IVL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IVL
Entrez Gene ID	3713
Full Name	involucrin
General protein information	Preferred Names involucrin Names involucrin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].
Disorder MIM:	147360

mRNA and Protein(s)

mRNA	Protein	Name
NM_005547.3	NP_005538.2	involucrin

Pathways from BioSystems

Homologies

Homo sapiens (human)	IVL	NP_005538.2
	IVL	XP_001109828.1
Pan troglodytes (chimpanzee)	IVL	XP_001136672.1

Gene Ontology
Bibliography

Related articles in PubMed

Glucocorticoid receptor enhances involucrin expression of keratinocyte in a ligand-independent manner.
Yoon HK, Li ZJ, Choi DK, Sohn KC, Lim EH, Lee YH, Kim S, Im M, Lee Y, Seo YJ, Lee JH, Kim CD
Molecular and cellular biochemistry390(1-2)289-95(2014 May)

Neuronatin is related to keratinocyte differentiation by up-regulating involucrin.
Dugu L, Nakahara T, Wu Z, Uchi H, Liu M, Hirano K, Yokomizo T, Furue M
Journal of dermatological science73(3)225-31(2014 Mar)

Regulation of involucrin in psoriatic epidermal keratinocytes: the roles of ERK1/2 and GSK-3?.
Chen JQ, Man XY, Li W, Zhou J, Landeck L, Cai SQ, Zheng M
Cell biochemistry and biophysics66(3)523-8(2013 Jul)

Protein kinase C ? increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytes.
Chew YC, Adhikary G, Xu W, Wilson GM, Eckert RL
The Journal of biological chemistry288(24)17759-68(2013 Jun)

The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, ?-defensin 2 and tumor necrosis factor-? genes.
Marzani B, Pinto D, Minervini F, Calasso M, Di Cagno R, Giuliani G, Gobbetti M, De Angelis M
Experimental dermatology21(9)665-71(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Together, these results suggest that GR modulates involucrin expression of keratinocytes by regulating the intracellular signaling network in a ligand-independent manner.
Title: Glucocorticoid receptor enhances involucrin expression of keratinocyte in a ligand-independent manner.

over-expression of Nnat was evident along with involucrin and cytokeratin1 expression
Title: Neuronatin is related to keratinocyte differentiation by up-regulating involucrin.

involucrin is up-regulated in psoriatic keratinocytes
Title: Regulation of involucrin in psoriatic epidermal keratinocytes: the roles of ERK1/2 and GSK-3?.

KLF4 is part of a multiprotein complex that interacts that the hINV promoter distal regulatory region to drive differentiation-dependent hINV gene expression in epidermis.
Title: Protein kinase C ? increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytes.

Compared with the control, the level of expression of the IVL gene in NCTC 2544 cells was increased after 8 h of treatment with hyaluronic acid or Plantaricin A preparations.
Title: The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, ?-defensin 2 and tumor necrosis factor-? genes.

The following IVL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IVL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19112	NM_005547.3 Latest version!	Homo sapiens involucrin (IVL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IVL ( NM_005547.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005538.2 Homo sapiens involucrin (IVL), mRNA.

