par-6 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	par-6
Entrez Gene ID	32752
Full Name	CG5884 gene product from transcript CG5884-RA
Synonyms	CG5884,DPar-6,DPar6,Dm-Par-6,Dm-Par6,DmPAR-6,DmPar-6,DmPar6,Dmel\CG5884,Dmpar6,PAR-6,PAR6,Par,Par-6,Par6,dPAR-6,dPar-6,dmPar-6,par,par6
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: X Map Location: 16C1-16C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_167575.2	NP_728094.1	par-6, isoform B
NM_133010.5	NP_573238.1	par-6, isoform A

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PARD6G	XP_001145392.1
Rattus norvegicus (Norway rat)	Pard6g	NP_001094443.1
Gallus gallus (chicken)	PARD6G	XP_426065.4
Homo sapiens (human)	PARD6G	NP_115899.1
Xenopus tropicalis (tropical clawed frog)	pard6g	NP_001017338.1
	PARD6G	XP_001090088.1
Bos taurus (cattle)	PARD6G	NP_001091569.1
Mus musculus (house mouse)	Pard6g	NP_444347.3
Drosophila melanogaster (fruit fly)	par-6	NP_573238.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010494	XP_314468.4
Canis lupus familiaris (dog)	PARD6G	XP_541043.2
Danio rerio (zebrafish)	pard6gb	NP_997728.1
Caenorhabditis elegans (roundworm)	par-6	NP_001040687.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Par-6 binds to Crumbs through a carboxyl-terminal peptide contributing to the crystal structure of the PDZ-peptide complex.
Title: Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42.

Slmb has a role in control of oocyte and epithelial polarity by antagonizing the aPKC/Par-6 complex
Title: Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity.

the Par-6-aPKC complex, is recruited to the apicomedial domain by actomyosin networks during dorsal closure of the embryo.
Title: Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constriction.

there is a mutual dependence between Par proteins and Cdc42 for their localization, regulation of the actin cytoskeleton and, consequently, for the establishment of oocyte polarity
Title: A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization.

in complex with Par-3 and integrins, direct asymmetric cell division in adult intestinal stem cells
Title: The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells.

The following par-6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the par-6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa01930	NM_167575.2 Latest version!	Drosophila melanogaster par-6, transcript variant B (par-6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OFa01930	NM_133010.5 Latest version!	Drosophila melanogaster par-6, transcript variant A (par-6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

par-6 ( NM_167575.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_728094.1 Drosophila melanogaster par-6, transcript variant B (par-6), mRNA.

Price & Availability↑

CloneID	OFa01930
Clone ID Related Accession (Same CDS sequence)	NM_167575.2 , NM_133010.5
Accession Version	NM_167575.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	par-6, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_167575.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCGAAGA ACAAGATAAA CACAACGTCC GCAACGGCGG CCAGTGACAC GAATCTAATC 
GAGGTGAAAT CGAAGTTCGA TGCAGAGTTT CGGAGGTGGA GCTTCAAGCG AAATGAGGCG 
GAGCAGAGCT TCGACAAATT CGCATCCCTC ATTGAGCAGC TGCACAAGCT GACCAACATC 
CAGTTTCTCA TACTCTACAT CGATCCGCGG GACAATGATC TGTTGCCGAT TAACAACGAC 
GATAACTTCG GCCGGGCCCT GAAAACAGCA CGTCCACTTT TACGGGTCAT TGTGCAGCGA 
AAGGATGATC TTAATGAGTA CTCTGGCTTT GGAACGATGA AACCGAGAAA CCTCATCGGC 
AGCATACTGA TGGGCCATAC GCCAGTGAAG ACAAAGGCGC CATCGATATC CATACCGCAC 
GATTTCCGTC AAGTCTCGGC CATTATAGAT GTGGATATAG TGCCGGAAAC GCATAGAAGA 
GTGCGGCTAC TGAAGCACGG CAGCGATAAG CCCCTGGGAT TCTACATACG GGATGGCACC 
TCTGTCAGGG TGACGGCCAG TGGGCTAGAG AAGCAGCCGG GCATTTTTAT ATCCCGTTTG 
GTTCCGGGCG GTCTGGCCGA AAGTACTGGC CTGCTGGCCG TCAACGATGA GGTGATCGAG 
GTAAATGGCA TCGAAGTGGC TGGCAAGACT CTGGATCAAG TCACCGACAT GATGGTGGCC 
AACAGCTCCA ATCTGATAAT CACCGTGAAG CCGGCCAATC AGCGCACACT GACGTCCACA 
CATCGCGGAT CCTTTTCAAG GAACAGCCAG CTGTCCAGTG GGTCACATCA CACTAATAAT 
ACAAACACCT CCGACGAGAT CGAGCACGAC GATCAGGACG ATATTGTGGA CTTAACGGGC 
GTCACCCTCG ACGAGAGTCC AACGTCCACG TCAGCCGGCA ATCACAACCA TCAGCCGCCA 
TTATCCTCAT CACCCTCGTC GCACCACCAG CAGGCAGCCT CCAATGCGTC CACGATAATG 
GCCAGCGATG TCAAGGATGG AGTGCTGCAT TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_728094.1
CDS	300..1355
Translation	MSKNKINTTSATAASDTNLIEVKSKFDAEFRRWSFKRNEAEQSFDKFASLIEQLHKLTNIQFLILYIDPRDNDLLPINNDDNFGRALKTARPLLRVIVQRKDDLNEYSGFGTMKPRNLIGSILMGHTPVKTKAPSISIPHDFRQVSAIIDVDIVPETHRRVRLLKHGSDKPLGFYIRDGTSVRVTASGLEKQPGIFISRLVPGGLAESTGLLAVNDEVIEVNGIEVAGKTLDQVTDMMVANSSNLIITVKPANQRTLTSTHRGSFSRNSQLSSGSHHTNNTNTSDEIEHDDQDDIVDLTGVTLDESPTSTSAGNHNHQPPLSSSPSSHHQQAASNASTIMASDVKDGVLHL

