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IL6 cDNA ORF clone, Homo sapiens (human)

Gene Symbol IL6
Entrez Gene ID 3569
Full Name interleukin 6
Synonyms BSF2, HGF, HSF, IFNB2, IL-6
General protein information
Preferred Names
interleukin-6
Names
interleukin-6
CDF
BSF-2
IFN-beta-2
interferon beta-2
interleukin BSF-2
hybridoma growth factor
CTL differentiation factor
B-cell stimulatory factor 2
B-cell differentiation factor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p21

Summary This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]. lac of sum
Disorder MIM:

147620

Disorder Html: {Rheumatoid arthritis, systemic juvenile}, 604302 (3); {Kaposi

mRNA and Protein(s)

mRNA Protein Name
XM_005249745 XP_005249802 interleukin-6 isoform X2
XM_011515390 XP_011513692 interleukin-6 isoform X1
XM_011515391 XP_011513693 interleukin-6 isoform X3
NM_000600 NP_000591 interleukin-6 precursor



Homo sapiens (human) IL6 NP_000591.1
Pan troglodytes (chimpanzee) IL6 XP_518992.2
Macaca mulatta (Rhesus monkey) IL6 NP_001036198.1
Canis lupus familiaris (dog) IL6 NP_001003301.1
Mus musculus (house mouse) Il6 NP_112445.1
Rattus norvegicus (Norway rat) Il6 NP_036721.1
Gallus gallus (chicken) IL6 NP_989959.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IL6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu41176 XM_005249745 PREDICTED: Homo sapiens interleukin 6 (IL6), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu23477
XM_011515390 PREDICTED: Homo sapiens interleukin 6 (IL6), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu58395 XM_011515391 PREDICTED: Homo sapiens interleukin 6 (IL6), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
OHu23477
NM_000600 Homo sapiens interleukin 6 (IL6), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu41176
Clone ID Related Accession (Same CDS sequence) XM_005249745
Accession Version XM_005249745.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 759bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product interleukin-6 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_007819.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578813494. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGAACTCCT TCTCCACAAG TAAGTGCAGG AAATCCTTAG CCCTGGAACT GCCAGCGGCG 
GTCGAGCCCT GTGTGAGGGA GGGGTGTGTG GCCCAGGGAG GGCTGGCGGG CGGCCAGCAG
CAGAGGCAGG CTCCCAGCTG TGCTGTCAGC TCACCCCTGC GCTCGCTCCC CTCCGGCACA
GGCGCCTTCG GTCCAGTTGC CTTCTCCCTG GGGCTGCTCC TGGTGTTGCC TGCTGCCTTC
CCTGCCCCAG TACCCCCAGG AGAAGATTCC AAAGATGTAG CCGCCCCACA CAGACAGCCA
CTCACCTCTT CAGAACGAAT TGACAAACAA ATTCGGTACA TCCTCGACGG CATCTCAGCC
CTGAGAAAGG AGACATGTAA CAAGAGTAAC ATGTGTGAAA GCAGCAAAGA GGCACTGGCA
GAAAACAACC TGAACCTTCC AAAGATGGCT GAAAAAGATG GATGCTTCCA ATCTGGATTC
AATGAGGAGA CTTGCCTGGT GAAAATCATC ACTGGTCTTT TGGAGTTTGA GGTATACCTA
GAGTACCTCC AGAACAGATT TGAGAGTAGT GAGGAACAAG CCAGAGCTGT GCAGATGAGT
ACAAAAGTCC TGATCCAGTT CCTGCAGAAA AAGGTGGGTG TGTCCTCATT CCCTCAACTT
GGTGTGGGGG AAGACAGGCT CAAAGACAGT GTCCTGGACA ACTCAGGGAT GCAATGCCAC
TTCCAAAAGA GAAGGCTACA CGTAAACAAA AGAGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005249802.1
CDS184..942
Misc Feature(1)514..>819(+)
Translation

