Gene Symbol | Bcl6 |
Entrez Gene ID | 12053 |
Full Name | B cell leukemia/lymphoma 6 |
Synonyms | Bcl5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Bcl6 cDNA ORF clone
gRNAs
Gene Symbol | Bcl6 |
Entrez Gene ID | 12053 |
Full Name | B cell leukemia/lymphoma 6 |
Synonyms | Bcl5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_030248940.1 | XP_030104800.1 | B-cell lymphoma 6 protein homolog isoform X1 |
NM_001348026.1 | NP_001334955.1 | B-cell lymphoma 6 protein homolog |
NM_009744.3 | NP_033874.1 | B-cell lymphoma 6 protein homolog |
XM_017316855.1 | XP_017172344.1 | B-cell lymphoma 6 protein homolog isoform X1 |
XM_030248941.1 | XP_030104801.1 | B-cell lymphoma 6 protein homolog isoform X1 |
NM_009744.4 | NP_033874.1 | B-cell lymphoma 6 protein homolog |
Bos taurus (cattle) | BCL6 | NP_001193379.1 |
Pan troglodytes (chimpanzee) | BCL6 | XP_001158812.1 |
Canis lupus familiaris (dog) | BCL6 | NP_001182333.1 |
Danio rerio (zebrafish) | bcl6a | NP_957028.1 |
Gallus gallus (chicken) | BCL6 | NP_001012948.1 |
Homo sapiens (human) | BCL6 | NP_001124317.1 |
BCL6 | XP_001103860.1 | |
Mus musculus (house mouse) | Bcl6 | NP_033874.1 |
Rattus norvegicus (Norway rat) | Bcl6 | NP_001100554.1 |
Xenopus tropicalis (tropical clawed frog) | bcl6 | NP_001116278.1 |
Control of inflammation, cytokine expression, and germinal center formation by BCL-6.
Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM
Science (New York, N.Y.)276(5312)589-92(1997 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These data describe a novel regulatory mechanism through which STAT3 and the Ikaros zinc finger transcription factors Aiolos and Ikaros cooperate to regulate Bcl-6 expression.
Title: Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4
Our data reveal a regulatory role of BCL6 in inhibiting antiviral resistance factors in follicular Th cells
Title: BCL6 represses antiviral resistance in follicular T helper cells.
data provide a novel mechanism for positive control of gene expression by Bcl6, and illuminate how Bcl6 and Blimp1 control follicular helper T cell differentiation
Title: Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice.
synergistic activity of Card11 mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model
Title: Synergistic activity of Card11 mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model.
The balance between CD4(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (encoding TCF-1) and by the expression of the inhibitory receptors PD-1 and LAG3.
Title: Opposing Development of Cytotoxic and Follicular Helper CD4?T Cells Controlled by the TCF-1-Bcl6 Nexus.
The following Bcl6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bcl6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu20603 | |
Clone ID Related Accession (Same CDS sequence) | XM_030248940.1 , NM_001348026.1 , NM_009744.3 , XM_017316855.1 , XM_030248941.1 , NM_009744.4 | |
Accession Version | NM_001348026.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2124bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | B-cell lymphoma 6 protein homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC158397.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001334955.1 |
CDS | 1546..3669 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20603 | |
Clone ID Related Accession (Same CDS sequence) | XM_030248940.1 , NM_001348026.1 , NM_009744.3 , XM_017316855.1 , XM_030248941.1 , NM_009744.4 | |
Accession Version | NM_009744.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2124bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-14 | |
Organism | Mus musculus(House mouse) | |
Product | B-cell lymphoma 6 protein homolog | |
Comment |
1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033874.1 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20603 | |
Clone ID Related Accession (Same CDS sequence) | XM_030248940.1 , NM_001348026.1 , NM_009744.3 , XM_017316855.1 , XM_030248941.1 , NM_009744.4 | |
Accession Version | NM_009744.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2124bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | B-cell lymphoma 6 protein homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC158397.2 and AK151229.1. On Jan 11, 2017 this sequence version replaced NM_009744.3. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK039228.1, AK036975.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033874.1 |
CDS | 329..2452 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20603 | |
Clone ID Related Accession (Same CDS sequence) | XM_030248940.1 , NM_001348026.1 , NM_009744.3 , XM_017316855.1 , XM_030248941.1 , NM_009744.4 | |
Accession Version | XM_030248940.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2124bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | B-cell lymphoma 6 protein homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030104800.1 |
CDS | 1618..3741 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20603 | |
Clone ID Related Accession (Same CDS sequence) | XM_030248940.1 , NM_001348026.1 , NM_009744.3 , XM_017316855.1 , XM_030248941.1 , NM_009744.4 | |
Accession Version | XM_017316855.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2124bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | B-cell lymphoma 6 protein homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017172344.1 |
CDS | 2078..4201 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20603 | |
Clone ID Related Accession (Same CDS sequence) | XM_030248940.1 , NM_001348026.1 , NM_009744.3 , XM_017316855.1 , XM_030248941.1 , NM_009744.4 | |
Accession Version | XM_030248941.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2124bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | B-cell lymphoma 6 protein homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030104801.1 |
CDS | 237..2360 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCCTCCC CGGCTGACAG CTGTATCCAG TTTACCCGGC ACGCTAGTGA TGTTCTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Control of inflammation, cytokine expression, and germinal center formation by BCL-6. |