NOL12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOL12
Entrez Gene ID	79159
Full Name	nucleolar protein 12
Synonyms	Nop25,dJ37E16.7
General protein information	Preferred Names nucleolar protein 12 Names nucleolar protein 12
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_024313.2	NP_077289.1	nucleolar protein 12
NM_024313.3	NP_077289.1	nucleolar protein 12

Pathways from BioSystems

Homologies

	NOL12	XP_001088681.1
Bos taurus (cattle)	NOL12	NP_001040022.1
Rattus norvegicus (Norway rat)	Nol12	NP_001012765.1
Danio rerio (zebrafish)	nol12	NP_956584.1
Mus musculus (house mouse)	Nol12	NP_598561.2
Gallus gallus (chicken)	NOL12	XP_416274.2
Homo sapiens (human)	NOL12	NP_077289.1
Canis lupus familiaris (dog)	NOL12	XP_850464.1
Pan troglodytes (chimpanzee)	NOL12	XP_001162216.1
Xenopus tropicalis (tropical clawed frog)	nol12	NP_001008168.1

Gene Ontology
Bibliography

Related articles in PubMed

Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.
Scott DD, Trahan C, Zindy PJ, Aguilar LC, Delubac MY, Van Nostrand EL, Adivarahan S, Wei KE, Yeo GW, Zenklusen D, Oeffinger M
Nucleic acids research45(21)12509-12528(2017 Dec)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Lee OH, Kim H, He Q, Baek HJ, Yang D, Chen LY, Liang J, Chae HK, Safari A, Liu D, Songyang Z
Molecular & cellular proteomics : MCP10(2)M110.001628(2011 Feb)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nol12 is an RNA binding protein required for both ribosome maturation and genome integrity
Title: Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following NOL12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOL12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30283	NM_024313.3 Latest version!	Homo sapiens nucleolar protein 12 (NOL12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30283	NM_024313.2	Homo sapiens nucleolar protein 12 (NOL12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOL12 ( NM_024313.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_077289.1 Homo sapiens nucleolar protein 12 (NOL12), mRNA.

Price & Availability↑

CloneID	OHu30283
Clone ID Related Accession (Same CDS sequence)	NM_024313.2 , NM_024313.3
Accession Version	NM_024313.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	nucleolar protein 12
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE241845.1, BC002808.1 and Z83844.5. On Jan 27, 2006 this sequence version replaced NM_024313.1. ##Evidence-Data-START## Transcript exon combination :: DC410033.1, SRR1803613.194870.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCGCA ACAAGAAGAA GAAGCGAGAT GGTGACGACC GGCGGCCGAG GCTCGTTCTT 
AGCTTCGACG AGGAGAAGAG GCGGGAGTAC CTGACAGGCT TCCACAAGCG GAAGGTCGAG 
CGAAAGAAGG CAGCCATTGA GGAGATTAAG CAGCGGCTGA AAGAGGAGCA GAGGAAGCTT 
CGGGAGGAGC GCCACCAGGA ATACTTGAAG ATGCTGGCAG AGAGAGAAGA GGCTCTGGAG 
GAGGCAGATG AGCTGGACCG GTTGGTGACA GCAAAGACGG AGTCGGTGCA GTATGACCAC 
CCCAACCACA CAGTCACCGT GACCACCATC AGTGACCTGG ACCTCTCGGG GGCCCGGCTG 
CTCGGGCTGA CCCCACCTGA GGGAGGGGCT GGAGACAGGT CTGAGGAGGA GGCGTCATCC 
ACGGAGAAAC CAACCAAAGC CTTGCCCAGG AAGTCCAGAG ACCCCCTGCT CTCTCAGCGG 
ATCTCCTCCC TCACAGCATC ACTACATGCA CACAGCCGCA AAAAGGTCAA GAGGAAACAT 
CCCCGACGGG CCCAGGACTC CAAAAAGCCC CCAAGGGCCC CTCGTACCAG CAAGGCCCAG 
CGCCGCCGTC TCACAGGCAA AGCACGGCAC AGCGGGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077289.1
CDS	57..698
Translation	MGRNKKKKRDGDDRRPRLVLSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQRKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLTPPEGGAGDRSEEEASSTEKPTKALPRKSRDPLLSQRISSLTASLHAHSRKKVKRKHPRRAQDSKKPPRAPRTSKAQRRRLTGKARHSGE

Target ORF information:

RefSeq Version	NM_024313.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nucleolar protein 12 (NOL12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024313.2

ORF Insert Sequence:

ATGGGCCGCA ACAAGAAGAA GAAGCGAGAT GGTGACGACC GGCGGCCGAG GCTCGTTCTT 
AGCTTCGACG AGGAGAAGAG GCGGGAGTAC CTGACAGGCT TCCACAAGCG GAAGGTCGAG 
CGAAAGAAGG CAGCCATTGA GGAGATTAAG CAGCGGCTGA AAGAGGAGCA GAGGAAGCTT 
CGGGAGGAGC GCCACCAGGA ATACTTGAAG ATGCTGGCAG AGAGAGAAGA GGCTCTGGAG 
GAGGCAGATG AGCTGGACCG GTTGGTGACA GCAAAGACGG AGTCGGTGCA GTATGACCAC 
CCCAACCACA CAGTCACCGT GACCACCATC AGTGACCTGG ACCTCTCGGG GGCCCGGCTG 
CTCGGGCTGA CCCCACCTGA GGGAGGGGCT GGAGACAGGT CTGAGGAGGA GGCGTCATCC 
ACGGAGAAAC CAACCAAAGC CTTGCCCAGG AAGTCCAGAG ACCCCCTGCT CTCTCAGCGG 
ATCTCCTCCC TCACAGCATC ACTACATGCA CACAGCCGCA AAAAGGTCAA GAGGAAACAT 
CCCCGACGGG CCCAGGACTC CAAAAAGCCC CCAAGGGCCC CTCGTACCAG CAAGGCCCAG 
CGCCGCCGTC TCACAGGCAA AGCACGGCAC AGCGGGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOL12 ( NM_024313.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_077289.1 Homo sapiens nucleolar protein 12 (NOL12), mRNA.