Target ORF information:

RefSeq Version XM_005249745
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens interleukin 6 (IL6), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005249745

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGAACTCCT TCTCCACAAG TAAGTGCAGG AAATCCTTAG CCCTGGAACT GCCAGCGGCG 
GTCGAGCCCT GTGTGAGGGA GGGGTGTGTG GCCCAGGGAG GGCTGGCGGG CGGCCAGCAG
CAGAGGCAGG CTCCCAGCTG TGCTGTCAGC TCACCCCTGC GCTCGCTCCC CTCCGGCACA
GGCGCCTTCG GTCCAGTTGC CTTCTCCCTG GGGCTGCTCC TGGTGTTGCC TGCTGCCTTC
CCTGCCCCAG TACCCCCAGG AGAAGATTCC AAAGATGTAG CCGCCCCACA CAGACAGCCA
CTCACCTCTT CAGAACGAAT TGACAAACAA ATTCGGTACA TCCTCGACGG CATCTCAGCC
CTGAGAAAGG AGACATGTAA CAAGAGTAAC ATGTGTGAAA GCAGCAAAGA GGCACTGGCA
GAAAACAACC TGAACCTTCC AAAGATGGCT GAAAAAGATG GATGCTTCCA ATCTGGATTC
AATGAGGAGA CTTGCCTGGT GAAAATCATC ACTGGTCTTT TGGAGTTTGA GGTATACCTA
GAGTACCTCC AGAACAGATT TGAGAGTAGT GAGGAACAAG CCAGAGCTGT GCAGATGAGT
ACAAAAGTCC TGATCCAGTT CCTGCAGAAA AAGGTGGGTG TGTCCTCATT CCCTCAACTT
GGTGTGGGGG AAGACAGGCT CAAAGACAGT GTCCTGGACA ACTCAGGGAT GCAATGCCAC
TTCCAAAAGA GAAGGCTACA CGTAAACAAA AGAGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23477
Clone ID Related Accession (Same CDS sequence) NM_000600 , XM_011515390
Accession Version XM_011515390.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 639bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product interleukin-6 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_007819.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
ATGAACTCCT TCTCCACAAG CGCCTTCGGT CCAGTTGCCT TCTCCCTGGG GCTGCTCCTG 
GTGTTGCCTG CTGCCTTCCC TGCCCCAGTA CCCCCAGGAG AAGATTCCAA AGATGTAGCC
GCCCCACACA GACAGCCACT CACCTCTTCA GAACGAATTG ACAAACAAAT TCGGTACATC
CTCGACGGCA TCTCAGCCCT GAGAAAGGAG ACATGTAACA AGAGTAACAT GTGTGAAAGC
AGCAAAGAGG CACTGGCAGA AAACAACCTG AACCTTCCAA AGATGGCTGA AAAAGATGGA
TGCTTCCAAT CTGGATTCAA TGAGGAGACT TGCCTGGTGA AAATCATCAC TGGTCTTTTG
GAGTTTGAGG TATACCTAGA GTACCTCCAG AACAGATTTG AGAGTAGTGA GGAACAAGCC
AGAGCTGTGC AGATGAGTAC AAAAGTCCTG ATCCAGTTCC TGCAGAAAAA GGCAAAGAAT
CTAGATGCAA TAACCACCCC TGACCCAACC ACAAATGCCA GCCTGCTGAC GAAGCTGCAG
GCACAGAACC AGTGGCTGCA GGACATGACA ACTCATCTCA TTCTGCGCAG CTTTAAGGAG
TTCCTGCAGT CCAGCCTGAG GGCTCTTCGG CAAATGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011513692.1
CDS902..1540
Misc Feature(1)1070..1531(+)
Translation

Target ORF information:

RefSeq Version XM_011515390
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens interleukin 6 (IL6), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011515390

