| Gene Symbol | Melt |
| Entrez Gene ID | 406130 |
| Full Name | melittin |
| Synonyms | GB10355 |
| Gene Type | protein-coding |
| Organism | Apis mellifera(honey bee) |
IVD Raw Materials
ORF » Species Summary » Apis mellifera » Melt cDNA ORF clone
| Gene Symbol | Melt |
| Entrez Gene ID | 406130 |
| Full Name | melittin |
| Synonyms | GB10355 |
| Gene Type | protein-coding |
| Organism | Apis mellifera(honey bee) |
| mRNA | Protein | Name |
|---|---|---|
| NM_001011607.1 | NP_001011607.1 | melittin precursor |
| NM_001011607.2 | NP_001011607.1 | melittin precursor |
A New Mixed All-Atom/Coarse-Grained Model: Application to Melittin Aggregation in Aqueous Solution.
Shelley MY, Selvan ME, Zhao J, Babin V, Liao C, Li J, Shelley JC
Journal of chemical theory and computation13(8)3881-3897(2017 Aug)
Dynamic Structure and Orientation of Melittin Bound to Acidic Lipid Bilayers, As Revealed by Solid-State NMR and Molecular Dynamics Simulation.
Norisada K, Javkhlantugs N, Mishima D, Kawamura I, Sait? H, Ueda K, Naito A
The journal of physical chemistry. B121(8)1802-1811(2017 Mar)
Expression and anticancer activity analysis of recombinant human uPA1?43-melittin.
Su M, Chang W, Cui M, Lin Y, Wu S, Xu T
International journal of oncology46(2)619-26(2015 Feb)
Finding the missing honey bee genes: lessons learned from a genome upgrade.
Elsik CG, Worley KC, Bennett AK, Beye M, Camara F, Childers CP, de Graaf DC, Debyser G, Deng J, Devreese B, Elhaik E, Evans JD, Foster LJ, Graur D, Guigo R, , Hoff KJ, Holder ME, Hudson ME, Hunt GJ, Jiang H, Joshi V, Khetani RS, Kosarev P, Kovar CL, Ma J, Maleszka R, Moritz RF, Munoz-Torres MC, Murphy TD, Muzny DM, Newsham IF, Reese JT, Robertson HM, Robinson GE, Rueppell O, Solovyev V, Stanke M, Stolle E, Tsuruda JM, Vaerenbergh MV, Waterhouse RM, Weaver DB, Whitfield CW, Wu Y, Zdobnov EM, Zhang L, Zhu D, Gibbs RA,
BMC genomics1586(2014 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Taking uPA(1-43) amino acids specifically binding to uPAR as targeted part of fusion protein, and making use of antitumor activity of melittin, the recombinant fusion protein it was able to inhibit growth of ovarian tumors .
Title: Expression and anticancer activity analysis of recombinant human uPA1?43-melittin.
These findings point to the preservation and, from more aqueous solvent conditions, the formation of an at least partially helical form of melittin in the gas-phase.
Title: Evidence for ?-helices in the gas phase: a case study using Melittin from honey bee venom.
isolation and biochemical characterization of melittin-S, an isoform of melittin comprising a Ser residue at the 10th position, from the venom of Africanized A. mellifera; seasonal variation in venom content of melittins
Title: Identification of a novel melittin isoform from Africanized Apis mellifera venom.
increases in plasma adrenaline, noradrenaline, vasopressin levels and renin activity mediate the pressor responses to melittin in normal and hypotensive conditions in rats
Title: Cardiovascular effects of centrally injected melittin in hemorrhaged hypotensive rats: the investigation of peripheral mechanisms.
Melittin does not block NF-kappa B-p50-DNA interactions; rather, the human cells tested show significantly increased mRNA levels of several inflammatory genes, elevated cyclooxygenase-2 protein levels, and release of large quantities of oxygen radicals.
Title: Apis mellifera venom and melittin block neither NF-kappa B-p50-DNA interactions nor the activation of NF-kappa B, instead they activate the transcription of proinflammatory genes and the release of reactive oxygen intermediates.
The following Melt gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Melt cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHd00116 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001011607.1 , NM_001011607.2 | |
| Accession Version | NM_001011607.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 213bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-09-30 | |
| Organism | Apis mellifera(honey bee) | |
| Product | melittin precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X02007.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X02007.1, HP466386.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00120364, SAMN00120365 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGAAATTCT TAGTCAACGT TGCCCTTGTT TTTATGGTCG TGTACATTTC TTACATCTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001011607.1 |
| CDS | 53..265 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001011607.1 |
1 | ATGAAATTCT TAGTCAACGT TGCCCTTGTT TTTATGGTCG TGTACATTTC TTACATCTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHd00116 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001011607.1 , NM_001011607.2 | |
| Accession Version | NM_001011607.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 213bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-05 | |
| Organism | Apis mellifera(honey bee) | |
| Product | melittin precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HP466386.1 and X02007.1. On Sep 13, 2018 this sequence version replaced NM_001011607.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X02007.1, GAZV01038130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00120364, SAMN00120365 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGAAATTCT TAGTCAACGT TGCCCTTGTT TTTATGGTCG TGTACATTTC TTACATCTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001011607.1 |
| CDS | 60..272 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001011607.2 |
1 | ATGAAATTCT TAGTCAACGT TGCCCTTGTT TTTATGGTCG TGTACATTTC TTACATCTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A New Mixed All-Atom/Coarse-Grained Model: Application to Melittin Aggregation in Aqueous Solution. |
Dynamic Structure and Orientation of Melittin Bound to Acidic Lipid Bilayers, As Revealed by Solid-State NMR and Molecular Dynamics Simulation. |
Expression and anticancer activity analysis of recombinant human uPA1?43-melittin. |
Finding the missing honey bee genes: lessons learned from a genome upgrade. |