UXT cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | UXT |
| Entrez Gene ID | 8409 |
| Full Name | ubiquitously expressed prefoldin like chaperone |
| Synonyms | ART-27,STAP1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_153477.2 | NP_705582.1 | protein UXT isoform 1 |
| NM_004182.3 | NP_004173.1 | protein UXT isoform 2 |
| UXT | XP_001101746.2 | |
| Canis lupus familiaris (dog) | UXT | XP_005641351.1 |
| Oryza sativa (rice) | Os07g0595800 | NP_001060168.1 |
| Mus musculus (house mouse) | Uxt | NP_038868.2 |
| Homo sapiens (human) | UXT | NP_004173.1 |
| Pan troglodytes (chimpanzee) | UXT | XP_521040.3 |
| Bos taurus (cattle) | UXT | NP_001032548.1 |
| Rattus norvegicus (Norway rat) | Uxt | NP_001006983.1 |
| Danio rerio (zebrafish) | uxt | NP_001004671.1 |
| Arabidopsis thaliana (thale cress) | AT1G26660 | NP_564253.2 |
Related articles in PubMed
UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.
S?nchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE
Journal of cellular biochemistry118(8)2347-2356(2017 Aug)
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Yadav L, Tamene F, G??s H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M
Cell systems4(4)430-444.e5(2017 Apr)
The EZH1-SUZ12 complex positively regulates the transcription of NF-?B target genes through interaction with UXT.
Su SK, Li CY, Lei PJ, Wang X, Zhao QY, Cai Y, Wang Z, Li L, Wu M
Journal of cell science129(12)2343-53(2016 06)
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)
UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-?B activity.
Qi M, Ganapathy S, Zeng W, Zhang J, Little JB, Yuan ZM
Oncotarget6(19)17584-93(2015 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.
Title: UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.
EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus.
Title: The EZH1-SUZ12 complex positively regulates the transcription of NF-?B target genes through interaction with UXT.
we describe the identification of UXT as a novel MDMX-interacting protein
Title: UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-?B activity.
UXT is a binding protein of PIAS2, and interaction between PIAS2 and UXT may be important for the transcriptional activation of AR.
Title: Ubiquitously expressed transcript is a novel interacting protein of protein inhibitor of activated signal transducer and activator of transcription 2.
Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.
Title: Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.
The following UXT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UXT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu19826 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_004182.3 | |
| Accession Version | NM_004182.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | COA |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-01-01 | |
| Organism | Homo sapiens(human) | |
| Product | protein UXT isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA372561.1, AF092737.1 and BQ681820.1. On Nov 23, 2011 this sequence version replaced NM_004182.2. Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ677168.1, SRR1163657.486355.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGACGC CCCCTAAGCG GCGGGCGGTG GAGGCCACGG GGGAGAAAGT GCTGCGCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_004173.1 |
| CDS | 76..549 |
| Misc Feature(1) | 127..516 |
| Misc Feature(2) | order(274..291,307..309,313..315,343..345,352..357,364..366,370..378) |
| Exon (1) | 1..66 |
| Exon (2) | 67..173 |
| Exon (3) | 174..255 |
| Exon (4) | 256..323 |
| Exon (5) | 324..431 |
| Exon (6) | 432..495 |
| Exon (7) | 496..599 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_004182.3 |
ORF Insert Sequence:
1 | ATGGCGACGC CCCCTAAGCG GCGGGCGGTG GAGGCCACGG GGGAGAAAGT GCTGCGCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20333 | |
| Clone ID Related Accession (Same CDS sequence) | NM_153477.2 | |
| Accession Version | NM_153477.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-01-01 | |
| Organism | Homo sapiens(human) | |
| Product | protein UXT isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA372561.1, AF083242.1 and BQ681820.1. On Nov 23, 2011 this sequence version replaced NM_153477.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.477039.1, BI603031.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGTCTTCC CCCTCCCCAC TCCCCAGGAG CCCATCATGG CGACGCCCCC TAAGCGGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_705582.1 |
| CDS | 218..727 |
| Misc Feature(1) | 194..196 |
| Misc Feature(2) | 305..694 |
| Misc Feature(3) | order(452..469,485..487,491..493,521..523,530..535,542..544,548..556) |
| Exon (1) | 1..351 |
| Exon (2) | 352..433 |
| Exon (3) | 434..501 |
| Exon (4) | 502..609 |
| Exon (5) | 610..673 |
| Exon (6) | 674..777 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_153477.2 |
ORF Insert Sequence:
1 | ATGGTCTTCC CCCTCCCCAC TCCCCAGGAG CCCATCATGG CGACGCCCCC TAAGCGGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. |
|
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. |
|
The EZH1-SUZ12 complex positively regulates the transcription of NF-?B target genes through interaction with UXT. |
|
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. |
|
UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-?B activity. |