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGAACTCCT TCTCCACAAG CGCCTTCGGT CCAGTTGCCT TCTCCCTGGG GCTGCTCCTG 
GTGTTGCCTG CTGCCTTCCC TGCCCCAGTA CCCCCAGGAG AAGATTCCAA AGATGTAGCC
GCCCCACACA GACAGCCACT CACCTCTTCA GAACGAATTG ACAAACAAAT TCGGTACATC
CTCGACGGCA TCTCAGCCCT GAGAAAGGAG ACATGTAACA AGAGTAACAT GTGTGAAAGC
AGCAAAGAGG CACTGGCAGA AAACAACCTG AACCTTCCAA AGATGGCTGA AAAAGATGGA
TGCTTCCAAT CTGGATTCAA TGAGGAGACT TGCCTGGTGA AAATCATCAC TGGTCTTTTG
GAGTTTGAGG TATACCTAGA GTACCTCCAG AACAGATTTG AGAGTAGTGA GGAACAAGCC
AGAGCTGTGC AGATGAGTAC AAAAGTCCTG ATCCAGTTCC TGCAGAAAAA GGCAAAGAAT
CTAGATGCAA TAACCACCCC TGACCCAACC ACAAATGCCA GCCTGCTGAC GAAGCTGCAG
GCACAGAACC AGTGGCTGCA GGACATGACA ACTCATCTCA TTCTGCGCAG CTTTAAGGAG
TTCCTGCAGT CCAGCCTGAG GGCTCTTCGG CAAATGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu58395
Clone ID Related Accession (Same CDS sequence) XM_011515391
Accession Version XM_011515391.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 411bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product interleukin-6 isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_007819.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
ATGTGTGAAA GCAGCAAAGA GGCACTGGCA GAAAACAACC TGAACCTTCC AAAGATGGCT 
GAAAAAGATG GATGCTTCCA ATCTGGATTC AATGAGGAGA CTTGCCTGGT GAAAATCATC
ACTGGTCTTT TGGAGTTTGA GGTATACCTA GAGTACCTCC AGAACAGATT TGAGAGTAGT
GAGGAACAAG CCAGAGCTGT GCAGATGAGT ACAAAAGTCC TGATCCAGTT CCTGCAGAAA
AAGGCAAAGA ATCTAGATGC AATAACCACC CCTGACCCAA CCACAAATGC CAGCCTGCTG
ACGAAGCTGC AGGCACAGAA CCAGTGGCTG CAGGACATGA CAACTCATCT CATTCTGCGC
AGCTTTAAGG AGTTCCTGCA GTCCAGCCTG AGGGCTCTTC GGCAAATGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011513693.1
CDS139..549
Misc Feature(1)139..540(+)
Translation

Target ORF information:

RefSeq Version XM_011515391
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens interleukin 6 (IL6), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011515391

