FUT5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FUT5
Entrez Gene ID	2527
Full Name	fucosyltransferase 5
Synonyms	FUC-TV
General protein information	Preferred Names fucosyltransferase 5 Names alpha-(1,3)-fucosyltransferase 5 alpha (1,3) fucosyltransferase fucT-V fucosyltransferase V galactoside 3-L-fucosyltransferase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Disorder MIM:	136835

mRNA and Protein(s)

mRNA	Protein	Name
NM_002034.2	NP_002025.2	alpha-(1,3)-fucosyltransferase 5

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FUT5	NP_001009088.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000365	XP_310745.5
Homo sapiens (human)	FUT5	NP_002025.2
Drosophila melanogaster (fruit fly)	FucTC	NP_001036320.3

Gene Ontology
Bibliography

Related articles in PubMed

miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.
Liang L, Gao C, Li Y, Sun M, Xu J, Li H, Jia L, Zhao Y
Cell death & disease8(8)e2968(2017 Aug)

[Distribution specificity of human fucosyltransferase 5 and its expression and localization in spermatids].
Li FR, Zhou YS, Zhu LH, Cui HG, Wang BJ, Ding M, Pang H
Fa yi xue za zhi28(2)112-4, 119(2012 Apr)

Down-regulation of FUT3 and FUT5 by shRNA alters Lewis antigens expression and reduces the adhesion capacities of gastric cancer cells.
Padr? M, Cobler L, Garrido M, de Bol?s C
Biochimica et biophysica acta1810(12)1141-9(2011 Dec)

[The genetic diversity in the full coding region of human FUT5 gene in a Chinese Han population].
Li FR, Tian XF, Zhou YS, Wang BJ, Ding M, Pang H
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics27(4)473-6(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FUT5 was expressed on spermatid membranes and in serum, but not in seminal plasma, vaginal fluid and saliva. Expression was localized on head of spermatids.
Title: [Distribution specificity of human fucosyltransferase 5 and its expression and localization in spermatids].

down-regulation of FUT3 and FUT5 reduces the expression of sialyl-Lewis antigens and the adhesion capacities of gastric cancer cells and allows to identify the specific alpha1-3,4 fucosyltransferases implicated in the Lewis antigens synthesis
Title: Down-regulation of FUT3 and FUT5 by shRNA alters Lewis antigens expression and reduces the adhesion capacities of gastric cancer cells.

Observational study of genotype prevalence. (HuGE Navigator)
Title: [The genetic diversity in the full coding region of human FUT5 gene in a Chinese Han population].

results suggested that PKR is the primary target for HSV-1 early RNA during induction of FUT3, FUT5, and FUT6
Title: Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cells.

FUT5 is a receptor of glycodelin-A and zona pellucida proteins, and glycodelin-A inhibits spermatozoa-zona binding by blocking the binding of sperm FUT5 to the zona pellucida
Title: Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding.

The following FUT5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FUT5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29705	NM_002034.2 Latest version!	Homo sapiens fucosyltransferase 5 (FUT5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FUT5 ( NM_002034.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002025.2 Homo sapiens fucosyltransferase 5 (FUT5), mRNA.

Price & Availability↑

CloneID	OHu29705
Clone ID Related Accession (Same CDS sequence)	NM_002034.2
Accession Version	NM_002034.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	alpha-(1,3)-fucosyltransferase 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC024592.5. On Sep 22, 2004 this sequence version replaced NM_002034.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U27330.1, U27329.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000588525.1/ ENSP00000466880.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGATCCCC TGGGCCCAGC CAAGCCACAG TGGCTGTGGC GCCGCTGTCT GGCCGGGCTG 
CTGTTTCAGC TGCTGGTGGC TGTGTGTTTC TTCTCCTACC TGCGTGTGTC CCGAGACGAT 
GCCACTGGAT CCCCTAGGCC AGGGCTTATG GCAGTGGAAC CTGTCACCGG GGCTCCCAAT 
GGGTCCCGCT GCCAGGACAG CATGGCGACC CCTGCCCACC CCACCCTACT GATCCTGCTG 
TGGACGTGGC CTTTTAACAC ACCCGTGGCT CTGCCCCGCT GCTCAGAGAT GGTGCCCGGC 
GCGGCCGACT GCAACATCAC TGCCGACTCC AGTGTGTACC CACAGGCAGA CGCGGTCATC 
GTGCACCACT GGGATATCAT GTACAACCCC AGTGCCAACC TCCCGCCCCC CACCAGGCCG 
CAGGGGCAGC GCTGGATCTG GTTCAGCATG GAGTCCCCCA GCAACTGCCG GCACCTGGAA 
GCCCTGGACG GATACTTCAA TCTCACCATG TCCTACCGCA GCGACTCCGA CATCTTCACG 
CCCTACGGCT GGCTGGAGCC GTGGTCCGGC CAGCCTGCCC ACCCACCGCT CAACCTCTCG 
GCCAAGACCG AGCTGGTGGC CTGGGCGGTG TCCAACTGGA AGCCGGACTC GGCCAGGGTG 
CGCTACTACC AGAGCCTGCA GGCTCATCTC AAGGTGGACG TGTACGGACG CTCCCACAAG 
CCCCTGCCCA AGGGGACCAT GATGGAGACG CTGTCCCGGT ACAAGTTCTA TCTGGCCTTC 
GAGAACTCCT TGCACCCCGA CTACATCACC GAGAAGCTGT GGAGGAACGC CCTGGAGGCC 
TGGGCCGTGC CCGTGGTGCT GGGCCCCAGC AGAAGCAACT ACGAGAGGTT CCTGCCACCC 
GACGCCTTCA TCCACGTGGA CGACTTCCAG AGCCCCAAGG ACCTGGCCCG GTACCTGCAG 
GAGCTGGACA AGGACCACGC CCGCTACCTG AGCTACTTTC ACTGGCGGGA GACGCTGCGG 
CCTCGCTCCT TCAGCTGGGC ACTGGCTTTC TGCAAGGCCT GCTGGAAGCT GCAGCAGGAA 
TCTAGGTACC AGACGGTGCG CAGCATAGCG GCTTGGTTCA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002025.2
CDS	89..1213
Translation	MDPLGPAKPQWLWRRCLAGLLFQLLVAVCFFSYLRVSRDDATGSPRPGLMAVEPVTGAPNGSRCQDSMATPAHPTLLILLWTWPFNTPVALPRCSEMVPGAADCNITADSSVYPQADAVIVHHWDIMYNPSANLPPPTRPQGQRWIWFSMESPSNCRHLEALDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFHWRETLRPRSFSWALAFCKACWKLQQESRYQTVRSIAAWFT

