Crhbp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Crhbp
Entrez Gene ID	12919
Full Name	corticotropin releasing hormone binding protein
Synonyms	CRH-BP
General protein information	Preferred Names corticotropin releasing hormone binding protein Names corticotropin-releasing factor-binding protein CRF-BP CRF-binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 D1\|13 49.5 cM

mRNA and Protein(s)

mRNA Protein Name

NM_198408.3 NP_940800.1 corticotropin-releasing factor-binding protein precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_198408.3	NP_940800.1	corticotropin-releasing factor-binding protein precursor

Homologies

	CRHBP	XP_001106453.1
Mus musculus (house mouse)	Crhbp	NP_940800.1
Gallus gallus (chicken)	CRHBP	XP_424801.3
Danio rerio (zebrafish)	crhbp	NP_001003459.1
Rattus norvegicus (Norway rat)	Crhbp	NP_631922.1
Drosophila melanogaster (fruit fly)	CG15537	NP_001097981.1
Xenopus tropicalis (tropical clawed frog)	crhbp	XP_002940913.1
Bos taurus (cattle)	CRHBP	NP_001094672.1
Homo sapiens (human)	CRHBP	NP_001873.2
Pan troglodytes (chimpanzee)	CRHBP	XP_001144864.1
Canis lupus familiaris (dog)	CRHBP	XP_853211.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000955	XP_309147.5

Gene Ontology
Bibliography

Related articles in PubMed

Lef1-dependent hypothalamic neurogenesis inhibits anxiety.
Xie Y, Kaufmann D, Moulton MJ, Panahi S, Gaynes JA, Watters HN, Zhou D, Xue HH, Fung CM, Levine EM, Letsou A, Brennan KC, Dorsky RI
PLoS biology15(8)e2002257(2017 Aug)

Binge Drinking Decreases Corticotropin-Releasing Factor-Binding Protein Expression in the Medial Prefrontal Cortex of Mice.
Ketchesin KD, Stinnett GS, Seasholtz AF
Alcoholism, clinical and experimental research40(8)1641-50(2016 Aug)

Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning.
Knoll AT, Halladay LR, Holmes AJ, Levitt P
The Journal of neuroscience : the official journal of the Society for Neuroscience36(23)6258-68(2016 06)

Pituitary CRH-binding protein and stress in female mice.
Stinnett GS, Westphal NJ, Seasholtz AF
Physiology & behavior15016-23(2015 Oct)

Corticotropin Releasing Factor Binding Protein and CRF2 Receptors in the Ventral Tegmental Area: Modulation of Ethanol Binge Drinking in C57BL/6J Mice.
Albrechet-Souza L, Hwa LS, Han X, Zhang EY, DeBold JF, Miczek KA
Alcoholism, clinical and experimental research39(9)1609-18(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Repeated cycles of binge drinking alter CRF-BP mRNA expression in the medial prefrontal cortex.
Title: Binge Drinking Decreases Corticotropin-Releasing Factor-Binding Protein Expression in the Medial Prefrontal Cortex of Mice.

These studies demonstrate a role for the pituitary CRH-BP in attenuating the HPA response to stress in female mice.
Title: Pituitary CRH-binding protein and stress in female mice.

Ventral tegmental area CRH-BP is involved in the initial stages of escalated ethanol drinking.
Title: Corticotropin Releasing Factor Binding Protein and CRF2 Receptors in the Ventral Tegmental Area: Modulation of Ethanol Binge Drinking in C57BL/6J Mice.

Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression.
Title: Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression.

analysis of regulation and function of CRH-BP [review]
Title: CRH-BP: the regulation and function of a phylogenetically conserved binding protein.

The following Crhbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crhbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08987	NM_198408.3 Latest version!	Mus musculus corticotropin releasing hormone binding protein (Crhbp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crhbp ( NM_198408.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_940800.1 Mus musculus corticotropin releasing hormone binding protein (Crhbp), mRNA.

