGAC GTGTCAACAT TTTTGGTGAA GAACTTGAAA GACTTCTTAA ACAGAAATAT 
GAAGGGCATT GGTATCCTGA GAAGCCATAC AAAGGCTCAG GGTTTAGATG CATACACGTA 
GGGGAGAAGG TGGACCCGGT GATCGAGCAA GCGTCCAAAG AGAGTGGTCT GGACATTGAC 
GATGTTCGTG GCAATCTGCC GCAGGATCTG AGCGTGTGGA TCGACCCGTT TGAGGTTTCC 
TACCAAATCG GTGAGAAGGG ACCAGTGAAG GTGCTGTACG TAGATGACAG TAATGAGAAC 
GGGTGTGAGC TGGATAAGGA GATCAAGAAC AGCTTTAACC CTGAGGCCCA GGTTTTCATG 
CCCATAAGCG ACCCAGCCTC CTCTGTGTCC AGCTCGCCGT CGCCTCCCTT TGGCCATTCT 
GCTGCCGTCA GCCCCACCTT CATGCCCCGG TCCACTCAGC CTTTAACCTT TACCACTGCC 
ACTTTTGCTG CCACCAAGTT TGGCTCCACC AAAATGAAGA ACAGTGGCCG TAGCAGCAAG 
GTAGCACGCA CTTCTCCCAT CAGCCTGGGC CTGAATGTCA ATGTGAACGA CCTCCTGAAG 
CAGAAAGCCA TCTCTTCCTC AATGCACTCT CTGTACGGGC TGGGCCTGGG CAGCCAGCAG 
CAGCCTCAGC CGCAGCCGCA GCAGCCGCCA TCCCAGCCAC CACCGCCGCC ACCACCTCCA 
CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAGCAGC AGCAACAGCA GCAGCAGCAG 
CCGCAGCAGC AAACCTCTGC TCTTTCTCCC AATGCCAAGG AATTTATTTT TCCTAACATG 
CAGGGTCAAG GTAGTAGTAC CAATGGAATG TTCCCAGGTG ACAGCCCCCT TAACCTCAGT 
CCCCTCCAGT ACAGTAATGC CTTTGATGTG TTTGCGGCCT ACGGAGGCCT CAACGAGAAG 
TCTTTCGTAG ACGGCTTGAA TTTTAGCTTA AATAACATTC AGTATTCTAA CCAGCAGTTC 
CAGCCCGTAA TGGCTAACTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_579851.2
CDS151..1251
Translation

Target ORF information:

RefSeq Version NM_133317.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus transducer of ErbB-2.1 (Tob1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_133317.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCAGCTTG AAATTCAAGT AGCACTAAAT TTTATTATTT CCTATTTGTA CAATAAGCTT 
CCCAGGAGAC GTGTCAACAT TTTTGGTGAA GAACTTGAAA GACTTCTTAA ACAGAAATAT 
GAAGGGCATT GGTATCCTGA GAAGCCATAC AAAGGCTCAG GGTTTAGATG CATACACGTA 
GGGGAGAAGG TGGACCCGGT GATCGAGCAA GCGTCCAAAG AGAGTGGTCT GGACATTGAC 
GATGTTCGTG GCAATCTGCC GCAGGATCTG AGCGTGTGGA TCGACCCGTT TGAGGTTTCC 
TACCAAATCG GTGAGAAGGG ACCAGTGAAG GTGCTGTACG TAGATGACAG TAATGAGAAC 
GGGTGTGAGC TGGATAAGGA GATCAAGAAC AGCTTTAACC CTGAGGCCCA GGTTTTCATG 
CCCATAAGCG ACCCAGCCTC CTCTGTGTCC AGCTCGCCGT CGCCTCCCTT TGGCCATTCT 
GCTGCCGTCA GCCCCACCTT CATGCCCCGG TCCACTCAGC CTTTAACCTT TACCACTGCC 
ACTTTTGCTG CCACCAAGTT TGGCTCCACC AAAATGAAGA ACAGTGGCCG TAGCAGCAAG 
GTAGCACGCA CTTCTCCCAT CAGCCTGGGC CTGAATGTCA ATGTGAACGA CCTCCTGAAG 
CAGAAAGCCA TCTCTTCCTC AATGCACTCT CTGTACGGGC TGGGCCTGGG CAGCCAGCAG 
CAGCCTCAGC CGCAGCCGCA GCAGCCGCCA TCCCAGCCAC CACCGCCGCC ACCACCTCCA 
CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAGCAGC AGCAACAGCA GCAGCAGCAG 
CCGCAGCAGC AAACCTCTGC TCTTTCTCCC AATGCCAAGG AATTTATTTT TCCTAACATG 
CAGGGTCAAG GTAGTAGTAC CAATGGAATG TTCCCAGGTG ACAGCCCCCT TAACCTCAGT 
CCCCTCCAGT ACAGTAATGC CTTTGATGTG TTTGCGGCCT ACGGAGGCCT CAACGAGAAG 
TCTTTCGTAG ACGGCTTGAA TTTTAGCTTA AATAACATTC AGTATTCTAA CCAGCAGTTC 
CAGCCCGTAA TGGCTAACTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
PloS one7(12)e51331(2012)
Doidge R,Mittal S,Aslam A,Winkler GS


book

Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.
The EMBO journal30(7)1311-23(2011 Apr)
Hosoda N,Funakoshi Y,Hirasawa M,Yamagishi R,Asano Y,Miyagawa R,Ogami K,Tsujimoto M,Hoshino S


book

Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
The Journal of biological chemistry284(19)13244-55(2009 May)
Horiuchi M,Takeuchi K,Noda N,Muroya N,Suzuki T,Nakamura T,Kawamura-Tsuzuku J,Takahasi K,Yamamoto T,Inagaki F


book

Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.
Cancer science99(4)755-61(2008 Apr)
Miyasaka T,Morita M,Ito K,Suzuki T,Fukuda H,Takeda S,Inoue J,Semba K,Yamamoto T


book

The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory.
Neuroscience131(3)647-59(2005)
Jin M,Wang XM,Tu Y,Zhang XH,Gao X,Guo N,Xie Z,Zhao G,Jing N,Li BM,Yu L