Target ORF information:

RefSeq Version	NM_167575.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster par-6, transcript variant B (par-6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_167575.2

ORF Insert Sequence:

ATGTCGAAGA ACAAGATAAA CACAACGTCC GCAACGGCGG CCAGTGACAC GAATCTAATC 
GAGGTGAAAT CGAAGTTCGA TGCAGAGTTT CGGAGGTGGA GCTTCAAGCG AAATGAGGCG 
GAGCAGAGCT TCGACAAATT CGCATCCCTC ATTGAGCAGC TGCACAAGCT GACCAACATC 
CAGTTTCTCA TACTCTACAT CGATCCGCGG GACAATGATC TGTTGCCGAT TAACAACGAC 
GATAACTTCG GCCGGGCCCT GAAAACAGCA CGTCCACTTT TACGGGTCAT TGTGCAGCGA 
AAGGATGATC TTAATGAGTA CTCTGGCTTT GGAACGATGA AACCGAGAAA CCTCATCGGC 
AGCATACTGA TGGGCCATAC GCCAGTGAAG ACAAAGGCGC CATCGATATC CATACCGCAC 
GATTTCCGTC AAGTCTCGGC CATTATAGAT GTGGATATAG TGCCGGAAAC GCATAGAAGA 
GTGCGGCTAC TGAAGCACGG CAGCGATAAG CCCCTGGGAT TCTACATACG GGATGGCACC 
TCTGTCAGGG TGACGGCCAG TGGGCTAGAG AAGCAGCCGG GCATTTTTAT ATCCCGTTTG 
GTTCCGGGCG GTCTGGCCGA AAGTACTGGC CTGCTGGCCG TCAACGATGA GGTGATCGAG 
GTAAATGGCA TCGAAGTGGC TGGCAAGACT CTGGATCAAG TCACCGACAT GATGGTGGCC 
AACAGCTCCA ATCTGATAAT CACCGTGAAG CCGGCCAATC AGCGCACACT GACGTCCACA 
CATCGCGGAT CCTTTTCAAG GAACAGCCAG CTGTCCAGTG GGTCACATCA CACTAATAAT 
ACAAACACCT CCGACGAGAT CGAGCACGAC GATCAGGACG ATATTGTGGA CTTAACGGGC 
GTCACCCTCG ACGAGAGTCC AACGTCCACG TCAGCCGGCA ATCACAACCA TCAGCCGCCA 
TTATCCTCAT CACCCTCGTC GCACCACCAG CAGGCAGCCT CCAATGCGTC CACGATAATG 
GCCAGCGATG TCAAGGATGG AGTGCTGCAT TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

par-6 ( NM_133010.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_573238.1 Drosophila melanogaster par-6, transcript variant A (par-6), mRNA.