Price & Availability↑

CloneID	OMu08987
Clone ID Related Accession (Same CDS sequence)	NM_198408.3
Accession Version	NM_198408.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	corticotropin-releasing factor-binding protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK135067.1 and AI854101.1. On Dec 11, 2007 this sequence version replaced NM_198408.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061247.1, AK135067.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCACCGA ACTTCAAACT CCAATGTCAC TTCATTCTGA TCCTCCTGAC AGCTCTAAGG 
GGAGAGAGCC GCTACCTAGA GGTGCAAGAA GCCGCGGTCT ACGACCCTCT CCTGCTCTTC 
AGTGCCAATC TGAAGCGGGA CCTGGCAGAG GAGCAGCCGT ACCGACGGGC TCTGCGGTGC 
CTGGACATGC TGAGCCTCCC TGGCCAGTTC ACCTTCACCG CAGACCGGCC GCAGCTGCAC 
TGCGCCGCCT TCTTCATCGG CGAACCCGAG GAATTCATCA CCATCCACTA TGACCTGGTC 
TCCATCGACT GCCAAGGCGG GGATTTCCTG AAGGTATTTG ATGGTTGGAT CCTAAAGGGA 
GAGAAATTCC CAAGTTCTCA GGATCACCCT CTGCCCACTA TGAAGAGGTA CACAGATTTC 
TGTGAGAGTG GTCTTACCAG AAGGAGCATC AGGTCTTCCC AGAATGTGGC CATGGTCTTC 
TTCCGGGTCC ACGAACCAGG AAATGGATTC ACGATAACCA TAAAGACAGA TCCCAACCTC 
TTCCCTTGCA ATGTCATCTC TCAGACTCCG AGTGGAAGGT TTACTTTAGT GGTTCCATAC 
CAGCACCAAA ACTGCAGCTT CTCCATCATC TATCCAGTGG CAATCAAAAT CTCTGATCTT 
ACCCTCGGAC ACTTGCATGG CCTTCAGTTA AAGAAACCTG CGGCTGGCTG CGGTGGGACT 
GGTGACTTTG TGGAGCTGCT GGGAGGAACT GGATTGGACC CCTCCAAGAT GATGCCCTTA 
GCAGACCTGT GTTACCCCTT TCTCGGCCCT GCCCAGATGA AAATTAGCTG CGACAATGCT 
GTGGTACGCA TGGTCTCCAG TGGGAAACAC ATTAACCGTG TGACATTTGA GTATCGTCAG 
CTGGAGCCAT TCGAGCTAGA AACCTCGACC GGAAACAGCA TCCCAGAATA CTGTTTGTCT 
AGTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_940800.1
CDS	152..1120
Translation	MSPNFKLQCHFILILLTALRGESRYLEVQEAAVYDPLLLFSANLKRDLAEEQPYRRALRCLDMLSLPGQFTFTADRPQLHCAAFFIGEPEEFITIHYDLVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPTMKRYTDFCESGLTRRSIRSSQNVAMVFFRVHEPGNGFTITIKTDPNLFPCNVISQTPSGRFTLVVPYQHQNCSFSIIYPVAIKISDLTLGHLHGLQLKKPAAGCGGTGDFVELLGGTGLDPSKMMPLADLCYPFLGPAQMKISCDNAVVRMVSSGKHINRVTFEYRQLEPFELETSTGNSIPEYCLSSL

Target ORF information:

RefSeq Version	NM_198408.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus corticotropin releasing hormone binding protein (Crhbp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198408.3

ORF Insert Sequence:

ATGTCACCGA ACTTCAAACT CCAATGTCAC TTCATTCTGA TCCTCCTGAC AGCTCTAAGG 
GGAGAGAGCC GCTACCTAGA GGTGCAAGAA GCCGCGGTCT ACGACCCTCT CCTGCTCTTC 
AGTGCCAATC TGAAGCGGGA CCTGGCAGAG GAGCAGCCGT ACCGACGGGC TCTGCGGTGC 
CTGGACATGC TGAGCCTCCC TGGCCAGTTC ACCTTCACCG CAGACCGGCC GCAGCTGCAC 
TGCGCCGCCT TCTTCATCGG CGAACCCGAG GAATTCATCA CCATCCACTA TGACCTGGTC 
TCCATCGACT GCCAAGGCGG GGATTTCCTG AAGGTATTTG ATGGTTGGAT CCTAAAGGGA 
GAGAAATTCC CAAGTTCTCA GGATCACCCT CTGCCCACTA TGAAGAGGTA CACAGATTTC 
TGTGAGAGTG GTCTTACCAG AAGGAGCATC AGGTCTTCCC AGAATGTGGC CATGGTCTTC 
TTCCGGGTCC ACGAACCAGG AAATGGATTC ACGATAACCA TAAAGACAGA TCCCAACCTC 
TTCCCTTGCA ATGTCATCTC TCAGACTCCG AGTGGAAGGT TTACTTTAGT GGTTCCATAC 
CAGCACCAAA ACTGCAGCTT CTCCATCATC TATCCAGTGG CAATCAAAAT CTCTGATCTT 
ACCCTCGGAC ACTTGCATGG CCTTCAGTTA AAGAAACCTG CGGCTGGCTG CGGTGGGACT 
GGTGACTTTG TGGAGCTGCT GGGAGGAACT GGATTGGACC CCTCCAAGAT GATGCCCTTA 
GCAGACCTGT GTTACCCCTT TCTCGGCCCT GCCCAGATGA AAATTAGCTG CGACAATGCT 
GTGGTACGCA TGGTCTCCAG TGGGAAACAC ATTAACCGTG TGACATTTGA GTATCGTCAG 
CTGGAGCCAT TCGAGCTAGA AACCTCGACC GGAAACAGCA TCCCAGAATA CTGTTTGTCT 
AGTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lef1-dependent hypothalamic neurogenesis inhibits anxiety.
PLoS biology15(8)e2002257(2017 Aug)
Xie Y,Kaufmann D,Moulton MJ,Panahi S,Gaynes JA,Watters HN,Zhou D,Xue HH,Fung CM,Levine EM,Letsou A,Brennan KC,Dorsky RI

Binge Drinking Decreases Corticotropin-Releasing Factor-Binding Protein Expression in the Medial Prefrontal Cortex of Mice.
Alcoholism, clinical and experimental research40(8)1641-50(2016 Aug)
Ketchesin KD,Stinnett GS,Seasholtz AF

Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience36(23)6258-68(2016 06)
Knoll AT,Halladay LR,Holmes AJ,Levitt P

Pituitary CRH-binding protein and stress in female mice.
Physiology & behavior15016-23(2015 Oct)
Stinnett GS,Westphal NJ,Seasholtz AF

Corticotropin Releasing Factor Binding Protein and CRF2 Receptors in the Ventral Tegmental Area: Modulation of Ethanol Binge Drinking in C57BL/6J Mice.
Alcoholism, clinical and experimental research39(9)1609-18(2015 Sep)
Albrechet-Souza L,Hwa LS,Han X,Zhang EY,DeBold JF,Miczek KA

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Crhbp cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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