Price & Availability↑

CloneID	OHu19112
Clone ID Related Accession (Same CDS sequence)	NM_005547.3
Accession Version	NM_005547.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1758bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	involucrin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC387410.1, BC046391.2, AL162596.30 and AK300492.1. This sequence is a reference standard in the RefSeqGene project. On Feb 27, 2017 this sequence version replaced NM_005547.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.342879.1, SRR1163658.163898.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCCAGC AACACACACT GCCAGTGACC CTCTCCCCTG CCCTCAGTCA GGAGCTCCTC 
AAGACTGTTC CTCCTCCAGT CAATACCCAT CAGGAGCAAA TGAAACAGCC AACTCCACTG 
CCTCCCCCAT GCCAGAAGGT GCCTGTCGAG CTCCCAGTGG AGGTCCCATC AAAGCAAGAG 
GAAAAGCACA TGACTGCTGT AAAGGGACTG CCTGAGCAAG AATGTGAGCA ACAGCAGAAG 
GAGCCACAGG AGCAGGAGCT GCAGCAACAG CACTGGGAAC AGCATGAGGA ATATCAGAAA 
GCAGAAAACC CAGAGCAGCA GCTTAAGCAG GAGAAAACAC AAAGGGATCA GCAGCTAAAC 
AAACAGCTGG AAGAAGAGAA GAAGCTCTTA GACCAGCAAC TGGATCAAGA GCTAGTCAAG 
AGAGATGAGC AACTGGGAAT GAAGAAAGAG CAACTGTTGG AGCTCCCAGA GCAGCAGGAG 
GGGCACCTGA AGCACCTAGA GCAGCAGGAG GGACAGCTGA AGCACCCGGA GCAGCAGGAG 
GGGCAGCTGG AGCTCCCAGA GCAGCAGGAG GGGCAGCTGG AGCTCCCAGA GCAGCAGGAG 
GGGCAGCTGG AGCTCCCAGA GCAGCAGGAG GGGCAGCTGG AGCTCCCAGA GCAGCAGGAG 
GGGCAGCTGG AGCTCCCAGA GCAGCAGGAG GGGCAGCTGG AGCTCCCACA GCAGCAGGAG 
GGGCAGCTGG AGCTCTCTGA GCAGCAGGAG GGGCAGCTGG AGCTCTCTGA GCAGCAGGAG 
GGACAGCTGA AGCACCTGGA GCACCAGGAG GGGCAGCTGG AGGTCCCAGA GGAGCAGATG 
GGGCAGCTGA AGTACCTGGA ACAGCAGGAG GGGCAGCTGA AGCACCTGGA TCAGCAGGAG 
AAGCAGCCAG AGCTCCCAGA GCAGCAGATG GGGCAGCTGA AGCACCTGGA GCAGCAGGAG 
GGGCAGCCTA AGCATCTGGA GCAGCAGGAG GGGCAACTGG AGCAGCTGGA GGAGCAGGAG 
GGGCAGCTGA AGCACCTGGA GCAGCAGGAG GGGCAGCTGG AGCACCTGGA GCACCAGGAA 
GGGCAGCTGG GGCTCCCAGA GCAGCAGGTG CTGCAGCTGA AGCAGCTAGA GAAGCAGCAG 
GGGCAGCCAA AGCACCTGGA GGAGGAGGAG GGGCAGCTGA AGCACCTGGT GCAGCAGGAG 
GGGCAGCTGA AGCATCTGGT GCAGCAGGAG GGGCAGCTGG AGCAGCAGGA GAGGCAGGTG 
GAGCACCTGG AGCAGCAGGT GGGGCAGCTG AAGCACCTAG AGGAGCAGGA GGGACAACTG 
AAGCATCTGG AGCAGCAGCA GGGGCAGTTG GAGGTCCCAG AGCAGCAGGT GGGGCAGCCA 
AAGAACCTGG AGCAGGAGGA GAAGCAACTG GAGCTCCCAG AGCAGCAAGA GGGCCAGGTG 
AAGCACCTGG AGAAGCAGGA GGCACAGCTG GAGCTCCCAG AGCAGCAGGT AGGACAGCCA 
AAGCACCTGG AACAGCAGGA AAAGCACCTA GAGCACCCAG AGCAGCAGGA CGGACAACTA 
AAACATCTGG AGCAGCAGGA GGGGCAGCTG AAGGACCTGG AGCAGCAGAA GGGGCAGCTG 
GAGCAGCCTG TGTTTGCCCC AGCTCCAGGC CAGGTCCAAG ACATTCAACC AGCCCTGCCC 
ACAAAGGGAG AAGTATTGCT TCCTGTAGAG CACCAGCAGC AGAAGCAGGA GGTGCAGTGG 
CCACCCAAAC ATAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005538.2
CDS	65..1822
Translation	MSQQHTLPVTLSPALSQELLKTVPPPVNTHQEQMKQPTPLPPPCQKVPVELPVEVPSKQEEKHMTAVKGLPEQECEQQQKEPQEQELQQQHWEQHEEYQKAENPEQQLKQEKTQRDQQLNKQLEEEKKLLDQQLDQELVKRDEQLGMKKEQLLELPEQQEGHLKHLEQQEGQLKHPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPQQQEGQLELSEQQEGQLELSEQQEGQLKHLEHQEGQLEVPEEQMGQLKYLEQQEGQLKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQEGQLEQLEEQEGQLKHLEQQEGQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEEGQLKHLVQQEGQLKHLVQQEGQLEQQERQVEHLEQQVGQLKHLEEQEGQLKHLEQQQGQLEVPEQQVGQPKNLEQEEKQLELPEQQEGQVKHLEKQEAQLELPEQQVGQPKHLEQQEKHLEHPEQQDGQLKHLEQQEGQLKDLEQQKGQLEQPVFAPAPGQVQDIQPALPTKGEVLLPVEHQQQKQEVQWPPKHK

Target ORF information:

RefSeq Version	NM_005547.3
Organism	Homo sapiens(human)
Definition	Homo sapiens involucrin (IVL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005547.3

ORF Insert Sequence:

