Gene Symbol | Pola1 |
Entrez Gene ID | 18968 |
Full Name | polymerase (DNA directed), alpha 1 |
Synonyms | AW321876,Pola |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Pola1 cDNA ORF clone
gRNAs
Gene Symbol | Pola1 |
Entrez Gene ID | 18968 |
Full Name | polymerase (DNA directed), alpha 1 |
Synonyms | AW321876,Pola |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006527905.4 | XP_006527968.1 | DNA polymerase alpha catalytic subunit isoform X1 |
NM_008892.2 | NP_032918.1 | DNA polymerase alpha catalytic subunit |
XM_006527905.3 | XP_006527968.1 | DNA polymerase alpha catalytic subunit isoform X1 |
POLA1 | XP_001091195.1 | |
Gallus gallus (chicken) | POLA1 | XP_416792.3 |
Eremothecium gossypii | AGOS_AER381C | NP_985237.1 |
Homo sapiens (human) | POLA1 | NP_058633.2 |
Rattus norvegicus (Norway rat) | Pola1 | NP_445931.1 |
Schizosaccharomyces pombe (fission yeast) | pol1 | NP_594186.1 |
Pan troglodytes (chimpanzee) | POLA1 | XP_003317445.2 |
Mus musculus (house mouse) | Pola1 | NP_032918.1 |
Danio rerio (zebrafish) | pola1 | XP_005162809.1 |
Drosophila melanogaster (fruit fly) | DNApol-alpha180 | NP_536736.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001929 | XP_321134.5 |
Caenorhabditis elegans (roundworm) | Y47D3A.29 | NP_001255109.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_06397 | XP_003717174.1 |
Neurospora crassa | NCU07870 | XP_963131.2 |
Arabidopsis thaliana (thale cress) | ICU2 | NP_201511.2 |
Xenopus tropicalis (tropical clawed frog) | pola1 | XP_004911812.1 |
Bos taurus (cattle) | POLA1 | NP_001192994.1 |
Saccharomyces cerevisiae (baker's yeast) | POL1 | NP_014297.3 |
Kluyveromyces lactis | KLLA0C13255g | XP_452791.1 |
Canis lupus familiaris (dog) | POLA1 | XP_005641271.1 |
Oryza sativa (rice) | Os01g0868300 | NP_001044920.1 |
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J
Immunity43(4)690-702(2015 Oct)
Phenotypic annotation of the mouse X chromosome.
Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, Gertsenstein M, van Campenhout C, Floss T, K?hn R, Wurst W, Lickert H, Rossant J
Genome research20(8)1154-64(2010 Aug)
Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus.
Eichinger CS, Mizuno T, Mizuno K, Miyake Y, Yanagi K, Imamoto N, Hanaoka F
The Journal of biological chemistry284(44)30604-14(2009 Oct)
Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha.
Maeda N, Kokai Y, Ohtani S, Sahara H, Kuriyama I, Kamisuki S, Takahashi S, Sakaguchi K, Sugawara F, Yoshida H, Sato N, Mizushina Y
Biochemical and biophysical research communications352(2)390-6(2007 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
two mechanisms that prevent the nuclear expression of aberrant DNA polymerase alpha p180
Title: Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus.
Therefore, dehydroaltenusin could be of interest as not only a mammalian pol alpha-specific inhibitor, but also as a candidate drug for anti-cancer treatment.
Title: Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha.
DNA polymerase alpha is essential for genome-wide DNA replication, hypomorphic activity and leads to a rather specific spectrum of chromosomal abnormality.
Title: Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha.
The following Pola1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pola1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu56208 | |
Clone ID Related Accession (Same CDS sequence) | XM_006527905.4 , XM_006527905.3 | |
Accession Version | XM_006527905.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4167bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase alpha catalytic subunit isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006527905.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGCCCA TGCACGAAGA GGACTGTAAA CTGGAGGCAA GCGCTGTGTC AGATTCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006527968.1 |
CDS | 277..4443 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCCCA TGCACGAAGA GGACTGTAAA CTGGAGGCAA GCGCTGTGTC AGATTCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu15413 | |
Clone ID Related Accession (Same CDS sequence) | NM_008892.2 | |
Accession Version | NM_008892.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4398bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase alpha catalytic subunit | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from D17384.1, BC138047.1 and CJ133126.1. On Oct 31, 2009 this sequence version replaced NM_008892.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D17384.1, D13543.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCGCCCA TGCACGAAGA GGACTGTAAA CTGGAGGCAA GCGCTGTGTC AGATTCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032918.1 |
CDS | 45..4442 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCCCA TGCACGAAGA GGACTGTAAA CTGGAGGCAA GCGCTGTGTC AGATTCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu56208 | |
Clone ID Related Accession (Same CDS sequence) | XM_006527905.4 , XM_006527905.3 | |
Accession Version | XM_006527905.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4167bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase alpha catalytic subunit isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006527905.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGCCCA TGCACGAAGA GGACTGTAAA CTGGAGGCAA GCGCTGTGTC AGATTCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006527968.1 |
CDS | 99..4265 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCCCA TGCACGAAGA GGACTGTAAA CTGGAGGCAA GCGCTGTGTC AGATTCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. |
Phenotypic annotation of the mouse X chromosome. |
Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus. |
Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha. |