Gene Symbol | CD72 |
Entrez Gene ID | 971 |
Full Name | CD72 molecule |
Synonyms | CD72b,LYB2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » CD72 cDNA ORF clone
gRNAs
Gene Symbol | CD72 |
Entrez Gene ID | 971 |
Full Name | CD72 molecule |
Synonyms | CD72b,LYB2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_006716894.3 | XP_006716957.1 | B-cell differentiation antigen CD72 isoform X2 |
XM_017015351.1 | XP_016870840.1 | B-cell differentiation antigen CD72 isoform X3 |
XM_011518074.2 | XP_011516376.1 | B-cell differentiation antigen CD72 isoform X2 |
NM_001782.3 | NP_001773.1 | B-cell differentiation antigen CD72 |
NM_001782.2 | NP_001773.1 | B-cell differentiation antigen CD72 |
XM_006716893.2 | XP_006716956.1 | B-cell differentiation antigen CD72 isoform X1 |
Interferon-?-induced CD100 on na?ve CD8
Li BJ, He Y, Zhang Y, Guo YH, Zhou Y, Zhang PX, Wang W, Zhao JR, Li JG, Zuo WZ, Fan C, Jia ZS
The Journal of international medical research45(1)89-100(2017 Feb)
Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis.
Vadasz Z, Goldeberg Y, Halasz K, Rosner I, Valesini G, Conti F, Perricone C, Sthoeger Z, Bezalel SR, Tzioufas AG, Levin NA, Shoenfeld Y, Toubi E
Clinical immunology (Orlando, Fla.)164114-8(2016 Mar)
A regulatory role for CD72 expression on B cells in systemic lupus erythematosus.
Vadasz Z, Haj T, Balbir A, Peri R, Rosner I, Slobodin G, Kessel A, Toubi E
Seminars in arthritis and rheumatism43(6)767-71(2014 Jun)
Modulation of B cell regulatory molecules CD22 and CD72 in myasthenia gravis and multiple sclerosis.
Lu J, Li J, Zhu TQ, Zhang L, Wang Y, Tian FF, Yang H
Inflammation36(3)521-8(2013 Jun)
Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum.
Hitomi Y, Adachi T, Tsuchiya N, Honda Z, Tokunaga K, Tsubata T
BMC immunology1372(2012 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Interferon-alpha-induced CD100 expression on naive CD8(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction.
Title: Interferon-?-induced CD100 on na?ve CD8
Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis
Title: Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis.
CD72 expression on activated B cells of SLE patients was significantly lower than that of normal controls. sema3A enhanced CD72 expression of B cells, but it was still lower in SLE patients than in normal individuals.
Title: A regulatory role for CD72 expression on B cells in systemic lupus erythematosus.
data demonstrated aberrant expression of CD72 exists on B cells of myasthenia gravis and multiple sclerosis patients and expression level of CD72 molecule has a significantly negative correlation with anti-AchR antibody levels in myasthenia gravis
Title: Modulation of B cell regulatory molecules CD22 and CD72 in myasthenia gravis and multiple sclerosis.
regulates serum immunoglobulin leveln and disease resistance in systemic lupus erythematosus
Title: Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum.
The following CD72 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD72 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu24370![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001782.3 , NM_001782.2 | |
Accession Version | NM_001782.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-14 | |
Organism | Homo sapiens(human) | |
Product | B-cell differentiation antigen CD72 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL357874.13, M54992.1 and BC030227.1. On Jul 3, 2019 this sequence version replaced NM_001782.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030227.1, M54992.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## |
1 | ATGGCTGAGG CCATCACCTA TGCAGATCTG AGGTTTGTGA AGGCTCCCCT GAAGAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001773.1 |
CDS | 111..1190 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGAGG CCATCACCTA TGCAGATCTG AGGTTTGTGA AGGCTCCCCT GAAGAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu24370![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001782.3 , NM_001782.2 | |
Accession Version | NM_001782.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-17 | |
Organism | Homo sapiens(human) | |
Product | B-cell differentiation antigen CD72 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL357874.13. On Jul 10, 2008 this sequence version replaced NM_001782.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M54992.1, BC030227.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCTGAGG CCATCACCTA TGCAGATCTG AGGTTTGTGA AGGCTCCCCT GAAGAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001773.1 |
CDS | 125..1204 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGAGG CCATCACCTA TGCAGATCTG AGGTTTGTGA AGGCTCCCCT GAAGAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu42882 | |
Clone ID Related Accession (Same CDS sequence) | XM_006716893.2 | |
Accession Version | XM_006716893.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1101bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | B-cell differentiation antigen CD72 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006716893.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGAGG CCATCACCTA TGCAGATCTG AGGTTTGTGA AGGCTCCCCT GAAGAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006716956.1 |
CDS | 125..1225 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGAGG CCATCACCTA TGCAGATCTG AGGTTTGTGA AGGCTCCCCT GAAGAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu42883 | |
Clone ID Related Accession (Same CDS sequence) | XM_006716894.3 , XM_011518074.2 | |
Accession Version | XM_006716894.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | B-cell differentiation antigen CD72 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006716894.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAAACCA GGAACCCCCA GTCTCATGGG GAGAACGGAG CCTCACCCTG GAGCTGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006716957.1 |
CDS | 510..1598 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAAACCA GGAACCCCCA GTCTCATGGG GAGAACGGAG CCTCACCCTG GAGCTGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu42883 | |
Clone ID Related Accession (Same CDS sequence) | XM_006716894.3 , XM_011518074.2 | |
Accession Version | XM_011518074.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | B-cell differentiation antigen CD72 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011518074.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAAACCA GGAACCCCCA GTCTCATGGG GAGAACGGAG CCTCACCCTG GAGCTGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011516376.1 |
CDS | 555..1643 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAAACCA GGAACCCCCA GTCTCATGGG GAGAACGGAG CCTCACCCTG GAGCTGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu99033 | |
Clone ID Related Accession (Same CDS sequence) | XM_017015351.1 | |
Accession Version | XM_017015351.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | B-cell differentiation antigen CD72 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAAACCA GGAACCCCCA GTCTCATGGG GAGAACGGAG CCTCACCCTG GAGCTGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016870840.1 |
CDS | 510..1577 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAAACCA GGAACCCCCA GTCTCATGGG GAGAACGGAG CCTCACCCTG GAGCTGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Interferon-?-induced CD100 on na?ve CD8 |
Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis. |
A regulatory role for CD72 expression on B cells in systemic lupus erythematosus. |
Modulation of B cell regulatory molecules CD22 and CD72 in myasthenia gravis and multiple sclerosis. |
Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum. |