ATGTCCCAGC AACACACACT GCCAGTGACC CTCTCCCCTG CCCTCAGTCA GGAGCTCCTC 
AAGACTGTTC CTCCTCCAGT CAATACCCAT CAGGAGCAAA TGAAACAGCC AACTCCACTG 
CCTCCCCCAT GCCAGAAGGT GCCTGTCGAG CTCCCAGTGG AGGTCCCATC AAAGCAAGAG 
GAAAAGCACA TGACTGCTGT AAAGGGACTG CCTGAGCAAG AATGTGAGCA ACAGCAGAAG 
GAGCCACAGG AGCAGGAGCT GCAGCAACAG CACTGGGAAC AGCATGAGGA ATATCAGAAA 
GCAGAAAACC CAGAGCAGCA GCTTAAGCAG GAGAAAACAC AAAGGGATCA GCAGCTAAAC 
AAACAGCTGG AAGAAGAGAA GAAGCTCTTA GACCAGCAAC TGGATCAAGA GCTAGTCAAG 
AGAGATGAGC AACTGGGAAT GAAGAAAGAG CAACTGTTGG AGCTCCCAGA GCAGCAGGAG 
GGGCACCTGA AGCACCTAGA GCAGCAGGAG GGACAGCTGA AGCACCCGGA GCAGCAGGAG 
GGGCAGCTGG AGCTCCCAGA GCAGCAGGAG GGGCAGCTGG AGCTCCCAGA GCAGCAGGAG 
GGGCAGCTGG AGCTCCCAGA GCAGCAGGAG GGGCAGCTGG AGCTCCCAGA GCAGCAGGAG 
GGGCAGCTGG AGCTCCCAGA GCAGCAGGAG GGGCAGCTGG AGCTCCCACA GCAGCAGGAG 
GGGCAGCTGG AGCTCTCTGA GCAGCAGGAG GGGCAGCTGG AGCTCTCTGA GCAGCAGGAG 
GGACAGCTGA AGCACCTGGA GCACCAGGAG GGGCAGCTGG AGGTCCCAGA GGAGCAGATG 
GGGCAGCTGA AGTACCTGGA ACAGCAGGAG GGGCAGCTGA AGCACCTGGA TCAGCAGGAG 
AAGCAGCCAG AGCTCCCAGA GCAGCAGATG GGGCAGCTGA AGCACCTGGA GCAGCAGGAG 
GGGCAGCCTA AGCATCTGGA GCAGCAGGAG GGGCAACTGG AGCAGCTGGA GGAGCAGGAG 
GGGCAGCTGA AGCACCTGGA GCAGCAGGAG GGGCAGCTGG AGCACCTGGA GCACCAGGAA 
GGGCAGCTGG GGCTCCCAGA GCAGCAGGTG CTGCAGCTGA AGCAGCTAGA GAAGCAGCAG 
GGGCAGCCAA AGCACCTGGA GGAGGAGGAG GGGCAGCTGA AGCACCTGGT GCAGCAGGAG 
GGGCAGCTGA AGCATCTGGT GCAGCAGGAG GGGCAGCTGG AGCAGCAGGA GAGGCAGGTG 
GAGCACCTGG AGCAGCAGGT GGGGCAGCTG AAGCACCTAG AGGAGCAGGA GGGACAACTG 
AAGCATCTGG AGCAGCAGCA GGGGCAGTTG GAGGTCCCAG AGCAGCAGGT GGGGCAGCCA 
AAGAACCTGG AGCAGGAGGA GAAGCAACTG GAGCTCCCAG AGCAGCAAGA GGGCCAGGTG 
AAGCACCTGG AGAAGCAGGA GGCACAGCTG GAGCTCCCAG AGCAGCAGGT AGGACAGCCA 
AAGCACCTGG AACAGCAGGA AAAGCACCTA GAGCACCCAG AGCAGCAGGA CGGACAACTA 
AAACATCTGG AGCAGCAGGA GGGGCAGCTG AAGGACCTGG AGCAGCAGAA GGGGCAGCTG 
GAGCAGCCTG TGTTTGCCCC AGCTCCAGGC CAGGTCCAAG ACATTCAACC AGCCCTGCCC 
ACAAAGGGAG AAGTATTGCT TCCTGTAGAG CACCAGCAGC AGAAGCAGGA GGTGCAGTGG 
CCACCCAAAC ATAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glucocorticoid receptor enhances involucrin expression of keratinocyte in a ligand-independent manner.
Molecular and cellular biochemistry390(1-2)289-95(2014 May)
Yoon HK,Li ZJ,Choi DK,Sohn KC,Lim EH,Lee YH,Kim S,Im M,Lee Y,Seo YJ,Lee JH,Kim CD

Neuronatin is related to keratinocyte differentiation by up-regulating involucrin.
Journal of dermatological science73(3)225-31(2014 Mar)
Dugu L,Nakahara T,Wu Z,Uchi H,Liu M,Hirano K,Yokomizo T,Furue M

Regulation of involucrin in psoriatic epidermal keratinocytes: the roles of ERK1/2 and GSK-3?.
Cell biochemistry and biophysics66(3)523-8(2013 Jul)
Chen JQ,Man XY,Li W,Zhou J,Landeck L,Cai SQ,Zheng M

Protein kinase C ? increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytes.
The Journal of biological chemistry288(24)17759-68(2013 Jun)
Chew YC,Adhikary G,Xu W,Wilson GM,Eckert RL

The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, ?-defensin 2 and tumor necrosis factor-? genes.
Experimental dermatology21(9)665-71(2012 Sep)
Marzani B,Pinto D,Minervini F,Calasso M,Di Cagno R,Giuliani G,Gobbetti M,De Angelis M

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IVL cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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