Price & Availability↑

CloneID	OHu30283
Clone ID Related Accession (Same CDS sequence)	NM_024313.2 , NM_024313.3
Accession Version	NM_024313.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	nucleolar protein 12
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE241845.1, BC002808.1 and Z83844.5. On Nov 23, 2018 this sequence version replaced NM_024313.2. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.169032.1, SRR1803613.194870.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000359114.9/ ENSP00000352021.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCCGCA ACAAGAAGAA GAAGCGAGAT GGTGACGACC GGCGGCCGAG GCTCGTTCTT 
AGCTTCGACG AGGAGAAGAG GCGGGAGTAC CTGACAGGCT TCCACAAGCG GAAGGTCGAG 
CGAAAGAAGG CAGCCATTGA GGAGATTAAG CAGCGGCTGA AAGAGGAGCA GAGGAAGCTT 
CGGGAGGAGC GCCACCAGGA ATACTTGAAG ATGCTGGCAG AGAGAGAAGA GGCTCTGGAG 
GAGGCAGATG AGCTGGACCG GTTGGTGACA GCAAAGACGG AGTCGGTGCA GTATGACCAC 
CCCAACCACA CAGTCACCGT GACCACCATC AGTGACCTGG ACCTCTCGGG GGCCCGGCTG 
CTCGGGCTGA CCCCACCTGA GGGAGGGGCT GGAGACAGGT CTGAGGAGGA GGCGTCATCC 
ACGGAGAAAC CAACCAAAGC CTTGCCCAGG AAGTCCAGAG ACCCCCTGCT CTCTCAGCGG 
ATCTCCTCCC TCACAGCATC ACTACATGCA CACAGCCGCA AAAAGGTCAA GAGGAAACAT 
CCCCGACGGG CCCAGGACTC CAAAAAGCCC CCAAGGGCCC CTCGTACCAG CAAGGCCCAG 
CGCCGCCGTC TCACAGGCAA AGCACGGCAC AGCGGGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077289.1
CDS	51..692
Translation	MGRNKKKKRDGDDRRPRLVLSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQRKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLTPPEGGAGDRSEEEASSTEKPTKALPRKSRDPLLSQRISSLTASLHAHSRKKVKRKHPRRAQDSKKPPRAPRTSKAQRRRLTGKARHSGE

Target ORF information:

RefSeq Version	NM_024313.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nucleolar protein 12 (NOL12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024313.3

ORF Insert Sequence:

ATGGGCCGCA ACAAGAAGAA GAAGCGAGAT GGTGACGACC GGCGGCCGAG GCTCGTTCTT 
AGCTTCGACG AGGAGAAGAG GCGGGAGTAC CTGACAGGCT TCCACAAGCG GAAGGTCGAG 
CGAAAGAAGG CAGCCATTGA GGAGATTAAG CAGCGGCTGA AAGAGGAGCA GAGGAAGCTT 
CGGGAGGAGC GCCACCAGGA ATACTTGAAG ATGCTGGCAG AGAGAGAAGA GGCTCTGGAG 
GAGGCAGATG AGCTGGACCG GTTGGTGACA GCAAAGACGG AGTCGGTGCA GTATGACCAC 
CCCAACCACA CAGTCACCGT GACCACCATC AGTGACCTGG ACCTCTCGGG GGCCCGGCTG 
CTCGGGCTGA CCCCACCTGA GGGAGGGGCT GGAGACAGGT CTGAGGAGGA GGCGTCATCC 
ACGGAGAAAC CAACCAAAGC CTTGCCCAGG AAGTCCAGAG ACCCCCTGCT CTCTCAGCGG 
ATCTCCTCCC TCACAGCATC ACTACATGCA CACAGCCGCA AAAAGGTCAA GAGGAAACAT 
CCCCGACGGG CCCAGGACTC CAAAAAGCCC CCAAGGGCCC CTCGTACCAG CAAGGCCCAG 
CGCCGCCGTC TCACAGGCAA AGCACGGCAC AGCGGGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.
Nucleic acids research45(21)12509-12528(2017 Dec)
Scott DD,Trahan C,Zindy PJ,Aguilar LC,Delubac MY,Van Nostrand EL,Adivarahan S,Wei KE,Yeo GW,Zenklusen D,Oeffinger M

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Molecular & cellular proteomics : MCP10(2)M110.001628(2011 Feb)
Lee OH,Kim H,He Q,Baek HJ,Yang D,Chen LY,Liang J,Chae HK,Safari A,Liu D,Songyang Z

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

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NOL12 cDNA ORF clone, Homo sapiens(human)

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