Price & Availability↑

CloneID	OFa01930
Clone ID Related Accession (Same CDS sequence)	NM_167575.2 , NM_133010.5
Accession Version	NM_133010.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	par-6, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_133010.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCGAAGA ACAAGATAAA CACAACGTCC GCAACGGCGG CCAGTGACAC GAATCTAATC 
GAGGTGAAAT CGAAGTTCGA TGCAGAGTTT CGGAGGTGGA GCTTCAAGCG AAATGAGGCG 
GAGCAGAGCT TCGACAAATT CGCATCCCTC ATTGAGCAGC TGCACAAGCT GACCAACATC 
CAGTTTCTCA TACTCTACAT CGATCCGCGG GACAATGATC TGTTGCCGAT TAACAACGAC 
GATAACTTCG GCCGGGCCCT GAAAACAGCA CGTCCACTTT TACGGGTCAT TGTGCAGCGA 
AAGGATGATC TTAATGAGTA CTCTGGCTTT GGAACGATGA AACCGAGAAA CCTCATCGGC 
AGCATACTGA TGGGCCATAC GCCAGTGAAG ACAAAGGCGC CATCGATATC CATACCGCAC 
GATTTCCGTC AAGTCTCGGC CATTATAGAT GTGGATATAG TGCCGGAAAC GCATAGAAGA 
GTGCGGCTAC TGAAGCACGG CAGCGATAAG CCCCTGGGAT TCTACATACG GGATGGCACC 
TCTGTCAGGG TGACGGCCAG TGGGCTAGAG AAGCAGCCGG GCATTTTTAT ATCCCGTTTG 
GTTCCGGGCG GTCTGGCCGA AAGTACTGGC CTGCTGGCCG TCAACGATGA GGTGATCGAG 
GTAAATGGCA TCGAAGTGGC TGGCAAGACT CTGGATCAAG TCACCGACAT GATGGTGGCC 
AACAGCTCCA ATCTGATAAT CACCGTGAAG CCGGCCAATC AGCGCACACT GACGTCCACA 
CATCGCGGAT CCTTTTCAAG GAACAGCCAG CTGTCCAGTG GGTCACATCA CACTAATAAT 
ACAAACACCT CCGACGAGAT CGAGCACGAC GATCAGGACG ATATTGTGGA CTTAACGGGC 
GTCACCCTCG ACGAGAGTCC AACGTCCACG TCAGCCGGCA ATCACAACCA TCAGCCGCCA 
TTATCCTCAT CACCCTCGTC GCACCACCAG CAGGCAGCCT CCAATGCGTC CACGATAATG 
GCCAGCGATG TCAAGGATGG AGTGCTGCAT TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573238.1
CDS	300..1355
Translation	MSKNKINTTSATAASDTNLIEVKSKFDAEFRRWSFKRNEAEQSFDKFASLIEQLHKLTNIQFLILYIDPRDNDLLPINNDDNFGRALKTARPLLRVIVQRKDDLNEYSGFGTMKPRNLIGSILMGHTPVKTKAPSISIPHDFRQVSAIIDVDIVPETHRRVRLLKHGSDKPLGFYIRDGTSVRVTASGLEKQPGIFISRLVPGGLAESTGLLAVNDEVIEVNGIEVAGKTLDQVTDMMVANSSNLIITVKPANQRTLTSTHRGSFSRNSQLSSGSHHTNNTNTSDEIEHDDQDDIVDLTGVTLDESPTSTSAGNHNHQPPLSSSPSSHHQQAASNASTIMASDVKDGVLHL

Target ORF information:

RefSeq Version	NM_133010.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster par-6, transcript variant A (par-6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133010.5

ORF Insert Sequence:

ATGTCGAAGA ACAAGATAAA CACAACGTCC GCAACGGCGG CCAGTGACAC GAATCTAATC 
GAGGTGAAAT CGAAGTTCGA TGCAGAGTTT CGGAGGTGGA GCTTCAAGCG AAATGAGGCG 
GAGCAGAGCT TCGACAAATT CGCATCCCTC ATTGAGCAGC TGCACAAGCT GACCAACATC 
CAGTTTCTCA TACTCTACAT CGATCCGCGG GACAATGATC TGTTGCCGAT TAACAACGAC 
GATAACTTCG GCCGGGCCCT GAAAACAGCA CGTCCACTTT TACGGGTCAT TGTGCAGCGA 
AAGGATGATC TTAATGAGTA CTCTGGCTTT GGAACGATGA AACCGAGAAA CCTCATCGGC 
AGCATACTGA TGGGCCATAC GCCAGTGAAG ACAAAGGCGC CATCGATATC CATACCGCAC 
GATTTCCGTC AAGTCTCGGC CATTATAGAT GTGGATATAG TGCCGGAAAC GCATAGAAGA 
GTGCGGCTAC TGAAGCACGG CAGCGATAAG CCCCTGGGAT TCTACATACG GGATGGCACC 
TCTGTCAGGG TGACGGCCAG TGGGCTAGAG AAGCAGCCGG GCATTTTTAT ATCCCGTTTG 
GTTCCGGGCG GTCTGGCCGA AAGTACTGGC CTGCTGGCCG TCAACGATGA GGTGATCGAG 
GTAAATGGCA TCGAAGTGGC TGGCAAGACT CTGGATCAAG TCACCGACAT GATGGTGGCC 
AACAGCTCCA ATCTGATAAT CACCGTGAAG CCGGCCAATC AGCGCACACT GACGTCCACA 
CATCGCGGAT CCTTTTCAAG GAACAGCCAG CTGTCCAGTG GGTCACATCA CACTAATAAT 
ACAAACACCT CCGACGAGAT CGAGCACGAC GATCAGGACG ATATTGTGGA CTTAACGGGC 
GTCACCCTCG ACGAGAGTCC AACGTCCACG TCAGCCGGCA ATCACAACCA TCAGCCGCCA 
TTATCCTCAT CACCCTCGTC GCACCACCAG CAGGCAGCCT CCAATGCGTC CACGATAATG 
GCCAGCGATG TCAAGGATGG AGTGCTGCAT TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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par-6 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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