Cd81 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd81
Entrez Gene ID	12520
Full Name	CD81 antigen
Synonyms	Tapa-1,Tapa1,Tspan28
General protein information	Preferred Names CD81 antigen Names CD81 antigen 26 kDa cell surface protein TAPA-1 target of the antiproliferative antibody 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 F5\|7 88.1 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_133655.2	NP_598416.1	CD81 antigen

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CD81	NP_001025510.1
Danio rerio (zebrafish)	zgc:92411	NP_001003735.1
Xenopus tropicalis (tropical clawed frog)	cd81	NP_989271.1
Pan troglodytes (chimpanzee)	CD81	NP_001009023.1
	CD81	XP_001093228.1
Bos taurus (cattle)	CD81	NP_001030271.1
Drosophila melanogaster (fruit fly)	Tsp96F	NP_524500.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000823	XP_316787.2
Homo sapiens (human)	CD81	NP_004347.1
Canis lupus familiaris (dog)	LOC611606	XP_005631797.1
Mus musculus (house mouse)	Cd81	NP_598416.1
Danio rerio (zebrafish)	cd81	NP_571593.2
Rattus norvegicus (Norway rat)	Cd81	NP_037219.1

Gene Ontology
Bibliography

Related articles in PubMed

Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo.
Ding Q, von Schaewen M, Hrebikova G, Heller B, Sandmann L, Plaas M, Ploss A
Journal of virology91(4)(2017 Feb)

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Chu VT, Graf R, Wirtz T, Weber T, Favret J, Li X, Petsch K, Tran NT, Sieweke MH, Berek C, K?hn R, Rajewsky K
Proceedings of the National Academy of Sciences of the United States of America113(44)12514-12519(2016 Nov)

Tetraspanin CD81 promotes tumor growth and metastasis by modulating the functions of T regulatory and myeloid-derived suppressor cells.
Vences-Catal?n F, Rajapaksa R, Srivastava MK, Marabelle A, Kuo CC, Levy R, Levy S
Cancer research75(21)4517-26(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

adoptive transfer of wild-type regulatory T cells into CD81-deficient mice was sufficient to promote tumor growth and metastasis; these findings suggested that CD81 modulates adaptive and innate immune responses
Title: Tetraspanin CD81 promotes tumor growth and metastasis by modulating the functions of T regulatory and myeloid-derived suppressor cells.

CD81-Rac interaction exerts an important regulatory role on the innate and adaptive immunity against bacterial infection and suggests a role for CD81 in the development of novel therapeutic targets during infectious diseases.
Title: CD81 controls immunity to Listeria infection through rac-dependent inhibition of proinflammatory mediator release and activation of cytotoxic T cells.

Plasmodium yoelii sporozoite rhoptry discharge occurs only in the presence of CD81, providing the first direct evidence for a role of CD81 during sporozoite productive invasion.
Title: CD81 is required for rhoptry discharge during host cell invasion by Plasmodium yoelii sporozoites.

Data suggest that GPC3 down-regulates hepatocyte proliferation by binding to hedgehog (HH) and down-regulating the HH signaling pathway and binding with CD81, thus making it unavailable to bind to Hhex and causing its nuclear translocation.
Title: Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex.

In vitro myotubes lacking CD9P-1 or both CD9 and CD81 fuse with a higher frequency than normal myotubes
Title: Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81.

The following Cd81 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd81 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13041	NM_133655.2 Latest version!	Mus musculus CD81 antigen (Cd81), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd81 ( NM_133655.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598416.1 Mus musculus CD81 antigen (Cd81), mRNA.

