Eif2b3 cDNA ORF clone, Rattus norvegicus(Norway rat)
Gene Symbol | Eif2b3 |
Entrez Gene ID | 171145 |
Full Name | eukaryotic translation initiation factor 2B subunit gamma |
General protein information |
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Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome | |
Summary | guanine nucleotide exchange factor that regulates key step in protein synthesis; restores eIF2 to its active GTP-bound state [RGD, Feb 2006]. |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_133609.2 | NP_598293.2 | translation initiation factor eIF-2B subunit gamma |
XM_006238630.3 | XP_006238692.1 | translation initiation factor eIF-2B subunit gamma isoform X1 |

Pan troglodytes (chimpanzee) | EIF2B3 | XP_001152272.1 |
EIF2B3 | XP_001094199.2 | |
Bos taurus (cattle) | EIF2B3 | NP_001076943.1 |
Gallus gallus (chicken) | EIF2B3 | NP_001026451.1 |
Drosophila melanogaster (fruit fly) | eIF2B-gamma | NP_611046.2 |
Neurospora crassa | NCU03548 | XP_955772.2 |
Arabidopsis thaliana (thale cress) | AT5G19485 | NP_001031908.1 |
Homo sapiens (human) | EIF2B3 | NP_065098.1 |
Caenorhabditis elegans (roundworm) | ppp-1 | NP_495428.1 |
Schizosaccharomyces pombe (fission yeast) | tif223 | NP_594962.2 |
Canis lupus familiaris (dog) | EIF2B3 | XP_005629136.1 |
Mus musculus (house mouse) | Eif2b3 | NP_001104747.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005210 | XP_314112.3 |
Rattus norvegicus (Norway rat) | Eif2b3 | NP_598293.2 |
Danio rerio (zebrafish) | eif2b3 | NP_957368.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_02390 | XP_003709167.1 |
Oryza sativa (rice) | Os06g0338900 | NP_001057561.1 |
Xenopus tropicalis (tropical clawed frog) | eif2b3 | NP_001016997.2 |

Related articles in PubMed
The mechanism of eukaryotic translation initiation: new insights and challenges.
Hinnebusch AG, Lorsch JR
Cold Spring Harbor perspectives in biology4(10)(2012 Oct)
An efficient mammalian cell-free translation system supplemented with translation factors.
Mikami S, Masutani M, Sonenberg N, Yokoyama S, Imataka H
Protein expression and purification46(2)348-57(2006 Apr)
Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients.
Fogli A, Schiffmann R, Hugendubler L, Combes P, Bertini E, Rodriguez D, Kimball SR, Boespflug-Tanguy O
European journal of human genetics : EJHG12(7)561-6(2004 Jul)
The life and death of oligodendrocytes in vanishing white matter disease.
Van Haren K, van der Voorn JP, Peterson DR, van der Knaap MS, Powers JM
Journal of neuropathology and experimental neurology63(6)618-30(2004 Jun)
Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways.
Li W, Wang X, Van Der Knaap MS, Proud CG
Molecular and cellular biology24(8)3295-306(2004 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Eif2b3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eif2b3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa01064 | |
Clone ID Related Accession (Same CDS sequence) | NM_133609.2 , XM_006238630.3 | |
Accession Version | NM_133609.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-19 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | translation initiation factor eIF-2B subunit gamma | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC072507.1. On Jun 13, 2004 this sequence version replaced NM_133609.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC072507.1, U38253.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGTTTC AAGCCGTAGT TATGGCCGTC GGTGGGGGAT CTCGGATGAC AGACTTGACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_598293.2 |
CDS | 109..1467 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGTTTC AAGCCGTAGT TATGGCCGTC GGTGGGGGAT CTCGGATGAC AGACTTGACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa01064 | |
Clone ID Related Accession (Same CDS sequence) | NM_133609.2 , XM_006238630.3 | |
Accession Version | XM_006238630.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | translation initiation factor eIF-2B subunit gamma isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006238630.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGTTTC AAGCCGTAGT TATGGCCGTC GGTGGGGGAT CTCGGATGAC AGACTTGACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006238692.1 |
CDS | 89..1447 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGTTTC AAGCCGTAGT TATGGCCGTC GGTGGGGGAT CTCGGATGAC AGACTTGACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
The mechanism of eukaryotic translation initiation: new insights and challenges. |
![]() |
An efficient mammalian cell-free translation system supplemented with translation factors. |
![]() |
Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients. |
![]() |
The life and death of oligodendrocytes in vanishing white matter disease. |
![]() |
Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. |