Efna2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Efna2
Entrez Gene ID	13637
Full Name	ephrin A2
Synonyms	CEK7L,Elf1,Epl6,Eplg6,Lerk6
General protein information	Preferred Names ephrin A2 Names ephrin-A2 CEK7-ligand EPH related receptor tyrosine kinase ligand 6 ephrin A6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 C1\|10 39.72 cM

mRNA and Protein(s)

mRNA Protein Name

NM_007909.3 NP_031935.3 ephrin-A2 precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_007909.3	NP_031935.3	ephrin-A2 precursor

Homologies

Pan troglodytes (chimpanzee)	EFNA2	XP_001172483.1
Bos taurus (cattle)	EFNA2	NP_001098470.1
Rattus norvegicus (Norway rat)	Efna2	NP_001162141.1
Danio rerio (zebrafish)	LOC100332852	XP_002663773.1
Homo sapiens (human)	EFNA2	NP_001396.2
Mus musculus (house mouse)	Efna2	NP_031935.3
Gallus gallus (chicken)	EFNA2	NP_990314.1
Danio rerio (zebrafish)	efna2	NP_571097.1
	LOC721231	XP_001117318.1
Xenopus tropicalis (tropical clawed frog)	efna2	NP_001116892.1

Gene Ontology
Bibliography

Related articles in PubMed

Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex.
Homman-Ludiye J, Kwan WC, de Souza MJ, Rodger J, Bourne JA
Scientific reports7(1)11813(2017 Sep)

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.
Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G, Mitchell KJ
PloS one12(5)e0177977(2017)

Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis.
Flenniken AM, Gale NW, Yancopoulos GD, Wilkinson DG
Developmental biology179(2)382-401(1996 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ephrin-A2 and Ephrin-A5 are important for the functional development of cutaneous innervation.
Title: Ephrin-A2 and Ephrin-A5 are important for the functional development of cutaneous innervation in a mouse model.

The ephrin-A2/-A3 DKO mice have utility as a novel ASD model with an emphasis on sensory abnormalities and restricted, repetitive behavioral symptoms.
Title: Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders.

The results of this study suggested that majority of the changes observed ephrin-A2 and ephrin-A5 KO mice appear to be mediated by the effects on motor neurons and their muscle targets, rather than changes in auditory sensitivity.
Title: The role of ephrin-A2 and ephrin-A5 in sensorimotor control and gating.

At high frequencies, the ephrin-A2A5(-/-) mice exhibited thresholds that were significantly lower than in wild-type mice by approximately 20 dB, suggesting ephrin-A2 and ephrin-A5 may have frequency-specific effects on the auditory system.
Title: Auditory brainstem responses of ephrin-A2, ephrin-A5(-/-) and ephrin-A2A5(-/-) mice.

Ephrin-A2 and -A3 are negative regulators of the proliferative and neurogenic potentials of Muller cells.
Title: Ephrin-A2 and -A3 are negative regulators of the regenerative potential of M?ller cells.

The following Efna2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Efna2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15916	NM_007909.3 Latest version!	Mus musculus ephrin A2 (Efna2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Efna2 ( NM_007909.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031935.3 Mus musculus ephrin A2 (Efna2), mRNA.

Price & Availability↑

CloneID	OMu15916
Clone ID Related Accession (Same CDS sequence)	NM_007909.3
Accession Version	NM_007909.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	ephrin-A2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK140544.1, AC159999.6 and CF740879.1. On Jul 2, 2009 this sequence version replaced NM_007909.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK140544.1, BC048697.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCCG CGCAGCGCCC GCTGCTGCCG CTGCTGCTGC TGCTGCTGCC GCTGCGTGCG 
CGCAACGAGG ACCCGGCCCG GGCCAACGCT GACCGATACG CAGTCTACTG GAACCGTAGC 
AACCCCAGGT TTCAGGTGAG CGCTGTGGGT GATGGCGGCG GCTATACCGT GGAGGTGAGC 
ATCAACGACT ACCTGGATAT CTACTGCCCA CACTACGGGG CGCCGCTGCC CCCGGCTGAG 
CGCATGGAGC GGTACATCCT GTACATGGTG AATGGTGAGG GCCACGCCTC CTGTGACCAC 
CGGCAGCGAG GCTTCAAGCG CTGGGAATGC AACCGGCCCG CAGCGCCCGG GGGACCCCTC 
AAGTTCTCAG AGAAGTTCCA ACTCTTCACC CCCTTTTCCC TGGGCTTTGA GTTCCGGCCT 
GGCCACGAAT ACTACTACAT CTCTGCCACA CCTCCCAACC TCGTGGACCG ACCCTGCCTG 
CGACTCAAGG TTTATGTGCG TCCAACCAAT GAGACCCTGT ATGAGGCTCC AGAGCCCATC 
TTCACCAGTA ACAGCTCCTG CAGCGGCCTG GGTGGCTGCC ACCTCTTCCT CACCACCGTC 
CCTGTGCTGT GGTCCCTTCT GGGCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031935.3
CDS	282..911
Translation	MAPAQRPLLPLLLLLLPLRARNEDPARANADRYAVYWNRSNPRFQVSAVGDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMERYILYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNLVDRPCLRLKVYVRPTNETLYEAPEPIFTSNSSCSGLGGCHLFLTTVPVLWSLLGS

Target ORF information:

RefSeq Version	NM_007909.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ephrin A2 (Efna2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007909.3

ORF Insert Sequence:

ATGGCGCCCG CGCAGCGCCC GCTGCTGCCG CTGCTGCTGC TGCTGCTGCC GCTGCGTGCG 
CGCAACGAGG ACCCGGCCCG GGCCAACGCT GACCGATACG CAGTCTACTG GAACCGTAGC 
AACCCCAGGT TTCAGGTGAG CGCTGTGGGT GATGGCGGCG GCTATACCGT GGAGGTGAGC 
ATCAACGACT ACCTGGATAT CTACTGCCCA CACTACGGGG CGCCGCTGCC CCCGGCTGAG 
CGCATGGAGC GGTACATCCT GTACATGGTG AATGGTGAGG GCCACGCCTC CTGTGACCAC 
CGGCAGCGAG GCTTCAAGCG CTGGGAATGC AACCGGCCCG CAGCGCCCGG GGGACCCCTC 
AAGTTCTCAG AGAAGTTCCA ACTCTTCACC CCCTTTTCCC TGGGCTTTGA GTTCCGGCCT 
GGCCACGAAT ACTACTACAT CTCTGCCACA CCTCCCAACC TCGTGGACCG ACCCTGCCTG 
CGACTCAAGG TTTATGTGCG TCCAACCAAT GAGACCCTGT ATGAGGCTCC AGAGCCCATC 
TTCACCAGTA ACAGCTCCTG CAGCGGCCTG GGTGGCTGCC ACCTCTTCCT CACCACCGTC 
CCTGTGCTGT GGTCCCTTCT GGGCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex.
Scientific reports7(1)11813(2017 Sep)
Homman-Ludiye J,Kwan WC,de Souza MJ,Rodger J,Bourne JA

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.
PloS one12(5)e0177977(2017)
Bibollet-Bahena O,Okafuji T,Hokamp K,Tear G,Mitchell KJ

Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis.
Developmental biology179(2)382-401(1996 Nov)
Flenniken AM,Gale NW,Yancopoulos GD,Wilkinson DG

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Efna2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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