Target ORF information:

RefSeq Version	NM_002034.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fucosyltransferase 5 (FUT5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002034.2

ORF Insert Sequence:

ATGGATCCCC TGGGCCCAGC CAAGCCACAG TGGCTGTGGC GCCGCTGTCT GGCCGGGCTG 
CTGTTTCAGC TGCTGGTGGC TGTGTGTTTC TTCTCCTACC TGCGTGTGTC CCGAGACGAT 
GCCACTGGAT CCCCTAGGCC AGGGCTTATG GCAGTGGAAC CTGTCACCGG GGCTCCCAAT 
GGGTCCCGCT GCCAGGACAG CATGGCGACC CCTGCCCACC CCACCCTACT GATCCTGCTG 
TGGACGTGGC CTTTTAACAC ACCCGTGGCT CTGCCCCGCT GCTCAGAGAT GGTGCCCGGC 
GCGGCCGACT GCAACATCAC TGCCGACTCC AGTGTGTACC CACAGGCAGA CGCGGTCATC 
GTGCACCACT GGGATATCAT GTACAACCCC AGTGCCAACC TCCCGCCCCC CACCAGGCCG 
CAGGGGCAGC GCTGGATCTG GTTCAGCATG GAGTCCCCCA GCAACTGCCG GCACCTGGAA 
GCCCTGGACG GATACTTCAA TCTCACCATG TCCTACCGCA GCGACTCCGA CATCTTCACG 
CCCTACGGCT GGCTGGAGCC GTGGTCCGGC CAGCCTGCCC ACCCACCGCT CAACCTCTCG 
GCCAAGACCG AGCTGGTGGC CTGGGCGGTG TCCAACTGGA AGCCGGACTC GGCCAGGGTG 
CGCTACTACC AGAGCCTGCA GGCTCATCTC AAGGTGGACG TGTACGGACG CTCCCACAAG 
CCCCTGCCCA AGGGGACCAT GATGGAGACG CTGTCCCGGT ACAAGTTCTA TCTGGCCTTC 
GAGAACTCCT TGCACCCCGA CTACATCACC GAGAAGCTGT GGAGGAACGC CCTGGAGGCC 
TGGGCCGTGC CCGTGGTGCT GGGCCCCAGC AGAAGCAACT ACGAGAGGTT CCTGCCACCC 
GACGCCTTCA TCCACGTGGA CGACTTCCAG AGCCCCAAGG ACCTGGCCCG GTACCTGCAG 
GAGCTGGACA AGGACCACGC CCGCTACCTG AGCTACTTTC ACTGGCGGGA GACGCTGCGG 
CCTCGCTCCT TCAGCTGGGC ACTGGCTTTC TGCAAGGCCT GCTGGAAGCT GCAGCAGGAA 
TCTAGGTACC AGACGGTGCG CAGCATAGCG GCTTGGTTCA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.
Cell death & disease8(8)e2968(2017 Aug)
Liang L,Gao C,Li Y,Sun M,Xu J,Li H,Jia L,Zhao Y

[Distribution specificity of human fucosyltransferase 5 and its expression and localization in spermatids].
Fa yi xue za zhi28(2)112-4, 119(2012 Apr)
Li FR,Zhou YS,Zhu LH,Cui HG,Wang BJ,Ding M,Pang H

Down-regulation of FUT3 and FUT5 by shRNA alters Lewis antigens expression and reduces the adhesion capacities of gastric cancer cells.
Biochimica et biophysica acta1810(12)1141-9(2011 Dec)
Padr? M,Cobler L,Garrido M,de Bol?s C

[The genetic diversity in the full coding region of human FUT5 gene in a Chinese Han population].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics27(4)473-6(2010 Aug)
Li FR,Tian XF,Zhou YS,Wang BJ,Ding M,Pang H

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FUT5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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