Price & Availability↑

CloneID	OMu13041
Clone ID Related Accession (Same CDS sequence)	NM_133655.2
Accession Version	NM_133655.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Mus musculus(house mouse)
Product	CD81 antigen
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY252638.1, AK166521.1, BQ175800.1 and BQ175686.1. On Dec 4, 2007 this sequence version replaced NM_133655.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.453457.1, BC011433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 20579434 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGTGG AGGGCTGCAC CAAATGCATC AAATACCTGC TCTTCGTCTT CAATTTCGTC 
TTCTGGCTGG CTGGAGGCGT GATCCTAGGT GTAGCTCTGT GGTTGCGTCA TGATCCACAG 
ACCACCAGCC TGCTGTACCT GGAACTGGGA AACAAACCGG CACCCAACAC CTTCTACGTG 
GGCATCTACA TTCTCATTGC TGTGGGAGCT GTGATGATGT TTGTAGGCTT CCTGGGGTGC 
TATGGGGCCA TCCAGGAGTC CCAGTGTCTG CTGGGGACGT TCTTCACCTG CCTTGTGATC 
CTGTTTGCCT GTGAGGTGGC TGCAGGCATC TGGGGCTTCG TAAACAAAGA CCAGATCGCC 
AAGGATGTGA AGCAGTTCTA TGACCAGGCC CTTCAGCAAG CTGTGATGGA TGATGATGCC 
AACAATGCCA AGGCTGTGGT GAAGACTTTC CATGAGACGC TCAACTGTTG TGGCTCCAAC 
GCACTGACCA CACTGACTAC CACCATACTG AGGAACAGCC TGTGTCCCTC AGGCGGCAAC 
ATACTCACCC CCTTACTGCA GCAAGATTGT CATCAGAAAA TCGATGAGCT CTTCTCTGGG 
AAGCTGTACC TCATTGGAAT TGCAGCCATT GTGGTAGCTG TCATTATGAT CTTTGAGATG 
ATTCTGAGCA TGGTGCTGTG CTGTGGCATC CGGAACAGCT CCGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598416.1
CDS	252..962
Translation	MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTSLLYLELGNKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVMDDDANNAKAVVKTFHETLNCCGSNALTTLTTTILRNSLCPSGGNILTPLLQQDCHQKIDELFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY

Target ORF information:

RefSeq Version	NM_133655.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD81 antigen (Cd81), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133655.2

ORF Insert Sequence:

ATGGGGGTGG AGGGCTGCAC CAAATGCATC AAATACCTGC TCTTCGTCTT CAATTTCGTC 
TTCTGGCTGG CTGGAGGCGT GATCCTAGGT GTAGCTCTGT GGTTGCGTCA TGATCCACAG 
ACCACCAGCC TGCTGTACCT GGAACTGGGA AACAAACCGG CACCCAACAC CTTCTACGTG 
GGCATCTACA TTCTCATTGC TGTGGGAGCT GTGATGATGT TTGTAGGCTT CCTGGGGTGC 
TATGGGGCCA TCCAGGAGTC CCAGTGTCTG CTGGGGACGT TCTTCACCTG CCTTGTGATC 
CTGTTTGCCT GTGAGGTGGC TGCAGGCATC TGGGGCTTCG TAAACAAAGA CCAGATCGCC 
AAGGATGTGA AGCAGTTCTA TGACCAGGCC CTTCAGCAAG CTGTGATGGA TGATGATGCC 
AACAATGCCA AGGCTGTGGT GAAGACTTTC CATGAGACGC TCAACTGTTG TGGCTCCAAC 
GCACTGACCA CACTGACTAC CACCATACTG AGGAACAGCC TGTGTCCCTC AGGCGGCAAC 
ATACTCACCC CCTTACTGCA GCAAGATTGT CATCAGAAAA TCGATGAGCT CTTCTCTGGG 
AAGCTGTACC TCATTGGAAT TGCAGCCATT GTGGTAGCTG TCATTATGAT CTTTGAGATG 
ATTCTGAGCA TGGTGCTGTG CTGTGGCATC CGGAACAGCT CCGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo.
Journal of virology91(4)(2017 Feb)
Ding Q,von Schaewen M,Hrebikova G,Heller B,Sandmann L,Plaas M,Ploss A

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Proceedings of the National Academy of Sciences of the United States of America113(44)12514-12519(2016 Nov)
Chu VT,Graf R,Wirtz T,Weber T,Favret J,Li X,Petsch K,Tran NT,Sieweke MH,Berek C,K?hn R,Rajewsky K

Tetraspanin CD81 promotes tumor growth and metastasis by modulating the functions of T regulatory and myeloid-derived suppressor cells.
Cancer research75(21)4517-26(2015 Nov)
Vences-Catal?n F,Rajapaksa R,Srivastava MK,Marabelle A,Kuo CC,Levy R,Levy S

REQUEST A QUOTE

EMAIL

[email protected]

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

FAX

1-732-210-0262

Cd81 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM

FAX