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGTGTGAAA GCAGCAAAGA GGCACTGGCA GAAAACAACC TGAACCTTCC AAAGATGGCT 
GAAAAAGATG GATGCTTCCA ATCTGGATTC AATGAGGAGA CTTGCCTGGT GAAAATCATC
ACTGGTCTTT TGGAGTTTGA GGTATACCTA GAGTACCTCC AGAACAGATT TGAGAGTAGT
GAGGAACAAG CCAGAGCTGT GCAGATGAGT ACAAAAGTCC TGATCCAGTT CCTGCAGAAA
AAGGCAAAGA ATCTAGATGC AATAACCACC CCTGACCCAA CCACAAATGC CAGCCTGCTG
ACGAAGCTGC AGGCACAGAA CCAGTGGCTG CAGGACATGA CAACTCATCT CATTCTGCGC
AGCTTTAAGG AGTTCCTGCA GTCCAGCCTG AGGGCTCTTC GGCAAATGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23477
Clone ID Related Accession (Same CDS sequence) NM_000600 , XM_011515390
Accession Version NM_000600.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 639bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product interleukin-6 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK301141.1, BC015511.1 and AA721478.1. This sequence is a reference standard in the RefSeqGene project. On Mar 11, 2009 this sequence version replaced gi:155369258. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X04430.1, BC015511.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGAACTCCT TCTCCACAAG CGCCTTCGGT CCAGTTGCCT TCTCCCTGGG GCTGCTCCTG 
GTGTTGCCTG CTGCCTTCCC TGCCCCAGTA CCCCCAGGAG AAGATTCCAA AGATGTAGCC
GCCCCACACA GACAGCCACT CACCTCTTCA GAACGAATTG ACAAACAAAT TCGGTACATC
CTCGACGGCA TCTCAGCCCT GAGAAAGGAG ACATGTAACA AGAGTAACAT GTGTGAAAGC
AGCAAAGAGG CACTGGCAGA AAACAACCTG AACCTTCCAA AGATGGCTGA AAAAGATGGA
TGCTTCCAAT CTGGATTCAA TGAGGAGACT TGCCTGGTGA AAATCATCAC TGGTCTTTTG
GAGTTTGAGG TATACCTAGA GTACCTCCAG AACAGATTTG AGAGTAGTGA GGAACAAGCC
AGAGCTGTGC AGATGAGTAC AAAAGTCCTG ATCCAGTTCC TGCAGAAAAA GGCAAAGAAT
CTAGATGCAA TAACCACCCC TGACCCAACC ACAAATGCCA GCCTGCTGAC GAAGCTGCAG
GCACAGAACC AGTGGCTGCA GGACATGACA ACTCATCTCA TTCTGCGCAG CTTTAAGGAG
TTCCTGCAGT CCAGCCTGAG GGCTCTTCGG CAAATGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000591.1
CDS117..755
Misc Feature(1)30..32(+)
Misc Feature(2)285..746(+)
Misc Feature(3)330..350(+)
Misc Feature(4)333..335(+)
Misc Feature(5)357..359(+)
Misc Feature(6)417..449(+)
Misc Feature(7)612..614(+)
Misc Feature(8)624..626(+)
Misc Feature(9)627..629(+)
Exon (1)1..135
Gene:IL6
Gene Synonym:
Exon (2)136..326
Gene:IL6
Gene Synonym:
Exon (3)327..440
Gene:IL6
Gene Synonym:
Exon (4)441..587
Gene:IL6
Gene Synonym:
Exon (5)588..1184
Gene:IL6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000600
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 6 (IL6), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000600

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGAACTCCT TCTCCACAAG CGCCTTCGGT CCAGTTGCCT TCTCCCTGGG GCTGCTCCTG 
GTGTTGCCTG CTGCCTTCCC TGCCCCAGTA CCCCCAGGAG AAGATTCCAA AGATGTAGCC
GCCCCACACA GACAGCCACT CACCTCTTCA GAACGAATTG ACAAACAAAT TCGGTACATC
CTCGACGGCA TCTCAGCCCT GAGAAAGGAG ACATGTAACA AGAGTAACAT GTGTGAAAGC
AGCAAAGAGG CACTGGCAGA AAACAACCTG AACCTTCCAA AGATGGCTGA AAAAGATGGA
TGCTTCCAAT CTGGATTCAA TGAGGAGACT TGCCTGGTGA AAATCATCAC TGGTCTTTTG
GAGTTTGAGG TATACCTAGA GTACCTCCAG AACAGATTTG AGAGTAGTGA GGAACAAGCC
AGAGCTGTGC AGATGAGTAC AAAAGTCCTG ATCCAGTTCC TGCAGAAAAA GGCAAAGAAT
CTAGATGCAA TAACCACCCC TGACCCAACC ACAAATGCCA GCCTGCTGAC GAAGCTGCAG
GCACAGAACC AGTGGCTGCA GGACATGACA ACTCATCTCA TTCTGCGCAG CTTTAAGGAG
TTCCTGCAGT CCAGCCTGAG GGCTCTTCGG CAAATGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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