Tob1 cDNA ORF clone, Rattus norvegicus(Norway rat)
Gene Symbol | Tob1 |
Entrez Gene ID | 170842 |
Full Name | transducer of ErbB-2.1 |
General protein information |
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Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome | |
Summary | human homolog is an antiproliferative protein involved in the negative regulation of osteoblast and T cell proliferation [RGD, Feb 2006]. |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_133317.2 | NP_579851.2 | protein Tob1 |

Mus musculus (house mouse) | Tob1 | NP_033453.2 |
Rattus norvegicus (Norway rat) | Tob1 | NP_579851.2 |
Xenopus tropicalis (tropical clawed frog) | tob1 | NP_001016611.1 |
Homo sapiens (human) | TOB1 | NP_001230806.1 |
Danio rerio (zebrafish) | tob1b | NP_998139.1 |
Pan troglodytes (chimpanzee) | TOB1 | XP_523795.3 |
LOC706873 | XP_001095282.1 | |
Canis lupus familiaris (dog) | TOB1 | XP_005624733.1 |
Danio rerio (zebrafish) | tob1a | NP_938177.1 |
Bos taurus (cattle) | TOB1 | NP_001070543.2 |
Gallus gallus (chicken) | TOB1 | NP_001001467.1 |

Related articles in PubMed
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
Doidge R, Mittal S, Aslam A, Winkler GS
PloS one7(12)e51331(2012)
Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.
Hosoda N, Funakoshi Y, Hirasawa M, Yamagishi R, Asano Y, Miyagawa R, Ogami K, Tsujimoto M, Hoshino S
The EMBO journal30(7)1311-23(2011 Apr)
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T, Kawamura-Tsuzuku J, Takahasi K, Yamamoto T, Inagaki F
The Journal of biological chemistry284(19)13244-55(2009 May)
Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.
Miyasaka T, Morita M, Ito K, Suzuki T, Fukuda H, Takeda S, Inoue J, Semba K, Yamamoto T
Cancer science99(4)755-61(2008 Apr)
The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory.
Jin M, Wang XM, Tu Y, Zhang XH, Gao X, Guo N, Xie Z, Zhao G, Jing N, Li BM, Yu L
Neuroscience131(3)647-59(2005)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Tob1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tob1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa42836 | |
Clone ID Related Accession (Same CDS sequence) | NM_133317.2 | |
Accession Version | NM_133317.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1101bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-16 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | protein Tob1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07030334.1. On Nov 23, 2005 this sequence version replaced NM_133317.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: AF349723.1 [ECO:0000345] ##Evidence-Data-END## |
1 | ATGCAGCTTG AAATTCAAGT AGCACTAAAT TTTATTATTT CCTATTTGTA CAATAAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_579851.2 |
CDS | 151..1251 |
Translation |

Target ORF information:
Target ORF information:
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ORF Insert Sequence:
1 | ATGCAGCTTG AAATTCAAGT AGCACTAAAT TTTATTATTT CCTATTTGTA CAATAAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. |
![]() |
Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase. |
![]() |
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. |
![]() |
Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex. |
![]() |
The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory. |